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Factors Associated With Visual Field Testing Reliability in Children With Glaucoma or Suspected Glaucoma Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-04-16 ANIKA KUMAR, NATAN HEKMATJAH, YINXI YU, YING HAN, GUI-SHUANG YING, JULIUS T. OATTS
To evaluate Humphrey Visual Field (HVF) test reliability and its associated risk factors in children with glaucoma or glaucoma suspect. Retrospective cohort study. None. Single-center childhood glaucoma clinic. One hundred thirty-six patients aged ≤18 years with glaucoma/glaucoma suspect, and least 1 completed 24 to 2 HVF test between 2018 and 2023. Demographic and clinical characteristics including
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Using Large Language Models to Generate Educational Materials on Childhood Glaucoma Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-04-16 Qais Dihan, Muhammad Z. Chauhan, Taher K. Eleiwa, Amr K. Hassan, Ahmed B. Sallam, Albert S. Khouri, Ta C. Chang, Abdelrahman M. Elhusseiny
To evaluate the quality, readability, and accuracy of large language model (LLM) generated patient education materials (PEMs) on childhood glaucoma, and their ability to improve existing online information's readability. Cross-sectional comparative study. We evaluated responses of ChatGPT-3.5, ChatGPT-4, and Bard to three separate prompts requesting they write PEMs on “childhood glaucoma.” Prompt A
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How to tame a tight DMEK-roll? The ‘bubble-in-the-roll’ technique Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-04-13 Gergely Losonczy
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Congenital Cataracts With Thin Lenses (Leptophakia) in Children: Morphology and Surgical Outcomes Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-04-04 Michelle G. Zhang, Ryan A. Gallo, Ta Chen Chang
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Effectiveness of the Spot tm Vision Screener With Variations in Ocular Pigments Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-04-04 Charles J. Pophal, Rupal H. Trivedi, James D. Bowsher, John David L. Peterseim, Samantha M. Smith, M. Edward Wilson, Mae Millicent W. Peterseim, Bethany J. Wolf
To evaluate Spot in detecting American Association for Pediatric Ophthalmology and Strabismus (AAPOS) Amblyopia risk factors (ARF) and for ARF myopia and hyperopia with variations in ocular pigments. Diagnostic screening test evaluation. Children presented for a complete eye examination in pediatric clinic. The study population included 1040 participants, of whom 273 had darkly pigmented eyes, 303
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Association of Long-Term Intraocular Pressure Variability and Rate of Ganglion Complex Thinning in Patients With Glaucoma Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-04-03 Golnoush Mahmoudinezhad, Sasan Moghimi, Takashi Nishida, Evan Walker, Kareem Latif, Jeffrey M. Liebmann, Massimo A. Fazio, Christopher A. Girkin, Linda Zangwill, Robert N. Weinreb
To evaluate the association of mean intraocular pressure (IOP) and IOP variability (IOP fluctuation [SD of IOP] and the IOP range) with the rate of ganglion cell complex (GCC) layer thinning over time in patients with glaucoma. Prospective cohort study. Participants with at least 4 visits and 2 years of follow-up of optical coherence tomography tests were included. A linear mixed-effect model was used
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Corneal Biomechanical Characteristics in Myopes and Emmetropes Measured by Corvis ST: A Meta-Analysis Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-29 MIN-XIN LIU, KE-YAO ZHU, DAN-LIN LI, XING-XUAN DONG, GANG LIANG, ANDRZEJ GRZYBOWSKI, CHEN-WEI PAN
To comprehensively identify the corneal biomechanical differences measured by Corvis ST between different degrees of myopia and emmetropia. Systematic review and meta-analysis. Electronic databases, including PubMed, Embase, and Web of Science, were systematically searched for studies comparing the corneal biomechanics among various degrees of myopes and emmetropes using Corvis ST. The weighted mean
