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Repurposing pexmetinib as an inhibitor of TKI-resistant BCR::ABL1 Leukemia (IF 11.4) Pub Date : 2024-05-15 Diletta Fontana, Federica Malighetti, Matteo Villa, Alfonso Zambon, Carlo Gambacorti-Passerini, Luca Mologni
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Chimeric antigen receptor T-cell infusion for large B-cell lymphoma in complete remission: a center for international blood and marrow transplant research analysis Leukemia (IF 11.4) Pub Date : 2024-05-15 Trent P. Wang, Kwang W. Ahn, Mazyar Shadman, Manmeet Kaur, Nausheen Ahmed, Ulrike Bacher, Jan Cerny, Andy Chen, Narendranath Epperla, Matthew Frigault, Natalie Grover, Bradley Haverkos, Brian Hill, Nasheed Hossain, Madiha Iqbal, Tania Jain, Maxwell M. Krem, Joseph Maakaron, Dipenkumar Modi, Muhamad Alhaj Moustafa, Peter Riedell, Bipin Savani, R. Alejandro Sica, Anna Sureda, Kitsada Wudhikarn, Alex
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Clinical implications of CSF-ctDNA positivity in newly diagnosed diffuse large B cell lymphoma Leukemia (IF 11.4) Pub Date : 2024-05-15 Jin-Hua Liang, Yi-Fan Wu, Hao-Rui Shen, Yue Li, Jun-Heng Liang, Rui Gao, Wei Hua, Chun-Yu Shang, Kai-Xin Du, Tong-Yao Xing, Xin-Yu Zhang, Chen-Xuan Wang, Liu-Qing Zhu, Yang W. Shao, Jian-Yong Li, Jia-Zhu Wu, Hua Yin, Li Wang, Wei Xu
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Molecular subgroups of T-cell acute lymphoblastic leukemia in adults treated according to pediatric-based GMALL protocols Leukemia (IF 11.4) Pub Date : 2024-05-14 Martin Neumann, Thomas Beder, Lorenz Bastian, Sonja Hänzelmann, Miriam Bultmann, Nadine Wolgast, Alina Hartmann, Heiko Trautmann, Jutta Ortiz-Tanchez, Cornelia Schlee, Michael Schroeder, Lars Fransecky, Sebastian Vosberg, Walter Fiedler, Nael Alakel, Lisa Heberling, Mustafa Kondakci, Michael Starck, Stefan Schwartz, Simon Raffel, Carsten Müller-Tidow, Folker Schneller, Albrecht Reichle, Thomas Burmeister
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Analysis of measurable residual disease by IG/TR gene rearrangements: quality assurance and updated EuroMRD guidelines Leukemia (IF 11.4) Pub Date : 2024-05-14 Vincent H. J. van der Velden, Isabel Dombrink, Julia Alten, Giovanni Cazzaniga, Emmanuelle Clappier, Daniela Drandi, Cornelia Eckert, Eva Fronkova, Jeremy Hancock, Michaela Kotrova, Rebekka Kraemer, Mirkka Montonen, Heike Pfeifer, Christiane Pott, Thorsten Raff, Heiko Trautmann, Hélène Cavé, Beat W. Schäfer, Jacques J. M. van Dongen, Jan Trka, Monika Brüggemann
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Integrated proteogenomic analysis for inherited bone marrow failure syndrome Leukemia (IF 11.4) Pub Date : 2024-05-13 Manabu Wakamatsu, Hideki Muramatsu, Hironori Sato, Masaki Ishikawa, Ryo Konno, Daisuke Nakajima, Motoharu Hamada, Yusuke Okuno, Yusuke Kawashima, Asahito Hama, Masafumi Ito, Hideto Iwafuchi, Yoshiyuki Takahashi, Osamu Ohara
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DNA damage response genes as biomarkers of therapeutic outcomes in acute myeloid leukemia patients Leukemia (IF 11.4) Pub Date : 2024-05-11 Adam Karami, Tomasz Skorski
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Context-dependent role of trisomy 6 in myelodysplastic neoplasms and acute myeloid leukemia: a multi-omics analysis Leukemia (IF 11.4) Pub Date : 2024-05-11 Hussein Awada, Arda Durmaz, Tariq Kewan, Fauzia Ullah, Danai Dima, Hassan Awada, Simona Pagliuca, Manja Meggendorfer, Torsten Haferlach, Carmelo Gurnari, Valeria Visconte, Jaroslaw P. Maciejewski
