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Structural deviations of the posterior fossa and the cerebellum and their cognitive links in a neurodevelopmental deletion syndrome Mol. Psychiatry (IF 11.0) Pub Date : 2024-05-14 Esra Sefik, Kuaikuai Duan, Yiheng Li, Brittney Sholar, Lindsey Evans, Jordan Pincus, Zeena Ammar, Melissa M. Murphy, Cheryl Klaiman, Celine A. Saulnier, Stormi L. Pulver, Adam E. Goldman-Yassen, Ying Guo, Elaine F. Walker, Longchuan Li, Jennifer G. Mulle, Sarah Shultz
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Gene – maltreatment interplay in adult ADHD symptoms: main role of a gene–environment correlation effect in a Brazilian population longitudinal study Mol. Psychiatry (IF 11.0) Pub Date : 2024-05-14 Luciana Tovo-Rodrigues, Laísa Camerini, Thais Martins-Silva, Marina Xavier Carpena, Carolina Bonilla, Isabel Oliveira Oliveira, Cristiane Silvestre de Paula, Joseph Murray, Aluísio J. D. Barros, Iná S. Santos, Luis Augusto Rohde, Mara Helena Hutz, Julia Pasqualini Genro, Alicia Matijasevich
Childhood maltreatment correlates with attention-deficit/hyperactivity disorder (ADHD) in previous research. The interaction between ADHD genetic predisposition and maltreatment’s impact on ADHD symptom risk remains unclear. We aimed to elucidate this relationship by examining the interplay between a polygenic score for ADHD (ADHD-PGS) and childhood maltreatment in predicting ADHD symptoms during young
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Adenosine mediates the amelioration of social novelty deficits during rhythmic light treatment of 16p11.2 deletion female mice Mol. Psychiatry (IF 11.0) Pub Date : 2024-05-13 Jun Ju, Xuanyi Li, Yifan Pan, Jun Du, Xinyi Yang, Siqi Men, Bo Liu, Zhenyu Zhang, Haolin Zhong, Jinyuan Mai, Yizheng Wang, Sheng-Tao Hou
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Reduction of APOE accounts for neurobehavioral deficits in fetal alcohol spectrum disorders Mol. Psychiatry (IF 11.0) Pub Date : 2024-05-11 Hye M. Hwang, Satoshi Yamashita, Yu Matsumoto, Mariko Ito, Alex Edwards, Junko Sasaki, Dipankar J. Dutta, Shahid Mohammad, Chiho Yamashita, Leah Wetherill, Tae-Hwi Schwantes-An, Marco Abreu, Amanda H. Mahnke, Sarah N. Mattson, Tatiana Foroud, Rajesh C. Miranda, Christina Chambers, Masaaki Torii, Kazue Hashimoto-Torii
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Occurrence and characteristics of suicidal ideation in psychiatrically healthy individuals based on ecological momentary assessment Mol. Psychiatry (IF 11.0) Pub Date : 2024-05-10 Maria A. Oquendo, Hanga C. Galfalvy, Tse-Hwei Choo, Sarah Herzog, Ainsley K. Burke, M. Elizabeth Sublette, J. John Mann, Barbara H. Stanley
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Functional connectivity of the amygdala subnuclei in various mood states of bipolar disorder Mol. Psychiatry (IF 11.0) Pub Date : 2024-05-09 Sidney Krystal, Laure Gracia, Camille Piguet, Chantal Henry, Mariana Alonso, Mircea Polosan, Julien Savatovsky, Josselin Houenou, Pauline Favre
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Genetic regulation of human brain proteome reveals proteins implicated in psychiatric disorders Mol. Psychiatry (IF 11.0) Pub Date : 2024-05-09 Jie Luo, Ling Li, Mingming Niu, Dehui Kong, Yi Jiang, Suresh Poudel, Annie W. Shieh, Lijun Cheng, Gina Giase, Kay Grennan, Kevin P. White, Chao Chen, Sidney H. Wang, Dalila Pinto, Yue Wang, Chunyu Liu, Junmin Peng, Xusheng Wang
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Neurogenesis-dependent remodeling of hippocampal circuits reduces PTSD-like behaviors in adult mice Mol. Psychiatry (IF 11.0) Pub Date : 2024-05-08 Risako Fujikawa, Adam I. Ramsaran, Axel Guskjolen, Juan de la Parra, Yi Zou, Andrew J. Mocle, Sheena A. Josselyn, Paul W. Frankland
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A transdiagnostic prodrome for severe mental disorders: an electronic health record study Mol. Psychiatry (IF 11.0) Pub Date : 2024-05-06 Maite Arribas, Dominic Oliver, Rashmi Patel, Daisy Kornblum, Hitesh Shetty, Stefano Damiani, Kamil Krakowski, Umberto Provenzani, Daniel Stahl, Nikolaos Koutsouleris, Philip McGuire, Paolo Fusar-Poli
