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Brain clearance is reduced during sleep and anesthesia Nat. Neurosci. (IF 25.0) Pub Date : 2024-05-13 Andawei Miao, Tianyuan Luo, Bryan Hsieh, Christopher J. Edge, Morgan Gridley, Ryan Tak Chun Wong, Timothy G. Constandinou, William Wisden, Nicholas P. Franks
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Cognitive representations of intracranial self-stimulation of midbrain dopamine neurons depend on stimulation frequency Nat. Neurosci. (IF 25.0) Pub Date : 2024-05-13 Samuel J. Millard, Ivy B. Hoang, Savannah Sherwood, Masakazu Taira, Vanessa Reyes, Zara Greer, Shayna L. O’Connor, Kate M. Wassum, Morgan H. James, David J. Barker, Melissa J. Sharpe
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The subcommissural organ regulates brain development via secreted peptides Nat. Neurosci. (IF 25.0) Pub Date : 2024-05-13 Tingting Zhang, Daosheng Ai, Pingli Wei, Ying Xu, Zhanying Bi, Fengfei Ma, Fengzhi Li, Xing-jun Chen, Zhaohuan Zhang, Xiaoxiao Zou, Zongpei Guo, Yue Zhao, Jun-Liszt Li, Meng Ye, Ziyan Feng, Xinshuang Zhang, Lijun Zheng, Jie Yu, Chunli Li, Tianqi Tu, Hongkui Zeng, Jianfeng Lei, Hongqi Zhang, Tao Hong, Li Zhang, Benyan Luo, Zhen Li, Chao Xing, Chenxi Jia, Lingjun Li, Wenzhi Sun, Woo-ping Ge
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Big data for everyone Nat. Neurosci. (IF 25.0) Pub Date : 2024-05-09 Henrietta Howells
Raw neuroimaging data require further processing before they can be used for scientific or clinical research. Traditionally, this could be accomplished with a single powerful computer. However, much greater computing power is required to analyze the large open-access cohorts that are increasingly being released to the community. And processing pipelines are inconsistently scripted, which can hinder
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A neuronally balanced diet Nat. Neurosci. (IF 25.0) Pub Date : 2024-05-09 George Andrew S. Inglis
The nucleus accumbens (NAc) is known for its role in reward processing or motivation, but more recently it has also been linked to altered eating behaviors in disorders such as anorexia nervosa. In a study published in Nature Communications, Walle et al. investigated the subtype-specific roles of medium spiny neurons (MSNs) in the NAc in mouse feeding behaviors. The authors chemogenetically manipulated
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Including tau inclusions Nat. Neurosci. (IF 25.0) Pub Date : 2024-05-09 Rebecca Wright
Neurons derived from human induced pluripotent stem cells (hIPSCs) hold great potential for unravelling the pathological mechanisms underlying neurological diseases. However, when it comes to tauopathies, hIPSC models are limited by their low expression of 4R tau and difficulty in reproducing the characteristic pathological tau protein inclusions. In a study published in Cell, Parra Bravo, Giani et
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Targeting pathological cells with senolytic drugs reduces seizures in neurodevelopmental mTOR-related epilepsy Nat. Neurosci. (IF 25.0) Pub Date : 2024-05-06 Théo Ribierre, Alexandre Bacq, Florian Donneger, Marion Doladilhe, Marina Maletic, Delphine Roussel, Isabelle Le Roux, Francine Chassoux, Bertrand Devaux, Homa Adle-Biassette, Sarah Ferrand-Sorbets, Georg Dorfmüller, Mathilde Chipaux, Sara Baldassari, Jean-Christophe Poncer, Stéphanie Baulac
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Dimensionality reduction beyond neural subspaces with slice tensor component analysis Nat. Neurosci. (IF 25.0) Pub Date : 2024-05-06 Arthur Pellegrino, Heike Stein, N. Alex Cayco-Gajic
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Closed-loop recruitment of striatal interneurons prevents compulsive-like grooming behaviors Nat. Neurosci. (IF 25.0) Pub Date : 2024-05-01 Sirenia Lizbeth Mondragón-González, Christiane Schreiweis, Eric Burguière