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TIF1β activates leukemic transcriptional program in HSCs and promotes BCR::ABL1-induced myeloid leukemia Leukemia (IF 11.4) Pub Date : 2024-05-11 Mariko Morii, Sho Kubota, Mihoko Iimori, Takako Yokomizo-Nakano, Ai Hamashima, Jie Bai, Akiho Nishimura, Masayoshi Tasaki, Yukio Ando, Kimi Araki, Goro Sashida
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Genomic landscape of CCUS compared to MDS and its implications on risk prediction Leukemia (IF 11.4) Pub Date : 2024-05-10 Sandra Huber, Constance Baer, Stephan Hutter, Natalie Wossidlo, Gregor Hoermann, Christian Pohlkamp, Wencke Walter, Manja Meggendorfer, Wolfgang Kern, Torsten Haferlach, Claudia Haferlach
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PD-1 expression contributes to functional impairment of NK cells in patients with B-CLL Leukemia (IF 11.4) Pub Date : 2024-05-09 Mustafa Farhat, Wayne Croft, Helen M. Parry, Kriti Verma, Francesca A. M. Kinsella, Jinsong Xu, David Bone, Tina McSkeane, Shankara Paneesha, Guy Pratt, Paul Moss, Jianmin Zuo
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AML/T cell interactomics uncover correlates of patient outcomes and the key role of ICAM1 in T cell killing of AML Leukemia (IF 11.4) Pub Date : 2024-05-09 Ece Canan Sayitoglu, Bogdan A. Luca, Allison Paige Boss, Benjamin Craig Thomas, Robert Arthur Freeborn, Molly Javier Uyeda, Pauline Ping Chen, Yusuke Nakauchi, Colin Waichler, Norman Lacayo, Rosa Bacchetta, Ravindra Majeti, Andrew J. Gentles, Alma-Martina Cepika, Maria Grazia Roncarolo
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Cre recombinase promotes leukemogenesis in the presence of both homozygous and heterozygous FLT3-ITD Leukemia (IF 11.4) Pub Date : 2024-05-08 Min Yang, Zhiyuan Ma, Chonggang Wang, Muammer Cihan Agca, Hongyun Liu, Kezhi Huang, Silke Glage, Regina Rumpel, Alexander Gerbaulet, Axel Roers, Xuemei Liu, Fatih Noyan, Nils von Neuhoff, Arnold Ganser, Ligen Liu, Haiyang Yun, Zhixiong Li
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Improved CAR-T cell activity associated with increased mitochondrial function primed by galactose Leukemia (IF 11.4) Pub Date : 2024-05-07 Golda Gross, Suha Alkadieri, Amilia Meir, Orit Itzhaki, Yarden Aharoni-Tevet, Shahar Ben Yosef, Angi Zenab, Liat Shbiro, Amos Toren, Tal Yardeni, Elad Jacoby
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Predicting survival in patients with myelodysplastic/myeloproliferative neoplasms with SF3B1 mutation and thrombocytosis Leukemia (IF 11.4) Pub Date : 2024-05-07 Fuhui Li, Tiejun Qin, Bing Li, Shiqiang Qu, Lijuan Pan, Peihong Zhang, Qi Sun, Wenyu Cai, Qingyan Gao, Meng Jiao, Junjie Li, Xiaofei Ai, Jiao Ma, Robert Peter Gale, Zefeng Xu, Zhijian Xiao
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Improved survival with younger HLA-matched unrelated donors versus older matched sibling donor HCT with PTCy-prophylaxis Leukemia (IF 11.4) Pub Date : 2024-05-02 Jeremy Ramdial, Partow Kebriaei, Richard E. Champlin, Uday Popat, Katayoun Rezvani, Elizabeth J. Shpall, Rohtesh S. Mehta
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Targeting myeloma essential genes using NOT Gated CAR T-cells, a computational approach Leukemia (IF 11.4) Pub Date : 2024-04-30 Ieuan G. Walker, James P. Roy, Georgina S. F. Anderson, Jose Guerrero Lopez, Michael A. Chapman
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Clonal hematopoiesis–derived therapy-related myeloid neoplasms after autologous hematopoietic stem cell transplant for lymphoid and non-lymphoid disorders Leukemia (IF 11.4) Pub Date : 2024-04-29 Hussein Awada, Carmelo Gurnari, Valeria Visconte, Arda Durmaz, Teodora Kuzmanovic, Hassan Awada, Zheng Jin Tu, James R. Cook, Brian J. Bolwell, Ronald Sobecks, Matt Kalaycio, David Bosler, Jaroslaw P. Maciejewski
