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The effect of oral probiotics on response to vaccination in older adults: a systematic review of randomised controlled trials Age Ageing (IF 6.7) Pub Date : 2024-05-15 Hediye Arioz Tunc, Caroline E Childs, Jonathan R Swann, Philip C Calder
This systematic review evaluated the impact of oral probiotics on the immune response to vaccination in older people. A literature search was performed in three electronic databases up to January 2023. Randomised controlled trials (RCTs) conducted in older people (age ≥ 60 years) investigating oral probiotics and vaccine response outcomes were included. Characteristics and outcome data of the included
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Dietary characteristics of community-dwelling older adults with poor appetite: a cross-sectional analysis Age Ageing (IF 6.7) Pub Date : 2024-05-15 Pia Scheufele, Anja Rappl, Marjolein Visser, Eva Kiesswetter, Dorothee Volkert
Rationale Poor appetite is considered a key factor in the development of malnutrition, a link that can be explained by alterations in dietary intake. Given the limited data on dietary characteristics in community-dwelling older adults with poor appetite, the present study aimed to examine whether poor appetite is associated with lower nutrient intake and more unfavourable food choices. Methods In 569
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Nutrition for dementia prevention: a state of the art update for clinicians Age Ageing (IF 6.7) Pub Date : 2024-05-15 Rebecca Townsend, Andrea Fairley, Sarah Gregory, Craig Ritchie, Emma Stevenson, Oliver M Shannon
Background and objectives Dementia prevalence continues to rise. It is therefore essential to provide feasible and effective recommendations to encourage healthy brain ageing and reduce dementia risk across the population. Appropriate nutrition represents a potential strategy to mitigate dementia risk and could be recommended by clinicians as part of mid-life health checks and other health initiatives
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The association between adherence to the EAT-Lancet diet and cognitive ageing Age Ageing (IF 6.7) Pub Date : 2024-05-15 Annick P M van Soest, Ondine van de Rest, Renger F Witkamp, Lisette C P G M de Groot
Background The EAT-Lancet commission has proposed a dietary pattern that is both sustainable and healthy. However, the impact of this diet on cognition in older adults remains unexplored. Therefore, we examined the association between adherence to the EAT-Lancet diet and cognitive ageing. Methods We used data from a previous intervention study involving cognitively healthy community-dwelling adults
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Association of dietary and nutritional factors with cognitive decline, dementia, and depressive symptomatology in older individuals according to a neurogenesis-centred biological susceptibility to brain ageing Age Ageing (IF 6.7) Pub Date : 2024-05-15 Andrea Du Preez, Sophie Lefèvre-Arbogast, Raúl González-Domínguez, Vikki Houghton, Chiara de Lucia, Hyunah Lee, Dorrain Y Low, Catherine Helmer, Catherine Féart, Cécile Delcourt, Cécile Proust-Lima, Mercè Pallàs, Alex Sánchez-Pla, Mireia Urpi-Sardà, Silvie R Ruigrok, Barbara Altendorfer, Ludwig Aigner, Paul J Lucassen, Aniko Korosi, Claudine Manach, Cristina Andres-Lacueva, Cécilia Samieri, Sandrine
Hippocampal neurogenesis (HN) occurs throughout the life course and is important for memory and mood. Declining with age, HN plays a pivotal role in cognitive decline (CD), dementia, and late-life depression, such that altered HN could represent a neurobiological susceptibility to these conditions. Pertinently, dietary patterns (e.g., Mediterranean diet) and/or individual nutrients (e.g., vitamin D
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The effect of increased fruit and vegetable consumption on blood pressure and lipids: a pooled analysis of six randomised controlled fruit and vegetable intervention trials Age Ageing (IF 6.7) Pub Date : 2024-05-15 Nour A Elsahoryi, Charlotte E Neville, Chris C Patterson, Michelle C McKinley, Francina R Baldrick, Ciara Mulligan, Damian O McCall, Rebecca L Noad, Ciara Rooney, Ian Wallace, Claire T McEvoy, Steven Hunter, David R McCance, David J Edgar, Stuart J Elborn, Pascal P McKeown, Ian S Young, Rachel E Moore, Anne P Nugent, Jayne V Woodside
Background Increasing fruit and vegetable (FV) consumption is associated with reduced cardiovascular disease risk in observational studies but with little evidence from randomised controlled trials (RCTs). The impact of concurrent pharmacological therapy is unknown. Objective To pool data from six RCTs to examine the effect of increasing FV intake on blood pressure (BP) and lipid profile, also exploring
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Identifying the relation between food groups and biological ageing: a data-driven approach Age Ageing (IF 6.7) Pub Date : 2024-05-15 Ynte Biemans, Daimy Bach, Pariya Behrouzi, Steve Horvath, Charlotte S Kramer, Simin Liu, JoAnn E Manson, Aladdin H Shadyab, James Stewart, Eric A Whitsel, Bo Yang, Lisette de Groot, Pol Grootswagers
Background Heterogeneity in ageing rates drives the need for research into lifestyle secrets of successful agers. Biological age, predicted by epigenetic clocks, has been shown to be a more reliable measure of ageing than chronological age. Dietary habits are known to affect the ageing process. However, much remains to be learnt about specific dietary habits that may directly affect the biological