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Association Between Quantitative and Qualitative Imaging Biomarkers and Geographic Atrophy Growth Rate Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-27 Talisa E. de Carlo Forest, Zafar Gill, Andres Lisker-Cervantes, Ramya Gnanaraj, Nathan Grove, Jennifer L. Patnaik, Anne M. Lynch, Alan G. Palestine, Marc Mathias, Niranjan Manoharan, Naresh Mandava
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Racial Disparities in Glaucoma Vision Outcomes and Eye Care Utilization: An IRIS Registry Analysis Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-27 Elizabeth C. Ciociola, Sayuri Sekimitsu, Sophie Smith, Alice C. Lorch, Joan W. Miller, Tobias Elze, Nazlee Zebardast, the IRIS Registry Analytic Center Consortium, Suzann Pershing, Leslie Hyman, Julia A. Haller, Aaron Y. Lee, Cecilia S. Lee, Flora Lum, Joan W. Miller, Alice Lorch
To evaluate racial disparities in vision outcomes and eye care utilization among glaucoma patients. Retrospective cohort study. In this population-based IRIS Registry (Intelligent Research in Sight) study, we included patients with minimum one diagnosis code for glaucoma at least 6 months prior to January 1, 2015 and at least one eye exam, visual field (VF), optical coherence tomography (OCT), or eye-related
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Correlation of Refractive Error with Anisometropia Development in Early Childhood Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-27 Michael Kinori, Itay Nitzan, Naava Sadi Szyper, Asaf Achiron, Oriel Spierer
This study aims to investigate the relationship between the type and severity of refractive error and anisometropia development in preschool children. Retrospective cohort study. Data from Maccabi Healthcare Services, Israel's second-largest Health Maintenance Organization (HMO), were analyzed. The study included all isometropic children aged 1 to 6 years, re-examined for refraction at least 2 years
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IQCB1 (NPHP5)-Retinopathy: Clinical and Genetic Characterization and Natural History Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-23 SAGNIK SEN, LORENZO FABOZZI, KAORU FUJINAMI, YU FUJINAMI-YOKOKAWA, GENEVIEVE A. WRIGHT, ANDREW WEBSTER, OMAR MAHROO, ANTHONY G. ROBSON, MICHALIS GEORGIOU, MICHEL MICHAELIDES
To describe the clinical and genetic features, and explore the natural history of retinopathy associated with variants in children and adults with retinopathy. Retrospective cohort study at a single tertiary care referral center. The study recruited 19 patients with retinopathy, harboring likely disease-causing variants in . Demographic data and clinical presentation, best corrected visual acuity (BCVA)
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Neuropathic Corneal Pain: Tear Proteomic and Neuromediator Profiles, Imaging Features, and Clinical Manifestations Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-21 Chang Liu, Molly Tzu-Yu Lin, Isabelle Xin Yu Lee, Jipson Hon Fai Wong, Daqian Lu, Thomas Chuen Lam, Lei Zhou, Jodhbir S. Mehta, Hon Shing Ong, Marcus Ang, Louis Tong, Yu-Chi Liu
To investigate the tear proteomic and neuromediator profiles, in vivo confocal microscopy (IVCM) imaging features, and clinical manifestations in neuropathic corneal pain (NCP) patients. Cross-sectional study. A total of 20 NCP patients and 20 age-matched controls were recruited. All subjects were evaluated by corneal sensitivity, Schirmer test, tear break-up time, and corneal and ocular surface staining
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Eight Years and Beyond Longitudinal Changes of Peripapillary Structures on OCT in Adult Myopia Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-21 Yi Dai, Li Wang, Jie Hong, Xinghuai Sun
To investigate the long-term changes of peripapillary structures detected by enhanced depth imaging of optical coherence tomography (OCT) in adult myopia. Observational case series. Myopic participants who had undergone a full baseline ophthalmologic examination and had been followed up for a minimum of 8 years were included. Using enhanced depth imaging of OCT, scans around the optic disc in the Spectralis
