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Clinical features of patients with mutations in genes for nanophthalmos Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-14 Xueqing Li, Hui Xiao, Yihua Su, Xueshan Xiao, Shiqiang Li, Shufen Lin, Lei Fang, Wenmin Sun, Panfeng Wang, James Fielding Hejtmancik, Minbin Yu, Liming Chen, Qingjiong Zhang, Xing Liu
Background/Aims To distinguish the clinical feature of nanophthalmos (NNO) caused by mutations in protease serine 56 ( PRSS56 ), membrane-type frizzled-related protein ( MFRP ), myelin regulatory factor ( MYRF ) and transmembrane protein 98 ( TMEM98 ) and to evaluate the association between angle-closure glaucoma (ACG) and NNO. Methods Variants in those four genes were identified through exome sequencing/whole
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Long-term outcomes after acute primary angle closure: case series from Moorfields Eye Hospital, UK Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-13 Sana Hamid, Francesco Matarazzo, Zihan Sun, Sandika Baboolal, Dhakshi Muhundhakumar, Paul J Foster
Background There is limited data regarding the morbidity and progression to primary angle closure glaucoma in those presenting with acute primary angle closure (APAC) in the UK. We aim to report on the vision and intraocular pressure (IOP) outcomes and treatment required after an APAC episode and to identify any risk factors that could predict worse outcomes. Methods A retrospective observational case
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Improved accuracy of spectral-domain optical coherence tomography and optical coherence tomography angiography for monitoring myopic macular neovascularisation activity Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-10 Danny Siu-Chun Ng, Li Jia Chen, Leo Ka Yu Chan, Fang Yao Tang, Wee-Min Teh, Linbin Zhou, Fiona Chan, Eleanor Sui Sum Lin, Ka Wai Yuen, Wai Kit Chu, Shaheeda Mohamed, Chi Wai Tsang, Xinyuan Zhang, Jason C Yam, Chi-Pui Pang, Timothy Y Y Lai
Background/aims To evaluate the diagnostic accuracy of spectral-domain optical coherence tomography (SD OCT) combined with OCT angiography (OCTA) for myopic myopic macular neovascularisation (MNV) activity. Methods Both eyes of patients with myopic MNV diagnosed with fluorescein angiography (FA), SD OCT and OCTA were assessed by unmasked investigators. The images were deidentified and randomised before
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METAVISION: a novel system for quantifying metamorphopsia in patients with myopic traction maculopathy Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-10 Qi Zhang, Xiujuan Zhao, Xia Huang, Qingxiu Wu, Shida Chen, Yonghao Li, Ping Lian, Lin Lu
Purpose To develop a novel system for quantifying metamorphopsia in patients with myopic traction maculopathy (MTM) and to explore the metamorphopsia pattern of MTM. Design Observational, cross-sectional study. Methods We designed a new system. Results Of the 445 eyes tested, 188 (42.25%) were deemed by patients to have metamorphopsia impacting their daily lives while 257 (57.75%) were considered to
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Randomised clinical trial of extended depth of focus lenses for controlling myopia progression: Outcomes from SEED LVPEI Indian Myopia Study Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-10 Manoj K Manoharan, Pavan K Verkicharla
Purpose To determine the efficacy of extended depth of focus (EDOF) contact lenses for controlling myopia progression in children through a 1-year randomised clinical trial. Methods A total of 104 children aged 7–15 years, with spherical equivalent refraction ≤−0.50 D, were randomly assigned to wear SEED 1 dayPure EDOF Mid contact lenses (n=48) or single vision spectacle lenses (n=56). Cycloplegic
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Best practice in myopia control: insights and innovations for myopia prevention and control – a round table discussion Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-10 Yanxian Chen, Andreas Mueller, Ian Morgan, Frank Larkin, Yan Wang, Junwen Zeng, Mingguang He
In August 2023, BJO and the Zhongshan Ophthalmic Center co-hosted a round table discussion on Best Practices in Myopia Control. This gathering provided a platform for the exchange of insights and discussion of evidence-based strategies to respond to the rapid increase in myopia prevalence. Participants from China, Hong Kong, the UK and Australia met in Guangzhou, China, to discuss the global status
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Place-Based Measures of Inequity and Vision Difficulty and Blindness JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-05-09 Patrice M. Hicks, George Lin, Paula Anne Newman-Casey, Leslie M. Niziol, Ming-Chen Lu, Maria A. Woodward, Angela R. Elam, David C. Musch, Roshanak Mehdipanah, Joshua R. Ehrlich, David B. Rein
ImportanceKnown social risk factors associated with poor visual and systemic health in the US include segregation, income inequality, and persistent poverty.ObjectiveTo investigate the association of vision difficulty, including blindness, in neighborhoods with measures of inequity (Theil H index, Gini index, and persistent poverty).Design, Setting, and ParticipantsThis cross-sectional study used data
