样式: 排序: IF: - GO 导出 标记为已读
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Mitochondrial dysfunction: mechanisms and advances in therapy Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-05-15 Yao Zong, Hao Li, Peng Liao, Long Chen, Yao Pan, Yongqiang Zheng, Changqing Zhang, Delin Liu, Minghao Zheng, Junjie Gao
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2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-05-15 Fu Peng, Minru Liao, Wenke Jin, Wei Liu, Zixiang Li, Zhichao Fan, Ling Zou, Siwei Chen, Lingjuan Zhu, Qian Zhao, Gu Zhan, Liang Ouyang, Cheng Peng, Bo Han, Jin Zhang, Leilei Fu
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Safety, immunogenicity and protective effect of sequential vaccination with inactivated and recombinant protein COVID-19 vaccine in the elderly: a prospective longitudinal study Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-05-13 Hong-Hong Liu, Yunbo Xie, Bao-Peng Yang, Huan-Yue Wen, Peng-Hui Yang, Jin-E Lu, Yan Liu, Xi Chen, Meng-Meng Qu, Yang Zhang, Wei-Guo Hong, Yong-Gang Li, Junliang Fu, Fu-Sheng Wang
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Enhanced potency of an IgM-like nanobody targeting conserved epitope in SARS-CoV-2 spike N-terminal domain Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-05-13 Bo Liu, Honghui Liu, Pu Han, Xiaoyun Wang, Chunmei Wang, Xinxin Yan, Wenwen Lei, Ke Xu, Jianjie Zhou, Jianxun Qi, Ruiwen Fan, Guizhen Wu, Wen-xia Tian, George F. Gao, Qihui Wang
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Structural basis of negative regulation of CRISPR-Cas7-11 by TPR-CHAT Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-05-13 Tian Hong, Qinghua Luo, Haiyun Ma, Xin Wang, Xinqiong Li, Chongrong Shen, Jie Pang, Yan Wang, Yuejia Chen, Changbin Zhang, Zhaoming Su, Haohao Dong, Xiaodi Tang
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SARS-CoV-2 aberrantly elevates mitochondrial bioenergetics to induce robust virus propagation Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-05-11 Hye Jin Shin, Wooseong Lee, Keun Bon Ku, Gun Young Yoon, Hyun-Woo Moon, Chonsaeng Kim, Mi-Hwa Kim, Yoon-Sun Yi, Sangmi Jun, Bum-Tae Kim, Jong-Won Oh, Aleem Siddiqui, Seong-Jun Kim
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Effect of plateletcrit and methylenetetrahydrofolate reductase (MTHFR) C677T genotypes on folic acid efficacy in stroke prevention Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-05-10 Yuncong Shi, Zhengzhipeng Zhang, Binyan Wang, Yu Wang, Xiangyi Kong, Yong Sun, Aimin Li, Yimin Cui, Yan Zhang, Jianping Li, Yong Huo, Hui Huang
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Robust neutralization of SARS-CoV-2 variants including JN.1 and BA.2.87.1 by trivalent XBB vaccine-induced antibodies Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-05-09 Xun Wang, Shujun Jiang, Wentai Ma, Yanliang Zhang, Pengfei Wang
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Unveiling the culprit: the fusobacterium lineage that populates colorectal cancer Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-05-08 Johannes Betge, Matthias P. Ebert
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A pathological joint–liver axis mediated by matrikine-activated CD4+ T cells Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-05-08 Junzhi Yi, Hui Zhang, Fangyuan Bao, Zhichu Chen, Yuliang Zhong, Tianning Ye, Xuri Chen, Jingyi Qian, Mengya Tian, Min Zhu, Zhi Peng, Zongyou Pan, Jianyou Li, Zihao Hu, Weiliang Shen, Jiaqi Xu, Xianzhu Zhang, Youzhi Cai, Mengjie Wu, Hua Liu, Jing Zhou, Hongwei Ouyang
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CAR-T overdrive: harnessing inosine for metabolic rewiring and stemness induction Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-05-07 Martí Farrera-Sal, Michael Schmueck-Henneresse