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Anterior cingulate cortex-related functional hyperconnectivity underlies sensory hypersensitivity in Grin2b-mutant mice Mol. Psychiatry (IF 11.0) Pub Date : 2024-05-04 Soowon Lee, Won Beom Jung, Heera Moon, Geun Ho Im, Young Woo Noh, Wangyong Shin, Yong Gyu Kim, Jee Hyun Yi, Seok Jun Hong, Yongwhan Jung, Sunjoo Ahn, Seong-Gi Kim, Eunjoon Kim
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Monozygotic twins discordant for schizophrenia differ in maturation and synaptic transmission Mol. Psychiatry (IF 11.0) Pub Date : 2024-05-04 Shani Stern, Lei Zhang, Meiyan Wang, Rebecca Wright, Idan Rosh, Yara Hussein, Tchelet Stern, Ashwani Choudhary, Utkarsh Tripathi, Patrick Reed, Hagit Sadis, Ritu Nayak, Aviram Shemen, Karishma Agarwal, Diogo Cordeiro, David Peles, Yuqing Hang, Ana P. D. Mendes, Tithi D. Baul, Julien G. Roth, Shashank Coorapati, Marco P. Boks, W. Richard McCombie, Hilleke Hulshoff Pol, Kristen J. Brennand, János M.
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Autism patient-derived SHANK2BY29X mutation affects the development of ALDH1A1 negative dopamine neuron Mol. Psychiatry (IF 11.0) Pub Date : 2024-05-04 Wanjing Lai, Yingying Zhao, Yalan Chen, Zhenzhu Dai, Ruhai Chen, Yimei Niu, Xiaoxia Chen, Shuting Chen, Guanqun Huang, Ziyun Shan, Jiajun Zheng, Yu Hu, Qingpei Chen, Siyi Gong, Sai Kang, Hui Guo, Xiaokuang Ma, Youqiang Song, Kun Xia, Jie Wang, Libing Zhou, Kwok-Fai So, Kai Wang, Shenfeng Qiu, Li Zhang, Jiekai Chen, Lingling Shi
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The role of environmental sensitivity in the mental health of Syrian refugee children: a multi-level analysis Mol. Psychiatry (IF 11.0) Pub Date : 2024-05-03 Andrew K. May, Demelza Smeeth, Fiona McEwen, Elie Karam, Michael J. Rieder, Abdelbaset A. Elzagallaai, Stan van Uum, Francesca Lionetti, Michael Pluess
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A disinhibitory microcircuit of the orbitofrontal cortex mediates cocaine preference in mice Mol. Psychiatry (IF 11.0) Pub Date : 2024-05-02 Ziran Huang, Xiaoyan Wei, Jing Tian, Yangxue Fu, Jihui Dong, Yihui Wang, Jie Shi, Lin Lu, Wen Zhang
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The interplay between polygenic score for tumor necrosis factor-α, brain structural connectivity, and processing speed in major depression Mol. Psychiatry (IF 11.0) Pub Date : 2024-05-01 Kira Flinkenflügel, Marius Gruber, Susanne Meinert, Katharina Thiel, Alexandra Winter, Janik Goltermann, Paula Usemann, Katharina Brosch, Frederike Stein, Florian Thomas-Odenthal, Adrian Wroblewski, Julia-Katharina Pfarr, Friederike S. David, Eva C. Beins, Dominik Grotegerd, Tim Hahn, Elisabeth J. Leehr, Katharina Dohm, Jochen Bauer, Andreas J. Forstner, Markus M. Nöthen, Hamidreza Jamalabadi, Benjamin
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Integration of multi-omics summary data reveals the role of N6-methyladenosine in neuropsychiatric disorders Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-29 Chao Liufu, Lingxue Luo, Tao Pang, Haohao Zheng, Li Yang, Lin Lu, Suhua Chang
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Integrative metabolomics-genomics analysis identifies key networks in a stem cell-based model of schizophrenia Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-29 Angeliki Spathopoulou, Gabriella A. Sauerwein, Valentin Marteau, Martina Podlesnic, Theresa Lindlbauer, Tobias Kipura, Madlen Hotze, Elisa Gabassi, Katharina Kruszewski, Marja Koskuvi, János M. Réthelyi, Ágota Apáti, Luciano Conti, Manching Ku, Therese Koal, Udo Müller, Radu A. Talmazan, Ilkka Ojansuu, Olli Vaurio, Markku Lähteenvuo, Šárka Lehtonen, Jerome Mertens, Marcel Kwiatkowski, Katharina Günther
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Psilocybin restrains activity-based anorexia in female rats by enhancing cognitive flexibility: contributions from 5-HT1A and 5-HT2A receptor mechanisms Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-27 K. Conn, L. K. Milton, K. Huang, H. Munguba, J. Ruuska, M. B. Lemus, E. Greaves, J. Homman-Ludiye, B. J. Oldfield, C. J. Foldi
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Clinical trajectories preceding incident dementia up to 15 years before diagnosis: a large prospective cohort study Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-27 Jia You, Yu Guo, Yu-Jia Wang, Yi Zhang, Hui-Fu Wang, Lin-Bo Wang, Ju-Jiao Kang, Jian-Feng Feng, Jin-Tai Yu, Wei Cheng