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Pegcetacoplan Treatment and Consensus Features of Geographic Atrophy Over 24 Months JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-05-09 Dun Jack Fu, Pallavi Bagga, Gunjan Naik, Sophie Glinton, Livia Faes, Bart Liefers, Rosana Lima, Georgina Wignall, Pearse A. Keane, Estelle Ioannidou, Ana Paula Ribeiro Reis, Alex McKeown, Lukas Scheibler, Praveen J. Patel, Ismail Moghul, Nikolas Pontikos, Konstantinos Balaskas
ImportanceDespite widespread availability and consensus on its advantages for detailed imaging of geographic atrophy (GA), spectral-domain optical coherence tomography (SD-OCT) might benefit from automated quantitative OCT analyses in GA diagnosis, monitoring, and reporting of its landmark clinical trials.ObjectiveTo analyze the association between pegcetacoplan and consensus GA SD-OCT end points.Design
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Medical education with large language models in ophthalmology: custom instructions and enhanced retrieval capabilities Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-07 Mertcan Sevgi, Fares Antaki, Pearse A Keane
Foundation models are the next generation of artificial intelligence that has the potential to provide novel use cases for healthcare. Large language models (LLMs), a type of foundation model, are capable of language comprehension and the ability to generate human-like text. Researchers and developers have been tuning LLMs to optimise their performance in specific tasks, such as medical challenge problems
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Enhancing the structure–function relationship in glaucoma using anatomical compensation of retinal nerve fibre layer Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-07 Jacqueline Chua, Chi Li, Rachel Chong, Tina T Wong, Rahat Husain, Tin Aung, Leopold Schmetterer, Damon Wing Kee Wong
Background/aims To investigate whether compensating retinal nerve fibre layer (RNFL) thickness measurements for demographic and anatomical ocular factors can strengthen the structure–function relationship in patients with glaucoma. Methods 600 eyes from 412 patients with glaucoma (mean deviation of the visual field (MD VF) −6.53±5.55 dB) were included in this cross-sectional study. Participants underwent
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OCT analysis of preoperative foveal microstructure in recent-onset macula-off rhegmatogenous retinal detachment: visual acuity prognostic factors Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-06 Maria Cristina Savastano, Matteo Mario Carlà, Federico Giannuzzi, Claudia Fossataro, Valentina Cestrone, Francesco Boselli, Ilaria Biagini, Flavia Beccia, Quatrale Raffaele, Gianni Gravina, Clara Rizzo, Alfonso Savastano, Stanislao Rizzo
Background To evaluate, in patients undergoing macula-off rhegmatogenous retinal detachment surgery (RRD), the correlation between preoperative optical coherence tomography (OCT) morphological features and postoperative visual acuity. Methods Retrospective interventional non-randomised clinical trial on 89 eyes of 89 patients undergoing pars plana vitrectomy for macula-off primary RRD at Policlinico
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Associations of quantitative contrast sensitivity with vascular metrics on widefield swept-source OCT angiography across stages of diabetic retinopathy Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-06 Filippos Vingopoulos, Grace Baldwin, Raviv Katz, Ying Cui, Jade Y Moon, Itika Garg, Rebecca Zeng, Nimesh A Patel, David Wu, Deeba Husain, Joan W Miller, Leo A Kim, Demetrios G Vavvas, John B Miller
Purpose To investigate structure–function associations between contrast sensitivity (CS) and widefield swept-source optical coherence tomography angiography (WF SS-OCTA) vascular metrics across stages of non-proliferative (NPDR) and proliferative diabetic retinopathy (PDR), without diabetic macular oedema. Methods Prospective cross-sectional study in 140 eyes of 99 patients: 33 mild NPDR, 24 moderate/severe
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Creating realistic anterior segment optical coherence tomography images using generative adversarial networks Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-02 Jad F Assaf, Anthony Abou Mrad, Dan Z Reinstein, Guillermo Amescua, Cyril Zakka, Timothy J Archer, Jeffrey Yammine, Elsa Lamah, Michèle Haykal, Shady T Awwad
Aims To develop a generative adversarial network (GAN) capable of generating realistic high-resolution anterior segment optical coherence tomography (AS-OCT) images. Methods This study included 142 628 AS-OCT B-scans from the American University of Beirut Medical Center. The Style and WAvelet based GAN architecture was trained to generate realistic AS-OCT images and was evaluated through the Fréchet
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Predicting the cognitive impairment with multimodal ophthalmic imaging and artificial neural network for community screening Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-02 Zi Jin, Xuhui Chen, Chunxia Jiang, Ximeng Feng, Da Zou, Yanye Lu, Jinying Li, Qiushi Ren, Chuanqing Zhou