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Dietary selection of commensal protists: expanding host immunity by impacting trans-kindom competition with bacteria Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-05-06 Bo Li, Min Wu, Huaqiong Li
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Haploidentical hematopoietic cell transplantation with or without an unrelated cord blood unit for adult acute myeloid leukemia: a multicenter, randomized, open-label, phase 3 trial Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-05-06 Biqi Zhou, Jia Chen, Tianhui Liu, Yishan Ye, Yanming Zhang, Yiyang Ding, Hong Liu, MingQing Zhu, Xiao Ma, Xiaoli Li, Longfei Zhao, Zhihong Lin, He Huang, Yang Xu, Depei Wu
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Cholangiocarcinoma combined with biliary obstruction: an exosomal circRNA signature for diagnosis and early recurrence monitoring Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-05-03 Ningyuan Wen, Dingzhong Peng, Xianze Xiong, Geng Liu, Guilin Nie, Yaoqun Wang, Jianrong Xu, Shaofeng Wang, Sishu Yang, Yuan Tian, Bei Li, Jiong Lu, Nansheng Cheng
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Combination therapy with oncolytic virus and T cells or mRNA vaccine amplifies antitumor effects Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-05-03 Rao Fu, Ruoyao Qi, Hualong Xiong, Xing Lei, Yao Jiang, Jinhang He, Feng Chen, Liang Zhang, Dekui Qiu, Yiyi Chen, Meifeng Nie, Xueran Guo, Yuhe Zhu, Jinlei Zhang, Mingxi Yue, Jiali Cao, Guosong Wang, Yuqiong Que, Mujing Fang, Yingbin Wang, Yixin Chen, Tong Cheng, Shengxiang Ge, Jun Zhang, Quan Yuan, Tianying Zhang, Ningshao Xia
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Harnessing naturally occurring mutations for T-cell therapy: a potential new avenue to enhance treatment efficacy Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-04-30 Michael Hiltensperger, Jürgen Ruland, Kilian Schober
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Two hits are better than one: rational dual strategy efficiently fights neuroblastoma Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-04-30 Jacques Zimmer, Camille Rolin, Markus Ollert
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Unraveling the role of METTL14 in metabolic dysfunction-associated fatty liver disease: insights and therapeutic implications Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-04-29 So Jung Kim, Jeongeun Hyun
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A positive feedback inhibition of isocitrate dehydrogenase 3β on paired-box gene 6 promotes Alzheimer-like pathology Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-04-29 Xin Wang, Qian Liu, Hai-tao Yu, Jia-zhao Xie, Jun-ning Zhao, Zhi-ting Fang, Min Qu, Yao Zhang, Ying Yang, Jian-Zhi Wang
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Nasal vaccination of triple-RBD scaffold protein with flagellin elicits long-term protection against SARS-CoV-2 variants including JN.1 Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-04-27 Xian Li, Mengxin Xu, Jingyi Yang, Li Zhou, Lin Liu, Min Li, Shasha Wang, Mei-Qin Liu, Zhixiang Huang, Zhen Zhang, Shuning Liu, Yunqi Hu, Haofeng Lin, Bowen Liu, Ying Sun, Qingguo Wu, Zheng-Li Shi, Ke Lan, Yu Chen, Huimin Yan, Yao-Qing Chen
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Cas13d-mediated gene knockdown in CAR T cells: towards off-the-shelf cancer treatment Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-04-26 Midori Johnston, Nadine Urban, Can Dincer
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Induced pluripotent stem cells (iPSCs): molecular mechanisms of induction and applications Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-04-26 Jonas Cerneckis, Hongxia Cai, Yanhong Shi
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Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-04-26 Joshua S. Fleishman, Sunil Kumar