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Long COVID: plasma levels of neurofilament light chain in mild COVID-19 patients with neurocognitive symptoms Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-27 Elisa Gouvea Gutman, Andreza Lemos Salvio, Renan Amphilophio Fernandes, Larissa Araujo Duarte, Jessica Vasques Raposo-Vedovi, Helena França Alcaraz, Milene Ataíde Teixeira, Giselle Fazzioni Passos, Karoline Queiroz Muniz de Medeiros, Mariana Beiral Hammerle, Karina Lebeis Pires, Claudia Cristina Ferreira Vasconcelos, Luciane Almeida Amado Leon, Cláudia Pinto Figueiredo, Soniza Vieira Alves-Leon
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Cell-type and sex-specific rhythmic gene expression in the nucleus accumbens Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-27 Lauren M. DePoy, Kaitlyn A. Petersen, Wei Zong, Kyle D. Ketchesin, Ross C. Matthaei, RuoFei Yin, Megan S. Perez, Chelsea A. Vadnie, Darius Becker-Krail, Madeline R. Scott, George C. Tseng, Colleen A. McClung
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Differences in the neural correlates of schizophrenia with positive and negative formal thought disorder in patients with schizophrenia in the ENIGMA dataset Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-26 Rachel J. Sharkey, Chelsea Bacon, Zeru Peterson, Kelly Rootes-Murdy, Raymond Salvador, Edith Pomarol-Clotet, Andriana Karuk, Philipp Homan, Ellen Ji, Wolfgang Omlor, Stephanie Homan, Foivos Georgiadis, Stefan Kaiser, Matthias Kirschner, Stefan Ehrlich, Udo Dannlowski, Dominik Grotegerd, Janik Goltermann, Susanne Meinert, Tilo Kircher, Frederike Stein, Katharina Brosch, Axel Krug, Igor Nenadic, Kang
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Resolution of tonic concentrations of highly similar neurotransmitters using voltammetry and deep learning Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-25 Abhinav Goyal, Jason Yuen, Stephen Sinicrope, Bailey Winter, Lindsey Randall, Aaron E. Rusheen, Charles D. Blaha, Kevin E. Bennet, Kendall H. Lee, Hojin Shin, Yoonbae Oh
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Gut microbiome predicts cognitive function and depressive symptoms in late life Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-25 A. Kolobaric, C. Andreescu, E. Jašarević, C. H. Hong, H. W. Roh, J. Y. Cheong, Y. K. Kim, T. S. Shin, C. S. Kang, C. O. Kwon, S. Y. Yoon, S. W. Hong, H. J. Aizenstein, H. T. Karim, S. J. Son
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Neuroactive steroid hormone trajectories across the menstrual cycle in premenstrual dysphoric disorder (PMDD): the PHASE study Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-25 Ajna Hamidovic, Sunni Mumford, Enrique Schisterman, John Davis, Fatimata Soumare
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The need for youth psychiatry fellowship: a physician-scientist trainee perspective Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-24 Cemal Demirlek
In a recent perspective article of Uhlhaas et al. [1] in Molecular Psychiatry, the authors discuss the importance of the age range between 12 and 25 for understanding and addressing mental disorders. They emphasize the importance of risk and protective factors, as well as brain development, in youth psychopathology, especially during sensitive periods. The authors propose the need for a youth mental
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Thy1-ApoE4/C/EBPβ double transgenic mice act as a sporadic model with Alzheimer’s disease Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-24 Zhengjiang Qian, ZhiHao Wang, Bowei Li, Xin Meng, Zhonghua Kuang, Yanjiao Li, Yongfeng Yang, Keqiang Ye
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The impact of psychosocial adversity on brain and behaviour: an overview of existing knowledge and directions for future research Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-24 Nilakshi Vaidya, Andre F. Marquand, Frauke Nees, Sebastian Siehl, Gunter Schumann
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How does the macroenvironment influence brain and behaviour—a review of current status and future perspectives Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-24 Elli Polemiti, Sören Hese, Kerstin Schepanski, Jiacan Yuan, Gunter Schumann