Background/aims To investigate the comprehensive prediction ability for cognitive impairment in a general elder population using the combination of the multimodal ophthalmic imaging and artificial neural networks. Methods Patients with cognitive impairment and cognitively healthy individuals were recruited. All subjects underwent medical history, blood pressure measurement, the Montreal Cognitive Assessment
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Proliferative vitreoretinopathy: a revised concept of retinal injury and response Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-02 Alexandre Assi, David Charteris
Previous concepts for the pathogenesis of proliferative vitreoretinopathy (PVR) have focused on the central role of retinal pigment epithelium cells only, potentially contributing to the lack of clinical advances. More recent studies have demonstrated the essential role of retinal glial cells in the PVR healing response but failed to identify a consistent triggering mechanism. We propose a revised
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Mitochondrial retinopathies and optic neuropathies: The impact of retinal imaging on modern understanding of pathogenesis, diagnosis, and management Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2024-05-03 Enrico Borrelli, Francesco Bandello, Camiel J.F. Boon, Valerio Carelli, Guy Lenaers, Michele Reibaldi, Srinivas R. Sadda, Alfredo A. Sadun, David Sarraf, Patrick Yu-Wai-Man, Piero Barboni
Advancements in ocular imaging have significantly broadened our comprehension of mitochondrial retinopathies and optic neuropathies by examining the structural and pathological aspects of the retina and optic nerve in these conditions. This article aims to review the prominent imaging characteristics associated with mitochondrial retinopathies and optic neuropathies, aiming to deepen our insight into
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Single-cell RNA-sequencing reveals the transcriptional landscape of lacrimal gland in GVHD mouse model Ocul. Surf. (IF 6.4) Pub Date : 2024-05-03 Jingliang He, Fang Zheng, Li Zhang, Jiangxiong Cai, Yoko Ogawa, Kazuo Tsubota, Shan Liu, Xiuming Jin
To investigate the global transcriptional landscape of lacrimal gland cell populations in the GVHD mouse model. Single-cell RNA sequencing and further bioinformatic analysis of dissociated lacrimal gland (LG) cells from the mouse model were performed. Parts of transcriptional results were confirmed by immunofluorescence staining. We identified 23 cell populations belonging to 11 cell types. In GVHD
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Acute Corneal Edema in a Middle-Aged Patient JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-05-02 Jennifer A. Tran, Aaron R. Kaufman, Joseph B. Ciolino
A middle-aged patient who had bilateral penetrating keratoplasty 20 years ago for keratoconus presented with pain and blurriness of the right eye for 2 days. Despite prompt corticosteroid therapy, they had no vision improvement and reported occasional pain. What would you do next?
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Rate of Initial Optic Nerve Head Capillary Density Loss and Risk of Visual Field Progression JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-05-02 Natchada Tansuebchueasai, Takashi Nishida, Sasan Moghimi, Jo-Hsuan Wu, Golnoush Mahmoudinezhad, Gopikasree Gunasegaran, Alireza Kamalipour, Linda M. Zangwill, Robert N. Weinreb
ImportanceRapid initial optic nerve head capillary density loss may be used to assess the risk of glaucoma visual field progression.ObjectiveTo investigate the association between the rate of initial optic nerve head capillary density loss from optical coherence tomography angiography (OCTA) and visual field progression.Design, Setting, ParticipantsThis was a retrospective study of a longitudinal cohort
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Vision-Language Models for Feature Detection of Macular Diseases on Optical Coherence Tomography JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-05-02 Fares Antaki, Reena Chopra, Pearse A. Keane
ImportanceVision-language models (VLMs) are a novel artificial intelligence technology capable of processing image and text inputs. While demonstrating strong generalist capabilities, their performance in ophthalmology has not been extensively studied.ObjectiveTo assess the performance of the Gemini Pro VLM in expert-level tasks for macular diseases from optical coherence tomography (OCT) scans.Design
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Photokeratitis in Outdoor Event Participants Exposed to UV Radiation Display JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-05-02 Julia Y. Y. Chan, Vanissa W. S. Chow, Carmen K. M. Chan, Edmund Y. M. Chan, James S. K. Lau, Timothy Y. Y. Lai, Alvin L. Young, Clement C. Y. Tham
ImportanceWhile UV radiation displays may be used for recreational purposes at outdoor events, unprotected eyes have been reported to have symptoms consistent with photokeratitis. Such symptoms warrant documentation and evaluation in ophthalmic peer reviewed literature.ObjectiveTo describe a case series of photokeratitis associated with a single ultraviolet radiation display at an outdoor event.Design
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Readership awareness series – Paper 11: Copyright licensing for scientific publications Ocul. Surf. (IF 6.4) Pub Date : 2024-04-28 Mohammad Javed Ali, Ali Djalilian