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Two common and distinct forms of variation in human functional brain networks Nat. Neurosci. (IF 25.0) Pub Date : 2024-04-30 Ally Dworetsky, Benjamin A. Seitzman, Babatunde Adeyemo, Ashley N. Nielsen, Alexander S. Hatoum, Derek M. Smith, Thomas E. Nichols, Maital Neta, Steven E. Petersen, Caterina Gratton
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Feature-selective responses in macaque visual cortex follow eye movements during natural vision Nat. Neurosci. (IF 25.0) Pub Date : 2024-04-29 Will Xiao, Saloni Sharma, Gabriel Kreiman, Margaret S. Livingstone
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Assessing the contribution of the chemical exposome to neurodegenerative disease Nat. Neurosci. (IF 25.0) Pub Date : 2024-04-29 S. Lefèvre-Arbogast, J. Chaker, F. Mercier, R. Barouki, X. Coumoul, G. W. Miller, A. David, C. Samieri
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Abstract deliberation by visuomotor neurons in prefrontal cortex Nat. Neurosci. (IF 25.0) Pub Date : 2024-04-29 Julie A. Charlton, Robbe L. T. Goris
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Unsupervised restoration of a complex learned behavior after large-scale neuronal perturbation Nat. Neurosci. (IF 25.0) Pub Date : 2024-04-29 Bo Wang, Zsofia Torok, Alison Duffy, David G. Bell, Shelyn Wongso, Tarciso A. F. Velho, Adrienne L. Fairhall, Carlos Lois
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A guide to science communication training for doctoral students Nat. Neurosci. (IF 25.0) Pub Date : 2024-04-26 Christina Maher, Trevonn Gyles, Eric J. Nestler, Daniela Schiller
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Three patterns link brain organization to genes in health and disease Nat. Neurosci. (IF 25.0) Pub Date : 2024-04-24
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Cortical gene expression architecture links healthy neurodevelopment to the imaging, transcriptomics and genetics of autism and schizophrenia Nat. Neurosci. (IF 25.0) Pub Date : 2024-04-22 Richard Dear, Konrad Wagstyl, Jakob Seidlitz, Ross D. Markello, Aurina Arnatkevičiūtė, Kevin M. Anderson, Richard A. I. Bethlehem, Armin Raznahan, Edward T. Bullmore, Petra E. Vértes
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In conversation with Fernando de Castro Soubriet Nat. Neurosci. (IF 25.0) Pub Date : 2024-04-18 Elisa Floriddia
As Nature Neuroscience celebrates its 25th anniversary, we are having conversations with both established leaders in the field and those earlier in their careers to discuss how the field has evolved and where it is heading. This month we are talking to Fernando de Castro Soubriet, principal investigator at the Instituto Cajal (Spain). He is a neurodevelopmental biologist who is actively involved in
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Identification of senescent, TREM2-expressing microglia in aging and Alzheimer’s disease model mouse brain Nat. Neurosci. (IF 25.0) Pub Date : 2024-04-18 Noa Rachmian, Sedi Medina, Ulysse Cherqui, Hagay Akiva, Daniel Deitch, Dunya Edilbi, Tommaso Croese, Tomer Meir Salame, Javier Maria Peralta Ramos, Liora Cahalon, Valery Krizhanovsky, Michal Schwartz
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Advancing the neuroscience of human pregnancy Nat. Neurosci. (IF 25.0) Pub Date : 2024-04-10 Magdalena Martínez-García, Emily G. Jacobs, Ann-Marie G. de Lange, Susana Carmona
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Messenger RNA transport on lysosomal vesicles maintains axonal mitochondrial homeostasis and prevents axonal degeneration Nat. Neurosci. (IF 25.0) Pub Date : 2024-04-10 Raffaella De Pace, Saikat Ghosh, Veronica H. Ryan, Mira Sohn, Michal Jarnik, Paniz Rezvan Sangsari, Nicole Y. Morgan, Ryan K. Dale, Michael E. Ward, Juan S. Bonifacino
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Widespread changes in alternative splicing in developing and adult mouse brain Nat. Neurosci. (IF 25.0) Pub Date : 2024-04-09