The environment influences brain and mental health, both detrimentally and beneficially. Existing research has emphasised the individual psychosocial ‘microenvironment’. Less attention has been paid to ‘macroenvironmental’ challenges, including climate change, pollution, urbanicity, and socioeconomic disparity. Notably, the implications of climate and pollution on brain and mental health have only
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Endogenous mutant Huntingtin alters the corticogenesis via lowering Golgi recruiting ARF1 in cortical organoid Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-23 Yang Liu, Xinyu Chen, Yunlong Ma, Chenyun Song, Jixin Ma, Cheng Chen, Jianzhong Su, Lixiang Ma, Hexige Saiyin
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Combined expansion and STED microscopy reveals altered fingerprints of postsynaptic nanostructure across brain regions in ASD-related SHANK3-deficiency Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-22 Jan Philipp Delling, Helen Friedericke Bauer, Susanne Gerlach-Arbeiter, Michael Schön, Christian Jacob, Jan Wagner, Maria Teresa Pedro, Bernd Knöll, Tobias M. Boeckers
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Characterization of transcriptional profiles associated with stress-induced neuronal activation in Arc-GFP mice Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-22 Tamer Butto, Monika Chanu Chongtham, Kanak Mungikar, Dewi Hartwich, Matthias Linke, Nicolas Ruffini, Konstantin Radyushkin, Susann Schweiger, Jennifer Winter, Susanne Gerber
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Neuroimaging of posttraumatic stress disorder in adults and youth: progress over the last decade on three leading questions of the field Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-17 Cecilia A. Hinojosa, Grace C. George, Ziv Ben-Zion
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Erythropoietin restrains the inhibitory potential of interneurons in the mouse hippocampus Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-15 Yasmina Curto, Héctor Carceller, Patrycja Klimczak, Marta Perez-Rando, Qing Wang, Katharina Grewe, Riki Kawaguchi, Silvio Rizzoli, Daniel Geschwind, Klaus-Armin Nave, Vicent Teruel-Marti, Manvendra Singh, Hannelore Ehrenreich, Juan Nácher
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Nuclear GAPDH in cortical microglia mediates cellular stress-induced cognitive inflexibility Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-13 Adriana Ramos, Koko Ishizuka, Arisa Hayashida, Ho Namkung, Lindsay N. Hayes, Rupali Srivastava, Manling Zhang, Taro Kariya, Noah Elkins, Trexy Palen, Elisa Carloni, Tsuyoshi Tsujimura, Coleman Calva, Satoshi Ikemoto, Rana Rais, Barbara S. Slusher, Minae Niwa, Atsushi Saito, Toshiaki Saitoh, Eiki Takimoto, Akira Sawa
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Dentate gyrus is needed for memory retrieval Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-12 Alejandro Carretero-Guillén, Mario Treviño, María Ángeles Gómez-Climent, Godwin K. Dogbevia, Ilaria Bertocchi, Rolf Sprengel, Matthew E. Larkum, Andreas Vlachos, Agnès Gruart, José M. Delgado-García, Mazahir T. Hasan
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Robust and replicable functional brain signatures of 22q11.2 deletion syndrome and associated psychosis: a deep neural network-based multi-cohort study Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-12 Kaustubh Supekar, Carlo de los Angeles, Srikanth Ryali, Leila Kushan, Charlie Schleifer, Gabriela Repetto, Nicolas A. Crossley, Tony Simon, Carrie E. Bearden, Vinod Menon
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Longitudinal inference of multiscale markers in psychosis: from hippocampal centrality to functional outcome Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-11 Jana F. Totzek, M. Mallar Chakravarty, Ridha Joober, Ashok Malla, Jai L. Shah, Delphine Raucher-Chéné, Alexandra L. Young, Dennis Hernaus, Martin Lepage, Katie M. Lavigne
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Exploring the genetic etiology across the continuum of the general psychopathology factor: a Swedish population-based family and twin study Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-10 Yangjun Liu, Paul Lichtenstein, Roman Kotov, Henrik Larsson, Brian M. D’Onofrio, Erik Pettersson
