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Chimeric autoantibody-receptor T cells mediate depletion of autoantibody-producing B cells Am. J. Transplant. (IF 8.8) Pub Date : 2024-05-01 Han S. Yin, Eva M. Gillis-Buck, James M. Gardner
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Calcineurin inhibitor toxicity in de novo thrombotic microangiopathy—Is the culprit what we think it is? Am. J. Transplant. (IF 8.8) Pub Date : 2024-04-25 Vojtech Petr, Ivan Zahradka, Ondrej Viklicky
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Interim effectiveness of the updated 2023-2024 COVID-19 vaccines in adults with immunocompromizing conditions Am. J. Transplant. (IF 8.8) Pub Date : 2024-04-25 Marcus R. Pereira
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Undocumented immigrants: A glaring inequity in transplant Am. J. Transplant. (IF 8.8) Pub Date : 2024-04-23 Lara C. Pullen PhD
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Cyclic guanosine monophosphate-adenosine monophosphate synthetase/stimulator of interferon genes signaling aggravated corneal allograft rejection through neutrophil extracellular traps Am. J. Transplant. (IF 8.8) Pub Date : 2024-04-20 Chao Wei, Qing Huang, Fanxing Zeng, Li Ma, Xiaofei Bai, Xuejing Zhu, Hua Gao, Xiaolin Qi
The activation of innate immunity following transplantation has been identified as a crucial factor in allograft inflammation and rejection. However, the role of cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)/stimulator of interferon genes (STING) signaling-mediated innate immunity in the pathogenesis of allograft rejection remains unclear. Utilizing a well-established murine
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Third-party virus-specific T cells for the treatment of double-stranded DNA viral reactivation and posttransplant lymphoproliferative disease after solid organ transplant Am. J. Transplant. (IF 8.8) Pub Date : 2024-04-19 Ruby Khoury, Michael S. Grimley, Adam S. Nelson, Tom Leemhuis, Jose A. Cancelas, Eleanor Cook, YunZu Wang, Daria Heyenbruch, Catherine M. Bollard, Michael D. Keller, Patrick J. Hanley, Carolyn Lutzko, Giang Pham, Stella M. Davies, Jeremy D. Rubinstein
Reactivation or primary infection with double-stranded DNA viruses is common in recipients of solid organ transplants (SOTs) and is associated with significant morbidity and mortality. Treatment with conventional antiviral medications is limited by toxicities, resistance, and a lack of effective options for adenovirus (ADV) and BK polyomavirus (BKPyV). Virus-specific T cells (VSTs) have been shown
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The emerging era of organ transplantation and anti-CD154mAb Am. J. Transplant. (IF 8.8) Pub Date : 2024-04-19 Jean Kwun, Allan D. Kirk, Stuart J. Knechtle
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Comparing the prognostic performance of iBOX and biopsy-proven acute rejection for long-term kidney graft survival Am. J. Transplant. (IF 8.8) Pub Date : 2024-04-19 Amanda Klein, Luke Kosinski, Alexandre Loupy, Eric Frey, Mark Stegall, Ilkka Helanterä, Kenneth Newell, Herwig-Ulf Meier-Kriesche, Roslyn B. Mannon, William E. Fitzsimmons, Transplant Therapeutics Consortium
Biopsy-proven acute rejection (BPAR) occurs in approximately 10% of kidney transplant recipients in the first year, making superiority trials unfeasible. iBOX, a quantitative composite of estimated glomerular filtration rate, proteinuria, antihuman leukocyte antigen donor-specific antibody, and + full/− abbreviated kidney histopathology, is a new proposed surrogate endpoint. BPAR’s prognostic ability
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Pretransplant use of immune checkpoint inhibitors for hepatocellular carcinoma: A multicenter, retrospective cohort study Am. J. Transplant. (IF 8.8) Pub Date : 2024-04-18 Zhiyong Guo, Yao Liu, Qi Ling, Leibo Xu, Tielong Wang, Jiaxing Zhu, Yimou Lin, Xinjun Lu, Wei Qu, Fan Zhang, Zhijun Zhu, Jian Zhang, Zehua Jia, Ping Zeng, Wenjing Wang, Qiang Sun, Qijie Luo, Zemin Hu, Zhouying Zheng, Yingbin Jia, Jian Li, Yujian Zheng, Mengchao Wang, Shaoping Wang, Zemin Han, Sheng Yu, Chuanjiang Li, Shuhua Zhang, Jun Xiong, Feiwen Deng, Ying Liu, Huanwei Chen, Yanfeng Wang, Ling Li
Immune checkpoint inhibitors (ICIs) as a downstaging or bridging therapy for liver transplantation (LT) in hepatocellular carcinoma patients are rapidly increasing. However, the evidence about the feasibility and safety of pre-LT ICI therapy is limited and controversial. To this end, a multicenter, retrospective cohort study was conducted in 11 Chinese centers. The results showed that 83 recipients
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An ethical analysis of conditional and partially directed live kidney donation among strangers—The Israeli experience Am. J. Transplant. (IF 8.8) Pub Date : 2024-04-17 Penina Dienstag, Rana Halaseh, Keren Tzukert, Ashraf Imam, Abed Khalaileh, Aryeh Dienstag