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Single-cell long-read sequencing-based mapping reveals specialized splicing patterns in developing and adult mouse and human brain Nat. Neurosci. (IF 25.0) Pub Date : 2024-04-09 Anoushka Joglekar, Wen Hu, Bei Zhang, Oleksandr Narykov, Mark Diekhans, Jordan Marrocco, Jennifer Balacco, Lishomwa C. Ndhlovu, Teresa A. Milner, Olivier Fedrigo, Erich D. Jarvis, Gloria Sheynkman, Dmitry Korkin, M. Elizabeth Ross, Hagen U. Tilgner
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Restoring sensation to prosthetics Nat. Neurosci. (IF 25.0) Pub Date : 2024-04-08 Henrietta Howells
Amputees often experience paresthesia and difficulties using prosthetic limbs because of impaired sensorimotor processing. Artificial peripheral nerve stimulation has shown promise in restoring brain–body communication for sensory processing. In a recent Nature Communications publication, Valle et al. report a biomimetic neurostimulation technique that improved mobility in people with lower-limb amputation
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HDAC3 stokes microglia in stroke Nat. Neurosci. (IF 25.0) Pub Date : 2024-04-08 George Andrew S. Inglis
Microglia play a complex role in the response to brain injury, with past work showing that these cells can both aid in the recovery from ischemic stroke and exacerbate its pathology. A recent study in Science Advances explores this topic through the chromatin remodeling protein HDAC3, which broadly activates the expression of target genes. The authors surgically induced transient focal cerebral ischemia
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Pushing the bounds on dimensionality Nat. Neurosci. (IF 25.0) Pub Date : 2024-04-08 Luis A. Mejia
Low-dimensional representations can capture structure in neural dynamics data, but it is unclear whether additional structure is being missed, especially when larger populations are sampled. Manley et al. have imaged the activity of up to a million neurons in dorsal cortex of awake head-fixed mice to directly measure how neural dimensionality scales with population size. Using shared variance component
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Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding Nat. Neurosci. (IF 25.0) Pub Date : 2024-04-08 Ezgi Hacisuleyman, Caryn R. Hale, Natalie Noble, Ji-dung Luo, John J. Fak, Misa Saito, Jin Chen, Jonathan S. Weissman, Robert B. Darnell
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Centripetal integration of past events in hippocampal astrocytes regulated by locus coeruleus Nat. Neurosci. (IF 25.0) Pub Date : 2024-04-03 Peter Rupprecht, Sian N. Duss, Denise Becker, Christopher M. Lewis, Johannes Bohacek, Fritjof Helmchen
An essential feature of neurons is their ability to centrally integrate information from their dendrites. The activity of astrocytes, in contrast, has been described as mostly uncoordinated across cellular compartments without clear central integration. Here we report conditional integration of calcium signals in astrocytic distal processes at their soma. In the hippocampus of adult mice of both sexes
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Climbing fibers provide essential instructive signals for associative learning Nat. Neurosci. (IF 25.0) Pub Date : 2024-04-02 N. Tatiana Silva, Jorge Ramírez-Buriticá, Dominique L. Pritchett, Megan R. Carey
Supervised learning depends on instructive signals that shape the output of neural circuits to support learned changes in behavior. Climbing fiber (CF) inputs to the cerebellar cortex represent one of the strongest candidates in the vertebrate brain for conveying neural instructive signals. However, recent studies have shown that Purkinje cell stimulation can also drive cerebellar learning and the
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Pervasive environmental chemicals impair oligodendrocyte development Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-25 Erin F. Cohn, Benjamin L. L. Clayton, Mayur Madhavan, Kristin A. Lee, Sara Yacoub, Yuriy Fedorov, Marissa A. Scavuzzo, Katie Paul Friedman, Timothy J. Shafer, Paul J. Tesar
