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Anaplastic histology and distinct molecular features in a small series of spinal cord ependymomas Acta Neuropathol. (IF 12.7) Pub Date : 2024-05-12 Ulrich Schüller, Antonia Gocke, Shweta Godbole, Claire Delbridge, Christian Thomas, Julia E. Neumann
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The shoulders we keep standing on: remembering Otto Marburg, a big brain in neurology and multiple sclerosis, at 150 Acta Neuropathol. (IF 12.7) Pub Date : 2024-05-08 Klaus Schmierer, Hans Lassmann
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Physiological aging and inflammation-induced cellular senescence may contribute to oligodendroglial dysfunction in MS Acta Neuropathol. (IF 12.7) Pub Date : 2024-05-09 Farina Windener, Laureen Grewing, Christian Thomas, Marie-France Dorion, Marie Otteken, Lara Kular, Maja Jagodic, Jack Antel, Stefanie Albrecht, Tanja Kuhlmann
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Sex differences in the extent of acute axonal pathologies after experimental concussion Acta Neuropathol. (IF 12.7) Pub Date : 2024-05-05 Hailong Song, Alexandra Tomasevich, Andrew Paolini, Kevin D. Browne, Kathryn L. Wofford, Brian Kelley, Eashwar Kantemneni, Justin Kennedy, Yue Qiu, Andrea L. C. Schneider, Jean-Pierre Dolle, D. Kacy Cullen, Douglas H. Smith
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Impaired GABAergic regulation and developmental immaturity in interneurons derived from the medial ganglionic eminence in the tuberous sclerosis complex Acta Neuropathol. (IF 12.7) Pub Date : 2024-05-07 Mirte Scheper, Frederik N. F. Sørensen, Gabriele Ruffolo, Alessandro Gaeta, Lilian J. Lissner, Jasper J. Anink, Irina Korshunova, Floor E. Jansen, Kate Riney, Wim van Hecke, Angelika Mühlebner, Konstantin Khodosevich, Dirk Schubert, Eleonora Palma, James D. Mills, Eleonora Aronica
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Characterisation of premature cell senescence in Alzheimer’s disease using single nuclear transcriptomics Acta Neuropathol. (IF 12.7) Pub Date : 2024-05-02 Nurun N. Fancy, Amy M. Smith, Alessia Caramello, Stergios Tsartsalis, Karen Davey, Robert C. J. Muirhead, Aisling McGarry, Marion H. Jenkyns, Eleonore Schneegans, Vicky Chau, Michael Thomas, Sam Boulger, To Ka Dorcas Cheung, Emily Adair, Marianna Papageorgopoulou, Nanet Willumsen, Combiz Khozoie, Diego Gomez-Nicola, Johanna S. Jackson, Paul M. Matthews
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Viral entry and translation in brain endothelia provoke influenza-associated encephalopathy Acta Neuropathol. (IF 12.7) Pub Date : 2024-04-30 Shihoko Kimura-Ohba, Mieko Kitamura, Yusuke Tsukamoto, Shigetoyo Kogaki, Shinsuke Sakai, Hiroaki Fushimi, Keiko Matsuoka, Makoto Takeuchi, Kyoko Itoh, Keiji Ueda, Tomonori Kimura
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Stage-dependent immunity orchestrates AQP4 antibody-guided NMOSD pathology: a role for netting neutrophils with resident memory T cells in situ Acta Neuropathol. (IF 12.7) Pub Date : 2024-04-24 Akihiro Nakajima, Fumihiro Yanagimura, Etsuji Saji, Hiroshi Shimizu, Yasuko Toyoshima, Kaori Yanagawa, Musashi Arakawa, Mariko Hokari, Akiko Yokoseki, Takahiro Wakasugi, Kouichirou Okamoto, Hirohide Takebayashi, Chihiro Fujii, Kyoko Itoh, Yo-ichi Takei, Shinji Ohara, Mitsunori Yamada, Hitoshi Takahashi, Masatoyo Nishizawa, Hironaka Igarashi, Akiyoshi Kakita, Osamu Onodera, Izumi Kawachi