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The addition of bortezomib to rituximab, high-dose cytarabine and dexamethasone in relapsed or refractory mantle cell lymphoma—a randomized, open-label phase III trial of the European mantle cell lymphoma network Leukemia (IF 11.4) Pub Date : 2024-04-27 Luca Fischer, Linmiao Jiang, Jan Dürig, Christian Schmidt, Stephan Stilgenbauer, Krimo Bouabdallah, Philippe Solal-Celigny, Christian W. Scholz, Pierre Feugier, Maike de Wit, Ralf Ulrich Trappe, Michael Hallek, Ullrich Graeven, Mathias Hänel, Martin Hoffmann, Vincent Delwail, Margaret Macro, Jochen Greiner, Aristoteles A. N. Giagounidis, Beate Dargel, Eric Durot, Charles Foussard, Elisabeth Silkenstedt
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The KMT2A/MLL consensus gene structure: a comprehensive update for research and diagnostic implications Leukemia (IF 11.4) Pub Date : 2024-04-27 C. Meyer, P. Larghero, B. A. Lopes, R. Marschalek
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Immunogenetics in hematopathology and hematology: why a common language is important Leukemia (IF 11.4) Pub Date : 2024-04-25 Kostas Stamatopoulos, Elspeth Bruford, Elias Campo, Marie-Paule Lefranc
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8-Cl-Ado and 8-NH2-Ado synergize with venetoclax to target the methionine-MAT2A-SAM axis in acute myeloid leukemia Leukemia (IF 11.4) Pub Date : 2024-04-20 Jiamin Guo, Ralf Buettner, Li Du, Zhenlong Li, Wei Liu, Rui Su, Zhenhua Chen, Yuan Che, Yi Zhang, Rui Ma, Le Xuan Truong Nguyen, Roger E. Moore, Pathak Khyatiben, Min-Hsuan Chen, Pirrotte Patrick, Xiwei Wu, Guido Marcucci, Lili Wang, David Horne, Jianjun Chen, Yanzhong Yang, Steven T. Rosen
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Measurable residual disease (MRD)-testing in haematological and solid cancers Leukemia (IF 11.4) Pub Date : 2024-04-18 Junren Chen, Robert Peter Gale, Yu Hu, Wen Yan, Tiantian Wang, Wei Zhang
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KRAS G12 mutations as adverse prognostic factors in KMT2A-rearranged acute myeloid leukemia Leukemia (IF 11.4) Pub Date : 2024-04-18 Shinju Iyoda, Kenichi Yoshida, Kota Shoji, Nana Ito, Miu Tanaka, Yasuhito Nannya, Genki Yamato, Shinichi Tsujimoto, Norio Shiba, Yasuhide Hayashi, Yusuke Shiozawa, Yuichi Shiraishi, Kenichi Chiba, Ai Okada, Hiroko Tanaka, Satoru Miyano, Yuhki Koga, Hiroaki Goto, Hiroshi Moritake, Kiminori Terui, Etsuro Ito, Nobutaka Kiyokawa, Daisuke Tomizawa, Takashi Taga, Akio Tawa, Junko Takita, Momoko Nishikori
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Dynamics of clonal hematopoiesis under DNA-damaging treatment in patients with ovarian cancer Leukemia (IF 11.4) Pub Date : 2024-04-18 Christopher Maximilian Arends, Klara Kopp, Raphael Hablesreiter, Natalia Estrada, Friederike Christen, Ute Martha Moll, Robert Zeillinger, Wolfgang Daniel Schmitt, Jalid Sehouli, Hagen Kulbe, Maximilian Fleischmann, Isabelle Ray-Coquard, Alain Zeimet, Francesco Raspagliesi, Claudio Zamagni, Ignace Vergote, Domenica Lorusso, Nicole Concin, Lars Bullinger, Elena Ioana Braicu, Frederik Damm
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Mutations in the splicing factor SF3B1 are linked to frequent emergence of HLA-DRlow/neg monocytes in lower-risk myelodysplastic neoplasms Leukemia (IF 11.4) Pub Date : 2024-04-17 Susann Winter, Marie Schneider, Uta Oelschlaegel, Giulia Maggioni, Elena Riva, Marco Gabriele Raddi, Sara Bencini, Benedetta Peruzzi, Desmond Choy, Rita Antunes Dos Reis, Esther Güse, Christopher Lischer, Julio Vera, Jessica A. Timms, Nicolas Sompairac, Katja Sockel, Antonella Poloni, Antje Tunger, Matteo Giovanni Della Porta, Valeria Santini, Marc Schmitz, Uwe Platzbecker, Shahram Kordasti