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External Validation of a Model to Predict Postoperative Globe Axial Length in Children After Bilateral Cataract Surgery Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-21 Antonio Carlos Lottelli, Rupal H. Trivedi, Eliane Chaves Jorge, M. Edward Wilson
To perform the external validation of a model to predict postoperative axial length (AL) in children over 2 years of age who were undergoing bilateral cataract surgery with primary intraocular lens (IOL) implantation. Validation study using a retrospective case series. Using a population different from the one that created the model, but with the same characteristics regarding age, bilateral cataract
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Peripheral Vision in Patients Following Intraocular Lens Implantation: A Systematic Review and Meta-Analysis Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-21 Pablo Artal, Maria Arvaniti, Panaghiota Dimou, Costas Stavrinos, Harilaos Ginis, Lucía Hervella, José Luis Güell
To update the literature on peripheral optics and vision following intraocular lens (IOLs) implantation. We investigated how current IOLs influence peripheral visual function, peripheral optical quality, and visual perception and performance, in patients following cataract surgery. Peripheral vision is described as vision outside the central foveal region of the eye (beyond 4-5° of eccentricity). We
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Comparison of Legacy and New No-History IOL Power Calculation Formulas in Postmyopic Laser Vision Correction Eyes Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-20 Abdelrahman M. Anter, Adam R. Bleeker, H. John Shammas, Sanjana Suraneni, Brandon Kingrey, David A. Murphy, Sebastian Leal, Seyyedehfatemeh Ghalibafan, Rahul S. Tonk, David L. Cooke, Kamran M. Riaz
To compare the refractive accuracy of legacy and new no-history formulas in eyes with previous myopic laser vision correction (M-LVC). Retrospective cohort study. Setting: Two academic centers Study Population: 576 eyes (400 patients) with previous M-LVC that underwent cataract surgery between 2019-2023. A SS-OCT biometer was used to obtain biometric measurements, including standard (K), posterior
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Diagnostic Utility of QuantiFERON-Gold Testing in Patients with Ocular Inflammation in a Low-Endemic Tuberculosis Region Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-20 JULIA XIA, ALAN G. PALESTINE, AMIT K. REDDY
To evaluate the diagnostic value of QuantiFERON Gold (QFT-G) testing for ocular inflammation in a low prevalence tuberculosis (TB) area. Diagnostic utility analysis. A review was performed for all uveitis patients who underwent QFT-G testing at the University of Colorado Eye Center from 2009 to 2022. Records were reviewed to assess QFT-G positivity rate and to identify which patients were tested for
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Retinal hemorrhages with Valsalva during laser photocoagulation in previously treated ROP Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-20 Tiffany A Chen, Julius T Oatts, Alejandra G de Alba Campomanes
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Efficacy and Safety of Lotilaner Ophthalmic Solution (0.25%) for the Treatment of Demodex Blepharitis: A GRADE Assessed Systematic Review and Meta-Analysis of Observational & Experimental Studies Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-19 Muhammad Talha, Mohammad Haris Ali, Eeshal Fatima, Arsalan Nadeem, Abdullah Ahmed, Abdulqadir J. Nashwan
Several treatments have been in use for Demodex blepharitis, before the discovery of lotilaner, like tea tree oil and antibiotics; however, they either have irritable effects or systemic adverse effects, respectively. Lotilaner, a novel ectoparasiticide, has been proposed as a treatment for patients grappling with Demodex blepharitis. This review aims to assess the safety and efficacy of lotilaner
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Bilateral doughnut-shaped macular edema in a pregnant woman with neuromyelitis optica spectrum disorders Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-16 Zhen Chao Du, Chun Xin Lai, Yong Jie Qin
