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Defining Benchmarks for Pelvic Exenteration Surgery: A Multicentre Analysis of Patients with Locally Advanced and Recurrent Rectal Cancer. Ann. Surg. (IF 9.0) Pub Date : 2024-05-15 Kilian G M Brown, Michael J Solomon, Cherry E Koh, Paul A Sutton, Samuel Aguiar, Tiago S Bezerra, Hamish W Clouston, Ashwin Desouza, Eric J Dozois, Amanda L Ersryd, Frank Frizelle, Jonas A Funder, Julio Garcia-Aguilar, Richard Garfinkle, Tamara Glyn, Alexander Heriot, Yukihide Kanemitsu, Chia Y Kong, Helle Ø Kristensen, Songphol Malakorn, David M Mens, Per J Nilsson, Gabriella J Palmer, Emmanouil Pappou
To establish globally applicable benchmark outcomes for pelvic exenteration (PE) in patients with locally advanced primary (LARC) and recurrent rectal cancer (LRRC), using outcomes achieved at highly specialised centres.
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Preoperative COVID-19 Vaccination is Associated with Decreased Perioperative Mortality after Major Vascular Surgery. Ann. Surg. (IF 9.0) Pub Date : 2024-05-10 Molly Ratner, Karan Garg, Heepeel Chang, Anjali Nigalaye, Steven Medvedosky, Glenn Jacobowitz, Jeffrey J Siracuse, Virendra Patel, Marc Schermerhorn, Charles DiMaggio, Caron B Rockman
The objective of this study was to examine the effect of corona virus 2019 (COVID-19) vaccination on perioperative outcomes after major vascular surgery.
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A New Functional Threshold for Minimally Invasive Lobectomy. Ann. Surg. (IF 9.0) Pub Date : 2024-05-10 Stijn Vanstraelen, Kay See Tan, Joe Dycoco, Prasad S Adusumilli, Manjit S Bains, Matthew J Bott, Robert J Downey, Katherine D Gray, James Huang, James M Isbell, Daniela Molena, Bernard J Park, Valerie W Rusch, Smita Sihag, David R Jones, Gaetano Rocco
To assess the performance of a lower predicted postoperative (ppo) forced expiratory volume in 1 second (FEV1) or diffusion capacity of the lung for carbon monoxide (DLCO) (ppoFEV1/ppoDLCO) threshold to predict cardiopulmonary complications after minimally invasive surgery (MIS) lobectomy.
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Making a Statement: Positions of Professional Medical Organizations Towards Gender-Affirming Care. Ann. Surg. (IF 9.0) Pub Date : 2024-05-10 Myles N LaValley, Danielle J Eble, William M Kuzon, Blair R Peters, Alexander J Skokan, Russell E Ettinger, Shane D Morrison
Despite politically charged media coverage and legislation surrounding gender affirming care (GAC), many organizations have released position statements to provide scientifically backed clinical practice standards, combat misinformation, and inform medicolegal policies. The purpose of this study is to objectively assess the availability and the content of the official position statements of relevant
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Resident Salary Compared to Living Wages at United States Training Institutions. Ann. Surg. (IF 9.0) Pub Date : 2024-05-10 Campbell Liles, Alan R Tang, Mark Petrovic, Robert J Dambrino, Reid C Thompson, Lola B Chambless
To compare living wages and salaries at US residency programs.
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Improving Environmental Sustainability of Operating Theatres: A Systematic Review of Staff Attitudes, Barriers, and Enablers. Ann. Surg. (IF 9.0) Pub Date : 2024-05-10 Siya Lodhia, Victoria Pegna, Ruth Abrams, Daniel Jackson, Timothy A Rockall, Chantelle Rizan
To understand views of staff in relation to attitudes, enablers, and barriers to implementation of environmentally sustainable surgery in operating theatres. This will ultimately help in the goal of successfully implementing more sustainable theatres.
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Predicting Mortality Prior to Interhospital Hospital for "Unseen" General Surgery Patients: Development, Validation and Feasibility Trial of a Mortality Risk Calculator. Ann. Surg. (IF 9.0) Pub Date : 2024-05-10 Sayf Al-Deen Said, Corey K Gentle, Abby Gross, Kelly Nimylowycz, Mir Shanaz Hossain, Allison Weathers, R Matthew Walsh, Scott R Steele, Miguel Regueiro, Toms Augustin
Develop and validate a mortality risk calculator that could be utilized at the time of transfer, leveraging routinely collected variables that could be obtained by trained non-clinical transfer personnel.
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Outcomes from 871,441 Consecutive Surgical Procedures without Overlap or with Maximally Permissible Non-Concurrent Overlap. Ann. Surg. (IF 9.0) Pub Date : 2024-05-10 Austin J Borja, Ritesh Karsalia, Ryan S Gallagher, Krista Strouz, Jianbo Na, Scott D McClintock, Ronald P DeMatteo, Neil R Malhotra
To isolate the impact of subsumed surgery (a shorter procedure completed entirely during overlapping non-critical portions of a longer antecedent procedure) on patient outcomes.