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Prophylactic donor-derived CD19 CAR-T cell infusion for preventing relapse in high-risk B-ALL after allogeneic hematopoietic stem cell transplantation Leukemia (IF 11.4) Pub Date : 2024-04-17 Wenyi Lu, Hairong Lyu, Xia Xiao, Xue Bai, Meng Zhang, Jiaxi Wang, Yedi Pu, Juanxia Meng, Xiaomei Zhang, Haibo Zhu, Ting Yuan, Bing Wang, Xin Jin, Xinping Cao, Zhao Wang, Tianle Xie, Haotian Meng, Alexey V. Stepanov, Alexander G. Gabibov, Yuxin An, Rui Sun, Yu Zhang, Mikhail A. Maschan, Zunmin Zhu, Hongkai Zhang, Mingfeng Zhao
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Autophagy degrades immunogenic endogenous retroelements induced by 5-azacytidine in acute myeloid leukemia Leukemia (IF 11.4) Pub Date : 2024-04-16 Nandita Noronha, Chantal Durette, Maxime Cahuzac, Bianca E Silva, Justine Courtois, Juliette Humeau, Allan Sauvat, Marie-Pierre Hardy, Krystel Vincent, Jean-Philippe Laverdure, Joël Lanoix, Frédéric Baron, Pierre Thibault, Claude Perreault, Gregory Ehx
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Combination therapies with ponatinib and asciminib in a preclinical model of chronic myeloid leukemia blast crisis with compound mutations Leukemia (IF 11.4) Pub Date : 2024-04-13 Nikola Curik, Adam Laznicka, Vaclava Polivkova, Jitka Krizkova, Eva Pokorna, Pavel Semerak, Pavla Suchankova, Pavel Burda, Andreas Hochhaus, Katerina Machova Polakova
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Metabolic reprogramming regulated by TRAF6 contributes to the leukemia progression Leukemia (IF 11.4) Pub Date : 2024-04-12 Shinichiro Matsui, Chihiro Ri, Lyndsey C. Bolanos, Kwangmin Choi, Asuka Shibamiya, Arata Ishii, Koji Takaishi, Nagisa Oshima-Hasegawa, Shokichi Tsukamoto, Yusuke Takeda, Naoya Mimura, Akihide Yoshimi, Koutaro Yokote, Daniel T. Starczynowski, Emiko Sakaida, Tomoya Muto
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Fluorescence in situ hybridization reveals the evolutionary biology of minor clone of gain/amp(1q) in multiple myeloma Leukemia (IF 11.4) Pub Date : 2024-04-12 Jian Cui, Yuntong Liu, Rui Lv, Wenqiang Yan, Jingyu Xu, Lingna Li, Chenxing Du, Tengteng Yu, Shuaishuai Zhang, Shuhui Deng, Weiwei Sui, Mu Hao, Shuhua Yi, Dehui Zou, Lugui Qiu, Yan Xu, Gang An
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Management of isocitrate dehydrogenase 1/2 mutated acute myeloid leukemia Leukemia (IF 11.4) Pub Date : 2024-04-10 Harry Fruchtman, Zachary M. Avigan, Julian A. Waksal, Nicole Brennan, John O. Mascarenhas
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Combination p53 activation and BCL-xL/BCL-2 inhibition as a therapeutic strategy in high-risk and relapsed acute lymphoblastic leukemia Leukemia (IF 11.4) Pub Date : 2024-04-10 Hayden L. Bell, Helen J. Blair, Samantha J. Jepson Gosling, Martin Galler, Daniel Astley, Anthony V. Moorman, Olaf Heidenreich, Gareth J. Veal, Frederik W. van Delft, John Lunec, Julie A. E. Irving
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Genome-wide DNA methylation-analysis of blastic plasmacytoid dendritic cell neoplasm identifies distinct molecular features Leukemia (IF 11.4) Pub Date : 2024-04-10 Axel Künstner, Julian Schwarting, Hanno M. Witte, Pengwei Xing, Veronica Bernard, Stephanie Stölting, Philipp Lohneis, Florian Janke, Maede Salehi, Xingqi Chen, Kathrin Kusch, Holger Sültmann, Emil Chteinberg, Anja Fischer, Reiner Siebert, Nikolas von Bubnoff, Hartmut Merz, Hauke Busch, Alfred C. Feller, Niklas Gebauer