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Genetic and Clinical Features of ABCA4-Associated Retinopathy in a Japanese Nationwide Cohort Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-16 Kei Mizobuchi, Takaaki Hayashi, Koji Tanaka, Kazuki Kuniyoshi, Yusuke Murakami, Natsuko Nakamura, Kaoruko Torii, Atsushi Mizota, Daiki Sakai, Akiko Maeda, Taro Kominami, Shinji Ueno, Shunji Kusaka, Koji M Nishiguchi, Yasuhiro Ikeda, Mineo Kondo, Kazushige Tsunoda, Yoshihiro Hotta, Tadashi Nakano
To clarify the genetic and clinical features of Japanese patients with -associated retinopathy. Retrospective, multicenter cohort study. Patients with retinal degeneration and biallelic variants were recruited from 13 different hospitals. Whole exome sequencing analysis was used for genetic testing. Comprehensive ophthalmic examinations were performed on matched patients. The primary outcome measure
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A Randomized, Controlled Comparison of NCX 470, a Nitric Oxide-Donating Bimatoprost, and Latanoprost in Subjects with Open-Angle Glaucoma or Ocular Hypertension: The MONT BLANC Study Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-16 Robert Fechtner, Steven Mansberger, James Branch, Jay Mulaney, Sara Ziebell, Krisi Lopez, Doug Hubatsch
To compare intraocular pressure (IOP)-lowering efficacy and safety of NCX 470, a nitric oxide (NO)-donating bimatoprost, to latanoprost in subjects with open-angle glaucoma (OAG) or ocular hypertension (OHT). Prospective, phase 3, randomized, adaptive dose-selection, double-masked, parallel-group trial. 691 subjects with OAG or OHT and unmedicated IOP ≥26 mmHg at 8AM, ≥24 mmHg at 10AM, and ≥22 mmHg
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Comment on: Association Between Physical Indicators and Myopia in American Adolescents: NHANES 1999-2008 Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-15 YOSSY MACHLUF, EEDY MEZER, YORAM CHAITER
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Thyroid Eye Disease: Pilot Study Comparison Between Patients in United States-Based and India-Based Practices Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-12 SATHYADEEPAK RAMESH, MILIND NAIK, ALISON WATSON, QIANG ZHANG, ELLEN PESKIN, JAMES SHARPE, KIERAN ALESSI, LESLIE HYMAN
Thyroid eye disease (TED) phenotype varies by ethnicity/race and genetic/environmental factors. This study compared demographic and clinical characteristics of TED patients from the US and India. Observational pilot study . Sixty-four patients with TED ages ≥18 years old with active disease (onset of symptoms ≤18 months presenting clinical activity score (CAS) ≥4) were recruited between March and October
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Reply to Comment on “Association Between Physical Indicators and Myopia in American Adolescents: National Health and Nutrition Examination Survey 1999-2008” Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-12 Ninghong Chen, Yonghong Sheng, Guoping Wang, Jing Liu
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Influence of sutureless scleral fixation techniques with 3-piece IOLs on dislocation force Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-10 Johannes Zeilinger MD, Martin Kronschläger MD PhD MHBA, Andreas Schlatter MD, Manuel Ruiss MSc., Natascha Bayer MSc., Oliver Findl MD MBA
To compare four different secondary IOL fixation techniques regarding the least required force to dislocate a scleral fixated 3-piece IOL in human corneoscleral donor tissue (CST). Experimental Laboratory investigation The least required dislocation force (LRDF) of four different secondary IOL fixation techniques, namely the techniques using transscleral tunnels (TT, as described by Scharioth), glued
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Characteristics of Eyes With CRB1-Associated EOSRD/LCA: Age-Related Changes Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-10 JAD AYASH, RUSSELL L. WOODS, JAMES D. AKULA, FARRAH RAJABI, BILAL K. ALWATTAR, PABLO ALTSCHWAGER, ANNE B. FULTON
To evaluate ocular and retinal features of -associated early onset severe retinal dystrophy/Leber congenital amaurosis (EOSRD/LCA) for age-related changes. Retrospective cohort study. Sixteen pediatric patients with biallelic EOSRD/LCA who had been followed for up to 18 years were reviewed. Results of comprehensive ophthalmic examinations—including visual acuity, refractive error, dark-adapted visual