Living donor kidney transplantation (LDKT) is one of the most effective treatment options for people with end-stage renal disease. Traditionally, LDKT can be either “directed” or “nondirected,” based on whether the recipient is specified by the donor. Recently, there has been an increase in conditional and semidirected live kidney donation among strangers, where the donor specifies the characteristics
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Incomplete reporting of clinically significant acute rejection episodes in the national kidney transplant registry Am. J. Transplant. (IF 8.8) Pub Date : 2024-04-16 Miko Yu, Kristen L. King, Lindsey M. Maclay, S. Ali Husain, Jesse D. Schold, Sumit Mohan
Administrative claims data could provide a unique opportunity to identify acute rejection (AR) events using specific antirejection medications and to validate rejected data reported to the Organ Procurement and Transplantation Network. This retrospective cohort study examined differences in registry-reported events and those identified using claims data among adult kidney transplant recipients from
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Magnetic resonance imaging as a noninvasive adjunct to conventional assessment of functional differences between kidneys in vivo and during ex vivo normothermic machine perfusion Am. J. Transplant. (IF 8.8) Pub Date : 2024-04-13 Tim L. Hamelink, Baran Ogurlu, Carolina C. Pamplona, Johannes Castelein, Sigrid S. Bennedsgaard, Haiyun Qi, Thomas Weiss, Veerle A. Lantinga, Merel B.F. Pool, Christoffer Laustsen, Bente Jespersen, Henri G.D. Leuvenink, Steffen Ringgaard, Ronald J.H. Borra, Anna K. Keller, Cyril Moers
Normothermic machine perfusion (NMP) is increasingly considered for pretransplant kidney quality assessment. However, fundamental questions about differences between in vivo and ex vivo renal function, as well as the impact of ischemic injury on ex vivo physiology, remain unanswered. This study utilized magnetic resonance imaging (MRI), alongside conventional parameters to explore differences between
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Activation of farnesoid X receptor enhances the efficacy of normothermic machine perfusion in ameliorating liver ischemia-reperfusion injury Am. J. Transplant. (IF 8.8) Pub Date : 2024-04-12 Qiang Zhao, Xiaobo Wang, Kunpeng Liu, Honghui Chen, Jia Dan, Zebin Zhu, Lili Guo, Huadi Chen, Weiqiang Ju, Dongping Wang, Yunhua Tang, Zhiyong Guo, Xiaoshun He
The shortage of transplant organs remains a severe global issue. Normothermic machine perfusion (NMP) has the potential to increase organ availability, yet its efficacy is hampered by the inflammatory response during machine perfusion. Mouse liver ischemia-reperfusion injury (IRI) models, discarded human liver models, and porcine marginal liver transplantation models were utilized to investigate whether
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China issued rules on human organ donation and transplantation Am. J. Transplant. (IF 8.8) Pub Date : 2024-04-12 Hao Chen, Di Lu, Shusen Zheng, Xiao Xu
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Anti-intercellular adhesion molecule 1 monomaintenance therapy induced long-term liver allograft survival without chronic rejection Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-30 Dong Kyu Han, Suk Kyun Hong, Il Hee Yun, Ji-Jing Yan, Jisu Park, Sang Wha Kim, Seung Hyeok Seok, Haeryoung Kim, Gilyong Ji, YoungRok Choi, Kwang-Woong Lee, Kyung-Suk Suh, Jaeseok Yang, Nam-Joon Yi
Calcineurin inhibitors (CNIs) are essential in liver transplantation (LT); however, their long-term use leads to various adverse effects. The anti–intercellular adhesion molecule (ICAM)-1 monoclonal antibody MD3 is a potential alternative to CNI. Despite its promising results with short-term therapy, overcoming the challenge of chronic rejection remains important. Thus, we aimed to investigate the
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Microbiome composition recovery after liver transplantation correlates with initial liver disease severity and antibiotics treatment Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-29 Sara Vega-Abellaneda, Cristina Dopazo, Francisca Yañez, Zaida Soler, Zixuan Xie, Aleix Canalda-Baltrons, Marc Pons-Tarín, Itxarone Bilbao, Chaysavanh Manichanh
Liver transplantation (LT) is crucial for end-stage liver disease, but it is linked to infection risks. Pathobionts, microorganisms potentially harmful under specific conditions, can cause complications posttransplant. Monitoring such pathogens in fecal samples can be challenging and therefore remains underexplored post-LT. This study aimed to analyze the gut microbiome before and after LT, tracking