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Treatment patterns for AL amyloidosis after frontline daratumumab, bortezomib, cyclophosphamide, and dexamethasone treatment failures Leukemia (IF 11.4) Pub Date : 2024-04-09 Saurabh Zanwar, Morie A. Gertz, Eli Muchtar, Francis K. Buadi, Taxiarchis Kourelis, Wilson Gonsalves, Ronald S. Go, Suzanne Hayman, Prashant Kapoor, Moritz Binder, Joselle Cook, David Dingli, Nelson Leung, Yi Lin, Rahma Warsame, Amie Fonder, Miriam Hobbs, Yi Lisa Hwa, Robert A. Kyle, S. Vincent Rajkumar, Shaji Kumar, Angela Dispenzieri
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Pre-frailty after blood or marrow transplantation and the risk of subsequent mortality Leukemia (IF 11.4) Pub Date : 2024-04-05 Nora Balas, Joshua S. Richman, Wendy Landier, Sadeep Shrestha, Katia J. Bruxvoort, Lindsey Hageman, Qingrui Meng, Elizabeth Ross, Alysia Bosworth, F. Lennie Wong, Ravi Bhatia, Stephen J. Forman, Saro H. Armenian, Daniel J. Weisdorf, Smita Bhatia
We examined the prevalence, risk factors, and association between pre-frailty and subsequent mortality after blood or marrow transplantation (BMT). Study participants were drawn from the BMT Survivor Study (BMTSS) and included 3346 individuals who underwent BMT between 1974 and 2014 at one of three transplant centers and survived ≥2 years post-BMT. Participants completed the BMTSS survey at a median
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High-plex imaging and cellular neighborhood spatial analysis reveals multiple immune escape and suppression patterns in diffuse large B-cell lymphoma Leukemia (IF 11.4) Pub Date : 2024-04-04 David J. Reiss, Yumi Nakayama, Andrew P. Weng, Matthew E. Stokes, Laurie Sehn, Christian Steidl, David W. Scott, C. Chris Huang, Anita K. Gandhi
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Loss of hematopoietic progenitors heterogeneity is an adverse prognostic factor in lower-risk myelodysplastic neoplasms Leukemia (IF 11.4) Pub Date : 2024-04-04 Charles Dussiau, Thibault Comont, Camille Knosp, Inès Vergnolle, Clotilde Bravetti, Alban Canali, Amandine Houvert, Laetitia Largeaud, Christian Daveaux, Laila Zaroili, Chloé Friedrich, Ismaël Boussaid, Loria Zalmai, Carole Almire, Odile Rauzy, Lise Willems, Rudy Birsen, Didier Bouscary, Michaela Fontenay, Olivier Kosmider, Nicolas Chapuis, François Vergez
Myelodysplastic neoplasms (MDS) are characterized by clonal evolution starting from the compartment of hematopoietic stem and progenitors cells (HSPCs), leading in some cases to leukemic transformation. We hypothesized that deciphering the diversity of the HSPCs compartment may allow for the early detection of an emergent sub-clone that drives disease progression. Deep analysis of HSPCs repartition
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IκBε deficiency accelerates disease development in chronic lymphocytic leukemia Leukemia (IF 11.4) Pub Date : 2024-04-04 Jessica Bordini, Chiara Lenzi, Michela Frenquelli, Alessia Morabito, Athanasios Pseftogas, Daniela Belloni, Larry Mansouri, George Tsiolas, Eleonora Perotta, Pamela Ranghetti, Francesca Gandini, Francesca Genova, Daniel Hägerstrand, Georgios Gavriilidis, Sofoklis Keisaris, Nikolaos Pechlivanis, Frederic Davi, Neil E. Kay, Anton W. Langerak, Sarka Pospisilova, Lydia Scarfò, Antonios Makris, Fotis E
The NFKBIE gene, which encodes the NF-κB inhibitor IκBε, is mutated in 3–7% of patients with chronic lymphocytic leukemia (CLL). The most recurrent alteration is a 4-bp frameshift deletion associated with NF-κB activation in leukemic B cells and poor clinical outcome. To study the functional consequences of NFKBIE gene inactivation, both in vitro and in vivo, we engineered CLL B cells and CLL-prone