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Biomarker signatures associated with ageing free of major chronic diseases: results from a population-based sample of the EPIC-Potsdam cohort Age Ageing (IF 6.7) Pub Date : 2024-05-15 Robin Reichmann, Matthias B Schulze, Tobias Pischon, Cornelia Weikert, Krasimira Aleksandrova
Background A number of biomarkers denoting various pathophysiological pathways have been implicated in the aetiology and risk of age-related diseases. Hence, the combined impact of multiple biomarkers in relation to ageing free of major chronic diseases, such as cancer, cardiovascular disease and type 2 diabetes, has not been sufficiently explored. Methods We measured concentrations of 13 biomarkers
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Quality of plant-based diets and frailty incidence: a prospective analysis of UK biobank participants Age Ageing (IF 6.7) Pub Date : 2024-05-10 Javier Maroto-Rodriguez, Rosario Ortolá, Esther García-Esquinas, Stefanos N Kales, Fernando Rodríguez-Artalejo, Mercedes Sotos-Prieto
Background Substantial evidence supports the inverse association between adherence to healthy dietary patterns and frailty risk. However, the role of plant-based diets, particularly their quality, is poorly known. Objective To examine the association of two plant-based diets with incidence of physical frailty in middle-aged and older adults. Design Prospective cohort. Setting United Kingdom Subjects
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Sarcopenia prevalence using handgrip strength or chair stand performance in adults living with type 2 diabetes mellitus Age Ageing (IF 6.7) Pub Date : 2024-05-06 Archie E Belfield, Thomas J Wilkinson, Joseph Henson, Jack A Sargeant, Leigh Breen, Andrew P Hall, Melanie J Davies, Thomas Yates
Background The updated European Working Group on Sarcopenia in Older People (EWGSOP2) recommends handgrip strength (HGS) and the chair stand test (CST) to assess muscle strength, with the CST being a convenient proxy for lower limb strength. However, adiposity may differentially influence these strength criteria and produce discrepant sarcopenia prevalence. Objective To determine the prevalence of
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How do primary care clinicians approach the management of frailty? A qualitative interview study Age Ageing (IF 6.7) Pub Date : 2024-05-06 Anna Seeley, Margaret Glogowska, Gail Hayward
Background Around 15% of adults aged over 65 live with moderate or severe frailty. Contractual requirements for management of frailty are minimal and neither incentivised nor reinforced. Previous research has shown frailty identification in primary care is ad hoc and opportunistic, but there has been little focus on the challenges of frailty management, particularly within the context of recent introduction
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Sporadic Creutzfeldt-Jakob disease in adults over 80 years: a 10-year review of United Kingdom surveillance Age Ageing (IF 6.7) Pub Date : 2024-05-06 Eugene Ace McDermott, Neil Watson, Johnny Tam, John Centola, Hatice Kurucu King, Jan Mackenzie, David Summers, Alison Green, Marcelo A Barria, Colin Smith, Suvankar Pal
Introduction Sporadic Creutzfeldt-Jakob disease (sCJD) is a rapidly progressive neurodegenerative disease with public health implications. Mean age of onset is 68 years. Age-specific incidence declines after 80 years. This may arise from under-ascertainment or other biological features of the disease. Accurate characterisation of late-onset sCJD is important for early diagnosis, avoiding unnecessary
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Efficacy of ferric carboxymaltose on haemoglobin response among older patients with gastrointestinal bleeding: a randomised clinical trial Age Ageing (IF 6.7) Pub Date : 2024-05-06 Nicolas Richard, Nadia Arab-Hocine, Margot Vannier, Rachida Leblanc-Boubchir, Agnès Pelaquier, Arnaud Boruchowicz, Marietta Musikas, Morgane Amil, Mathurin Fumery, Stéphane Nahon, Ramuntcho Arotcarena, Eve Gelsi, Arnaud Maurin, Xavier Hébuterne, Guillaume Savoye
Background Acute gastrointestinal bleeding (AGIB) is common in older patients but the use of iron in this context remains understudied. Aims This study aimed to evaluate prospectively the efficacy of ferric carboxymaltose to treat anaemia in older patients after AGIB. Methods This randomised double-blinded placebo-controlled clinical trial was conducted in 10 French centres. Eligible patients were
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‘I think we could probably do more’: an interview study to explore community pharmacists’ experiences and perspectives of frailty and optimising medicines use in frail older adults Age Ageing (IF 6.7) Pub Date : 2024-05-06 Lucy Faulkner, Carmel M Hughes, Heather E Barry
Background Community pharmacists potentially have an important role to play in identification of frailty and delivery of interventions to optimise medicines use for frail older adults. However, little is known about their knowledge or views about this role. Aim To explore community pharmacists’ knowledge of frailty and assessment, experiences and contact with frail older adults, and perceptions of
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New horizon in improving ageing with improvisational theatre Age Ageing (IF 6.7) Pub Date : 2024-05-06 Shoshi Keisari, Kristin R Krueger, Boaz M Ben-David, Mathieu Hainselin
Cognitive decline, mental health and mindset factors can all affect the autonomy and well-being of older adults. As the number of older adults across the globe increases, interventions to improve well-being are urgently needed. Improvisational theatre (improv) and improv-based interventions are well-suited to address this need. Studies have shown that participation in improv-based interventions has