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Re: Thibault et al.: Drug-induced uveitis related to checkpoint inhibitors and MAP-kinase inhibitors (Ophthalmology. 2024;131:249–251) Ophthalmology (IF 13.7) Pub Date : 2024-04-27 Jasmine H. Francis MD FACS, Julia Canestraro OD, David H. Abramson MD FACS
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Reply Ophthalmology (IF 13.7) Pub Date : 2024-04-27 Thomas Thibault MD, Romane Freppel PharmD, Hervé Devilliers MD PhD, Aurélie Grandvuillemin PharmD
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Age–period–cohort analysis of the global burden of visual impairment according to major causes: an analysis of the Global Burden of Disease Study 2019 Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-25 Jianqi Chen, Yingting Zhu, Zhidong Li, Xiaohua Zhuo, Shaochong Zhang, Yehong Zhuo
Background Cataract, glaucoma and age-related macular degeneration (AMD) are major causes of visual impairment. As these are age-related conditions, the prevalence of associated visual impairment is anticipated to increase as the population ages. However, age–period–cohort effects on the disease burden have not been investigated. Methods This was a population-based study using aggregated data from
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Survival of medical treatment success in primary open-angle glaucoma and ocular hypertension Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-25 Dun Jack Fu, Ebenezer Ademisoye, Vanessa Shih, Andrew Ian McNaught, Anthony Khawaja
Background/aims Topical agents to lower intraocular pressure (IOP) are the most common initial therapeutic measure in glaucoma prevention. This study aims to assess treatment success duration among patients initiating or intensifying topical glaucoma medication. Methods Medical records (2013‒2018) for adults initiating/intensifying topical glaucoma medication were extracted from five secondary-care
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HDAC1/2 and HDAC3 play distinct roles in controlling adult Meibomian gland homeostasis Ocul. Surf. (IF 6.4) Pub Date : 2024-04-26 Xuming Zhu, Mingang Xu, Sarah E. Millar
To investigate the roles of HDAC1/2 and HDAC3 in adult Meibomian gland (MG) homeostasis. HDAC1/2 or HDAC3 were inducibly deleted in MG epithelial cells of adult mice. The morphology of MG was examined. Proliferation, apoptosis, and expression of MG acinus and duct marker genes, meibocyte differentiation genes, and HDAC target genes, were analyzed via immunofluorescence, TUNEL assay, and RNA in situ
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Prediction of retinopathy progression using deep learning on retinal images within the Scottish screening programme Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-24 Joseph Mellor, Wenhua Jiang, Alan Fleming, Stuart J McGurnaghan, Luke A K Blackbourn, Caroline Styles, Amos Storkey, Paul M McKeigue, Helen M Colhoun
Background/aims National guidelines of many countries set screening intervals for diabetic retinopathy (DR) based on grading of the last screening retinal images. We explore the potential of deep learning (DL) on images to predict progression to referable DR beyond DR grading, and the potential impact on assigned screening intervals, within the Scottish screening programme. Methods We consider 21 346
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Home-Monitoring Vision Tests to Detect Active Neovascular Age-Related Macular Degeneration JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-04-25 Ruth E. Hogg, Sobha Sivaprasad, Robin Wickens, Sean O’Connor, Eleanor Gidman, Elizabeth Ward, Charlene Treanor, Tunde Peto, Ben J. L. Burton, Paul Knox, Andrew J. Lotery, Michael Donnelly, Chris A. Rogers, Barnaby C. Reeves
ImportanceMost neovascular age-related macular degeneration (nAMD) treatments involve long-term follow-up of disease activity. Home-monitoring would reduce the burden on patients and their caregivers and release clinic capacity.ObjectiveTo evaluate 3 vision home-monitoring tests for patients to use to detect active nAMD compared with diagnosing active nAMD at hospital follow-up during the after-treatment
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Daily Low-Level Red Light for Spherical Equivalent Error and Axial Length in Children With Myopia JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-04-25 Kai Cao, Lei Tian, Dong-Li Ma, Shi-Qiang Zhao, Ao Li, Zi-Bing Jin, Ying Jie
ImportanceTreatments are needed to slow progression of or reduce incidence of myopia.ObjectiveTo evaluate the efficacy and safety of daily 650-nm low-level red light (LLRL) for myopia treatment.Design, Setting, and ParticipantsSingle-masked, randomized clinical trial at 1 site in China. Baseline measurements were completed from August to September 2021. Participants were children aged 6 to 12 years
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Place, Race, and Lapses in Diabetic Retinopathy Care JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-04-25 Tina Tang, Diep Tran, Dingfen Han, Scott L. Zeger, Deidra C. Crews, Cindy X. Cai
This cohort study investigates the association of neighborhood-level social determinants of health with lapses in diabetic retinopathy care by race and ethnicity.