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BTK inhibition limits microglia-perpetuated CNS inflammation and promotes myelin repair Acta Neuropathol. (IF 12.7) Pub Date : 2024-04-24 Anastasia Geladaris, Sebastian Torke, Darius Saberi, Yasemin B. Alankus, Frank Streit, Sabrina Zechel, Christine Stadelmann-Nessler, Andreas Fischer, Ursula Boschert, Darius Häusler, Martin S. Weber
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Nanopore sequencing from formalin-fixed paraffin-embedded specimens for copy-number profiling and methylation-based CNS tumor classification Acta Neuropathol. (IF 12.7) Pub Date : 2024-04-20 Ann-Kristin Afflerbach, Anne Albers, Anton Appelt, Leonille Schweizer, Werner Paulus, Michael Bockmayr, Ulrich Schüller, Christian Thomas
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Abundant transcriptomic alterations in the human cerebellum of patients with a C9orf72 repeat expansion Acta Neuropathol. (IF 12.7) Pub Date : 2024-04-19 Evan Udine, Mariely DeJesus-Hernandez, Shulan Tian, Sofia Pereira das Neves, Richard Crook, NiCole A. Finch, Matthew C. Baker, Cyril Pottier, Neill R. Graff-Radford, Bradley F. Boeve, Ronald C. Petersen, David S. Knopman, Keith A. Josephs, Björn Oskarsson, Sandro Da Mesquita, Leonard Petrucelli, Tania F. Gendron, Dennis W. Dickson, Rosa Rademakers, Marka van Blitterswijk
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Characterization of NEB pathogenic variants in patients reveals novel nemaline myopathy disease mechanisms and omecamtiv mecarbil force effects Acta Neuropathol. (IF 12.7) Pub Date : 2024-04-18 Esmat Karimi, Jochen Gohlke, Mila van der Borgh, Johan Lindqvist, Zaynab Hourani, Justin Kolb, Stacy Cossette, Michael W. Lawlor, Coen Ottenheijm, Henk Granzier
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Histologic correlates of “Choroidal abnormalities” in Neurofibromatosis type 1 (NF1) Acta Neuropathol. (IF 12.7) Pub Date : 2024-04-12 Anat O. Stemmer-Rachamimov, Liana Kozanno, Scott R. Plotkin, Justin T. Jordan, Joseph F. 3rd Rizzo
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Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer’s disease Acta Neuropathol. (IF 12.7) Pub Date : 2024-04-10 Prabesh Bhattarai, Tamil Iniyan Gunasekaran, Michael E. Belloy, Dolly Reyes-Dumeyer, Dörthe Jülich, Hüseyin Tayran, Elanur Yilmaz, Delaney Flaherty, Bengisu Turgutalp, Gauthaman Sukumar, Camille Alba, Elisa Martinez McGrath, Daniel N. Hupalo, Dagmar Bacikova, Yann Le Guen, Rafael Lantigua, Martin Medrano, Diones Rivera, Patricia Recio, Tal Nuriel, Nilüfer Ertekin-Taner, Andrew F. Teich, Dennis W. Dickson
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Regulated cell death and its role in Alzheimer’s disease and amyotrophic lateral sclerosis Acta Neuropathol. (IF 12.7) Pub Date : 2024-04-07 Dietmar Rudolf Thal, Klara Gawor, Sebastiaan Moonen
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Metabologenomic characterization uncovers a clinically aggressive IDH mutant glioma subtype Acta Neuropathol. (IF 12.7) Pub Date : 2024-04-07 Farshad Nassiri, Andrew Ajisebutu, Vikas Patil, Yasin Mamatjan, Jeff Liu, Justin Z. Wang, Mathew R. Voisin, Romina Nejad, Sheila Mansouri, Shirin Karimi, Ankur Chakravarthy, Eric Chen, Daniel D. De Carvalho, Kenneth Aldape, Gelareh Zadeh