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New horizons in undergraduate geriatric medicine education Age Ageing (IF 6.7) Pub Date : 2024-05-01 Andrew Teodorczuk, Petal S Abdool, Chloe X Yap, James M Fisher
Current projections show that between 2000 and 2050, increasing proportions of older individuals will be cared for by a smaller number of healthcare workers, which will exacerbate the existing challenges faced by those who support this patient demographic. This review of a collection of Age and Ageing papers on the topic in the past 10 years explores (1) what best practice geriatrics education is and
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Barriers and motivators to undertaking physical activity in adults over 70—a systematic review of the quantitative literature Age Ageing (IF 6.7) Pub Date : 2024-04-23 Alixe H M Kilgour, Matthew Rutherford, Joanna Higson, Samantha J Meredith, Jessica McNiff, Stephanie Mitchell, Anusan Wijayendran, Stephen E R Lim, Susan D Shenkin
Background Physical activity (PA) has multiple benefits for older adults (≥70 years old). Despite this many older adults do not undertake the World Health Organisation guideline recommended amount of PA. This systematic review examines barriers and motivators to PA in adults aged ≥70 years. Methods We analysed the quantitative literature, including observational studies and baseline data from randomised
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The impact of a hospital-based special care unit on behavioural and psychological symptoms in older people living with dementia Age Ageing (IF 6.7) Pub Date : 2024-04-22 Frederick A Graham, Lisa Kelly, Elizabeth A Burmeister, Amanda Henderson, Annette Broome, Ruth E Hubbard, Emily H Gordon
Background Hospital patients with behavioural and psychological symptoms of dementia (BPSD) are vulnerable to a range of adverse outcomes. Hospital-based Special Care Units (SCUs) are secure dementia-enabling environments providing specialised gerontological care. Due to a scarcity of research, their value remains unconfirmed. Objective To compare hospital based SCU management of BPSD with standard
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Sex differences in cognitive decline among middle-aged and older adults: a cohort study in Europe Age Ageing (IF 6.7) Pub Date : 2024-04-19 Katrin Wolfova, Barbora Frycova, Dominika Seblova, Sarah Tom, Vegard Fykse Skirbekk, Pavla Brennan Kearns
Objectives Previous studies on sex differences in cognitive decline provide inconsistent findings, with many European countries being underrepresented. We determined the association between sex and cognitive decline in a sample of Europeans and explored differences across birth cohorts and regions. Methods Participants 50+ years old enrolled in the Survey of Health, Ageing and Retirement in Europe
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Plasma metabolomic markers underlying skeletal muscle mitochondrial function relationships with cognition and motor function Age Ageing (IF 6.7) Pub Date : 2024-04-14 Qu Tian, Erin E Greig, Keenan A Walker, Kenneth W Fishbein, Richard G Spencer, Susan M Resnick, Luigi Ferrucci
Background Lower skeletal muscle mitochondrial function is associated with future cognitive impairment and mobility decline, but the biological underpinnings for these associations are unclear. We examined metabolomic markers underlying skeletal muscle mitochondrial function, cognition and motor function. Methods We analysed data from 560 participants from the Baltimore Longitudinal Study of Aging
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Understanding the association between pain and delirium in older hospital inpatients: systematic review and meta-analysis Age Ageing (IF 6.7) Pub Date : 2024-04-13 Nicola White, Juan Carlos Bazo-Alvarez, Michel Koopmans, Emily West, Elizabeth L Sampson
Objective Delirium and pain are common in older adults admitted to hospital. The relationship between these is unclear, but clinically important. We aimed to systematically review the association between pain (at rest, movement, pain severity) and delirium in this population. Methods PubMed, EMBASE, CINAHL, PsycINFO, Cochrane and Web of Science were searched (January 1982–November 2022) for Medical
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Discrepancies in corrected calcium versus ionised calcium in a geriatric population: an observational study Age Ageing (IF 6.7) Pub Date : 2024-04-13 Alexandra P S P Suryapranata, Carolina J P W Keijsers, Steef Kurstjens, Astrid M Van Strien
Background Calcium can be measured as ionised (Ca-ionised) or albumin-adjusted total calcium (Ca-albumin). Current clinical guidelines predominantly utilise Ca-albumin, despite Ca-ionised being the gold standard. Discrepancies can occur between these measurement modalities and can lead to clinical dilemmas. It remains unclear how large these discrepancies are in older patients. This study investigated
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The association between cannabis use and neuroimaging measures in older adults: findings from the UK biobank Age Ageing (IF 6.7) Pub Date : 2024-04-08 Shiraz Vered, Sharon Sznitman, Galit Weinstein
Background Cannabis use has increased in recent years. However, the long-term implications of cannabis use on brain health remain unknown. We explored the associations of cannabis use with volumetric brain magnetic resonance imaging (MRI) measures in dementia-free older adults. Methods This cross-sectional and longitudinal study included dementia-free participants of the UK Biobank aged ≥60 years.