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Maternal-fetal microchimerism as a durable but finite and replaceable alloantigen reservoir Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-29 Eva M. Gillis-Buck, James M. Gardner
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Xenotransplantation moves toward clinical trials Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-29 Lara C. Pullen PhD
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Total robotic liver transplant: the final frontier of minimally invasive surgery Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-29 Adeel S. Khan, Meranda Scherer, Roheena Panni, Darren Cullinan, Greg Martens, Ivan Kangarga, Christopher R. King, Richard Benzinger, Jason R. Wellen MD, William C. Chapman, Majella B. Doyle
The use of robotic surgery in transplantation is increasing; however, robotic liver transplantation (RLT) remains a challenging undertaking. To our knowledge, this is a report of the first RLT in North America and the first RLT using a whole graft from a deceased donor in the world. This paper describes the preparation leading to the RLT and the surgical technique of the operation. The operation was
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Do you transplant hearts from donation after circulatory determination of death donors? Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-29 Lara C. Pullen PhD
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Type 2 cytokines safeguard against cellular senescence and aging Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-27 Xian C. Li
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Molecular diagnosis of antibody-mediated rejection: Evaluating biopsy-based transcript diagnostics in the presence of donor-specific antibodies but without microvascular inflammation, a single-center descriptive analysis Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-27 Dusan Harmacek, Lukas Weidmann, Kai Castrezana Lopez, Nicolas Schmid, Raphael Korach, Nicola Bortel, Seraina von Moos, Elena Rho, Birgit Helmchen, Ariana Gaspert, Thomas Schachtner
Biopsy-based transcript diagnostics may identify molecular antibody-mediated rejection (AMR) when microvascular inflammation (MVI) is absent. In this single-center cohort, biopsy-based transcript diagnostics were validated in 326 kidney allograft biopsies. A total of 71 histological AMR and 35 T cell–mediated rejection (TCMR) cases were identified as molecular AMR and TCMR in 55% and 63%, respectively
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Differential induction of donor-reactive Foxp3+ regulatory T cell via blockade of CD154 vs CD40 Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-27 Danya Liu, Hongmin Yao, Ivana R. Ferrer, Mandy L. Ford
Recently published studies in both murine models and a meta-analysis of non-human primate renal transplant studies showed that anti-CD154 reagents conferred a significant survival advantage over CD40 blockers in both animal models and across multiple organs. Here we sought to compare the induction of donor-reactive forkhead box P3+-induced regulatory T cells (Foxp3 iTreg) in mice treated with anti-CD154
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Redefining the molecular rejection states in 3230 heart transplant biopsies: Relationships to parenchymal injury and graft survival Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-26 Philip F. Halloran, Katelynn Madill-Thomsen, Arezu Z. Aliabadi-Zuckermann, Martin Cadeiras, Marisa G. Crespo-Leiro, Eugene C. Depasquale, Mario Deng, Johannes Gökler, Shelley Hall, Aayla Jamil, Daniel H. Kim, Jon Kobashigawa, Peter Macdonald, Vojtech Melenovsky, Jignesh Patel, Luciano Potena, Keyur Shah, Josef Stehlik, Andreas Zuckermann
The first-generation Molecular Microscope (MMDx) system for heart transplant endomyocardial biopsies used expression of rejection-associated transcripts (RATs) to diagnose not only T cell–mediated rejection (TCMR) and antibody-mediated rejection (ABMR) but also acute injury. However, the ideal system should detect rejection without being influenced by injury, to permit analysis of the relationship
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Bridging the critically ill patient with acute to chronic liver failure to liver transplantation Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-26 Javier Fernández, Annabel Blasi, Ernest Hidalgo, Constantine J. Karvellas
Liver transplantation (LT) has emerged as an effective therapy for severe forms of acute-on-chronic liver failure (ACLF), an entity characterized by the development of multiorgan failure and high short-term mortality. The aim of critical care management of ACLF patients is to rapidly treat precipitating events and aggressively support failing organs to ensure that patients may successfully undergo