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Tau pathology is associated with synaptic density and longitudinal synaptic loss in Alzheimer’s disease Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-08 Jie Wang, Qi Huang, Xing Chen, Zhiwen You, Kun He, Qihao Guo, Yiyun Huang, Yang Yang, Zengping Lin, Tengfei Guo, Jun Zhao, Yihui Guan, Binyin Li, Fang Xie
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Genetic influences and causal pathways shared between cannabis use disorder and other substance use traits Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-05 Marco Galimberti, Daniel F. Levey, Joseph D. Deak, Hang Zhou, Murray B. Stein, Joel Gelernter
Cannabis use disorder (CanUD) has increased with the legalization of the use of cannabis. Around 20% of individuals using cannabis develop CanUD, and the number of users has grown with increasing ease of access. CanUD and other substance use disorders (SUDs) are associated phenotypically and genetically. We leveraged new CanUD genomics data to undertake genetically-informed analyses with unprecedented
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Social experience in adolescence shapes prefrontal cortex structure and function in adulthood Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-05 Dan C. Li, Elizabeth A. Hinton, Jidong Guo, Kristopher A. Knight, Michelle K. Sequeira, Meghan E. Wynne, Niharika M. Dighe, Shannon L. Gourley
During adolescence, the prefrontal cortex (PFC) undergoes dramatic reorganization. PFC development is profoundly influenced by the social environment, disruptions to which may prime the emergence of psychopathology across the lifespan. We investigated the neurobehavioral consequences of isolation experienced in adolescence in mice, and in particular, the long-term consequences that were detectable
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Loss of mGlu5 receptors in somatostatin-expressing neurons alters negative emotional states Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-04 Arnau Ramos-Prats, Pawel Matulewicz, Marie-Luise Edenhofer, Kai-Yi Wang, Chia-Wei Yeh, Ana Fajardo-Serrano, Michaela Kress, Kai Kummer, Cheng-Chang Lien, Francesco Ferraguti
Subtype 5 metabotropic glutamate receptors (mGlu5) are known to play an important role in regulating cognitive, social and valence systems. However, it remains largely unknown at which circuits and neuronal types mGlu5 act to influence these behavioral domains. Altered tissue- or cell-specific expression or function of mGlu5 has been proposed to contribute to the exacerbation of neuropsychiatric disorders
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Substance use and spine density: a systematic review and meta-analysis of preclinical studies Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-02 Henrique Nunes Pereira Oliva, Tiago Paiva Prudente, Eric J. Nunes, Kelly P. Cosgrove, Rajiv Radhakrishnan, Marc N. Potenza, Gustavo A. Angarita
The elucidation of synaptic density changes provides valuable insights into the underlying brain mechanisms of substance use. In preclinical studies, synaptic density markers, like spine density, are altered by substances of abuse (e.g., alcohol, amphetamine, cannabis, cocaine, opioids, nicotine). These changes could be linked to phenomena including behavioral sensitization and drug self-administration
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Patterns of stressful life events and polygenic scores for five mental disorders and neuroticism among adults with depression Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-04 Jacob J. Crouse, Shin Ho Park, Enda M. Byrne, Brittany L. Mitchell, Jan Scott, Sarah E. Medland, Tian Lin, Naomi R. Wray, Nicholas G. Martin, Ian B. Hickie
The dominant (‘general’) version of the diathesis-stress theory of depression views stressors and genetic vulnerability as independent risks. In the Australian Genetics of Depression Study (N = 14,146; 75% female), we tested whether polygenic scores (PGS) for major depression, bipolar disorder, schizophrenia, anxiety, ADHD, and neuroticism were associated with reported exposure to 32 childhood, past-year
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Ketamine’s mechanism of action with an emphasis on neuroimmune regulation: can the complement system complement ketamine’s antidepressant effects? Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-04 Brandi Quintanilla, Carlos A. Zarate, Anilkumar Pillai