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Prevalence of swallowing disorder in different dementia subtypes among older adults: a meta-analysis Age Ageing (IF 6.7) Pub Date : 2024-03-27 Alfiani Rahmi Putri, Yu-Hao Chu, Ruey Chen, Kai-Jo Chiang, Kondwani Joseph Banda, Doresses Liu, Hui-Chen Lin, Shu-Fen Niu, Kuei-Ru Chou
Background Ageing process and abnormal protein accumulation in dementia damage neural pathways affecting the swallowing process and leading to swallowing disorder. Objective To estimate the prevalence of swallowing disorder among older adults with different dementia subtypes. Methods We conducted a systematic search across multiple databases, including PubMed, Embase, Scopus, Web of Science and OVID
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Navigating complexity of the medication management system within the home setting—a functional resonance analysis method (FRAM) analysis of people with dementia and their carers’ experiences Age Ageing (IF 6.7) Pub Date : 2024-03-25 Rosemary Lim, Mais Iflaifel, Zahra A L Qamariat, Clare Crowley, Taniya Sharmeen
Background There is a strong imperative to support people with dementia to live independently in their homes for as long as possible. A starting point is to understand how they manage medications on a daily basis. Aim To understand how people with dementia and their informal carers manage medications within the home setting to inform the identification of opportunities to improve medication management
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Pain trajectories and their associations with cognition among older adults: a 10-year cohort study from network perspective Age Ageing (IF 6.7) Pub Date : 2024-03-24 He-Li Sun, Wei Bai, Pan Chen, Ling Zhang, Robert D Smith, Zhaohui Su, Teris Cheung, Gabor S Ungvari, Chee H Ng, Qinge Zhang, Yu-Tao Xiang
Background Few studies have examined the associations between pain trajectories and cognitive function in older adults. This study explored the associations between pain trajectories and different cognitive domains in older adults from a network perspective. Methods Data on pain trajectories were derived from the Health and Retirement Study between 2010 and 2020 using latent class growth analyses.
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Measurement properties of the usual and fast gait speed tests in community-dwelling older adults: a COSMIN-based systematic review Age Ageing (IF 6.7) Pub Date : 2024-03-22 Ava Mehdipour, Selina Malouka, Marla Beauchamp, Julie Richardson, Ayse Kuspinar
Objective The gait speed test is one of the most widely used mobility assessments for older adults. We conducted a systematic review to evaluate and compare the measurement properties of the usual and fast gait speed tests in community-dwelling older adults. Methods Three databases were searched: MEDLINE, EMBASE and CINAHL. Peer-reviewed articles evaluating the gait speed test’s measurement properties
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Strategies used during the cognitive evaluation of older adults with dual sensory impairment: a scoping review Age Ageing (IF 6.7) Pub Date : 2024-03-20 Shirley Dumassais, Margaret Kathleen Pichora-Fuller, Dawn Guthrie, Natalie A Phillips, Marie Savundranayagam, Walter Wittich
Background Dual sensory impairment (DSI), the combination of visual and hearing impairments, is associated with increased risk for age-related cognitive decline and dementia. Administering cognitive tests to individuals with sensory impairment is challenging because most cognitive measures require sufficient hearing and vision. Considering sensory limitations during cognitive test administration is
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Short- and long-term safety of discontinuing chronic opioid therapy among older adults with Alzheimer’s disease and related dementia Age Ageing (IF 6.7) Pub Date : 2024-03-18 Yu-Jung Jenny Wei, Almut G Winterstein, Siegfried Schmidt, Roger B Fillingim, Stephan Schmidt, Michael J Daniels, Steven T DeKosky
Background Limited evidence exists on the short- and long-term safety of discontinuing versus continuing chronic opioid therapy (COT) among patients with Alzheimer’s disease and related dementias (ADRD). Methods This cohort study was conducted among 162,677 older residents with ADRD and receipt of COT using a 100% Medicare nursing home sample. Discontinuation of COT was defined as no opioid refills
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Multivariable machine learning models for clinical prediction of subsequent hip fractures in older people using the Chinese population database Age Ageing (IF 6.7) Pub Date : 2024-03-18 Wenbo Huang, Jie Wang, Jilai Xu, Guinan Guo, Zhenlei Chen, Haolei Xue
Purpose This study aimed to develop and validate clinical prediction models using machine learning (ML) algorithms for reliable prediction of subsequent hip fractures in older individuals, who had previously sustained a first hip fracture, and facilitate early prevention and diagnosis, therefore effectively managing rapidly rising healthcare costs in China. Methods Data were obtained from Grade A Tertiary
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Characteristics of older unpaid carers in England: a study of social patterning from the English Longitudinal Study of Ageing Age Ageing (IF 6.7) Pub Date : 2024-03-18 Laurie E Davies, Gemma F Spiers, David R Sinclair, Andrew Kingston, Barbara Hanratty