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COVID-19 Vaccine–Associated Uveitis in Patients With a History of Uveitis JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-04-25 Jiyeong Kim, Hyeon Yoon Kwon, Seong Joon Ahn
ImportanceUnderstanding the potential risk of uveitis recurrence after COVID-19 vaccination in individuals with a history of uveitis is crucial for vaccination strategies and clinical monitoring.ObjectiveTo investigate the risk of uveitis recurrence after COVID-19 vaccination in a cohort of individuals with a history of uveitis.Design, Setting, and ParticipantsThis retrospective population-based cohort
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Effectiveness of repeated low-level red light in myopia prevention and myopia control Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-17 Guihua Liu, Hua Rong, Yipu Liu, Biying Wang, Bei Du, Desheng Song, Ruihua Wei
Background/aims To compare the effects of repeated low-level red light (RLRL) treatment on axial length growth and refractive error changes in myopic and premyopic children. Methods Subjects were assigned randomly to four subgroups: myopia-RLRL group (M-RL), myopia-control group (M-C), premyopia-RLRL group (PM-RL) and premyopia-control group (PM-C). Subjects in the RLRL group completed a 12-month treatment
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Morning Glory Syndrome in a Newborn Aged 2 Weeks JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-04-18 Francesco Pozzo Giuffrida, Marco Nassisi, Silvia Osnaghi
This case report describes a diagnosis of morning glory syndrome in a 2-week-old infant who presented with divergent strabismus, cleft lip, and hypertelorism.
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Facial Swelling After External Dacryocystorhinostomy JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-04-18 Tyler Herod, Rami Darwich, Ahsen Hussain
A 67-year-old woman underwent elective external dacryocystorhinostomy to treat symptomatic nasolacrimal duct obstruction and developed persistent cervicofacial swelling and ecchymoses of the eyelids and cheek. Head computed tomography revealed extensive emphysema throughout the soft tissues of the face and neck. What would you do next?
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Oral Sirolimus for Diffuse Choroidal Hemangioma in Sturge-Weber Syndrome JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-04-18 Amy Kalantary, Anne Halbert, Maria Franchina, Rachael C. Heath Jeffery, Rod O’Day, Fred K. Chen
This case report describes an 8-year-old girl who received oral sirolimus as an adjuvant therapy for pulse dye laser of her port-wine stain and as an off-label treatment of exudative retinal detachment secondary to diffuse choroidal hemangioma.
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Patching in Children With Unilateral Congenital Cataract and Child Functioning and Parenting Stress JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-04-18 Carolyn Drews-Botsch, George Cotsonis, Marianne Celano, E. Eugenie Hartmann, Jaffer Zaidi, Scott R. Lambert
ImportanceParents may be concerned about the adverse outcomes of occlusion therapy in children treated for unilateral congenital cataract (UCC).ObjectiveTo determine whether occlusion therapy in children treated for UCC with poor visual outcomes is negatively associated with poorer child and/or family functioning.Design, Setting, and ParticipantsThis cohort study was conducted in 2023 using data collected
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Social history and glaucoma progression: the effect of body mass index, tobacco and alcohol consumption on the rates of structural change in patients with glaucoma Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-15 Asmaa A Youssif, Ndidi-Amaka Onyekaba, Rizul Naithani, Khaled Abdelazeem, Ahmed M Fathalla, Mohamed S Abdel‐Rhaman, Alessandro A Jammal, Felipe A Medeiros
Background/aims Although obesity, tobacco and alcohol consumption were linked to the progression of numerous chronic diseases, an association of these social history aspects with glaucoma progression is not yet determined. This study aims to investigate the effect of body mass index (BMI) and history of tobacco and alcohol use on the rates of retinal nerve fibre layer (RNFL) change over time in glaucoma
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Corrigendum to “New insights into lacrimal gland anatomy using 7T MRI and electron microscopy: Relevance for lacrimal gland targeted therapies and bioengineering” [Ocul. Surf. 30 (October 2023) 204–212] Ocul. Surf. (IF 6.4) Pub Date : 2024-04-16 Swati Singh, Zoltan Winter, Fabian Necker, Tobias Bäuerle, Michael Scholz, Lars Bräuer, Friedrich Paulsen
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Readership awareness series – Paper 10: Open Access Publishing Ocul. Surf. (IF 6.4) Pub Date : 2024-04-16 Mohammad Javed Ali, Ali Djalilian