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Validation of a novel donor lung scoring system based on the updated lung Composite Allocation Score Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-24 Zhizhou Yang, Yun Zhu Bai, Yan Yan, Ramsey R. Hachem, Chad A. Witt, Rodrigo Vazquez Guillamet, Derek E. Byers, Gary F. Marklin, Daniel Kreisel, Ruben G. Nava, Bryan F. Meyers, Benjamin D. Kozower, G. Alexander Patterson, Matthew G. Hartwig, Brendan T. Heiden, Varun Puri
Lung transplantation (LTx) continues to have lower rates of long-term graft survival compared with other organs. Additionally, lung utilization rates from brain-dead donors remain substantially lower compared with other solid organs, despite a growing need for LTx and the significant risk of waitlist mortality. This study aims to examine the effects of using a combination of the recently described
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Nanoparticle targeting of neutrophil glycolysis prevents lung ischemia-reperfusion injury Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-24 Fuyi Liao, Davide Scozzi, Dequan Zhou, Mina Maksimos, Camila Diedrich, Marlene Cano, Laneshia K. Tague, Zhyi Liu, Jeffrey A. Haspel, Jennifer M. Leonard, Wenjun Li, Alexander S. Krupnick, Brian W. Wong, Daniel Kreisel, Abdel Kareem Azab, Andrew E. Gelman
Neutrophils exacerbate pulmonary ischemia-reperfusion injury (IRI) resulting in poor short and long-term outcomes for lung transplant recipients. Glycolysis powers neutrophil activation, but it remains unclear if neutrophil-specific targeting of this pathway will inhibit IRI. Lipid nanoparticles containing the glycolysis flux inhibitor 2-deoxyglucose (2-DG) were conjugated to neutrophil-specific Ly6G
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Association of procurement technique with organ yield and cost following donation after circulatory death Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-21 Syed Shahyan Bakhtiyar, Tiffany E. Maksimuk, John Gutowski, Sarah Y. Park, Michael T. Cain, Jessica Y. Rove, T. Brett Reece, Joseph C. Cleveland Jr., James J. Pomposelli, Yanik J. Bababekov, Trevor L. Nydam, Jesse D. Schold, Elizabeth A. Pomfret, Jordan R.H. Hoffman
Donation after circulatory death (DCD) could account for the largest expansion of the donor allograft pool in the contemporary era. However, the organ yield and associated costs of normothermic regional perfusion (NRP) compared to super-rapid recovery (SRR) with ex-situ normothermic machine perfusion, remain unreported. The Organ Procurement and Transplantation Network (December 2019 to June 2023)
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Are the Centers for Medicare & Medicaid Services metrics evaluating organ procurement organization performance too fragile? Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-20 Jesse D. Schold, Rocio Lopez, Sumit Mohan
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Coordinated elimination of bacterial taxa optimally attenuates alloimmunity and prolongs allograft survival Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-20 Martin Sepulveda, Mladen Rasic, Yuk Man Lei, Montserrat Kwan, Luqiu Chen, Yang Chen, David Perkins, Maria-Luisa Alegre
This study aimed to dissect the relationship between specific gut commensal bacterial subgroups, their functional metabolic pathways, and their impact on skin allograft outcome and alloimmunity. We previously showed that oral broad-spectrum antibiotic (Abx) pretreatment in mice delayed skin, heart, and lung allograft rejection and dampened alloimmune responses. Here, rationally designed Abx combinations
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Excess mortality in COVID-19-affected solid organ transplant recipients across the pandemic Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-20 Shigeyoshi Yamanaga, Keita Shimata, Satoko Ohfuji, Mikiko Yoshikawa, Yoichiro Natori, Taizo Hibi, Kenji Yuzawa, Hiroto Egawa, Japan Society for Transplantation COVID-19 Registry Study Group, Kohei Unagami, Hideki Ishida, Kazuya Omoto, Mureo Kasahara, Hajime Uchida, Seisuke Sakamoto, Kenta Futamura, Kenta Nishikawa, Ryoichi Imamura, Shigeaki Nakazawa, Etsuro Hatano, Takashi Ito, Yuki Masano, Morikuni
The excess mortality of coronavirus disease 2019 (COVID-19) solid organ transplant recipients (SOTRs) throughout the pandemic remains unclear. This prospective cohort study based on the Japanese nationwide registry included 1632 SOTRs diagnosed with COVID-19 between February 1, 2020, and July 31, 2022, categorized based on dominant phases of variants of concern (VOCs): Waves 1 to 3 (Beta), 4 (Alpha)
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Down to the coronary arteries: When spatial multiomics open up a narrow path Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-19 Alessandro Alessandrini, Ivy A. Rosales