Background A growing number of older people provide unpaid care, but contemporary research evidence on this group is limited. Aim This study aims to describe the characteristics of older people who provide unpaid care and how these vary by socioeconomic position. Methods Using recent information from the English Longitudinal Study of Ageing (ELSA wave 9, 2019), we analysed cross-sectional data on 1
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Delirium is more common and associated with worse outcomes in Parkinson’s disease compared to older adult controls: results of two prospective longitudinal cohort studies Age Ageing (IF 6.7) Pub Date : 2024-03-18 Florence Gerakios, Alison J Yarnall, Gemma Bate, Laura Wright, Daniel Davis, Blossom C M Stephan, Louise Robinson, Carol Brayne, Glenn Stebbins, John-Paul Taylor, David J Burn, Louise M Allan, Sarah J Richardson, Rachael A Lawson
Background Inpatient prevalence of Parkinson’s disease (PD) delirium varies widely across the literature. Delirium in general older populations is associated with adverse outcomes, such as increased mortality, dementia, and institutionalisation. However, to date there are no comprehensive prospective studies in PD delirium. This study aimed to determine delirium prevalence in hospitalised PD participants
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Place of death in Parkinson’s disease and related disorders in England and Wales: post-pandemic trends and implications for care planning Age Ageing (IF 6.7) Pub Date : 2024-03-18 Elisabeth Wilson, Amy Baker, Lauren Stockley, Victoria Allgar, Edward Richfield
Background With growing emphasis on palliative care for neurodegenerative conditions, understanding trends in place of death helps improve quality of end-of-life care for people with Parkinson’s disease and related disorders (PDRDs), focusing allocation of resources and training and identifying inequalities. Objectives Review national and regional place of death trends for people with PDRD including
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What influences life expectancy in people with dementia? Social support as an emerging protective factor Age Ageing (IF 6.7) Pub Date : 2024-03-18 Iris Blotenberg, Melanie Boekholt, Bernhard Michalowsky, Moritz Platen, Francisca S Rodriguez, Stefan Teipel, Wolfgang Hoffmann, Jochen René Thyrian
Background The aim of this study was to investigate the role of support from the social environment for the life expectancy in people with dementia beyond well-established individual demographic and clinical predictors over a period of up to 8 years. Methods The analyses are based on data from 500 community-dwelling individuals in Germany who tested positive for dementia and were followed up for up
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Strategies to increase the coverage of influenza and pneumonia vaccination in older adults: a systematic review and network meta-analysis Age Ageing (IF 6.7) Pub Date : 2024-03-13 Peipei Du, Shuyan Jin, Shuya Lu, Li Wang, Xiaofeng Ma, Jie Wang, Runting Huang, Qingyue Luo, Shu Yang, Xixi Feng
Background It is urgent to implement interventions to increase vaccination rates of influenza/pneumonia vaccines in older adults, yet the effectiveness of different intervention strategies has not been thoroughly evaluated. Objective We aimed to assess the effectiveness of intervention strategies for increasing the coverage of influenza/pneumonia vaccination in older adults. Methods PubMed, Web of
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Cost-effectiveness of proactive health support—telephone-based self-management support compared with standard care for persons at risk of hospital admission Age Ageing (IF 6.7) Pub Date : 2024-03-13 Maja Kjær Rasmussen, Kirstine Skov Benthien, Camilla Palmhøj Nielsen, Knud Rasmussen, Mette Grønkjær, Ulla Toft, Kristian Kidholm
Background A small share of patients account for a large proportion of costs to the healthcare system in Denmark as in many Western countries. A telephone-based self-management support, proactive health support (PaHS), was suggested for prevention of hospitalisations for persons at risk of hospital admission. These persons have chronic diseases, unplanned hospitalisations and age ≥ 65 years. However
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Finding the balance between person-centred and treatment-centred discussions in advance care planning—a qualitative analysis of conversations within the MUTUAL (Multidisciplinary Timely Undertaken Advance Care Planning conversations) intervention using a narrative analysis Age Ageing (IF 6.7) Pub Date : 2024-03-07 Eline V T J van Lummel, Larissa Ietswaard, Marloes Rigter, Dave H T Tjan, Johannes J M van Delden, Megan Milota
Introduction Advance care planning (ACP) aims to create conditions for more person-centred care. We aimed to explore variations in person-centred care discussions and treatment-centred care discussions within ACP conversations in the Multidisciplinary Timely Undertaken Advance Care Planning (MUTUAL) intervention and how person-centred care discussions could be encouraged. The MUTUAL intervention consists