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Health Expenditures After Bariatric Surgery: A Retrospective Cohort Study. Ann. Surg. (IF 9.0) Pub Date : 2024-05-10 Valerie A Smith, Lindsay Zepel, Aniket A Kawatkar, David E Arterburn, Aileen Baecker, Mary K Theis, Caroline Sloan, Amy G Clark, Shireesh Saurabh, Karen J Coleman, Matthew L Maciejewski
Bariatric surgery leads to substantial improvements in weight and weight-related conditions, but prior literature on post-surgical health expenditures is equivocal. In a retrospective cohort study, we compared expenditures between surgical and matched non-surgical patients.
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Comparison of Postoperative outcomes Among Patients Treated by Male Versus Female Surgeons: A Systematic Review and Meta-analysis. Ann. Surg. (IF 9.0) Pub Date : 2024-05-10 Natsumi Saka, Norio Yamamoto, Jun Watanabe, Christopher Wallis, Angela Jerath, Hidehiro Someko, Minoru Hayashi, Kyosuke Kamijo, Takashi Ariie, Toshiki Kuno, Hirotaka Kato, Hodan Mohamud, Ashton Chang, Raj Satkunasivam, Yusuke Tsugawa
To compare clinical outcomes of patients treated by female surgeons versus those treated by male surgeons.
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A Novel Objective Pathologic Criterion for Isolated Hypoganglionosis. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2024-05-10 Akihiko Tamaki, Kenichi Kohashi, Koichiro Yoshimaru, Yuko Hino, Hiroshi Hamada, Naonori Kawakubo, Tomoaki Taguchi, Tatsuro Tajiri, Yoshinao Oda
Isolated hypoganglionosis (IHG) is histologically characterized by small numbers of myenteric ganglion cells and small myenteric ganglia; however, no numerical diagnostic criteria for IHG have been established. Therefore, this study aimed to develop quantitative pathologic criteria for IHG. We evaluated 160 resected intestinal tissue specimens from 29 pediatric autopsies and 10 IHG cases. These specimens
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Histologic Features of Mycobacterial Spindle Cell Pseudotumors: A Multi-institutional Clinicopathologic Analysis of 14 Cases. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2024-05-10 Julianne M Szczepanski, Joshua A Lieberman, Laura W Lamps, Raul S Gonzalez, Yue Xue, Xuchen Zhang, Osman H Yilmaz, John Hart, Thomas Krausz, Jose G Mantilla, Jonathan B McHugh, Maria Westerhoff
Mycobacterial spindle cell pseudotumors (MSPs) are a rare and diagnostically challenging manifestation of non-tuberculous mycobacterial (NTM) infections. Proper recognition of these pseudotumors is important because they are treatable and benign. In this study, we evaluated the morphologic patterns of MSPs to improve their pathologic identification. Clinical and morphologic features of 14 MSPs were
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Transcriptionally Active Human Papillomavirus Infection in a Minority of Esophageal Squamous Cell Carcinomas in North America. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2024-05-10 Anna H Bauer, Khaled J Alkhateeb, Agoston T Agoston, Robert D Odze, Megha G Joshi, Brandon M Huffman, Peter Enzinger, Kimberly Perez, Vikram Deshpande, James M Cleary, Jon O Wee, Fei Dong, Lei Zhao
The role of Human papillomavirus (HPV) infection in esophageal squamous cell carcinoma (ESCC) is a topic of ongoing debate. This study used two screening approaches to look for evidence of HPV infection in esophageal squamous cell carcinoma. We initially checked for HPV infection in a randomly selected group of 53 ESCC cases. We did not detect any tumors positive for high-risk HPV. However, during
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Benign Islet Cells Within Peripancreatic Lymph Nodes: A Potential Diagnostic Pitfall. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2024-05-09 Ezra Baraban, Elizabeth D Thompson, Andres Matoso, Ralph H Hruban, Pedram Argani
The presence of epithelial cells within lymph node parenchyma is typically indicative of a metastatic malignancy. However, there are rare instances in which non-neoplastic epithelial or epithelioid cells may be found within lymph nodes, either due to aberrant embryologic migration, mechanical displacement, or physiological trafficking. These can potentially lead to serious potential diagnostic pitfalls
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Collaborative Care for Injured Older Adults JAMA Surg. (IF 16.9) Pub Date : 2024-05-08 Ben L. Zarzaur, Emma Holler, Damaris Ortiz, Anthony Perkins, Sue Lasister, Sujuan Gao, Dustin D. French, Babar Khan, Malaz Boustani
ImportanceOlder adults with recent injuries can have impaired long-term biopsychosocial function and may benefit from interventions adapted to their needs.ObjectiveTo determine if a collaborative care intervention, Trauma Medical Home (TMH), improved the biopsychosocial function of older patients in the year after injury.Design, Setting, and ParticipantsThis was a single-blinded, randomized clinical
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Decision-Making Confidence of Clinical Competency Committees for Entrustable Professional Activities JAMA Surg. (IF 16.9) Pub Date : 2024-05-08 Kelsey B. Montgomery, John D. Mellinger, M. Chandler McLeod, Andrew Jones, Polina Zmijewski, George A. Sarosi, Karen J. Brasel, Mary E. Klingensmith, Rebecca M. Minter, Jo Buyske, Brenessa Lindeman
ImportanceA competency-based assessment framework using entrustable professional activities (EPAs) was endorsed by the American Board of Surgery following a 2-year feasibility pilot study. Pilot study programs’ clinical competency committees (CCCs) rated residents on EPA entrustment semiannually using this newly developed assessment tool, but factors associated with their decision-making are not yet
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Prophylactic Regenerative Peripheral Nerve Interface (RPNI) Surgery in Pediatric Lower Limb Amputation Patients. Ann. Surg. (IF 9.0) Pub Date : 2024-05-08 Ahneesh J Mohanty, Paul S Cederna, Stephen W P Kemp, Theodore A Kung
To evaluate the prophylactic effect of Regenerative Peripheral Nerve Interface (RPNI) surgery on pediatric post-amputation pain.