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Factors Associated With Visual Field Testing Reliability in Children With Glaucoma or Suspected Glaucoma Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-04-16 ANIKA KUMAR, NATAN HEKMATJAH, YINXI YU, YING HAN, GUI-SHUANG YING, JULIUS T. OATTS
To evaluate Humphrey Visual Field (HVF) test reliability and its associated risk factors in children with glaucoma or glaucoma suspect. Retrospective cohort study. None. Single-center childhood glaucoma clinic. One hundred thirty-six patients aged ≤18 years with glaucoma/glaucoma suspect, and least 1 completed 24 to 2 HVF test between 2018 and 2023. Demographic and clinical characteristics including
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Using Large Language Models to Generate Educational Materials on Childhood Glaucoma Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-04-16 Qais Dihan, Muhammad Z. Chauhan, Taher K. Eleiwa, Amr K. Hassan, Ahmed B. Sallam, Albert S. Khouri, Ta C. Chang, Abdelrahman M. Elhusseiny
To evaluate the quality, readability, and accuracy of large language model (LLM) generated patient education materials (PEMs) on childhood glaucoma, and their ability to improve existing online information's readability. Cross-sectional comparative study. We evaluated responses of ChatGPT-3.5, ChatGPT-4, and Bard to three separate prompts requesting they write PEMs on “childhood glaucoma.” Prompt A
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Relapse in ocular tuberculosis: relapse rate, risk factors and clinical management in a non-endemic country Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-12 Ikhwanuliman Putera, Josianne C. E. M. ten Berge, Alberta A. H. J. Thiadens, Willem A. Dik, Rupesh Agrawal, P. Martin van Hagen, Rina La Distia Nora, Saskia M. Rombach
Aims To assess the risk of uveitis relapse in ocular tuberculosis (OTB) following clinical inactivity, to analyse clinical factors associated with relapses and to describe the management strategies for relapses. Methods A retrospective study was conducted on a 10-year patient registry of patients with OTB diagnosed at Erasmus MC in Rotterdam, The Netherlands. Time-to-relapse of uveitis was evaluated
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Manhattan Vision Screening and Follow-up Study (NYC-SIGHT): a nested cross-sectional assessment of falls risk within a cluster randomised trial Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-12 Lisa A Hark, Yujia Wang, Prakash Gorroochurn, Phyllis R Simon, Stefania C Maruri, Desiree R Henriquez, Daniel F Diamond, Jason D Horowitz, Lisa Park, Qing Wang, James D Auran, Jailine Carrion, David S Friedman, Jeffrey L Liebmann, George A Cioffi, Noga Harizman
Background To investigate the feasibility of using the Stopping Elderly Accidents, Deaths and Injuries (STEADI) Falls Risk Tool Kit during community-based eye health screenings to assess falls risk of participants enrolled in the Manhattan Vision Screening and Follow-Up Study (NYC-SIGHT). Methods Cross-sectional analysis of data from a 5-year prospective, cluster-randomised clinical trial conducted
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Predictive model for iris melanoma Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-12 Arun Singh, Alexander Melendez-Moreno, Jørgen Krohn, Emily C Zabor
To develop a predictive model for the diagnosis of iris melanoma. Methods Retrospective consecutive case series that included 100 cases of pathologically confirmed iris melanoma and 112 cases of Iris naevus, either pathological confirmation or documented stability of >1 year. Patient demographic data, features of clinical presentation, tumour characteristics and follow-up were collected. Iris melanoma
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How to tame a tight DMEK-roll? The ‘bubble-in-the-roll’ technique Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-04-13 Gergely Losonczy
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Influencing factors of effective lens position in patients with Marfan syndrome and ectopia lentis Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-10 Xin Shen, Zexu Chen, WanNan Jia, Yalei Wang, Tianhui Chen, Yang Sun, Yongxiang Jiang
Aims The aim of this study was to analyse the effective lens position (ELP) in patients with Marfan syndrome (MFS) and ectopia lentis (EL). Methods Patients with MFS undergoing lens removal and primary intraocular lens (IOL) implantation were enrolled in the study. The back-calculated ELP was obtained with the vergence formula and compared with the theoretical ELPs. The back-calculated ELP and ELP