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Myeloid-derived suppressor cells promote allograft survival by suppressing regulatory T cell dysfunction in high-risk corneal transplantation Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-19 Seokjoo Lee, Tomas Blanco, Aytan Musayeva, Shima Dehghani, Akitomo Narimatsu, Katayoon Forouzanfar, Gustavo Ortiz, Francesca Kahale, Shudan Wang, Yihe Chen, Thomas H. Dohlman, Sunil K. Chauhan, Reza Dana
Highly inflamed and neovascularized corneal graft beds are known as high-risk (HR) environments for transplant survival. One of the primary factors leading to this rejection is reduction in the suppressive function of regulatory T cells (Treg). Our results show that myeloid-derived suppressor cells (MDSC) counteract interleukin-6–mediated Treg dysfunction by expressing interleukin-10. Additionally
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Should advanced perfusion be the standard of care for donation after circulatory death liver transplant? Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-19 Kristopher P. Croome
As an alternative to static cold storage (SCS), advanced perfusion techniques such as normothermic regional perfusion and ex-situ perfusion (normothermic or hypothermic) have emerged as a way to improve the ischemic injury suffered by donation after circulatory death (DCD) livers. Multiple studies have been published that have demonstrated superior post-DCD liver transplant outcomes when using advanced
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Research opportunities and ethical considerations for heart and lung xenotransplantation research: A report from the National Heart, Lung, and Blood Institute workshop Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-19 Kiran K. Khush, James L. Bernat, Richard N. Pierson III, Henry J. Silverman, Brendan Parent, Alexandra K. Glazier, Andrew B. Adams, Jay A. Fishman, Michael Gusmano, Wayne J. Hawthorne, Mary E. Homan, Daniel J. Hurst, Stephen Latham, Chung-Gyu Park, Karen J. Maschke, Muhammad M. Mohiuddin, Robert A. Montgomery, Jonah Odim, Rebecca D. Pentz, Bruno Reichart, Julian Savulescu, Paul Root Wolpe, Renee P
Xenotransplantation offers the potential to meet the critical need for heart and lung transplantation presently constrained by the current human donor organ supply. Much was learned over the past decades regarding gene editing to prevent the immune activation and inflammation that cause early organ injury, and strategies for maintenance of immunosuppression to promote longer-term xenograft survival
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Untangling genetic and environmental risks in kidney transplant outcomes: The interplay of self-identified race, genetic ancestry, monogenic risk alleles, and socioeconomic factors Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-18 Yasar Caliskan, Krista L. Lentine
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Tiny heroes: Microbiota-modified bile acid metabolites protect against drug-induced gut damage Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-18 Montserrat Kwan, Maria-Luisa Alegre
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Liver machine perfusion technology: Expanding the donor pool to improve access to liver transplantation Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-18 Stalin Canizares, Adriana Montalvan, Ritah Chumdermpadetsuk, Anna Modest, Devin Eckhoff, David D. Lee
The imbalance between organ supply and demand continues to limit the broader benefits of organ transplantation. Machine perfusion (MP) may increase the supply of donor livers by expanding the use of extended-criteria donors. Using the United Network for Organ Sharing/Organ Procurement and Transplantation Network and the Standard Transplant Analysis and Research dataset, we reviewed the effect of MP
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Longitudinal outcomes of COVID-19 in solid organ transplant recipients from 2020 to 2023 Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-17 Javier T. Solera, Berta G. Árbol, Ankit Mittal, Victoria Hall, Tina Marinelli, Ilona Bahinskaya, Nazia Selzner, Michael McDonald, Jeffrey Schiff, Aman Sidhu, Atul Humar, Deepali Kumar
Data regarding coronavirus disease 2019 (COVID-19) outcomes in solid organ transplant recipients (SOTr) across severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) waves, including the impact of different measures, are lacking. This cohort study, conducted from March 2020 to May 2023 in Toronto, Canada, aimed to analyze COVID-19 outcomes in 1975 SOTr across various SARS-CoV-2 waves and assess
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Measles outbreak in the United States Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-16 Marcus R. Pereira