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Dysfunction of the adhesion G protein-coupled receptor latrophilin 1 (ADGRL1/LPHN1) increases the risk of obesity Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-04-26 André Nguyen Dietzsch, Hadi Al-Hasani, Joachim Altschmied, Katharina Bottermann, Jana Brendler, Judith Haendeler, Susanne Horn, Isabell Kaczmarek, Antje Körner, Kerstin Krause, Kathrin Landgraf, Diana Le Duc, Laura Lehmann, Stefan Lehr, Stephanie Pick, Albert Ricken, Rene Schnorr, Angela Schulz, Martina Strnadová, Akhil Velluva, Heba Zabri, Torsten Schöneberg, Doreen Thor, Simone Prömel
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Modularization of adhesion G protein-coupled receptor (aGPCR) structure: how alternative splicing regulates synaptogenesis Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-04-24 Tobias Langenhan
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Gene replacement therapy in Bietti crystalline corneoretinal dystrophy: an open-label, single-arm, exploratory trial Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-04-24 Jinyuan Wang, Jinlu Zhang, Shicheng Yu, Hongyan Li, Shaohong Chen, Jingting Luo, Haibo Wang, Yuxia Guan, Haihan Zhang, Shiyi Yin, Huili Wang, Heping Li, Junle Liu, Jingyuan Zhu, Qiong Yang, Ying Sha, Chuan Zhang, Yuhang Yang, Xuan Yang, Xifang Zhang, Xiuli Zhao, Likun Wang, Liping Yang, Wenbin Wei
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SRY-Box transcription factor 9 triggers YAP nuclear entry via direct interaction in tumors Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-04-24 Hui Qian, Chen-Hong Ding, Fang Liu, Shi-Jie Chen, Chen-Kai Huang, Meng-Chao Xiao, Xia-Lu Hong, Ming-Chen Wang, Fang-Zhi Yan, Kai Ding, Ya-Lu Cui, Bai-Nan Zheng, Jin Ding, Cheng Luo, Xin Zhang, Wei-Fen Xie
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FGF7 enhances the expression of ACE2 in human islet organoids aggravating SARS-CoV-2 infection Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-04-23 Hao Meng, Zhiying Liao, Yanting Ji, Dong Wang, Yang Han, Chaolin Huang, Xujuan Hu, Jingyi Chen, Hengrui Zhang, Zonghong Li, Changliang Wang, Hui Sun, Jiaqi Sun, Lihua Chen, Jiaxiang Yin, Jincun Zhao, Tao Xu, Huisheng Liu
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Efficacy and safety of human umbilical cord-derived mesenchymal stem cells in the treatment of refractory immune thrombocytopenia: a prospective, single arm, phase I trial Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-04-23 Yunfei Chen, Yanmei Xu, Ying Chi, Ting Sun, Yuchen Gao, Xueqing Dou, Zhibo Han, Feng Xue, Huiyuan Li, Wei Liu, Xiaofan Liu, Huan Dong, Rongfeng Fu, Mankai Ju, Xinyue Dai, Wentian Wang, Yueshen Ma, Zhen Song, Jundong Gu, Wei Gong, Renchi Yang, Lei Zhang
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PBX/Knotted 1 homeobox-2 (PKNOX2) is a novel regulator of myocardial fibrosis Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-04-22 Liang Chen, Haotong Li, Xiaorui Liu, Ningning Zhang, Kui Wang, Anteng Shi, Hang Gao, Deniz Akdis, Ardan M. Saguner, Xinjie Xu, Elena Osto, Willem Van de Veen, Guangyu Li, Antoni Bayés-Genís, Firat Duru, Jiangping Song, Xiangjie Li, Shengshou Hu
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A novel engineered IL-21 receptor arms T-cell receptor-engineered T cells (TCR-T cells) against hepatocellular carcinoma Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-04-20 Wei Zhu, Zhiming Zhang, Jinzhang Chen, Xiaolan Chen, Lei Huang, Xiaoyong Zhang, Xuan Huang, Na Ma, Weikang Xu, Xuan Yi, Xinyu Lu, Xin Fu, Siwei Li, Guoheng Mo, Yiyue Wang, Guosheng Yuan, Mengya Zang, Qi Li, Xiaotao Jiang, Yajing He, Sha Wu, Yukai He, Yongyin Li, Jinlin Hou