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Altered TFEB subcellular localization in nigral neurons of subjects with incidental, sporadic and GBA-related Lewy body diseases Acta Neuropathol. (IF 12.7) Pub Date : 2024-04-06 Tim E. Moors, Martino L. Morella, Cesc Bertran-Cobo, Hanneke Geut, Vinod Udayar, Evelien Timmermans-Huisman, Angela M. T. Ingrassia, John J. P. Brevé, John G. J. M. Bol, Vincenzo Bonifati, Ravi Jagasia, Wilma D. J. van de Berg
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Characterization of monoamine oxidase-B (MAO-B) as a biomarker of reactive astrogliosis in Alzheimer’s disease and related dementias Acta Neuropathol. (IF 12.7) Pub Date : 2024-04-03 Methasit Jaisa-aad, Clara Muñoz-Castro, Molly A. Healey, Bradley T. Hyman, Alberto Serrano-Pozo
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Landscape of brain myeloid cell transcriptome along the spatiotemporal progression of Alzheimer’s disease reveals distinct sequential responses to Aβ and tau Acta Neuropathol. (IF 12.7) Pub Date : 2024-04-01 Astrid Wachter, Maya E. Woodbury, Sylvia Lombardo, Aicha Abdourahman, Carolin Wuest, Emily McGlame, Timothy Pastika, Joseph Tamm, Nandini Romanul, Kiran Yanamandra, Rachel Bennett, Gen Lin, Taekyung Kwon, Fan Liao, Corinna Klein, Yelena Grinberg, Methasit Jaisa-aad, Huan Li, Matthew. P. Frosch, Markus P. Kummer, Sudeshna Das, Tammy Dellovade, Eric H. Karran, Xavier Langlois, Janina S. Ried, Alberto
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Microglial phagolysosome dysfunction and altered neural communication amplify phenotypic severity in Prader-Willi Syndrome with larger deletion Acta Neuropathol. (IF 12.7) Pub Date : 2024-03-31 Felipe Correa-da-Silva, Jenny Carter, Xin-Yuan Wang, Rui Sun, Ekta Pathak, José Manuel Monroy Kuhn, Sonja C. Schriever, Clarissa M. Maya-Monteiro, Han Jiao, Martin J. Kalsbeek, Pedro M. M. Moraes-Vieira, Johan J. P. Gille, Margje Sinnema, Constance T. R. M. Stumpel, Leopold M. G. Curfs, Dirk Jan Stenvers, Paul T. Pfluger, Dominik Lutter, Alberto M. Pereira, Andries Kalsbeek, Eric Fliers, Dick F. Swaab
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Correction: Abeta targets of the biosimilar antibodies of Bapineuzumab, Crenezumab, Solanezumab in comparison to an antibody against N-truncted Abeta in sporadic Alzheimer disease cases and mouse models Acta Neuropathol. (IF 12.7) Pub Date : 2024-03-25 Yvonne Bouter, Jose Socrates Lopez Noguerola, Petra Tucholla, Gabriela A. N. Crespi, Michael W. Parker, Jens Wiltfang, Luke A. Miles, Thomas A. Bayer
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Loss of TMEM106B exacerbates Tau pathology and neurodegeneration in PS19 mice Acta Neuropathol. (IF 12.7) Pub Date : 2024-03-25 Tuancheng Feng, Huan Du, Cha Yang, Ya Wang, Fenghua Hu
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A muscarinic receptor antagonist reverses multiple indices of diabetic peripheral neuropathy: preclinical and clinical studies using oxybutynin Acta Neuropathol. (IF 12.7) Pub Date : 2024-03-25 Carolina M. Casselini, Henri K. Parson, Katie E. Frizzi, Alex Marquez, Darrell R. Smith, Lucie Guernsey, Rakesh Nemmani, Alireza Tayarani, Corinne G. Jolivalt, Jessica Weaver, Paul Fernyhough, Aaron I. Vinik, Nigel A. Calcutt