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Generating strategies for a national comeback in pancreas transplantation: A Delphi survey and US conference report Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-16 Ronald F. Parsons, Krista L. Lentine, Mona Doshi, Ty B. Dunn, Rachel Forbes, Jonathan A. Fridell, Michelle T. Jesse, Martha Pavlakis, Deirdre Sawinski, Neeraj Singh, David A. Axelrod, Matthew Cooper, Workshop Participants, Peter Abrams, Nada Alachkar, Tarek Alhamad, Nicole Ali, David Axelrod, Arpita Basu, Roy Bloom, George Burke, Beatrice Concepcion, Matthew Cooper, Rebecca Craig-Shapiro, Darshana
In the United States, potential transplant candidates with insulin-dependent diabetes mellitus are inconsistently offered pancreas transplantation (PTx), contributing to a dramatic decline in pancreas allograft utilization over the past 2 decades. The American Society of Transplantation organized a workshop to identify barriers inhibiting PTx and to develop strategies for a national comeback. The 2-day
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Iron deficiency, anemia, and patient-reported outcomes in kidney transplant recipients Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-15 Daan Kremer, Tim J. Knobbe, Joanna Sophia J. Vinke, Dion Groothof, Adrian Post, Coby Annema, Alferso C. Abrahams, Brigit C. van Jaarsveld, Martin H. de Borst, Stefan P. Berger, TransplantLines Investigators, Adelta V. Ranchor, Antonio W. Gomes Neto, Arjan Diepstra, Bouke G. Hepkema, C. Tji Gan, Caecilia S.E. Doorenbos, Charlotte A. te Velde-Keyzer, Coretta van Leer-Buter, Daan J. Touw, Eelko Hak, Erik
Kidney transplant recipients (KTRs) experience more fatigue, anxiety, and depressive symptoms and lower concentration and health-related quality of life (HRQoL) compared with the general population. Anemia is a potential cause that is well-recognized and treated. Iron deficiency, however, is often unrecognized, despite its potential detrimental effects related to and unrelated to anemia. We investigated
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The use of extracorporeal photopheresis in solid organ transplantation—current status and future directions Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-14 Markus J. Barten, Andrew J. Fisher, Alexandre Hertig
Prevention and management of allograft rejection urgently require more effective therapeutic solutions. Current immunosuppressive therapies used in solid organ transplantation, while effective in reducing the risk of acute rejection, are associated with substantial adverse effects. There is, therefore, a need for agents that can provide immunomodulation, supporting graft tolerance, while minimizing
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Immunosuppression withdrawal in living-donor renal transplant recipients following induction with antithymocyte globulin and rituximab: Results of a prospective clinical trial Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-11 James F. Markmann, Bryna E. Burrell, Jonathan S. Bromberg, Choli Hartono, Dixon B. Kaufman, Andrew M. Possselt, Ali Naji, Nancy D. Bridges, Cynthia Breeden, Sai Kanaparthi, Jorge Pardo, Heather Kopetskie, Kristen Mason, Noha Lim, Sindhu Chandran
Durable tolerance in kidney transplant recipients remains an important but elusive goal. We hypothesized that adding B cell depletion to T cell depletion would generate an immune milieu postreconstitution dominated by immature transitional B cells, favoring tolerance. The Immune Tolerance Network ITN039ST Research Study of ATG and Rituximab in Renal Transplantation was a prospective multicenter pilot
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Banff 2022 Liver Group Meeting report: Monitoring long-term allograft health Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-09 Christopher O.C. Bellamy, Jacqueline G. O'Leary, Oyedele Adeyi, Nahed Baddour, Ibrahim Batal, John Bucuvalas, Arnaud Del Bello, Mohamed El Hag, Magda El-Monayeri, Alton B. Farris III, Sandy Feng, Maria Isabel Fiel, Sandra E. Fischer, John Fung, Krzysztof Grzyb, Maha Guimei, Hironori Haga, John Hart, Annette M. Jackson, Elmar Jaeckel, Nigar A. Khurram, Stuart J. Knechtle, Drew Lesniak, Josh Levitsky
The Banff Working Group on Liver Allograft Pathology met in September 2022. Participants included hepatologists, surgeons, pathologists, immunologists, and histocompatibility specialists. Presentations and discussions focused on the evaluation of long-term allograft health, including noninvasive and tissue monitoring, immunosuppression optimization, and long-term structural changes. Potential revision
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Living organ donation in polarized societies Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-08 Eytan Mor
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Morning administration enhances humoral response to SARS-CoV-2 vaccination in kidney transplant recipients Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-08 Ivan Zahradka, Filip Tichanek, Maria Magicova, Istvan Modos, Ondrej Viklicky, Vojtech Petr