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Role of lens in early refractive development: evidence from a large cohort of Chinese children Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-10 Xiaotong Han, Ruilin Xiong, Ling Jin, Shuai Chang, Qianyun Chen, Decai Wang, Xiang Chen, Yabin Qu, Weijia Liu, Mingguang He, Ian Morgan, Yangfa Zeng, Yizhi Liu
Aims To document longitudinal changes in spherical equivalent refraction (SER) and related biometric factors during early refractive development. Methods This was a prospective cohort study of Chinese children, starting in 2018 with annual follow-ups. At each visit, children received cycloplegic autorefraction and ocular biometry measurements. Lens power (LP) was calculated using Bennett’s formula
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Access to Pediatric Eye Care by Practitioner Type, Geographic Distribution, and US Population Demographics JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-04-11 Nora E. Siegler, Hannah L. Walsh, Kara M. Cavuoto
ImportanceInvestigating disparities in service coverage of pediatric optometrists and pediatric ophthalmologists in relation to patient demographics will illuminate vulnerable populations and inform future interventions.ObjectiveTo characterize the geographic distribution of pediatric eye care practitioners and analyze its association with population demographics.Design, Setting, and ParticipantsIn
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Increased incidence of adult gonococcal keratoconjunctivitis at two tertiary eye hospitals in Western Europe: clinical features, complications and antimicrobial susceptibility Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-09 Alice L Milligan, Anna C Randag, Sybren Lekkerkerk, Helen Fifer
Background Gonorrhoea is on the rise: between 2021 and 2022, a 50% and a 33% increase in diagnoses was seen, respectively, in England and the Netherlands. A concurrent rise in gonococcal keratoconjunctivitis (GKC) is a serious concern due to the potentially devastating visual complications. Methods This is a retrospective case series of adult GKC from two Western European tertiary ophthalmology centres
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Diagnostic criteria of anterior segment swept-source optical coherence tomography to detect gonioscopic angle closure Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-09 Philip Yawen Guo, Xiulan Zhang, Fei Li, Chen Lin, Anwell Nguyen, Rei Sakata, Risa Higashita, Keiichiro Okamoto, Marco Yu, Makoto Aihara, Tin Aung, Shan Lin, Christopher Kai-Shun Leung
Aims To compare the diagnostic performance of 360° anterior segment optical coherence tomography assessment by applying normative percentile cut-offs versus iris trabecular contact (ITC) for detecting gonioscopic angle closure. Methods In this multicentre study, 394 healthy individuals were included in the normative dataset to derive the age-specific and angle location-specific normative percentiles
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Incidence and analysis of intraoperative complications in femtosecond laser-assisted cataract surgery: a large-scale cohort study to establish the learning curve Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-08 Xiaobo Zhang, Wen Xu, Xingchao Shentu, Peiqing Chen, Yibo Yu, Kairan Lai, Jiayong Li, Wei Wang, Xinyi Chen, Ke Yao
Aims To assess the safety of femtosecond laser-assisted cataract surgery (FLACS) based on surgical parameters and intraoperative complications analysis and to determine the length of the learning curve for FLACS. Methods A prospective consecutive cohort study was conducted on Chinese patients who underwent either FLACS (3289 cases) or contemporaneous conventional phacoemulsification cataract surgery
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Femtosecond laser-assisted astigmatic keratotomy versus toric IOL implantation for correcting astigmatism in cataract patients: a systematic review and meta-analysis with trial sequential analysis Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-04 Wei-Ting Yen, Tzu-Heng Weng, Ting-Yi Lin, Ming-Cheng Tai, Yi-Hao Chen, Yu-Min Chang
Aims To compare the refractive and visual outcomes of femtosecond laser-assisted astigmatic keratotomy (FSAK) and toric intraocular lens (IOL) implantation for correcting astigmatism in cataract patients. Methods Studies were retrieved from the Ovid-Medline, EMBASE, Cochrane Central Register of Controlled Trials and Scopus which compared FSAK and toric IOL for astigmatism correction in cataract patients
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Structural and functional changes of binocular corneal innervation and ocular surface function after unilateral SMILE and tPRK Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-04 Qianwen Gong, Kaiyan Huang, Kexin Li, Yixuan Tong, Jian Zhao, Hui Wang, Zhiqiang Xu, Meng Lin, Fan Lu, Liang Hu