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The activity and immune dynamics of PD-1 inhibition on high-risk pulmonary ground glass opacity lesions: insights from a single-arm, phase II trial Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-04-19 Bo Cheng, Caichen Li, Jianfu Li, Longlong Gong, Peng Liang, Ying Chen, Shuting Zhan, Shan Xiong, Ran Zhong, Hengrui Liang, Yi Feng, Runchen Wang, Haixuan Wang, Hongbo Zheng, Jun Liu, Chengzhi Zhou, Wenlong Shao, Yuan Qiu, Jiancong Sun, Zhanhong Xie, Zhu Liang, Chenglin Yang, Xiuyu Cai, Chunxia Su, Wei Wang, Jianxing He, Wenhua Liang
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Drug repurposing for cancer therapy Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-04-19 Ying Xia, Ming Sun, Hai Huang, Wei-Lin Jin
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METTL14 downregulation drives S100A4+ monocyte-derived macrophages via MyD88/NF-κB pathway to promote MAFLD progression Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-04-17 Yue-fan Wang, Wen-li Zhang, Zhi-xuan Li, Yue Liu, Jian Tan, Hao-zan Yin, Zhi-chao Zhang, Xian-jie Piao, Min-hao Ruan, Zhi-hui Dai, Si-jie Wang, Chen-yang Mu, Ji-hang Yuan, Shu-han Sun, Hui Liu, Fu Yang
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Phase II study of novel orally PI3Kα/δ inhibitor TQ-B3525 in relapsed and/or refractory follicular lymphoma Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-04-17 Huaqing Wang, Jifeng Feng, Yanyan Liu, Zhengzi Qian, Da Gao, Xuehong Ran, Hui Zhou, Lihong Liu, Binghua Wang, Meiyun Fang, Hebing Zhou, Zhenqian Huang, Shi Tao, Zhuowen Chen, Liping Su, Hang Su, Yu Yang, Xiaobao Xie, Huijing Wu, Ping Sun, Guoyu Hu, Aibin Liang, Zhiming Li
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Pandemic punch: SARS-CoV-2 hits pancreas Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-04-16 Ninel Azoitei, Sandra Heller, Alexander Kleger
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Poly(A)-specific RNase (PARN) generates and regulates miR-125a-5p 3’-isoforms, displaying an altered expression in breast cancer Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-04-15 Luisa Tomasello, Shoshanah M. Holub, Giovanni Nigita, Rosario Distefano, Carlo M. Croce
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Anti-lymphangiogenesis for boosting drug accumulation in tumors Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-04-15 Chunling Wang, Junchao Xu, Xiaoyu Cheng, Ge Sun, Fenfen Li, Guangjun Nie, Yinlong Zhang
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Infection with SARS-CoV-2 can cause pancreatic impairment Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-04-12 Wei Deng, Linlin Bao, Zhiqi Song, Ling Zhang, Pin Yu, Yanfeng Xu, Jue Wang, Wenjie Zhao, Xiuqin Zhang, Yunlin Han, Yanhong Li, Jiangning Liu, Qi Lv, Xujian Liang, Fengdi Li, Feifei Qi, Ran Deng, Siyuan Wang, Yibai Xiong, Ruiping Xiao, Hongyang Wang, Chuan Qin
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G protein-coupled receptors (GPCRs): advances in structures, mechanisms, and drug discovery Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-04-10 Mingyang Zhang, Ting Chen, Xun Lu, Xiaobing Lan, Ziqiang Chen, Shaoyong Lu
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The gasdermin family: emerging therapeutic targets in diseases Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-04-08 Chenglong Zhu, Sheng Xu, Ruoyu Jiang, Yizhi Yu, Jinjun Bian, Zui Zou
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Thiamine-modified metabolic reprogramming of human pluripotent stem cell-derived cardiomyocyte under space microgravity Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-04-08 Xinglong Han, Lina Qu, Miao Yu, Lingqun Ye, Liujia Shi, Guangfu Ye, Jingsi Yang, Yaning Wang, Hao Fan, Yong Wang, Yingjun Tan, Chunyan Wang, Qi Li, Wei Lei, Jianghai Chen, Zhaoxia Liu, Zhenya Shen, Yinghui Li, Shijun Hu
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Circulating tumor cells shielded with extracellular vesicle-derived CD45 evade T cell attack to enable metastasis Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-04-05 Chuan Yang, Xueping Wang, Kenneth K. W. To, Caimei Cui, Min Luo, Shaocong Wu, Lamei Huang, Kai Fu, Can Pan, Zeyu Liu, Teng Fan, Caibo Yang, Fang Wang, Liwu Fu