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Xenografted human microglia display diverse transcriptomic states in response to Alzheimer’s disease-related amyloid-β pathology Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-27 Renzo Mancuso, Nicola Fattorelli, Anna Martinez-Muriana, Emma Davis, Leen Wolfs, Johanna Van Den Daele, Ivana Geric, Jessie Premereur, Paula Polanco, Baukje Bijnens, Pranav Preman, Lutgarde Serneels, Suresh Poovathingal, Sriram Balusu, Catherine Verfaillie, Mark Fiers, Bart De Strooper
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TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer disease mouse models Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-27 Edward N. Wilson, Congcong Wang, Michelle S. Swarovski, Kristy A. Zera, Hannah E. Ennerfelt, Qian Wang, Aisling Chaney, Esha Gauba, Javier A. Ramos Benitez, Yann Le Guen, Paras S. Minhas, Maharshi Panchal, Yuting J. Tan, Eran Blacher, Chinyere A. Iweka, Haley Cropper, Poorva Jain, Qingkun Liu, Swapnil S. Mehta, Abigail J. Zuckerman, Matthew Xin, Jacob Umans, Jolie Huang, Aarooran S. Durairaj, Geidy
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Long-term in vivo three-photon imaging reveals region-specific differences in healthy and regenerative oligodendrogenesis Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-27 Michael A. Thornton, Gregory L. Futia, Michael E. Stockton, Samuel A. Budoff, Alexandra N. Ramirez, Baris Ozbay, Omer Tzang, Karl Kilborn, Alon Poleg-Polsky, Diego Restrepo, Emily A. Gibson, Ethan G. Hughes
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A precision functional atlas of personalized network topography and probabilities Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-26 Robert J. M. Hermosillo, Lucille A. Moore, Eric Feczko, Óscar Miranda-Domínguez, Adam Pines, Ally Dworetsky, Gregory Conan, Michael A. Mooney, Anita Randolph, Alice Graham, Babatunde Adeyemo, Eric Earl, Anders Perrone, Cristian Morales Carrasco, Johnny Uriarte-Lopez, Kathy Snider, Olivia Doyle, Michaela Cordova, Sanju Koirala, Gracie J. Grimsrud, Nora Byington, Steven M. Nelson, Caterina Gratton, Steven
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Piezo1 regulates meningeal lymphatic vessel drainage and alleviates excessive CSF accumulation Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-25 Dongwon Choi, Eunkyung Park, Joshua Choi, Renhao Lu, Jin Suh Yu, Chiyoon Kim, Luping Zhao, James Yu, Brandon Nakashima, Sunju Lee, Dhruv Singhal, Joshua P. Scallan, Bin Zhou, Chester J. Koh, Esak Lee, Young-Kwon Hong
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Spatial enhancer activation influences inhibitory neuron identity during mouse embryonic development Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-25 Elena Dvoretskova, May C. Ho, Volker Kittke, Florian Neuhaus, Ilaria Vitali, Daniel D. Lam, Irene Delgado, Chao Feng, Miguel Torres, Juliane Winkelmann, Christian Mayer
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Recommendations for the responsible use and communication of race and ethnicity in neuroimaging research Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-22 Carlos Cardenas-Iniguez, Marybel Robledo Gonzalez
The growing availability of large-population human biomedical datasets provides researchers with unique opportunities to conduct rigorous and impactful studies on brain and behavioral development, allowing for a more comprehensive understanding of neurodevelopment in diverse populations. However, the patterns observed in these datasets are more likely to be influenced by upstream structural inequities
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A systems identification approach using Bayes factors to deconstruct the brain bases of emotion regulation Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-22 Ke Bo, Thomas E. Kraynak, Mijin Kwon, Michael Sun, Peter J. Gianaros, Tor D. Wager