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TMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathy Acta Neuropathol. (IF 12.7) Pub Date : 2024-03-25 George A. Edwards, Caleb A. Wood, Yang He, Quynh Nguyen, Peter J. Kim, Ruben Gomez-Gutierrez, Kyung-Won Park, Yong Xu, Cody Zurhellen, Ismael Al-Ramahi, Joanna L. Jankowsky
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Disentangling and quantifying the relative cognitive impact of concurrent mixed neurodegenerative pathologies Acta Neuropathol. (IF 12.7) Pub Date : 2024-03-23 Carolina Maldonado-Díaz, Satomi Hiya, Raquel T. Yokoda, Kurt Farrell, Gabriel A. Marx, Justin Kauffman, Elena V. Daoud, Mitzi M. Gonzales, Alicia S. Parker, Leyla Canbeldek, Lakshmi Shree Kulumani Mahadevan, John F. Crary, Charles L. White, Jamie M. Walker, Timothy E. Richardson
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Gene transcript fusions are associated with clinical outcomes and molecular groups of meningiomas Acta Neuropathol. (IF 12.7) Pub Date : 2024-03-20 Naomi Zakimi, Minh P. Nguyen, David R. Raleigh
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Neuronal STING activation in amyotrophic lateral sclerosis and frontotemporal dementia Acta Neuropathol. (IF 12.7) Pub Date : 2024-03-13 Christine Marques, Aaron Held, Katherine Dorfman, Joon Sung, Catherine Song, Amey S. Kavuturu, Corey Aguilar, Tommaso Russo, Derek H. Oakley, Mark W. Albers, Bradley T. Hyman, Leonard Petrucelli, Clotilde Lagier-Tourenne, Brian J. Wainger
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MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons Acta Neuropathol. (IF 12.7) Pub Date : 2024-03-12 Hong Xu, Qi Qiu, Peng Hu, Kevt’her Hoxha, Elliot Jang, Mia O’Reilly, Christopher Kim, Zhuohao He, Nicholas Marotta, Lakshmi Changolkar, Bin Zhang, Hao Wu, Gerard D. Schellenberg, Brian Kraemer, Kelvin C. Luk, Edward B. Lee, John Q. Trojanowski, Kurt R. Brunden, Virginia M.-Y. Lee
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Role of GBA variants in Lewy body disease neuropathology Acta Neuropathol. (IF 12.7) Pub Date : 2024-03-12 Ronald L. Walton, Shunsuke Koga, Alexandra I. Beasley, Launia J. White, Teresa Griesacker, Melissa E. Murray, Koji Kasanuki, Xu Hou, Fabienne C. Fiesel, Wolfdieter Springer, Ryan J. Uitti, Julie A. Fields, Hugo Botha, Vijay K. Ramanan, Kejal Kantarci, Val J. Lowe, Clifford R. Jack, Nilufer Ertekin-Taner, Rodolfo Savica, Jonathan Graff-Radford, Ronald C. Petersen, Joseph E. Parisi, R. Ross Reichard
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Alteration of LARGE1 abundance in patients and a mouse model of 5q-associated spinal muscular atrophy Acta Neuropathol. (IF 12.7) Pub Date : 2024-03-12 Andreas Roos, Linda-Isabell Schmitt, Christina Hansmann, Stefanie Hezel, Schahin Salmanian, Andreas Hentschel, Nancy Meyer, Adela Della Marina, Heike Kölbel, Christoph Kleinschnitz, Ulrike Schara-Schmidt, Markus Leo, Tim Hagenacker
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Comprehensive proteomics of CSF, plasma, and urine identify DDC and other biomarkers of early Parkinson’s disease Acta Neuropathol. (IF 12.7) Pub Date : 2024-03-11 Jarod Rutledge, Benoit Lehallier, Pardis Zarifkar, Patricia Moran Losada, Marian Shahid-Besanti, Dan Western, Priyanka Gorijala, Sephira Ryman, Maya Yutsis, Gayle K. Deutsch, Elizabeth Mormino, Alexandra Trelle, Anthony D. Wagner, Geoffrey A. Kerchner, Lu Tian, Carlos Cruchaga, Victor W. Henderson, Thomas J. Montine, Per Borghammer, Tony Wyss-Coray, Kathleen L. Poston