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New horizons in frailty identification via electronic frailty indices: early implementation lessons from experiences in England and the United States Age Ageing (IF 6.7) Pub Date : 2024-02-29 Ariela R Orkaby, Kathryn E Callahan, Jane A Driver, Kristian Hudson, Andrew J Clegg, Nicholas M Pajewski
Frailty represents an integrative prognostic marker of risk that associates with a myriad of age-related adverse outcomes in older adults. As a concept, frailty can help to target scarce resources and identify subgroups of vulnerable older adults that may benefit from interventions or changes in medical management, such as pursing less aggressive glycaemic targets for frail older adults with diabetes
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Prevalence of postprandial hypotension in older adults: a systematic review and meta-analysis Age Ageing (IF 6.7) Pub Date : 2024-02-27 Lei Huang, Sheyu Li, Xiaofeng Xie, Xiaoli Huang, Lily Dongxia Xiao, Ying Zou, Wenyi Jiang, Fengying Zhang
Background Older adults with postprandial hypotension (PPH) increase susceptibility to falls, syncope, stroke, acute cardiovascular diseases and even death. However, the prevalence of this condition varies significantly across studies. We aimed to determine the prevalence of PPH in older adults. Methods Web of Science, PubMed, Cochrane Library, Embase and CINAHL were searched from their inception until
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A mixed-methods study on the pharmacological management of pain in Australian and Japanese nursing homes Age Ageing (IF 6.7) Pub Date : 2024-02-27 Laura A Dowd, Shota Hamada, Yukari Hattori, Felicity C Veal, Reina Taguchi, Nobuo Sakata, Agathe D Jadczak, Renuka Visvanathan, Eriko Koujiya, Madhu Rajan, Stefan Doube, Ai Suzuki, Maree Bernoth, Helen Rawson, Hiroshi Maruoka, Amelia Wood, Jo Wagner, Dee-Anne Hull, Mizuki Katsuhisa, Justin Turner, Shin J Liau, Emily Reeve, J Simon Bell, Amanda J Cross
Background Understanding how analgesics are used in different countries can inform initiatives to improve the pharmacological management of pain in nursing homes. Aims To compare patterns of analgesic use among Australian and Japanese nursing home residents; and explore Australian and Japanese healthcare professionals’ perspectives on analgesic use. Methods Part one involved a cross-sectional comparison
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Monoclonal antibodies for treating early Alzheimer disease—a commentary on recent ‘positive’ trials Age Ageing (IF 6.7) Pub Date : 2024-02-27 Ian A Scott
Recent phase 3 randomised controlled trials of amyloid-targeting monoclonal antibodies in people with pre-clinical or early Alzheimer disease have reported positive results, raising hope of finally having disease-modifying drugs. Given their far-reaching implications for clinical practice, the methods and findings of these trials, and the disease causation theory underpinning the mechanism of drug
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Association between social vulnerability and place of death during the first 2 years of COVID-19 in Massachusetts Age Ageing (IF 6.7) Pub Date : 2024-02-19 Marie-Laure Charpignon, Shauna Onofrey, Yea-Hung Chen, Alex Rewegan, Medellena Maria Glymour, R Monina Klevens, Maimuna Shahnaz Majumder
We investigated the relationship between individual-level social vulnerability and place of death during the infectious disease emergency of the COVID-19 pandemic in Massachusetts. Our research represents a unique contribution by matching individual-level death certificates with COVID-19 test data to analyse differences in distributions of place of death.
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Shared decision making in older people after severe stroke Age Ageing (IF 6.7) Pub Date : 2024-02-17 Gillian Mead
Stroke is a major cause of death and lifelong disability. Although stroke treatments have improved, many patients are left with life-changing deficits. Shared decision making and consent are fundamental to good medical practice. This is challenging because stroke often causes mental incapacity, prior views might not be known and prognosis early after stroke is often uncertain. There are no large trials
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Topic evolution before fall incidents in new fallers through natural language processing of general practitioners’ clinical notes Age Ageing (IF 6.7) Pub Date : 2024-02-16 Noman Dormosh, Ameen Abu-Hanna, Iacer Calixto, Martijn C Schut, Martijn W Heymans, Nathalie van der Velde
Background Falls involve dynamic risk factors that change over time, but most studies on fall-risk factors are cross-sectional and do not capture this temporal aspect. The longitudinal clinical notes within electronic health records (EHR) provide an opportunity to analyse fall risk factor trajectories through Natural Language Processing techniques, specifically dynamic topic modelling (DTM). This study
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Syncope in older adults: challenges, approach and treatment Age Ageing (IF 6.7) Pub Date : 2024-02-09 Sofie Jansen, Nathalie van der Velde
Syncope can have devastating consequences, resulting in injuries, accidents or even death. In our ageing society, the subsequent healthcare usage, such as emergency room presentations, surgeries and hospital admissions, forms a significant and growing socioeconomic burden. Causes of syncope in the older adult include orthostatic hypotension, carotid sinus syndrome, vasovagal syncope, structural cardiac