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Association Between Prescription Drug Monitoring Program Use Mandate and Opioid Prescribing and Patient-Reported Outcomes After Surgery. Ann. Surg. (IF 9.0) Pub Date : 2024-05-08 Kao-Ping Chua, Thuy D Nguyen, Chad M Brummett, Amy S Bohnert, Vidhya Gunaseelan, Michael J Englesbe, Stephanie Lee, Jennifer F Waljee
To evaluate changes in opioid prescribing and patient-reported outcomes after surgery following implementation of Michigan's prescription drug monitoring program (PDMP) use mandate in June 2018.
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Myxoid Inflammatory Myofibroblastic Sarcoma: Clinicopathologic Analysis of 25 Cases of a Distinctive Sarcoma With Deceptively Bland Morphology and Aggressive Clinical Behavior. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2024-05-08 David J Papke, Igor Odintsov, Brendan C Dickson, Marisa R Nucci, Abbas Agaimy, Christopher D M Fletcher
The number of recognized sarcoma types harboring targetable molecular alterations continues to increase. Here we present 25 examples of a distinctive myofibroblastic tumor, provisionally termed "myxoid inflammatory myofibroblastic sarcoma," which might be related to inflammatory myofibroblastic tumor, and which occurred in 13 males (52%) and 12 females at a median age of 37 years (range: 7 to 79 years)
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Laparoscopic Spleen-Preserving Hilar Lymphadenectomy for Advanced Proximal Gastric Cancer Without Greater Curvature Invasion JAMA Surg. (IF 16.9) Pub Date : 2024-05-01 Jian-xian Lin, Bin-bin Xu, Hua-Long Zheng, Ping Li, Jian-wei Xie, Jia-bin Wang, Jun Lu, Qi-yue Chen, Long-long Cao, Mi Lin, Ru-hong Tu, Ze-ning Huang, Ju-li Lin, Zi-hao Yao, Chao-Hui Zheng, Chang-Ming Huang
ImportanceSplenic hilar lymphadenectomy has been recommended for locally advanced proximal gastric cancer (APGC) involving the greater curvature. However, it is unclear whether laparoscopic spleen-preserving splenic hilar lymphadenectomy (LSPSHL) is associated with a long-term survival benefit for APGC without greater curvature invasion.ObjectiveTo present the 5-year follow-up data from a randomized
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Management of Gallstone Pancreatitis JAMA Surg. (IF 16.9) Pub Date : 2024-05-01 James McDermott, Lillian S. Kao, Jessica A. Keeley, Jeffry Nahmias, Christian de Virgilio
ImportanceGallstone pancreatitis (GSP) is the leading cause of acute pancreatitis, accounting for approximately 50% of cases. Without appropriate and timely treatment, patients are at increased risk of disease progression and recurrence. While there is increasing consensus among guidelines for the management of mild GSP, adherence to these guidelines remains poor. In addition, there is minimal evidence
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Serratus Anterior Plane Blocks for Early Rib Fracture Pain Management JAMA Surg. (IF 16.9) Pub Date : 2024-05-01 Christopher Partyka, Stephen Asha, Melanie Berry, Ian Ferguson, Brian Burns, Katerina Tsacalos, Daniel Gaetani, Matthew Oliver, Georgina Luscombe, Anthony Delaney, Kate Curtis
ImportanceRib fractures secondary to blunt thoracic trauma typically result in severe pain that is notoriously difficult to manage. The serratus anterior plane block (SAPB) is a regional anesthesia technique that provides analgesia to most of the hemithorax; however, SAPB has limited evidence for analgesic benefits in rib fractures.ObjectiveTo determine whether the addition of an SAPB to protocolized
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Chimeric autoantibody-receptor T cells mediate depletion of autoantibody-producing B cells Am. J. Transplant. (IF 8.8) Pub Date : 2024-05-01 Han S. Yin, Eva M. Gillis-Buck, James M. Gardner