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The prevalence and topography of spinal cord demyelination in multiple sclerosis: a retrospective study Acta Neuropathol. (IF 12.7) Pub Date : 2024-03-09 Alex D. Waldman, Cecilia Catania, Marco Pisa, Mark Jenkinson, Michael J. Lenardo, Gabriele C. DeLuca
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Methylation class oligosarcoma, IDH-mutant could exhibit astrocytoma-like molecular features Acta Neuropathol. (IF 12.7) Pub Date : 2024-03-05 Lingyu Liu, Yuqing Liu, Jing Chen, Tao Jiang, Xing Liu, Ke-Nan Zhang
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RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS Acta Neuropathol. (IF 12.7) Pub Date : 2024-03-05 Holly Spence, Fergal M. Waldron, Rebecca S. Saleeb, Anna-Leigh Brown, Olivia M. Rifai, Martina Gilodi, Fiona Read, Kristine Roberts, Gillian Milne, Debbie Wilkinson, Judi O’Shaughnessy, Annalisa Pastore, Pietro Fratta, Neil Shneider, Gian Gaetano Tartaglia, Elsa Zacco, Mathew H. Horrocks, Jenna M. Gregory
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Astroglial calcium signaling and homeostasis in tuberous sclerosis complex Acta Neuropathol. (IF 12.7) Pub Date : 2024-02-28 Alessia Romagnolo, Giulia Dematteis, Mirte Scheper, Mark J. Luinenburg, Angelika Mühlebner, Wim Van Hecke, Marcello Manfredi, Veronica De Giorgis, Simone Reano, Nicoletta Filigheddu, Valeria Bortolotto, Laura Tapella, Jasper J. Anink, Liesbeth François, Stefanie Dedeurwaerdere, James D. Mills, Armando A. Genazzani, Dmitry Lim, Eleonora Aronica
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Disruption of the blood–brain barrier is correlated with spike endocytosis by ACE2 + endothelia in the CNS microvasculature in fatal COVID-19. Scientific commentary on Acta Neuropathol. (IF 12.7) Pub Date : 2024-02-27 Cynthia Magro, Esmerina Tili, Gerard Nuovo
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Myofiber-type-dependent ‘boulder’ or ‘multitudinous pebble’ formations across distinct amylopectinoses Acta Neuropathol. (IF 12.7) Pub Date : 2024-02-27 Sharmistha Mitra, Baozhi Chen, John M. Shelton, Silvia Nitschke, Jun Wu, Lindsay Covington, Mathew Dear, Tori Lynn, Mayank Verma, Felix Nitschke, Yasuhiro Fuseya, Kazuhiro Iwai, Bret M. Evers, Berge A. Minassian
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Cortical-sparing chronic traumatic encephalopathy (CSCTE): a distinct subtype of CTE Acta Neuropathol. (IF 12.7) Pub Date : 2024-02-26 Abigail Alexander, Victor E. Alvarez, Bertrand R. Huber, Michael L. Alosco, Jesse Mez, Yorghos Tripodis, Raymond Nicks, Douglas I. Katz, Brigid Dwyer, Daniel H. Daneshvar, Brett Martin, Joseph Palmisano, Lee E. Goldstein, John F. Crary, Christopher Nowinski, Robert C. Cantu, Neil W. Kowall, Robert A. Stern, Ivana Delalle, Ann C. McKee, Thor D. Stein
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MET receptor serves as a promising target in melanoma brain metastases Acta Neuropathol. (IF 12.7) Pub Date : 2024-02-22 Torben Redmer, Elisa Schumann, Kristin Peters, Martin E. Weidemeier, Stephan Nowak, Henry W. S. Schroeder, Anna Vidal, Helena Radbruch, Annika Lehmann, Susanne Kreuzer-Redmer, Karsten Jürchott, Josefine Radke