Circulating tumor cells (CTCs) are precursors of distant metastasis in a subset of cancer patients. A better understanding of CTCs heterogeneity and how these CTCs survive during hematogenous dissemination could lay the foundation for therapeutic prevention of cancer metastasis. It remains elusive how CTCs evade immune surveillance and elimination by immune cells. In this study, we unequivocally identified
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Protein neddylation and its role in health and diseases Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-04-05 Shizhen Zhang, Qing Yu, Zhijian Li, Yongchao Zhao, Yi Sun
NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate through a process known as neddylation, catalyzed by the enzyme cascade, namely NEDD8 activating enzyme (E1), NEDD8 conjugating enzyme (E2), and NEDD8 ligase (E3). The substrates of neddylation are categorized into cullins
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Adeno-associated virus as a delivery vector for gene therapy of human diseases Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-04-03 Jiang-Hui Wang, Dominic J. Gessler, Wei Zhan, Thomas L. Gallagher, Guangping Gao
Adeno-associated virus (AAV) has emerged as a pivotal delivery tool in clinical gene therapy owing to its minimal pathogenicity and ability to establish long-term gene expression in different tissues. Recombinant AAV (rAAV) has been engineered for enhanced specificity and developed as a tool for treating various diseases. However, as rAAV is being more widely used as a therapy, the increased demand
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XELOX (capecitabine plus oxaliplatin) plus bevacizumab (anti-VEGF-A antibody) with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer: a multicenter, open-label, randomized, controlled, phase 3 trial Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-04-03 Qiu-Zhong Pan, Jing-Jing Zhao, Liang Liu, Dong-Sheng Zhang, Li-Ping Wang, Wen-Wei Hu, De-Sheng Weng, Xiang Xu, Yi-Zhuo Li, Yan Tang, Wei-Hong Zhang, Jie-Yao Li, Xiao Zheng, Qi-Jing Wang, Yong-Qiang Li, Tong Xiang, Li Zhou, Shuang-Ning Yang, Chen Wu, Rong-Xing Huang, Jia He, Wei-Jiao Du, Lu-Jun Chen, Yue-Na Wu, Bin Xu, Qiong Shen, Yi Zhang, Jing-Ting Jiang, Xiu-Bao Ren, Jian-Chuan Xia
Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer (mCRC), but the prognosis remains poor. This phase 3 trial (ClinicalTrials.gov: NCT03950154) assessed the efficacy and adverse events (AEs) of the combination of PD-1 blockade-activated DC-CIK (PD1-T) cells with XELOX plus bevacizumab as a first-line
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Progression from ductal carcinoma in situ to invasive breast cancer: molecular features and clinical significance Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-04-03 Jing Wang, Baizhou Li, Meng Luo, Jia Huang, Kun Zhang, Shu Zheng, Suzhan Zhang, Jiaojiao Zhou
Ductal carcinoma in situ (DCIS) represents pre-invasive breast carcinoma. In untreated cases, 25–60% DCIS progress to invasive ductal carcinoma (IDC). The challenge lies in distinguishing between non-progressive and progressive DCIS, often resulting in over- or under-treatment in many cases. With increasing screen-detected DCIS in these years, the nature of DCIS has aroused worldwide attention. A deeper
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Macrocyclic peptides: up-and-coming weapons to combat antimicrobial resistance Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-04-02 Wen-Jing Wang, Xiang-Min Dong, Guo-Bo Li
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Neutrophils are shaped by the tumor microenvironment: novel possibilities for targeting neutrophils in cancer Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-04-02 Carlos Silvestre-Roig, Lydia Kalafati, Triantafyllos Chavakis