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PON3::LCN1 and HTN3::MSANTD3 Gene Fusions With NR4A3/NR4A2 Expression in Salivary Acinic Cell Carcinoma. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2024-04-29 Lijing Zhu, Lisha Sun, Ye Zhang, Xiaoxiao Liu, XueFen Li, Zheng Zhou, Yajuan Cui, Chuan-Xiang Zhou, Tie-Jun Li
Acinic cell carcinoma of the salivary gland (AciCC) is a low-grade carcinoma characterized by the overexpression of the transcription factor nuclear receptor subfamily 4 group A member 3 (NR4A3). AciCC has been the subject of a few molecular research projects. This study delves into AciCC's molecular landscape to identify additional alterations and explore their clinical implications. RNA sequencing
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Somatostatin vs. Octreotide for Prevention of Postoperative Pancreatic Fistula The PREFIPS Randomized Clinical Trial A FRENCH 007 - ACHBT Study. Ann. Surg. (IF 9.0) Pub Date : 2024-04-25 Sébastien Gaujoux, Jean-Marc Regimbeau, Guillaume Piessen, Stéphanie Truant, Frantz Foissac, Louise Barbier, Emmanuel Buc, Mustapha Adham, David Fuks, Sophie Deguelte, Fabrice Muscari, Laurent Sulpice, Jean-Christophe Vaillant, Lilian Schwarz, Antonio Sa Cunha, Milena Muzzolini, Bertrand Dousset, Alain Sauvanet
Pharmacological prevention of postoperative pancreatic fistula (POPF) after pancreatectomy is open to debate. The present study compares clinically significant POPF rates in patients randomized between somatostatin versus octreotide as prophylactic treatment.
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Disparities in Access to Outpatient Surgery Related to Removal of Procedures from Medicare's Inpatient Only List. Ann. Surg. (IF 9.0) Pub Date : 2024-04-25 Thomas C Tsai, Sarah A Brownlee, Dannie Dai, Mark Soto, Ning Rosenthal, E John Orav, Austin B Frakt, Jose F Figueroa
We assessed the shift from inpatient to outpatient surgical care related to changes to the Inpatient Only List in 2020 and 2021 compared to 2019.
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Evaluating the Quality of Narrative Feedback for Entrustable Professional Activities in a Surgery Residency Program. Ann. Surg. (IF 9.0) Pub Date : 2024-04-25 Rosephine Del Fernandes, Ingrid de Vries, Laura McEwen, Steve Mann, Timothy Phillips, Boris Zevin
We assessed the quality of narrative feedback given to surgical residents during the first five years of Competency-Based Medical Education (CBME) implementation.
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Calcineurin inhibitor toxicity in de novo thrombotic microangiopathy—Is the culprit what we think it is? Am. J. Transplant. (IF 8.8) Pub Date : 2024-04-25 Vojtech Petr, Ivan Zahradka, Ondrej Viklicky
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Interim effectiveness of the updated 2023-2024 COVID-19 vaccines in adults with immunocompromizing conditions Am. J. Transplant. (IF 8.8) Pub Date : 2024-04-25 Marcus R. Pereira
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Elective Appendectomy Following Antibiotics for Appendicitis JAMA Surg. (IF 16.9) Pub Date : 2024-04-24 Dimitrios Moris, Theodore Pappas
This Viewpoint considers which may be the better long-term approach to appendicitis—interval elective appendectomy or nonsurgical treatment with antibiotics.
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Interval Appendectomy After Successful Antibiotic Treatment? JAMA Surg. (IF 16.9) Pub Date : 2024-04-24 David A. Talan, Peter C. Minneci
This Viewpoint discusses the pros and cons of performing interval appendectomy in patients who have recovered from successful antibiotic treatment of acute uncomplicated appendicitis.