Over 300 million people worldwide suffer from major depressive disorder (MDD). Unfortunately, only 30–40% of patients with MDD achieve complete remission after conventional monoamine antidepressant therapy. In recent years, ketamine has revolutionized the treatment of MDD, with its rapid antidepressant effects manifesting within a few hours as opposed to weeks with conventional antidepressants. Many
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Pharmacological fingerprint of antipsychotic drugs at the serotonin 5-HT2A receptor Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-02 Supriya A. Gaitonde, Charlotte Avet, Mario de la Fuente Revenga, Elodie Blondel-Tepaz, Aida Shahraki, Adrian Morales Pastor, Valerij Talagayev, Patricia Robledo, Peter Kolb, Jana Selent, Javier González-Maeso, Michel Bouvier
The intricate involvement of the serotonin 5-HT2A receptor (5-HT2AR) both in schizophrenia and in the activity of antipsychotic drugs is widely acknowledged. The currently marketed antipsychotic drugs, although effective in managing the symptoms of schizophrenia to a certain extent, are not without their repertoire of serious side effects. There is a need for better therapeutics to treat schizophrenia
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Gestational epigenetic age and ADHD symptoms in childhood: a prospective, multi-cohort study Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-02
Epigenetic age acceleration (EAA), defined as the difference between chronological age and epigenetically predicted age, was calculated from multiple gestational epigenetic clocks (Bohlin, EPIC overlap, and Knight) using DNA methylation levels from cord blood in three large population-based birth cohorts: the Generation R Study (The Netherlands), the Avon Longitudinal Study of Parents and Children
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Differential DNA methylation in iPSC-derived dopaminergic neurons: a step forward on the role of SNORD116 microdeletion in the pathophysiology of addictive behavior in Prader-Willi syndrome Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-02 Juliette Salles, Sanaa Eddiry, Saber Amri, Mélissa Galindo, Emmanuelle Lacassagne, Simon George, Xavier Mialhe, Émeline Lhuillier, Nicolas Franchitto, Freddy Jeanneteau, Isabelle Gennero, Jean-Pierre Salles, Maithé Tauber
Introduction A microdeletion including the SNORD116 gene (SNORD116 MD) has been shown to drive the Prader-Willi syndrome (PWS) features. PWS is a neurodevelopmental disorder clinically characterized by endocrine impairment, intellectual disability and psychiatric symptoms such as a lack of emotional regulation, impulsivity, and intense temper tantrums with outbursts. In addition, this syndrome is associated
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Genetic contribution to disease-course severity and progression in the SUPER-Finland study, a cohort of 10,403 individuals with psychotic disorders Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-01 Anders Kämpe, Jaana Suvisaari, Markku Lähteenvuo, Tarjinder Singh, Ari Ahola-Olli, Lea Urpa, Willehard Haaki, Jarmo Hietala, Erkki Isometsä, Tuomas Jukuri, Olli Kampman, Tuula Kieseppä, Kaisla Lahdensuo, Jouko Lönnqvist, Teemu Männynsalo, Tiina Paunio, Jussi Niemi-Pynttäri, Kimmo Suokas, Annamari Tuulio-Henriksson, Juha Veijola, Asko Wegelius, Mark Daly, Jacob Taylor, Kenneth S. Kendler, Aarno Palotie
Genetic factors contribute to the susceptibility of psychotic disorders, but less is known how they affect psychotic disease-course development. Utilizing polygenic scores (PGSs) in combination with longitudinal healthcare data with decades of follow-up we investigated the contributing genetics to psychotic disease-course severity and diagnostic shifts in the SUPER-Finland study, encompassing 10 403
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Brain stars take the lead during critical periods of early postnatal brain development: relevance of astrocytes in health and mental disorders Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-29 Eugenia Vivi, Barbara Di Benedetto
In the brain, astrocytes regulate shape and functions of the synaptic and vascular compartments through a variety of released factors and membrane-bound proteins. An imbalanced astrocyte activity can therefore have drastic negative impacts on brain development, leading to the onset of severe pathologies. Clinical and pre-clinical studies show alterations in astrocyte cell number, morphology, molecular