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En Face and Volumetric Comparison of Hypertransmission Defects Evaluated by Cirrus and Spectralis Optical Coherence Tomography Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-09 Jiwon Baek, Maryam Ashrafkhorasani, Alireza Mahmoudi, Muneeswar Gupta Nittala, Giulia Corradetti, SriniVas R. Sadda
To evaluate and compare en face and 3-dimensional (3-D) properties of hypertransmission defects (HTDs) between different optical coherence tomography (OCT) devices using OCT volumes and reconstructed en face images. Comparative diagnostic evaluation study. Thirty eyes with dry age-related macular degeneration (AMD) that underwent dense OCT macular volume scans with both the Spectralis (97 B-scans/volume;
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Incidence of Blepharoptosis Following Intravitreal Anti-Vascular Endothelial Growth Factor Injections Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-08 Andrew Y. Lee BS, Kyle Kovacs MD, Anton Orlin MD, Szilard Kiss, Donald J. D'Amico MD, Kira L. Segal MD, Gary J. Lelli Jr. MD, Kyle J. Godfrey MD
We aimed to determine the incidence of blepharoptosis following intravitreal anti-vascular endothelial growth factor (VEGF) injections and compare the rates of blepharoptosis between patients injected with an eyelid speculum and those injected without a speculum. Retrospective cohort study International Classification of Diseases (ICD-10) was used to identify patients with exudative age-related macular
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The LISA-PPV Formula: An Ensemble Artificial Intelligence-Based Thick Intraocular Lens Calculation Formula for Vitrectomized Eyes Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-06 Jiaqing Zhang, Aixia Jin, Xiaotong Han, Zhixin Chen, Chunli Diao, Yu Zhang, Xinhua Liu, Fan Xu, Jiewei Liu, Xiaozhang Qiu, Xuhua Tan, Lixia Luo, Yizhi Liu
To investigate the relationship between effective lens position (ELP) and patient characteristics, and to further develop a new intraocular lens (IOL) calculation formula for cataract patients with previous pars plana vitrectomy (PPV). Cross-sectional study. A total of 2793 age-related cataract patients (group 1) and 915 post-PPV cataract patients (group 2) who underwent phacoemulsification with IOL
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Efficacy of Intravitreal Injections Anti-Vascular Endothelial Growth Factor Treatment for Radiation Retinopathy: A Systematic Review and Meta-analysis Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-06 Jiayuan Zhuang, Yang Yang, Yuexia Liao, Chenghao Li, Wen-an Wang, Xiangxia Luo, Heng Zhou
This study aims to appraise the therapeutic effectiveness of intravitreal injections anti-vascular endothelial growth factor (anti-VEGF) vs alternative therapies in managing radiation retinopathy (RR). Systematic review and meta-analysis. We obtained comprehensive data retrieval using PubMed, Embase, Web of Science, Scopus, and the Cochrane Library from their inception until December 15, 2023. This
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A Comparison of Chemodnervation to Incisional Surgery for Acute, Acquired, Comitant Esotropia: An International Study Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-04 CRYSTAL S.Y. CHEUNG, MICHAEL J. WAN, DAVID ZURAKOWSKI, SYLVIA KODSI, NOHA S. EKDAWI, HEATHER C. RUSSELL, SHASHIKANT SHETTY, ALINA V. DUMITRESCU, LINDA R. DAGI, ANKOOR S. SHAH, DAVID G. HUNTER, AACE Outcomes Consortium
To compare the efficacy of botulinum toxin injections to strabismus surgery in children with acute, acquired, comitant esotropia (ACE), and to investigate factors predicting success. International, multi-center nonrandomized comparative study Setting: Cloud-based survey. Study population: Children aged 2 to 17 years who underwent a single surgical intervention for ACE. Interventions: Botulinum toxin