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Myeloid cell replacement is neuroprotective in chronic experimental autoimmune encephalomyelitis Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-21 Marius Marc-Daniel Mader, Alan Napole, Danwei Wu, Micaiah Atkins, Alexa Scavetti, Yohei Shibuya, Aulden Foltz, Oliver Hahn, Yongjin Yoo, Ron Danziger, Christina Tan, Tony Wyss-Coray, Lawrence Steinman, Marius Wernig
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The dynamic state of a prefrontal–hypothalamic–midbrain circuit commands behavioral transitions Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-18 Changwan Chen, Mahsa Altafi, Mihaela-Anca Corbu, Aleksandra Trenk, Hanna van den Munkhof, Kristin Weineck, Franziska Bender, Marta Carus-Cadavieco, Alisa Bakhareva, Tatiana Korotkova, Alexey Ponomarenko
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Co-dependent excitatory and inhibitory plasticity accounts for quick, stable and long-lasting memories in biological networks Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-20 Everton J. Agnes, Tim P. Vogels
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Natural language instructions induce compositional generalization in networks of neurons Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-18 Reidar Riveland, Alexandre Pouget
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Local origin of excitatory–inhibitory tuning equivalence in a cortical network Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-15 Adrian J. Duszkiewicz, Pierre Orhan, Sofia Skromne Carrasco, Eleanor H. Brown, Eliott Owczarek, Gilberto R. Vite, Emma R. Wood, Adrien Peyrache
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Real-time analysis of large-scale neuronal imaging enables closed-loop investigation of neural dynamics Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-11 Chun-Feng Shang, Yu-Fan Wang, Mei-Ting Zhao, Qiu-Xiang Fan, Shan Zhao, Yu Qian, Sheng-Jin Xu, Yu Mu, Jie Hao, Jiu-Lin Du
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In conversation with Igor Adameyko Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-12 Elisa Floriddia
As Nature Neuroscience celebrates its 25th anniversary, we are having conversations with both established leaders in the field and those earlier in their careers to discuss how the field has evolved, and where it is heading. This month, we are talking to Igor Adameyko (Department Chair at the Center for Brain Research of the Medical University of Vienna, Austria, and a group leader at the Karolinska
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Liprin-α proteins are master regulators of human presynapse assembly Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-12 Berta Marcó de la Cruz, Joaquín Campos, Angela Molinaro, Xingqiao Xie, Gaowei Jin, Zhiyi Wei, Claudio Acuna, Fredrik H. Sterky
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Identification of a cold sensor in peripheral somatosensory neurons Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-11
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The kainate receptor GluK2 mediates cold sensing in mice Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-11 Wei Cai, Wenwen Zhang, Qin Zheng, Chia Chun Hor, Tong Pan, Mahar Fatima, Xinzhong Dong, Bo Duan, X. Z. Shawn Xu
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Learning with baby Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-07 Rebecca Wright
The rate at which young children learn new words astounds care-givers and scientists alike. Most models of early language acquisition have only been tested in laboratory settings using highly controlled stimuli. In a recent publication in Science, Vong et al. decided to take a more naturalistic approach. They collected 61 h of video footage of a toddler wearing a head-mounted camera as they went about
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The eyes have it Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-07 Leonie Welberg