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Neural foundation of the diathesis-stress model: longitudinal gray matter volume changes in response to stressful life events in major depressive disorder and healthy controls Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-29 Florian Thomas-Odenthal, Kai Ringwald, Lea Teutenberg, Frederike Stein, Nina Alexander, Linda M. Bonnekoh, Katharina Brosch, Katharina Dohm, Kira Flinkenflügel, Dominik Grotegerd, Tim Hahn, Andreas Jansen, Elisabeth J. Leehr, Susanne Meinert, Julia-Katharina Pfarr, Harald Renz, Navid Schürmeyer, Thomas Stief, Benjamin Straube, Katharina Thiel, Paula Usemann, Alexandra Winter, Axel Krug, Igor Nenadić
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The relationship between prefrontal cortex gray matter volume and subcortical dopamine release - an addendum Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-28 Matthäus Willeit, Ulrich Sauerzopf, Nicole Praschak-Rieder, Ana Weidenauer
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Clinical and genetic contributions to medical comorbidity in bipolar disorder: a study using electronic health records-linked biobank data Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-28 Jorge A. Sanchez-Ruiz, Brandon J. Coombes, Vanessa M. Pazdernik, Lindsay M. Melhuish Beaupre, Greg D. Jenkins, Richard S. Pendegraft, Anthony Batzler, Aysegul Ozerdem, Susan L. McElroy, Manuel A. Gardea-Resendez, Alfredo B. Cuellar-Barboza, Miguel L. Prieto, Mark A. Frye, Joanna M. Biernacka
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Genome-Wide Association Study of Obsessive-Compulsive Symptoms including 33,943 individuals from the general population Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-28 Nora I. Strom, Christie L. Burton, Conrad Iyegbe, Talisa Silzer, Lilit Antonyan, René Pool, Mathieu Lemire, James J. Crowley, Jouke-Jan Hottenga, Volen Z. Ivanov, Henrik Larsson, Paul Lichtenstein, Patrik Magnusson, Christian Rück, Russell Schachar, Hei Man Wu, Danielle Cath, Jennifer Crosbie, David Mataix-Cols, Dorret I. Boomsma, Manuel Mattheisen, Sandra M. Meier, Dirk J. A. Smit, Paul D. Arnold
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Serotonin effects on human iPSC-derived neural cell functions: from mitochondria to depression Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-26 Iseline Cardon, Sonja Grobecker, Frederike Jenne, Tatjana Jahner, Rainer Rupprecht, Vladimir M. Milenkovic, Christian H. Wetzel
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Sex dimorphism controls dysbindin-related cognitive dysfunctions in mice and humans with the contribution of COMT Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-26 Federica Geraci, Roberta Passiatore, Nora Penzel, Samuele Laudani, Alessandro Bertolino, Giuseppe Blasi, Adriana C. E. Graziano, Gianluca C. Kikidis, Ciro Mazza, Madhur Parihar, Antonio Rampino, Leonardo Sportelli, Nicolò Trevisan, Filippo Drago, Francesco Papaleo, Fabio Sambataro, Giulio Pergola, Gian Marco Leggio
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Immunophenotypes in psychosis: is it a premature inflamm-aging disorder? Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-26 Song Chen, Yunlong Tan, Li Tian
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Chronometric TMS-fMRI of personalized left dorsolateral prefrontal target reveals state-dependency of subgenual anterior cingulate cortex effects Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-26 Sarah Grosshagauer, Michael Woletz, Maria Vasileiadi, David Linhardt, Lena Nohava, Anna-Lisa Schuler, Christian Windischberger, Nolan Williams, Martin Tik
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Transcriptomic dysregulation and autistic-like behaviors in Kmt2c haploinsufficient mice rescued by an LSD1 inhibitor Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-26 Takumi Nakamura, Toru Yoshihara, Chiharu Tanegashima, Mitsutaka Kadota, Yuki Kobayashi, Kurara Honda, Mizuho Ishiwata, Junko Ueda, Tomonori Hara, Moe Nakanishi, Toru Takumi, Shigeyoshi Itohara, Shigehiro Kuraku, Masahide Asano, Takaoki Kasahara, Kazuo Nakajima, Takashi Tsuboi, Atsushi Takata, Tadafumi Kato