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Aggressive human MenG C meningiomas have a molecular counterpart in canines Acta Neuropathol. (IF 12.7) Pub Date : 2024-02-20 Akdes S. Harmanci, Beth Boudreau, Sean Lau, Shervin Hosseingholi Nouri, Jacob J. Mandel, Hsiang-Chih Lu, Arif O. Harmanci, Tiemo J. Klisch, Jonathan M. Levine, Akash J. Patel
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Canine meningiomas are comprised of 3 DNA methylation groups that resemble the molecular characteristics of human meningiomas Acta Neuropathol. (IF 12.7) Pub Date : 2024-02-20 Naomi Zakimi, Christina N. Mazcko, Christine Toedebusch, Gregory Tawa, Kevin Woolard, Amy K. LeBlanc, Peter J. Dickinson, David R. Raleigh
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PP2A and GSK3 act as modifiers of FUS-ALS by modulating mitochondrial transport Acta Neuropathol. (IF 12.7) Pub Date : 2024-02-16 Paraskevi Tziortzouda, Jolien Steyaert, Wendy Scheveneels, Adria Sicart, Katarina Stoklund Dittlau, Adriana Margarida Barbosa Correia, Thibaut Burg, Arun Pal, Andreas Hermann, Philip Van Damme, Thomas G. Moens, Ludo Van Den Bosch
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Regional AT-8 reactive tau species correlate with intracellular Aβ levels in cases of low AD neuropathologic change Acta Neuropathol. (IF 12.7) Pub Date : 2024-02-14 Nauman Malik, Mohi-Uddin Miah, Alessandro Galgani, Kirsty McAleese, Lauren Walker, Fiona E. LeBeau, Johannes Attems, Tiago F. Outeiro, Alan Thomas, David J. Koss
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The niche matters: origin, function and fate of CNS-associated macrophages during health and disease Acta Neuropathol. (IF 12.7) Pub Date : 2024-02-12 Adrià Dalmau Gasull, Martina Glavan, Sai K. Reddy Samawar, Kishan Kapupara, Joe Kelk, Marina Rubio, Stefano Fumagalli, Lydia Sorokin, Denis Vivien, Marco Prinz
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The contribution of β-amyloid, Tau and α-synuclein to blood–brain barrier damage in neurodegenerative disorders Acta Neuropathol. (IF 12.7) Pub Date : 2024-02-12 Ying-Chieh Wu, Tizibt Ashine Bogale, Jari Koistinaho, Marina Pizzi, Taisia Rolova, Arianna Bellucci
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Endothelial cells and macrophages as allies in the healthy and diseased brain Acta Neuropathol. (IF 12.7) Pub Date : 2024-02-12 Adam Denes, Cathrin E. Hansen, Uemit Oezorhan, Sara Figuerola, Helga E. de Vries, Lydia Sorokin, Anna M. Planas, Britta Engelhardt, Markus Schwaninger
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Pineal parenchymal tumors of intermediate differentiation: in need of a stringent definition to avoid confusion. Scientific commentary on ‘Genetical and epigenetical profiling identifies two subgroups of pineal parenchymal tumors of intermediate differentiation (PPTID) with distinct molecular, histological and clinical characteristics’ Acta Neuropathol. (IF 12.7) Pub Date : 2024-02-10 Alexandre Vasiljevic