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Plastic Wound Protector vs Surgical Gauze for Surgical Site Infection Reduction in Open GI Surgery JAMA Surg. (IF 16.9) Pub Date : 2024-04-24 Nina Yoo, Ji Yeon Mun, Bong-Hyeon Kye, Chang Woo Kim, Jae Im Lee, Youn Young Park, Byung Mo Kang, Byung Kwan Park, Han Deok Kwak, Won-Kyung Kang, Sung Uk Bae, Heung-Kwon Oh, Youngki Hong, Hyung Jin Kim
ImportanceSurgical site infections (SSIs) are prevalent hospital-acquired infections with significant patient impacts and global health care burdens. The World Health Organization recommends using wound protector devices in abdominal surgery as a preventive measure to lower the risk of SSIs despite limited evidence.ObjectiveTo examine the efficacy of a dual-ring, plastic wound protector in lowering
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Incisional Wound Irrigation for the Prevention of Surgical Site Infection JAMA Surg. (IF 16.9) Pub Date : 2024-04-24 Hannah Groenen, Nathan Bontekoning, Hasti Jalalzadeh, Dennis R. Buis, Yasmine E. M. Dreissen, Jon H. M. Goosen, Haitske Graveland, Mitchel Griekspoor, Frank F. A. IJpma, Maarten J. van der Laan, Roald R. Schaad, Patrique Segers, Wil C. van der Zwet, Ricardo G. Orsini, Anne M. Eskes, Niels Wolfhagen, Stijn W. de Jonge, Marja A. Boermeester
ImportanceSurgical site infections (SSIs) are common postoperative complications and associated with significant morbidity, mortality, and costs. Prophylactic intraoperative incisional wound irrigation is used to reduce the risk of SSIs, and there is great variation in the type of irrigation solutions and their use.ObjectiveTo compare the outcomes of different types of incisional prophylactic intraoperative
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Career Trajectory After General Surgery Residency: Do Academic Program Graduates Pursue Academic Surgery? Ann. Surg. (IF 9.0) Pub Date : 2024-04-23 Allen Green, Elijah R Sommer, Max R Johnson, Hector Gonzalez, Twan Sia, David A Spain, Jeff Choi
Determine the proportion of contemporary US academic general surgery residency program graduates who pursue academic careers and identify factors associated with pursuing academic careers.
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Undocumented immigrants: A glaring inequity in transplant Am. J. Transplant. (IF 8.8) Pub Date : 2024-04-23 Lara C. Pullen PhD
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Yolk Sac Differentiation in Endometrial Carcinoma: Incidence and Clinicopathologic Features of Somatically Derived Yolk Sac Tumors Versus Carcinomas With Nonspecific Immunoexpression of Yolk Sac Markers. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2024-04-23 Anne M Mills, Taylor M Jenkins, Megan E Dibbern, Kristen A Atkins, Kari L Ring
Endometrial somatically derived yolk sac tumors are characterized by yolk sac morphology with AFP, SALL-4, and/or Glypican-3 immunoexpression. Yolk sac marker expression, however, is not limited to tumors with overt yolk sac histology. Three hundred consecutive endometrial malignancies were assessed for immunomarkers of yolk sac differentiation. Of these, 9% expressed ≥1 yolk sac marker, including
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Association of Lateral Pelvic Lymph Nodes with Disease Recurrence and Organ Preservation in Patients with Distal Rectal Adenocarcinoma Treated with Total Neoadjuvant Therapy. Ann. Surg. (IF 9.0) Pub Date : 2024-04-22 Nathalie R A Beets, Floris S Verheij, Hannah Williams, Dana M Omer, Sabrina T Lin, Li-Xuan Qin, Geerard L Beets, Regina G H Beets-Tan, Iris H Wei, Maria Widmar, Emmanouil P Pappou, Martin R Weiser, Garrett M Nash, J Joshua Smith, Philip B Paty, Joao Miranda, Tae-Hyung Kim, Marc J Gollub, Julio Garcia-Aguilar
Assess the significance of enlarged lateral lymph nodes (LLN) for disease recurrence, metastasis, and organ preservation in patients with rectal cancer.
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International Collaborative Study Comparing Outcomes of Fenestrated Endovascular Aortic Repair in OCtogenarian vs Non-Octogenarian Patients: The FEVOC study. Ann. Surg. (IF 9.0) Pub Date : 2024-04-22 Carlota F Prendes, Paolo Spath, Manar Khashram, Nuno Dias, Federico Furlan, Ryan Gouveia E Melo, Enrico Gallitto, Björn Sonesson, Luis Mendes Pedro, Sinead Gormley, Mauro Gargiulo, Anders Wanhainen, Nikolaos Tsilimparis, Kevin Mani
With an increasing life expectancy, more octogenarian patients are referred with complex aortic aneurysms (cAAA). The aim of this study was to evaluate short and mid-term outcomes following fenestrated aortic repair (FEVAR) in octogenarians.
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A Novel Macroglossia Severity Index for Beckwith-Wiedemann Syndrome. Ann. Surg. (IF 9.0) Pub Date : 2024-04-22 Dominic J Romeo, Manisha Banala, Meagan Wu, Jinggang J Ng, Benjamin B Massenburg, Andrew George, Madison DeMarchis, Eric C Liao, Jennifer M Kalish, Jesse A Taylor
We propose the first classification scheme for macroglossia in patients with Beckwith-Wiedemann Syndrome (BWS), the BWS Index of macroGlossia (BIG).