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Summary of best evidence for prevention and management of frailty Age Ageing (IF 6.7) Pub Date : 2024-02-01 Yinning Guo, Xueyi Miao, Jieman Hu, Li Chen, Yimeng Chen, Kang Zhao, Ting Xu, Xiaoman Jiang, Hanfei Zhu, Xinyi Xu, Qin Xu
Background Frailty in older people can seriously affect their quality of life and increase the demand for long-term care and health care expenses. Aims of this study are to provide an evidence-based basis for clinical practice of frailty in older people by systematically searching for the best current evidence on interventions for the prevention and management of frailty. Methods According to the ‘6S’
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L-shaped association between dietary zinc intake and cognitive decline in Chinese older people Age Ageing (IF 6.7) Pub Date : 2024-01-30 Qiguo Meng, Mengyi Liu, Cheng Zu, Xinyue Su, Yuanxiu Wei, Xiaoqin Gan, Yuanyuan Zhang, Panpan He, Chun Zhou, Ziliang Ye, Chengzhang Liu, Xianhui Qin
Background and Objective The prospective association between dietary zinc (Zn) intake and cognitive decline remains uncertain. We aimed to assess the relationship of dietary Zn intake with the risk of cognitive decline in the Chinese older people, and examine the possible effect modifiers on this association. Methods A total of 3,106 older Chinese adults aged 55 years or older from China Health and
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Sodium-glucose cotransporter-2 inhibitors (SGLT2) in frail or older people with type 2 diabetes and heart failure: a systematic review and meta-analysis Age Ageing (IF 6.7) Pub Date : 2024-01-30 Rami Aldafas, Tomas Crabtree, Mohammed Alkharaiji, Yana Vinogradova, Iskandar Idris
Objective Sodium-glucose cotransporter-2 inhibitors (SGLT2Is) reduce cardio-metabolic and renal outcomes in patients with type 2 diabetes (T2D) but their efficacy and safety in older or frail individuals remains unclear. Methods We searched PubMed, Scopus, Web of Science, Cochrane CENTRA and Google Scholar and selected randomised controlled trials and observational studies comparing SGLT2Is versus
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Care pathways in older patients seen in a multidisciplinary same day emergency care (SDEC) unit Age Ageing (IF 6.7) Pub Date : 2024-01-26 Tania C N Elias, Chloe Jacklin, Jordan Bowen, Daniel S Lasserson, Sarah T Pendlebury
Background Same day emergency care (SDEC) services are being advocated in the UK for frail, older patients in whom hospitalisation may be associated with harm but there are few data on the ‘ambulatory pathway’. We therefore determined the patient pathways pre- and post-first assessment in a SDEC unit focussed on older people. Methods In consecutive patients, we prospectively recorded follow-up SDEC
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Preventing hospital falls: feasibility of care workforce redesign to optimise patient falls education Age Ageing (IF 6.7) Pub Date : 2024-01-26 Meg E Morris, Claire Thwaites, Rosalie Lui, Steven M McPhail, Terry Haines, Debra Kiegaldie, Hazel Heng, Louise Shaw, Susan Hammond, Jonathan P McKercher, Matthew Knight, Leeanne M Carey, Richard Gray, Ron Shorr, Anne-Marie Hill
Objective To examine the feasibility of using allied health assistants to deliver patient falls prevention education within 48 h after hospital admission. Design and setting Feasibility study with hospital patients randomly allocated to usual care or usual care plus additional patient falls prevention education delivered by supervised allied health assistants using an evidence-based scripted conversation
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Long-term impact of the COVID-19 pandemic on the quality of life of people with dementia and their family carers Age Ageing (IF 6.7) Pub Date : 2024-01-26 Sanna Read, Ben Hicks, Emily Budden, Jacob Douglass, Amanda Grahamslaw, Elena Herrero, Gregory Joseph, Christine Kirkup, Martha Pusey, Alice Russell, Harsharon Sondh, Sharon Sondh, Bryony Storey, Georgia Towson, Kate Baxter, Yvonne Birks, Carol Brayne, Carmen Colclough, Margaret Dangoor, Josie Dixon, Paul Donaghy, Kate Gridley, Peter R Harris, Bo Hu, Derek King, Martin Knapp, Eleanor Miles, Christoph
Introduction Few studies have longitudinally mapped quality of life (QoL) trajectories of newly diagnosed people with dementia and their carers, particularly during coronavirus disease-2019 (COVID-19). Methods In a UK cohort study, 261 newly diagnosed people with dementia and 206 family carers were assessed prior to the pandemic (July 2019–March 2020), followed up after the first lockdown (July–October
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Interaction between plant-based dietary pattern and frailty on cognitive decline: a longitudinal analysis of the Chinese Longitudinal Healthy Longevity Survey cohort Age Ageing (IF 6.7) Pub Date : 2024-01-26 Xia Gao, Qianrong Wu, Yan Long, Xiaotong Hu, Zongming Yang, Liang Huang
Objectives Frailty is a risk factor for faster cognitive decline, while plant-based dietary patterns are associated with decreased risk of cognitive decline. We aimed to explore their interaction with cognitive function among older adults. Methods We used data from the Chinese Longitudinal Healthy Longevity Survey between 2008 and 2018. Frailty was evaluated based on the frailty index (FI), and the