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A complex interplay of intra- and extracellular factors regulates the outcome of fetal- and adult-derived MLL-rearranged leukemia Leukemia (IF 11.4) Pub Date : 2024-03-30 Maria Jassinskaja, Sudip Ghosh, Joanna Watral, Mina Davoudi, Melina Claesson Stern, Ugarit Daher, Mohamed Eldeeb, Qinyu Zhang, David Bryder, Jenny Hansson
Infant and adult MLL1/KMT2A-rearranged (MLLr) leukemia represents a disease with a dismal prognosis. Here, we present a functional and proteomic characterization of in utero-initiated and adult-onset MLLr leukemia. We reveal that fetal MLL::ENL-expressing lymphomyeloid multipotent progenitors (LMPPs) are intrinsically programmed towards a lymphoid fate but give rise to myeloid leukemia in vivo, highlighting
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The role of quiescent thymic progenitors in TAL/LMO2-induced T-ALL chemotolerance Leukemia (IF 11.4) Pub Date : 2024-03-29 Kevin W. O’Connor, Kensei Kishimoto, Irena O. Kuzma, Kelsey P. Wagner, Jonathan S. Selway, Justine E. Roderick, Keshab K. Karna, Kayleigh M. Gallagher, Kai Hu, Haibo Liu, Rui Li, Michael A. Brehm, Lihua Julie Zhu, David J. Curtis, Cedric S. Tremblay, Michelle A. Kelliher
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Management and outcome of patients with chronic myeloid leukemia in blast phase in the tyrosine kinase inhibitor era – analysis of the European LeukemiaNet Blast Phase Registry Leukemia (IF 11.4) Pub Date : 2024-03-28 Annamaria Brioli, Elza Lomaia, Christian Fabisch, Tomasz Sacha, Hana Klamova, Elena Morozova, Aleksandra Golos, Philipp Ernst, Ulla Olsson-Stromberg, Daniela Zackova, Franck E. Nicolini, Han Bao, Fausto Castagnetti, Elzbieta Patkowska, Jiri Mayer, Klaus Hirschbühl, Helena Podgornik, Edyta Paczkowska, Anne Parry, Thomas Ernst, Astghik Voskanyan, Elzbieta Szczepanek, Susanne Saussele, Georg-Nikolaus
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Mitigating immortal-time bias: exploring osteonecrosis and survival in pediatric ALL - AALL0232 trial insights Leukemia (IF 11.4) Pub Date : 2024-03-28 Shyam Srinivasan, Swaminathan Keerthivasagam
In this issue, Mattano et al. report on the development of osteonecrosis among patients with acute lymphoblastic leukemia (ALL) treated in the Children’s Oncology Group trial AALL0232 [1]. Apart from analyzing the incidence and risk factors for osteonecrosis, the authors also analyze the impact of osteonecrosis on event-free survival (EFS) and overall survival (OS). Surprisingly, both EFS and OS were
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ATG or post-transplant cyclophosphamide to prevent GVHD in matched unrelated stem cell transplantation? Leukemia (IF 11.4) Pub Date : 2024-03-27 Olaf Penack, Mouad Abouqateb, Christophe Peczynski, William Boreland, Nicolaus Kröger, Matthias Stelljes, Tobias Gedde-Dahl, Igor Wolfgang Blau, Thomas Schroeder, Urpu Salmenniemi, Alexander Kulagin, Régis Peffault de Latour, Stephan Mielke, Robert Zeiser, Ivan Moiseev, Hélène Schoemans, Christian Koenecke, Zinaida Peric
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Radiotherapy in younger patients with advanced aggressive B-cell lymphoma—long-term results from the phase 3 R-MegaCHOEP trial Leukemia (IF 11.4) Pub Date : 2024-03-27 Michael Oertel, Marita Ziepert, Fabian Frontzek, Nina Nacke, Bettina Altmann, Maike Nickelsen, Bertram Glass, Viola Poeschel, Christian Ruebe, Georg Lenz, Norbert Schmitz, Hans Theodor Eich
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Molecular ontogeny underlies the benefit of adding venetoclax to hypomethylating agents in newly diagnosed AML patients Leukemia (IF 11.4) Pub Date : 2024-03-27 Shai Shimony, Jacqueline S. Garcia, Julia Keating, Evan C. Chen, Marlise R. Luskin, Maximilian Stahl, Donna S. Neuberg, Daniel J. DeAngelo, Richard M. Stone, R. Coleman Lindsley