Many social species use eye contact to guide social behaviors. To study how visual cues shape social decision making, Franch et al. wirelessly recorded eye movements and activity in the visual and prefrontal cortices in two pairs of freely moving macaque monkeys. To retrieve food rewards, paired monkeys — who could see each other through a transparent screen — each had to press and hold a button and
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Slowing human neurons Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-07 Shari Wiseman
Human neurodevelopment is slower than that of other mammalian species, and this timescale appears to be intrinsic to human neural cells. However, not much is known about the mechanisms that govern this maturational timing. In a recent paper in Nature, Ciceri et al. developed a human pluripotent stem cell culture protocol that synchronously generates a uniform population of cortical neurons. The authors
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Population coding of strategic variables during foraging in freely moving macaques Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-05 Neda Shahidi, Melissa Franch, Arun Parajuli, Paul Schrater, Anthony Wright, Xaq Pitkow, Valentin Dragoi
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The silence of the reactive astrocytes Nat. Neurosci. (IF 25.0) Pub Date : 2024-02-29 Francesco Limone, Shane Liddelow
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PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons Nat. Neurosci. (IF 25.0) Pub Date : 2024-02-29 Carmelo Milioto, Mireia Carcolé, Ashling Giblin, Rachel Coneys, Olivia Attrebi, Mhoriam Ahmed, Samuel S. Harris, Byung Il Lee, Mengke Yang, Robert A. Ellingford, Raja S. Nirujogi, Daniel Biggs, Sally Salomonsson, Matteo Zanovello, Paula de Oliveira, Eszter Katona, Idoia Glaria, Alla Mikheenko, Bethany Geary, Evan Udine, Deniz Vaizoglu, Sharifah Anoar, Khrisha Jotangiya, Gerard Crowley, Demelza M. Smeeth
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Mapping dysfunctional circuits in the frontal cortex using deep brain stimulation Nat. Neurosci. (IF 25.0) Pub Date : 2024-02-22 Barbara Hollunder, Jill L. Ostrem, Ilkem Aysu Sahin, Nanditha Rajamani, Simón Oxenford, Konstantin Butenko, Clemens Neudorfer, Pablo Reinhardt, Patricia Zvarova, Mircea Polosan, Harith Akram, Matteo Vissani, Chencheng Zhang, Bomin Sun, Pavel Navratil, Martin M. Reich, Jens Volkmann, Fang-Cheng Yeh, Juan Carlos Baldermann, Till A. Dembek, Veerle Visser-Vandewalle, Eduardo Joaquim Lopes Alho, Paulo Roberto
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Dopamine projections to the basolateral amygdala drive the encoding of identity-specific reward memories Nat. Neurosci. (IF 25.0) Pub Date : 2024-02-23 Ana C. Sias, Yousif Jafar, Caitlin M. Goodpaster, Kathia Ramírez-Armenta, Tyler M. Wrenn, Nicholas K. Griffin, Keshav Patel, Alexander C. Lamparelli, Melissa J. Sharpe, Kate M. Wassum
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Mapping the dysfunctome provides an avenue for targeted brain circuit therapy Nat. Neurosci. (IF 25.0) Pub Date : 2024-02-22
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Leaky blood–brain barrier in long-COVID-associated brain fog Nat. Neurosci. (IF 25.0) Pub Date : 2024-02-22
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Blood–brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment Nat. Neurosci. (IF 25.0) Pub Date : 2024-02-22 Chris Greene, Ruairi Connolly, Declan Brennan, Aoife Laffan, Eoin O’Keeffe, Lilia Zaporojan, Jeffrey O’Callaghan, Bennett Thomson, Emma Connolly, Ruth Argue, Ignacio Martin-Loeches, Aideen Long, Cliona Ni Cheallaigh, Niall Conlon, Colin P. Doherty, Matthew Campbell
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A phenotypic screening platform for identifying chemical modulators of astrocyte reactivity Nat. Neurosci. (IF 25.0) Pub Date : 2024-02-20 Benjamin L. L. Clayton, James D. Kristell, Kevin C. Allan, Erin F. Cohn, Molly Karl, Andrew D. Jerome, Eric Garrison, Yuka Maeno-Hikichi, Annalise M. Sturno, Alexis Kerr, H. Elizabeth Shick, Jesse A. Sepeda, Eric C. Freundt, Andrew R. Sas, Benjamin M. Segal, Robert H. Miller, Paul J. Tesar