Aims To evaluate the bilateral changes in the sub-basal nerve plexus of the cornea and ocular surface function after unilateral small incision lenticule extraction (SMILE) and transepithelial photorefractive keratectomy (tPRK) procedures. Methods 34 patients were enrolled in the study and underwent unilateral SMILE (21 of 34 patients) or unilateral tPRK (13 of 34 patients). Complete ophthalmic examinations
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A practical approach to uveitis screening in children with juvenile idiopathic arthritis Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-04 Ivan Foeldvari, Marcela Bohn, Harry Petrushkin, S Angeles Han, Regitze Bangsgaard, Joan Calzada-Hernández, Tamas Constantin, Joke H de Boer, Jesus Díaz-Cascajosa, Clive Edelsten, Mia Glerup, Helene Ingels, Sebastian Kramer, Elisabetta Miserocchi, Ellen Nordal, Rotraud K Saurenmann, Gabriele Simonini, Ameenat Lola Solebo, Jan Titz, Jordi Anton
Background Juvenile idiopathic arthritis (JIA)-associated uveitis typically presents as a silent chronic anterior uveitis and can lead to blindness. Adherence to current screening guidelines is hampered by complex protocols which rely on the knowledge of specific JIA characteristics. The Multinational Interdisciplinary Working Group for Uveitis in Childhood identified the need to simplify screening
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Visual Field Outcomes in the Primary Tube Versus Trabeculectomy Study Ophthalmology (IF 13.7) Pub Date : 2024-04-04 Swarup S. Swaminathan MD, Alessandro A. Jammal MD PhD, Felipe A. Medeiros MD PhD, Steven J. Gedde MD, Primary Tube Versus Trabeculectomy Study Group, Steven Gedde M.D., Michael Banitt M.D., Donald Budenz M.D. M.P.H., Ta Chang M.D., Richard Lee M.D. Ph.D., Paul Palmberg M.D. Ph.D., Richard Parrish II M.D., Swarup Swaminathan M.D., Luis Vazquez M.D. Ph.D., Sarah Wellik M.D., Mark Werner M.D., Jeffrey
To describe visual field outcomes in the Primary Tube Versus Trabeculectomy (PTVT) Study. Cohort analysis. A total of 155 eyes (155 subjects) randomly assigned to treatment with tube shunt surgery (n = 84) or trabeculectomy with mitomycin C (n = 71). The PTVT Study was a multicenter randomized clinical trial comparing the safety and efficacy of trabeculectomy and tube shunt surgery in eyes without
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Triamcinolone Acetonide Subconjunctival Injection as Stand-alone Inflammation Prophylaxis after Phacoemulsification Cataract Surgery Ophthalmology (IF 13.7) Pub Date : 2024-04-04 Neal H. Shorstein MD, Shannon E. McCabe MD, Mubarika Alavi MS, Marilyn L. Kwan PhD, Naveen S. Chandra MD
To compare the effectiveness and safety of a single injection of subconjunctival triamcinolone acetonide (TA) with that of postoperative topical prednisolone acetate (PA) with and without nonsteroidal anti-inflammatory drugs (NSAIDs) for cataract surgery prophylaxis. Retrospective, comparative effectiveness cohort study. Patients at Kaiser Permanente Northern California from 2018 through 2021. Exposure
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Digital Technology Use Among Older Adults With Vision Impairment JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-04-04 Jonathan Thomas, Louay Almidani, Bonnielin K. Swenor, Varshini Varadaraj
ImportanceTelehealth has the potential to improve health for older adults, but many access disparities exist, including for those with vision impairment (VI).ObjectiveTo examine the associations between VI and digital technology access measures in US older adults.Design, Setting, and ParticipantsThis was a cross-sectional study that included Medicare beneficiaries 65 years and older. Beneficiary data
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Postoperative Inflammation After Anterior Segment Surgery JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-04-04 Matthew Schulgit, Danny A. Mammo, Sunil K. Srivastava
A 71-year-old woman had 2 months of worsening vision and pain in her right eye. Examination revealed retrocorneal plaque, peaking of the pupil, and temporal prominent scleral vessels with inferotemporal scleral thinning. What would you do next?
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Mental Health Conditions Associated With Strabismus in a Diverse Cohort of US Adults JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-04-04 Kimberly Jin, Inas F. Aboobakar, Mary C. Whitman, Isdin Oke
ImportanceGreater understanding of the association between strabismus and mental health conditions across sociodemographic backgrounds may inform strategies to improve mental well-being in this population.ObjectiveTo describe the association of strabismus with mental health conditions in a diverse cohort of US adults.Design, Setting, and ParticipantsThis cross-sectional study used data from the National