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1964 Wearable devices to measure gait and balance remotely that could be used in Comprehensive Geriatric Assessment: A scoping review Age Ageing (IF 6.7) Pub Date : 2024-01-25 J Bollen, N Morley, E Arjunaidi Jamaludin, A Hall, A Bethel, A Mahmoud, T Crocker, H Lyndon, S Del Din, J Frost, V Goodwin, J Whitney
Introduction Comprehensive Geriatric Assessment (CGA) is widely used in the management and assessment of older people living with frailty, however optimal ways of delivering CGA are not well understood. Gait and balance impairments, common in those living with frailty, are assessed in CGA. Advancements in digital technology provide opportunities to improve patient outcomes by digital monitoring, rather
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1895 Three-year nationwide analysis of falls risk prescribing for over 65 care home and non-care home patients Age Ageing (IF 6.7) Pub Date : 2024-01-25 A Shroufi, M Garbuzov, M McPherson
Introduction In 2021 the NHS Business Services Authority Data Science team openly published the first comprehensive nationwide analysis of over 65 care home versus non-care home prescribing (https://nhsbsa-data-analytics.shinyapps.io/estimated-prescribing-patterns-for-care-home-patients/). The analysis has been expanded to include three years of prescribing data and key falls risk prescribing metrics
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1853 Improving treatment for urinary tract infections for older adults in the Health and Ageing Unit Age Ageing (IF 6.7) Pub Date : 2024-01-25 H Petho, S Maruthan, O Poole-Wilson
Introduction A suspected urinary tract infection (UTI) is the most common reason to prescribe antibiotics in a frail older patient. Therefore, correct recognition and documentation of UTIs, as well prescribing of antibiotics, is important for optimising patient care. Methods We reviewed UTI antibiotic prescribing practice across the Health and Ageing Unit (HAU) wards at Kings College Hospital over
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2002 An observational study of the effectiveness of FIT test as a risk stratification tool in frail patients presenting with anaemia Age Ageing (IF 6.7) Pub Date : 2024-01-25 M Khatun, S Khanom, R Rasheed
Introduction Faecal-immunochemical-test is employed as a screening tool for colorectal cancer. Our observational study examined the FIT in primary care as a risk stratification tool in frail patients. Method The records of 217 frail patients over a 24-month period were analysed. Patients with haematological indices of anaemia were offered FIT to detect GI haemorrhage as part of assessment for selection
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1851 Increasing number of deaths related to Parkinson’s disease (PD) and Parkinsonism Age Ageing (IF 6.7) Pub Date : 2024-01-25 V Adhiyaman, P Hobson
Introduction The burden of PD has exponentially risen from 2.5 million in 1990, to 6.1 million in 2016 (PD Collaborators. Lancet Neurol. 2018; 17(11):939-53). This is due to ageing population, increased longevity, increased duration of the disease and improved diagnosis. The aim of our study was to identify the trend on deaths related to PD and Parkinsonism over the last decade. Methods We collected
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1868 Eight to Hydrate: Promoting oral hydration of elderly patients in hospital Age Ageing (IF 6.7) Pub Date : 2024-01-25 M Williams, R Anketell, E Georgiakakis, R Mizoguchi
Introduction Dehydration is associated with prolonged hospital admissions and complications. Elderly patients are more susceptible due to physiology, dexterity and cognition. The British Dietetic Association recommends minimum 7 beverages per day whilst The British Nutrition Foundation advises proactive dehydration risk management in hospital. This project aimed to reduce the proportion of elderly
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1912 Reviewing the effect of COVID pandemic on changing clinical practice of administrating Zoledronic Acid to hip fracture patients Age Ageing (IF 6.7) Pub Date : 2024-01-25 Z L Tun, R Melrose, R Saharia, U Tazeen
Introduction Reduction in outpatient appointments during the COVID-19 pandemic and patient concern surrounding risk of contracting COVID-19 by attending day-case settings, resulted in delayed or cancelled medical treatments including Zoledronic Acid infusions as management for Osteoporosis. This, alongside recent research concluding that these treatments can be given safely as early as 1-2 weeks post-fracture
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1720 Frailty and the impact of Electronic Advance Care Planning records on readmission rates and location of end of life care Age Ageing (IF 6.7) Pub Date : 2024-01-25 L Stapleton, L Marsh, T Rajeevan
Introduction Older people with severe frailty are 5 times more likely to die in the next 12 months than older non-frail people however prognosis and disease trajectory in frailty remains difficult to predict. Advance care planning (ACP) is often not fully discussed or documented due to these prognostic uncertainties, plus time/workload constraints. This can result in multiple admissions for people