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Proteomics for optimizing therapy in acute myeloid leukemia: venetoclax plus hypomethylating agents versus conventional chemotherapy Leukemia (IF 11.4) Pub Date : 2024-03-26 Eduardo Sabino de Camargo Magalhães, Stefan Edward Hubner, Brandon Douglas Brown, Yihua Qiu, Steven Mitchell Kornblau
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Are there new relevant therapeutic endpoints in the modern era of the BCR::ABL1 tyrosine kinase inhibitors in chronic myeloid leukemia? Leukemia (IF 11.4) Pub Date : 2024-03-26 Hagop Kantarjian, Susan Branford, Massimo Breccia, Jorge Cortes, Fadi G. Haddad, Andreas Hochhaus, Timothy Hughes, Ghayas C. Issa, Elias Jabbour, Franck E. Nicolini, Koji Sasaki, Francois Xavier-Mahon
The availability and affordability of multiple BCR::ABL1 tyrosine kinase inhibitors (TKIs) beginning in 2000 have changed the prognosis and treatment dynamics in Philadelphia-chromosome (Ph)-positive (or BCR::ABL1-positive) chronic myeloid leukemia (CML) [1,2,3]. Evolving discussions relate to the optimal biologic (lower) dose schedules; frontline versus later-line therapies; management of toxicities
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Measurable residual disease quantification in adult patients with KMT2A-rearranged acute lymphoblastic leukemia Leukemia (IF 11.4) Pub Date : 2024-03-22 Thomas Burmeister, Aeint-Steffen Ströh, Britta Kehden, Heiko Trautmann, Claus Meyer, Rolf Marschalek, Patrizia Larghero, Stefan Schwartz, Björn Steffen, Bernd Spriewald, Thomas Heinicke, Nadja Jäkel, Jörg Westermann, Kathrin Nachtkamp, Andreas Viardot, Max S. Topp, Martin Neumann, Claudia D. Baldus, Nicola Gökbuget, Monika Brüggemann
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Impaired binding affinity of YTHDC1 with METTL3/METTL14 results in R-loop accumulation in myelodysplastic neoplasms with DDX41 mutation Leukemia (IF 11.4) Pub Date : 2024-03-21 Won Chan Hwang, Kibeom Park, Silvia Park, Na Young Cheon, Ja Yil Lee, Taejoo Hwang, Semin Lee, Jong-Mi Lee, Min Kyung Ju, Joo Rak Lee, Yong-Rim Kwon, Woo-Lam Jo, Myungshin Kim, Yoo-Jin Kim, Hongtae Kim
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The Eμ-Ret mouse is a novel model of hyperdiploid B-cell acute lymphoblastic leukemia Leukemia (IF 11.4) Pub Date : 2024-03-22 Ali Farrokhi, Tanmaya Atre, Jenna Rever, Mario Fidanza, Wendy Duey, Samuel Salitra, Junia Myung, Meiyun Guo, Sumin Jo, Anuli Uzozie, Fatemeh Baharvand, Nina Rolf, Franziska Auer, Julia Hauer, Stephan A. Grupp, Patrice Eydoux, Philipp F. Lange, Alix E. Seif, Christopher A. Maxwell, Gregor S. D. Reid
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Clonal hematopoiesis and its impact on the aging osteo-hematopoietic niche Leukemia (IF 11.4) Pub Date : 2024-03-21 Susann Winter, Katharina S. Götze, Judith S. Hecker, Klaus H. Metzeler, Borhane Guezguez, Kevin Woods, Hind Medyouf, Alexander Schäffer, Marc Schmitz, Rebekka Wehner, Ingmar Glauche, Ingo Roeder, Martina Rauner, Lorenz C. Hofbauer, Uwe Platzbecker
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Treatment and survival for patients with localized primary ocular adnexal extranodal marginal zone lymphoma Leukemia (IF 11.4) Pub Date : 2024-03-19 Lin-Rui Gao, Xin Li, Xinyue Wang, Yuanzheng Liang, Yunpeng Wu, Xiao-Li Feng, Wei Rao, Xin Liu, Yong-Wen Song, Hui Fang, Bo Chen, Jing Jin, Yue-Ping Liu, Hao Jing, Yuan Tang, Ning-Ning Lu, Shu-Lian Wang, Ye-Xiong Li, Liang Wang, Shu-Nan Qi