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TRPS1 is a Highly Sensitive Marker for Breast Cancer: A Tissue Microarray Study Evaluating More Than 19,000 Tumors From 152 Different Tumor Entities. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2024-04-22 Maximilian Lennartz, Neele Löhr, Doris Höflmayer, Sebastian Dwertmann Rico, Clara von Bargen, Simon Kind, Viktor Reiswich, Florian Viehweger, Florian Lutz, Veit Bertram, Christoph Fraune, Natalia Gorbokon, Sören Weidemann, Niclas C Blessin, Claudia Hube-Magg, Anne Menz, Ria Schlichter, Till Krech, Andrea Hinsch, Eike Burandt, Guido Sauter, Ronald Simon, Martina Kluth, Andreas H Marx, Patrick Lebok
Trichorhinophalangeal syndrome 1 (TRPS1) is a nuclear protein highly expressed in breast epithelial cells. TRPS1 immunohistochemistry (IHC) has been suggested as a breast cancer marker. To determine the diagnostic and prognostic utility of TRPS1 IHC, tissue microarrays containing 19,201 samples from 152 different tumor types and subtypes were analyzed. GATA3 IHC was performed in a previous study. TRPS1
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Cyclic guanosine monophosphate-adenosine monophosphate synthetase/stimulator of interferon genes signaling aggravated corneal allograft rejection through neutrophil extracellular traps Am. J. Transplant. (IF 8.8) Pub Date : 2024-04-20 Chao Wei, Qing Huang, Fanxing Zeng, Li Ma, Xiaofei Bai, Xuejing Zhu, Hua Gao, Xiaolin Qi
The activation of innate immunity following transplantation has been identified as a crucial factor in allograft inflammation and rejection. However, the role of cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)/stimulator of interferon genes (STING) signaling-mediated innate immunity in the pathogenesis of allograft rejection remains unclear. Utilizing a well-established murine
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Post-discharge Mental Healthcare and Emergency General Surgery Readmission for Patients with Serious Mental Illness. Ann. Surg. (IF 9.0) Pub Date : 2024-04-19 Danielle E Brown, Claire B Rosen, Sanford E Roberts, Adora Moneme, Chris Wirtalla, Rachel Kelz
To determine the association between post-discharge mental healthcare and odds of readmission after emergency general surgery (EGS) hospitalization for patients with serious mental illness (SMI).
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Accuracy of Conflicts in Interest in General Surgical Journals. Ann. Surg. (IF 9.0) Pub Date : 2024-04-19 Tina Bharani, Claire Yuan, Karina Mahida, Suheila Mukhtar, Hudson Bosch, Mia Linson, Eric Sheu, Divyansh Agarwal
To evaluate the accuracy of self-reported conflicts of interest (COIs) for articles published in prominent minimally invasive and general surgical journals.
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Third-party virus-specific T cells for the treatment of double-stranded DNA viral reactivation and posttransplant lymphoproliferative disease after solid organ transplant Am. J. Transplant. (IF 8.8) Pub Date : 2024-04-19 Ruby Khoury, Michael S. Grimley, Adam S. Nelson, Tom Leemhuis, Jose A. Cancelas, Eleanor Cook, YunZu Wang, Daria Heyenbruch, Catherine M. Bollard, Michael D. Keller, Patrick J. Hanley, Carolyn Lutzko, Giang Pham, Stella M. Davies, Jeremy D. Rubinstein
Reactivation or primary infection with double-stranded DNA viruses is common in recipients of solid organ transplants (SOTs) and is associated with significant morbidity and mortality. Treatment with conventional antiviral medications is limited by toxicities, resistance, and a lack of effective options for adenovirus (ADV) and BK polyomavirus (BKPyV). Virus-specific T cells (VSTs) have been shown
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The emerging era of organ transplantation and anti-CD154mAb Am. J. Transplant. (IF 8.8) Pub Date : 2024-04-19 Jean Kwun, Allan D. Kirk, Stuart J. Knechtle
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Comparing the prognostic performance of iBOX and biopsy-proven acute rejection for long-term kidney graft survival Am. J. Transplant. (IF 8.8) Pub Date : 2024-04-19 Amanda Klein, Luke Kosinski, Alexandre Loupy, Eric Frey, Mark Stegall, Ilkka Helanterä, Kenneth Newell, Herwig-Ulf Meier-Kriesche, Roslyn B. Mannon, William E. Fitzsimmons, Transplant Therapeutics Consortium
Biopsy-proven acute rejection (BPAR) occurs in approximately 10% of kidney transplant recipients in the first year, making superiority trials unfeasible. iBOX, a quantitative composite of estimated glomerular filtration rate, proteinuria, antihuman leukocyte antigen donor-specific antibody, and + full/− abbreviated kidney histopathology, is a new proposed surrogate endpoint. BPAR’s prognostic ability