Although severe acute respiratory syndrome coronavirus 2 messenger ribonucleic acid (SARS-CoV-2 mRNA) vaccines are effective in kidney transplant recipients (KTRs), their immune response to vaccination is blunted by immunosuppression. Other tools enhancing vaccination response are therefore needed. Interestingly, aligning vaccine administration with circadian rhythms (chronovaccination) has been shown
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Successful lung transplantation in genetic methionyl-tRNA synthetase–related alveolar proteinosis/lung fibrosis without recurrence under methionine supplementation: Medium-term outcome in 4 cases Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-08 Charlotte Roy, Nathalie Allou, Aurore Coulomb, Dominique Grenet, Raphaël Borie, Benjamin Zuber, Abdulmonem Hamid, Matthieu Glorion, Anne-Laure Brun, Elizabeth Longchamps, Alice Hadchouel, Olivier Brugiere
Pulmonary alveolar proteinosis (PAP) results from the accumulation of lipoproteinaceous material in the alveoli and alveolar macrophages, and can be associated with pulmonary fibrosis, with a need for lung transplantation (LTx). Causes of PAP are autoimmune (90%-95%), secondary (5%), or hereditary (<1%). Patients with hereditary PAP are generally not considered for isolated LTx, due to the high probability
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Racism and tolerance in live kidney donation in Israel—response to Nesher et al Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-08 Ayelet Shai
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Impact of removing donation service area and region from pancreas allocation Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-06 Sarah E. Booker, Katrina Gauntt, Jesse Howell, Joann White, Oyedolamu Olaitan, Rachel C. Forbes
On March 15, 2021, the Organ Procurement and Transplantation Network (OPTN) replaced donation service area (DSA) and OPTN region as units of pancreas (PA) allocation with a 250 nautical mile (NM) circle with proximity points. We analyzed OPTN data for kidney-pancreas (KP) and PA candidates, transplants, and donors in the 2 years pre-policy (March 16, 2019, to March 14, 2021) and post-policy (March
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Incidence and clearance of cervical and anal high-risk human papillomavirus in kidney transplant recipients: Results from a Danish prospective clinical study Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-06 Linea Landgrebe Ring, Helle Kiellberg Larsen, Kirsten Frederiksen, Merete Hædersdal, Søren Schwartz Sørensen, Jesper Hansen Bonde, Louise Thirstrup Thomsen, Susanne K. Kjær
This study investigates the incidence and clearance of cervical and anal high-risk human papillomavirus (hrHPV) infection in kidney transplant recipients (KTRs) compared to immunocompetent controls. During 2016-2017, we enrolled 125 female KTRs and 125 female controls. Liquid-based cervical and anal cytology samples collected at enrollment and follow-up were tested for human papillomavirus (HPV) DNA
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Microbial bile acid metabolite ameliorates mycophenolate mofetil-induced gastrointestinal toxicity through vitamin D3 receptor Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-05 Di Zhang, Wei Lv, Yue Xu, Zijian Zhang, Song Zeng, Weixun Zhang, Lian Gong, Limei Shao, Min Zhang, Tian He, Yingying Liu, Yuxuan Wang, Ling Liu, Xiaopeng Hu
Mycophenolate mofetil (MMF) is one of the most used immunosuppressive drugs in organ transplantation, but frequent gastrointestinal (GI) side effects through unknown mechanisms limit its clinical use. Gut microbiota and its metabolites were recently reported to play a vital role in MMF-induced GI toxicity, but the specific mechanism of how they interact with the human body is still unclear. Here, we
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Tissue-resident memory T cells in human kidney transplants have alloreactive potential Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-04 Daphne M. Hullegie-Peelen, Hector Tejeda-Mora, Marjolein Dieterich, Sebastiaan Heidt, Eric M.J. Bindels, Martin J. Hoogduijn, Dennis A. Hesselink, Carla C. Baan
The extent to which tissue-resident memory T (T) cells in transplanted organs possess alloreactivity is uncertain. This study investigates the alloreactive potential of T cells in kidney explants from 4 patients who experienced severe acute rejection leading to graft loss. Alloreactive T cell receptor (TCR) clones were identified in pretransplant blood samples through mixed lymphocyte reactions, followed
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The impact of induction therapy on the risk of posttransplant lymphoproliferative disorder in adult kidney transplant recipients with donor-recipient serological Epstein-Barr virus mismatch Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-04 Rose Mary Attieh, Hani M. Wadei, Michael A. Mao, Shennen A. Mao, Surakit Pungpapong, C. Burcin Taner, Tambi Jarmi, Wisit Cheungpasitporn, Napat Leeaphorn