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“RYR1 and the cerebellum”: scientific commentary on “Defective Cerebellar Ryanodine Receptor Type 1 and Endoplasmic Reticulum Calcium ‘Leak’ in Tremor Pathophysiology” Acta Neuropathol. (IF 12.7) Pub Date : 2024-02-07 Heinz Jungbluth, Dennis T. Famili, Rick C. Helmich, Stefano Previtali, Nicol C. Voermans
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Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer’s disease Acta Neuropathol. (IF 12.7) Pub Date : 2024-02-06 Martí Colom-Cadena, Jamie Toombs, Elizabeth Simzer, Kristjan Holt, Robert McGeachan, Jane Tulloch, Rosemary J. Jackson, James H. Catterson, Maxwell P. Spires-Jones, Jamie Rose, Lora Waybright, Anthony O. Caggiano, Declan King, Francesco Gobbo, Caitlin Davies, Monique Hooley, Sophie Dunnett, Robert Tempelaar, Soraya Meftah, Makis Tzioras, Mary E. Hamby, Nicholas J. Izzo, Susan M. Catalano, Claire S
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Cryptic exon inclusion is a molecular signature of LATE-NC in aging brains Acta Neuropathol. (IF 12.7) Pub Date : 2024-02-03
Abstract The aggregation, mislocalization, and phosphorylation of TDP-43 are pathologic hallmarks of several neurodegenerative diseases and provide a defining criterion for the neuropathologic diagnosis of Limbic-predominant Age-related TDP-43 Encephalopathy (LATE). LATE neuropathologic changes (LATE-NC) are often comorbid with other neurodegenerative pathologies including Alzheimer’s disease neuropathologic
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Neuroinflammatory disease signatures in SPG11-related hereditary spastic paraplegia patients Acta Neuropathol. (IF 12.7) Pub Date : 2024-02-02 Laura Krumm, Tatyana Pozner, Naime Zagha, Roland Coras, Philipp Arnold, Thanos Tsaktanis, Kathryn Scherpelz, Marie Y. Davis, Johanna Kaindl, Iris Stolzer, Patrick Süß, Mukhran Khundadze, Christian A. Hübner, Markus J. Riemenschneider, Jonathan Baets, Claudia Günther, Suman Jayadev, Veit Rothhammer, Florian Krach, Jürgen Winkler, Beate Winner, Martin Regensburger
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Scientific commentary on: “Phosphorylated tau in the retina correlates with tau pathology in the brain in Alzheimer’s disease and primary tauopathies” Acta Neuropathol. (IF 12.7) Pub Date : 2024-02-03 Frederike C. Oertel, Daniel Casillas, Yann Cobigo, Shivany Condor Montes, Hilary W. Heuer, Makenna Chapman, Alexandra Beaudry-Richard, Henriette Reinsberg, Ahmed Abdelhak, Christian Cordano, Bradley F. Boeve, Bradford C. Dickerson, Murray Grossman, Edward Huey, David J. Irwin, Irene Litvan, Alexander Pantelyat, M. Carmela Tartaglia, Lawren Vandevrede, Adam Boxer, Ari J. Green
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New insights into neuropathology and pathogenesis of autoimmune glial fibrillary acidic protein meningoencephalomyelitis Acta Neuropathol. (IF 12.7) Pub Date : 2024-02-03 Yong Guo, Verena Endmayr, Anastasia Zekeridou, Andrew McKeon, Frank Leypoldt, Katharina Hess, Alicja Kalinowska-Lyszczarz, Andrea Klang, Akos Pakozdy, Elisabeth Höftberger, Simon Hametner, Carmen Haider, Désirée De Simoni, Sönke Peters, Ellen Gelpi, Christoph Röcken, Stefan Oberndorfer, Hans Lassmann, Claudia F. Lucchinetti, Romana Höftberger
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Similar brain proteomic signatures in Alzheimer’s disease and epilepsy Acta Neuropathol. (IF 12.7) Pub Date : 2024-01-30 Dominique Leitner, Geoffrey Pires, Tomas Kavanagh, Evgeny Kanshin, Manor Askenazi, Beatrix Ueberheide, Orrin Devinsky, Thomas Wisniewski, Eleanor Drummond