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Beyond the marrow: insights from comprehensive next-generation sequencing of extramedullary multiple myeloma tumors Leukemia (IF 11.4) Pub Date : 2024-03-16 T. Jelinek, D. Zihala, T. Sevcikova, A. Anilkumar Sithara, V. Kapustova, H. Sahinbegovic, O. Venglar, L. Muronova, L. Broskevicova, S. Nenarokov, D. Bilek, T. Popkova, H. Plonkova, J. Vrana, V. Zidlik, P. Hurnik, M. Havel, M. Hrdinka, Z. Chyra, G. Stracquadanio, M. Simicek, R. Hajek
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CD22 CAR T cells demonstrate high response rates and safety in pediatric and adult B-ALL: Phase 1b results Leukemia (IF 11.4) Pub Date : 2024-03-15 Liora M. Schultz, Nikeshan Jeyakumar, Anne Marijn Kramer, Bita Sahaf, Hrishi Srinagesh, Parveen Shiraz, Neha Agarwal, Mark Hamilton, Courtney Erickson, Ashley Jacobs, Jennifer Moon, Christina Baggott, Sally Arai, Sushma Bharadwaj, Laura J. Johnston, Michaela Liedtke, Robert Lowsky, Everett Meyer, Robert Negrin, Andrew Rezvani, Judy Shizuru, Surbhi Sidana, Emily Egeler, Sharon Mavroukakis, Ramya Tunuguntla
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Differential in vivo roles of Mpl cytoplasmic tyrosine residues in murine hematopoiesis and myeloproliferative disease Leukemia (IF 11.4) Pub Date : 2024-03-15 Kira Behrens, Maria Kauppi, Elizabeth M. Viney, Andrew J. Kueh, Craig D. Hyland, Tracy A. Willson, Liam Salleh, Carolyn A. de Graaf, Jeffrey J. Babon, Marco J. Herold, Nicos A. Nicola, Warren S. Alexander
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NFKBIE mutations are selected by the tumor microenvironment and contribute to immune escape in chronic lymphocytic leukemia Leukemia (IF 11.4) Pub Date : 2024-03-15 Alice Bonato, Supriya Chakraborty, Riccardo Bomben, Giulia Canarutto, Giulia Felician, Claudio Martines, Antonella Zucchetto, Federico Pozzo, Marija Vujovikj, Jerry Polesel, Annalisa Chiarenza, Maria Ilaria Del Principe, Giovanni Del Poeta, Giovanni D’Arena, Roberto Marasca, Agostino Tafuri, Luca Laurenti, Silvano Piazza, Aleksandar J. Dimovski, Valter Gattei, Dimitar G. Efremov
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Flow cytometric analysis of peripheral blood neutrophil myeloperoxidase expression in myelodysplastic neoplasms Leukemia (IF 11.4) Pub Date : 2024-03-14 Tatiana Raskovalova, Marie-Christine Jacob, Sophie Park
In a letter to the editor, Oelschlaegel et al. [1] describes the new flow cytometry score (MDS-PB13) for the diagnosis of myelodysplastic syndromes (MDS) that relies on aberrant antigen expression of thirteen parameters in different cell populations of peripheral blood with 79–81% specificity and 61–70% sensibility. Suspicion of MDS is the commonest reason for bone marrow aspirate and biopsy in older
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Mutation order in acute myeloid leukemia identifies uncommon patterns of evolution and illuminates phenotypic heterogeneity Leukemia (IF 11.4) Pub Date : 2024-03-11 Matthew Schwede, Katharina Jahn, Jack Kuipers, Linde A. Miles, Robert L. Bowman, Troy Robinson, Ken Furudate, Hidetaka Uryu, Tomoyuki Tanaka, Yuya Sasaki, Asiri Ediriwickrema, Brooks Benard, Andrew J. Gentles, Ross Levine, Niko Beerenwinkel, Koichi Takahashi, Ravindra Majeti
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Why are not all eligible chronic myeloid leukemia patients willing to attempt tyrosine kinase inhibitor discontinuation? A Czech nationwide analysis related to the TKI stopping trial HALF Leukemia (IF 11.4) Pub Date : 2024-03-12 Daniela Žáčková, Lukáš Semerád, Edgar Faber, Hana Klamová, Lukáš Stejskal, Petra Bělohlávková, Michal Karas, Eduard Cmunt, Olga Černá, Jiřina Procházková, Petra Čičátková, Anežka Kvetková, Tomáš Horňák, Ivana Skoumalová, Dana Srbová, Cyril Šálek, David Buffa, Jaroslava Voglová, Tomáš Jurček, Adam Folta, Ivana Ježíšková, Hana Žižková, Kateřina Machová Poláková, Tomáš Papajík, Pavel Žák, Pavel Jindra