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Pretransplant use of immune checkpoint inhibitors for hepatocellular carcinoma: A multicenter, retrospective cohort study Am. J. Transplant. (IF 8.8) Pub Date : 2024-04-18 Zhiyong Guo, Yao Liu, Qi Ling, Leibo Xu, Tielong Wang, Jiaxing Zhu, Yimou Lin, Xinjun Lu, Wei Qu, Fan Zhang, Zhijun Zhu, Jian Zhang, Zehua Jia, Ping Zeng, Wenjing Wang, Qiang Sun, Qijie Luo, Zemin Hu, Zhouying Zheng, Yingbin Jia, Jian Li, Yujian Zheng, Mengchao Wang, Shaoping Wang, Zemin Han, Sheng Yu, Chuanjiang Li, Shuhua Zhang, Jun Xiong, Feiwen Deng, Ying Liu, Huanwei Chen, Yanfeng Wang, Ling Li
Immune checkpoint inhibitors (ICIs) as a downstaging or bridging therapy for liver transplantation (LT) in hepatocellular carcinoma patients are rapidly increasing. However, the evidence about the feasibility and safety of pre-LT ICI therapy is limited and controversial. To this end, a multicenter, retrospective cohort study was conducted in 11 Chinese centers. The results showed that 83 recipients
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Genomic Catastrophe (Chromothripsis and Polyploidy) Correlates With Tumor Distribution in Extrauterine High-grade Serous Carcinoma. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2024-04-18 Ju-Yoon Yoon, Aarti Sharma, Azra H Ligon, Rebecca G Ramesh, T Rinda Soong, Wa Xian, David B Chapel, Christopher P Crum
Most extrauterine high-grade serous carcinomas (HGSCs) are thought to develop first in the distal fallopian tube. Most models of HGSC assume origin from relatively stable, noninvasive serous tubal intraepithelial carcinomas. However, widespread tumor involvement in the absence of a serous tubal intraepithelial carcinoma could occur after catastrophic genomic events (CGEs; such as chromothripsis or
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Management of Diverticulitis JAMA Surg. (IF 16.9) Pub Date : 2024-04-17 Olivia A. Sacks, Jason Hall
ImportanceCare of patients with diverticulitis is undergoing a paradigm shift. This narrative review summarizes the current evidence for left-sided uncomplicated and complicated diverticulitis. The latest pathophysiology, advances in diagnosis, and prevention strategies are also reviewed.ObservationsTreatment is moving to the outpatient setting, physicians are forgoing antibiotics for uncomplicated
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Placebo Control and Blinding in Randomized Trials of Procedural Interventions JAMA Surg. (IF 16.9) Pub Date : 2024-04-17 Christopher A. Rajkumar, Katharine E. Thomas, Michael Foley, Sashiananthan Ganesananthan, Holli Evans, Florentina Simader, Sharan Syam, Daniel Nour, Catherine Beattie, Caitlin Khan, Rohin K. Reddy, Fiyyaz Ahmed-Jushuf, Darrel P. Francis, Matthew Shun-Shin, Rasha K. Al-Lamee
ImportanceUnlike medications, procedural interventions are rarely trialed against placebo prior to becoming accepted in clinical practice. When placebo-controlled trials are eventually conducted, procedural interventions may be less effective than previously believed.ObjectiveTo investigate the importance of including a placebo arm in trials of surgical and interventional procedures by comparing effect
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Three-Year Outcomes of Oral Antibiotics vs Intravenous and Oral Antibiotics for Uncomplicated Acute Appendicitis JAMA Surg. (IF 16.9) Pub Date : 2024-04-17 Liisa Selänne, Jussi Haijanen, Suvi Sippola, Saija Hurme, Tero Rautio, Pia Nordström, Tuomo Rantanen, Tarja Pinta, Imre Ilves, Anne Mattila, Jukka Rintala, Harri Marttila, Sanna Meriläinen, Johanna Laukkarinen, Eeva-Liisa Sävelä, Hannu Paajanen, Juha Grönroos, Paulina Salminen
ImportanceCurrent short-term evidence has shown that uncomplicated acute appendicitis can be treated successfully with oral antibiotics alone, but longer-term results are lacking.ObjectiveTo assess the treatment effectiveness of oral antibiotic monotherapy compared with combined intravenous (IV) and oral antibiotics in computed tomography–confirmed uncomplicated acute appendicitis at a longer-term
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An ethical analysis of conditional and partially directed live kidney donation among strangers—The Israeli experience Am. J. Transplant. (IF 8.8) Pub Date : 2024-04-17 Penina Dienstag, Rana Halaseh, Keren Tzukert, Ashraf Imam, Abed Khalaileh, Aryeh Dienstag
Living donor kidney transplantation (LDKT) is one of the most effective treatment options for people with end-stage renal disease. Traditionally, LDKT can be either “directed” or “nondirected,” based on whether the recipient is specified by the donor. Recently, there has been an increase in conditional and semidirected live kidney donation among strangers, where the donor specifies the characteristics
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Comprehensive Assessment of the Intrinsic Pancreatic Microbiome. Ann. Surg. (IF 9.0) Pub Date : 2024-04-16 Austin M Eckhoff, Ashley A Fletcher, Matthew S Kelly, Anders Dohlman, Caitlin A McIntyre, Xiling Shen, Matthew K Iyer, Daniel P Nussbaum, Peter J Allen
We sought to comprehensively profile tissue and cyst fluid in patients with benign, precancerous, and cancerous conditions of the pancreas to characterize the intrinsic pancreatic microbiome.