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Mitochondrial damage and impaired mitophagy contribute to disease progression in SCA6 Acta Neuropathol. (IF 12.7) Pub Date : 2024-01-29 Tsz Chui Sophia Leung, Eviatar Fields, Namrata Rana, Ru Yi Louisa Shen, Alexandra E. Bernstein, Anna A. Cook, Daniel E. Phillips, Alanna J. Watt
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Head-to-head comparison of [18F]-Flortaucipir, [18F]-MK-6240 and [18F]-PI-2620 postmortem binding across the spectrum of neurodegenerative diseases Acta Neuropathol. (IF 12.7) Pub Date : 2024-01-27 Cinthya Aguero, Maeva Dhaynaut, Ana C. Amaral, S.-H. Moon, Ramesh Neelamegam, Margaret Scapellato, Carlos Carazo-Casas, Sunny Kumar, Georges El Fakhri, Keith Johnson, Matthew P. Frosch, Marc D. Normandin, Teresa Gómez-Isla
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Molecular characteristics and improved survival prediction in a cohort of 2023 ependymomas Acta Neuropathol. (IF 12.7) Pub Date : 2024-01-24
Abstract The diagnosis of ependymoma has moved from a purely histopathological review with limited prognostic value to an integrated diagnosis, relying heavily on molecular information. However, as the integrated approach is still novel and some molecular ependymoma subtypes are quite rare, few studies have correlated integrated pathology and clinical outcome, often focusing on small series of single
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Clinically relevant molecular hallmarks of PFA ependymomas display intratumoral heterogeneity and correlate with tumor morphology Acta Neuropathol. (IF 12.7) Pub Date : 2024-01-24 Swenja Gödicke, Catena Kresbach, Max Ehlert, Denise Obrecht, Lea Altendorf, Karoline Hack, Katja von Hoff, Helena Carén, Viktoria Melcher, Kornelius Kerl, Bernhard Englinger, Mariella Filbin, Kristian W. Pajtler, Johannes Gojo, Torsten Pietsch, Stefan Rutkowski, Ulrich Schüller
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Transcriptomic and epigenetic dissection of spinal ependymoma (SP-EPN) identifies clinically relevant subtypes enriched for tumors with and without NF2 mutation Acta Neuropathol. (IF 12.7) Pub Date : 2024-01-24 Sina Neyazi, Erika Yamazawa, Karoline Hack, Shota Tanaka, Genta Nagae, Catena Kresbach, Takayoshi Umeda, Alicia Eckhardt, Kenji Tatsuno, Lara Pohl, Taijun Hana, Michael Bockmayr, Phyo Kim, Mario M. Dorostkar, Toshihiro Takami, Denise Obrecht, Keisuke Takai, Abigail K. Suwala, Takashi Komori, Shweta Godbole, Annika K. Wefers, Ryohei Otani, Julia E. Neumann, Fumi Higuchi, Leonille Schweizer, Yuta Nakanishi
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Temporal change of DNA methylation subclasses between matched newly diagnosed and recurrent glioblastoma Acta Neuropathol. (IF 12.7) Pub Date : 2024-01-20 Richard Drexler, Robin Khatri, Ulrich Schüller, Alicia Eckhardt, Alice Ryba, Thomas Sauvigny, Lasse Dührsen, Malte Mohme, Tammo Ricklefs, Helena Bode, Fabian Hausmann, Tobias B. Huber, Stefan Bonn, Hannah Voß, Julia E. Neumann, Dana Silverbush, Volker Hovestadt, Mario L. Suvà, Katrin Lamszus, Jens Gempt, Manfred Westphal, Dieter H. Heiland, Sonja Hänzelmann, Franz L. Ricklefs