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Optimizing oncolytic virus design: a “Swiss army knife” approach to create a systemically delivered therapeutic Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-04-02 Carolina S. Ilkow, John Cameron Bell
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Mex-3 RNA binding family member A (MEX3A)/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-04-02 Ri-Xin Chen, Shui-Dan Xu, Min-Hua Deng, Shi-Hui Hao, Jie-Wei Chen, Xiao-Dan Ma, Wei-Tao Zhuang, Jing-Hua Cao, Yong-Rui Lv, Jin-Long Lin, Si-Yu Li, Gui-Bin Qiao, Dan Xie, Feng-Wei Wang
RNA-binding proteins (RBPs)-RNA networks have contributed to cancer development. Circular RNAs (circRNAs) are considered as protein recruiters; nevertheless, the patterns of circRNA-protein interactions in colorectal cancer (CRC) are still lacking. Processing bodies (PBs) formed through liquid-liquid phase separation (LLPS) are membrane-less organelles (MLOs) consisting of RBPs and RNA. Previous evidence
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Messing with cancer therapy: how the melanoma phenotype predicts checkpoint inhibitor response Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-04-01 Svenja Meierjohann, Corine Bertolotto
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The two sides of chromosomal instability: drivers and brakes in cancer Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-03-29 Rendy Hosea, Sharon Hillary, Sumera Naqvi, Shourong Wu, Vivi Kasim
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Rapid development of double-hit mRNA antibody cocktail against orthopoxviruses Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-03-27 Hang Chi, Suo-Qun Zhao, Ru-Yi Chen, Xing-Xing Suo, Rong-Rong Zhang, Wen-Hui Yang, Dong-Sheng Zhou, Min Fang, Bo Ying, Yong-Qiang Deng, Cheng-Feng Qin
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RNA modifications in cellular metabolism: implications for metabolism-targeted therapy and immunotherapy Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-03-27 Wei-Wei Liu, Si-Qing Zheng, Tian Li, Yun-Fei Fei, Chen Wang, Shuang Zhang, Fei Wang, Guan-Min Jiang, Hao Wang
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First-line camrelizumab (a PD-1 inhibitor) plus apatinib (an VEGFR-2 inhibitor) and chemotherapy for advanced gastric cancer (SPACE): a phase 1 study Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-03-25 Xiaofeng Chen, Hao Xu, Xiaobing Chen, Tongpeng Xu, Yitong Tian, Deqiang Wang, Fen Guo, Kangxin Wang, Guangfu Jin, Xiao Li, Rong Wang, Fengyuan Li, Yongbin Ding, Jie Tang, Yueyu Fang, Jing Zhao, Liang Liu, Ling Ma, Lijuan Meng, Zhiguo Hou, Rongrong Zheng, Yang Liu, Ni Guan, Bei Zhang, Shuang Tong, Shiqing Chen, Xing Li, Yongqian Shu
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SARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl− concentration Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-03-25 Jian-Bang Xu, Wei-Jie Guan, Yi-Lin Zhang, Zhuo-Er Qiu, Lei Chen, Xiao-Chun Hou, Junqing Yue, Yu-Yun Zhou, Jie Sheng, Lei Zhao, Yun-Xin Zhu, Jing Sun, Jincun Zhao, Wen-Liang Zhou, Nan-Shan Zhong
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Harnessing innate immune pathways for therapeutic advancement in cancer Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-03-25 Ankang Hu, Li Sun, Hao Lin, Yuheng Liao, Hui Yang, Ying Mao
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TGF-β signaling in health, disease, and therapeutics Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-03-22 Ziqin Deng, Tao Fan, Chu Xiao, He Tian, Yujia Zheng, Chunxiang Li, Jie He
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Cholesterol business: life or death by rust Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-03-21 Shubhangi Gavali, Francesca Maremonti, Andreas Linkermann