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Portal Hemodynamics in Liver Resection and Transplantation. Ann. Surg. (IF 9.0) Pub Date : 2024-04-16 Mohamed Rela, Ashwin Rammohan, Rajesh Rajalingam, Pierre-Alain Clavien
The hepatic blood supply and its several homeostatic and pathologic processes has always been a matter of great interest. Many views commonly held today are derived from an earlier era, but major reorientations have occurred recently in almost all aspects of knowledge of the role and regulation of hepatic blood flow. Moreover, with the advent of liver transplantation (LT), especially living donor LT
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Incomplete reporting of clinically significant acute rejection episodes in the national kidney transplant registry Am. J. Transplant. (IF 8.8) Pub Date : 2024-04-16 Miko Yu, Kristen L. King, Lindsey M. Maclay, S. Ali Husain, Jesse D. Schold, Sumit Mohan
Administrative claims data could provide a unique opportunity to identify acute rejection (AR) events using specific antirejection medications and to validate rejected data reported to the Organ Procurement and Transplantation Network. This retrospective cohort study examined differences in registry-reported events and those identified using claims data among adult kidney transplant recipients from
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Utilization and Cost of Gender-affirming Surgery in the United States from 2012-2019. Ann. Surg. (IF 9.0) Pub Date : 2024-04-15 Jacky Chu, Meera Nagpal, Amy D Dobberfuhl
To characterize the trends in and characteristics associated with the utilization and cost of gender-affirming surgery (GAS) in the United States from 2012-2019.
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Magnetic resonance imaging as a noninvasive adjunct to conventional assessment of functional differences between kidneys in vivo and during ex vivo normothermic machine perfusion Am. J. Transplant. (IF 8.8) Pub Date : 2024-04-13 Tim L. Hamelink, Baran Ogurlu, Carolina C. Pamplona, Johannes Castelein, Sigrid S. Bennedsgaard, Haiyun Qi, Thomas Weiss, Veerle A. Lantinga, Merel B.F. Pool, Christoffer Laustsen, Bente Jespersen, Henri G.D. Leuvenink, Steffen Ringgaard, Ronald J.H. Borra, Anna K. Keller, Cyril Moers
Normothermic machine perfusion (NMP) is increasingly considered for pretransplant kidney quality assessment. However, fundamental questions about differences between in vivo and ex vivo renal function, as well as the impact of ischemic injury on ex vivo physiology, remain unanswered. This study utilized magnetic resonance imaging (MRI), alongside conventional parameters to explore differences between
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Defining the Minimal and Optimal Thresholds for Lymph Node Resection and Examination for Intraductal Papillary Mucinous Neoplasm Derived Pancreatic Cancer: A Multicenter Retrospective Analysis. Ann. Surg. (IF 9.0) Pub Date : 2024-04-12 Joseph R Habib, Ingmar F Rompen, Sarah R Kaslow, Mahip Grewal, Paul C M Andel, Shuang Zhang, D Brock Hewitt, Steven M Cohen, Hjalmar C van Santvoort, Marc G Besselink, I Quintus Molenaar, Jin He, Christopher L Wolfgang, Ammar A Javed, Lois A Daamen
To establish minimal and optimal lymphadenectomy thresholds for intraductal papillary mucinous neoplasm (IPMN)-derived pancreatic ductal adenocarcinoma (PDAC) and evaluate their prognostic value.
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Characteristics and Practice Patterns of Non-certified Surgeons Treating Medicare Patients. Ann. Surg. (IF 9.0) Pub Date : 2024-04-12 Rebecca Moreci, Rebecca S Gates, John Luckoski, Kayla Marcotte, Cody L Mullens, Chia Chye Yee, Tanvi Gupta, Daniel Kendrick, Angela Thelen, Andrew E Krumm, Brian C George
The objective of this study is to explore the patient characteristics and practice patterns of non-certified surgeons who treat Medicare patients in the United States.
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The Role of High-Resolution Manometry Prior to and Following Antireflux Surgery: The Padova Consensus. Ann. Surg. (IF 9.0) Pub Date : 2024-04-12 Renato Salvador, John E Pandolfino, Mario Costantini, C Prakash Gyawali, Jutta Keller, Sumeet Mittal, Sabine Roman, Edoardo Vincenzo Savarino, Roger Tatum, Salvatore Tolone, Frank Zerbib, Giovanni Capovilla, Anand Jain, Priya Kathpalia, Luca Provenzano, Rena Yadlapati
In the last two decades the development of high-resolution manometry (HRM) has changed and revolutionized the diagnostic assessment of patients complain foregut symptoms. The role of HRM before and after antireflux procedure remains unclear, especially in surgical practice, where a clear understanding of esophageal physiology and hiatus anatomy is essential for optimal outcome of antireflux surgery