Posttransplant lymphoproliferative disorder (PTLD) poses a significant concern in Epstein-Barr virus (EBV)–negative patients transplanted from EBV-positive donors (EBV R-/D+). Previous studies investigating the association between different induction agents and PTLD in these patients have yielded conflicting results. Using the Organ Procurement and Transplant Network database, we identified EBV R-/D+
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Functional maturation and longitudinal imaging of intraportal neonatal porcine islet grafts in genetically diabetic pigs Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-01 Johanna Pilz, Nicol Gloddek, Felix Lindheimer, Magdalena J. Lindner, Daniel Puhr-Westerheide, Muzzafer Ümütlü, Clemens Cyran, Max Seidensticker, Richard Lindner, Martin Kraetzl, Simone Renner, Daphne Merkus, Daniel Teupser, Peter Bartenstein, Sibylle I. Ziegler, Eckhard Wolf, Elisabeth Kemter
Allogeneic intraportal islet transplantation (ITx) has become an established treatment for patients with poorly controlled type 1 diabetes. However, the loss of viable beta-cell mass after transplantation remains a major challenge. Therefore, noninvasive imaging methods for long-term monitoring of the transplant fate are required. In this study, [Ga]Ga-DOTA-exendin-4 positron emission tomography/computed
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OPTN/SRTR 2022 Annual Data Report: Vascularized Composite Allograft Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-29 J. Andres Hernandez, Jonathan M. Miller, Emmanuel Emovon III, Jesse N. Howell, Guiliano Testa, Ajay K. Israni, Jon J. Snyder, Linda C. Cendales
This year’s chapter on vascularized composite allograft (VCA) encompasses reviews of data collected from 2014 (when VCA was included in the Final Rule) through 2022. The present Annual Data Report shows that the number of VCA recipients in the United States continues to be small and has remained consistent from the prior report. The data continue to be limited by sample size, with trends persistently
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OPTN/SRTR 2022 Annual Data Report: COVID-19 Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-29 Jonathan M. Miller, Yoon Son Ahn, Allyson Hart, Dorry L. Segev, David P. Schladt, Kathryn T. Livelli, Kelsi A. Lindblad, Ajay K. Israni, Jon J. Snyder
This chapter updates the COVID-19 chapter from the 2021 Annual Data Report with trends through November 12, 2022, and introduces trends in recovery and use of organs from donors with a positive COVID-19 test. Posttransplant mortality and graft failure, which remained a concern in all organs at the last report due to the Omicron variant wave, have returned to lower levels in the most recent available
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OPTN/SRTR 2022 Annual Data Report: Deceased Organ Donation Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-29 Ajay K. Israni, David A. Zaun, Katrina Gauntt, Cory R. Schaffhausen, Cinthia Lozano, Warren T. McKinney, Jonathan M. Miller, Jon J. Snyder
The Scientific Registry of Transplant Recipients uses data collected by the Organ Procurement and Transplantation Network to calculate metrics such as organs recovered per donor, organs transplanted per donor, and organs recovered for transplant but not transplanted (ie, nonuse). In 2022, there were 14,905 deceased donors, a 7.5% increase from 13,863 in 2021, and this number has been increasing since
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OPTN/SRTR 2022 Annual Data Report: Lung Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-29 Maryam Valapour, Carli J. Lehr, David P. Schladt, Jodi M. Smith, Kaitlin Swanner, Chelsea J. Weibel, Samantha Weiss, Jon J. Snyder
For the first time since the COVID-19 pandemic, the annual number of lung transplants performed in the United States increased. The year 2022, encompassed in this report, marks the last full calendar year where the Lung Allocation Score was used for ranking transplant candidates based on their estimated transplant benefit and donor lung allocation in the United States. In March 2023, a major change
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OPTN/SRTR 2022 Annual Data Report: Heart Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-29 Monica M. Colvin, Jodi M. Smith, Yoon Son Ahn, Dzhuliyana K. Handarova, Alina C. Martinez, Kelsi A. Lindblad, Ajay K. Israni, Jon J. Snyder
The number of heart transplants in the United States has continued to increase. Since 2011, pediatric heart transplants have increased 31.7% to 494 and adult heart transplants have increased 85.8% to 3,668 in 2022. The numbers of new candidates for pediatric and adult heart transplants have also increased, with 703 new pediatric candidates and 4,446 new adult candidates in 2022. Adult heart transplant