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Diagnostic Accuracy of Artificial Intelligence-Based Automated Diabetic Retinopathy Screening in Real-World Settings: A Systematic Review and Meta-Analysis Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-02 SANIL JOSEPH, JERROME SELVARAJ, ISWARYA MANI, THANDAVARAYAN KUMARAGURUPARI, XIANWEN SHANG, POONAM MUDGIL, THULASIRAJ RAVILLA, MINGGUANG HE
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Brachytherapy Plaque Removal in Office Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-01 Angela J. Oh, Colin A. McCannel, Tara A. McCannel
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Gonioscopy-Assisted Transluminal Trabeculotomy Outcomes Under Different Levels of Glaucoma Severity: A Multicenter, Comparative Study Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-01 Leopoldo Magacho, Cláudia Gomide Vilela de S. Franco, Eduardo Akio I, Ana Cláudia Alves Pereira, Bruno Teno, Francisco Lucena-Neto, Bruno M. Faria, Júlia Maggi Vieira, Marcos Pereira Vianello, Fábio N. Kanadani
To evaluate the outcomes of gonioscopy-assisted transluminal trabeculotomy (GATT) under different levels of glaucoma severity. Retrospective, multicenter, before-and-after study. One eye from all primary open-angle glaucoma patients who underwent GATT combined with cataract surgery (Phaco-GATT) or GATT stand-alone with 12 months of follow-up were included and divided according to glaucoma severity
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An Automated Comparative Analysis of the Exudative Biomarkers in Neovascular Age-Related Macular Degeneration, The RAP Study: Report 6 Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-29 Bilal Haj Najeeb, Bianca S. Gerendas, Gabor G. Deak, Oliver Leingang, Hrvoje Bogunovic, Ursula Schmidt-Erfurth
To investigate differences in volume and distribution of the main exudative biomarkers across all types and subtypes of macular neovascularization (MNV) using artificial intelligence (AI). Cross-sectional study. An AI-based analysis was conducted on 34,528 OCT B-scans consisting of 281 (250 unifocal, 31 multifocal) MNV3, 55 MNV2, and 121 (30 polypoidal, 91 non-polypoidal) MNV1 treatment-naive eyes
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Microvascular Flow Imaging in Anterior Segment Tumors Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-29 ALEX H BROWN, MONIQUE RIEMANN, APARNA RAMASUBRAMANIAN
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Complete Resolution of Vitreomacular Traction Syndrome Following External Globe Manipulation Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-28 Camryn Thompson, Janet E. Tuttle, Sharon Fekrat
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Macular Neural and Microvascular Alterations in Type 2 Diabetes Without Retinopathy: A SS-OCT Study Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-28 Yining Dai, Dongping Zheng, Juwei Zhao, Kailu Wang, Binzhe Fu, Zhiling Xu, Sheng Wang, Chenxi Li, Guohong Zhou
To identify specific markers indicative of macular neural and microvascular alterations in individuals with Type 2 Diabetes Mellitus (T2DM) without clinically observable retinopathy. Prospective cross-sectional study. Using the PLEX Elite 9000, all eyes underwent swept-source optical coherence tomography (SS-OCT) angiography. Quantitative analysis of acquired images compared macular neural and microvascular
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Inner Choroidal Fibrosis: An Optical Coherence Tomography Biomarker of Severity in Chronic Central Serous Chorioretinopathy Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-28 Saarang Hansraj, Jay Chhablani, Umesh Chandra Behera, Ritesh Narula, Raja Narayanan, Niroj Kumar Sahoo
To describe a potential biomarker termed as inner choroidal fibrosis in cases of chronic central serous chorioretinopathy (CSCR) presenting to a tertiary referral center. Observational case series. Five eyes of 4 patients with CSCR were noted to have a gray-white subretinal lesion in the macula, which was analyzed with multimodal imaging. The lesions were hypofluorescent on autofluorescence, fundus
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Anti-myopia Spectacles: The Standard of Care in the Future? Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-27 Carla Lanca, Chen-Wei Pan, Andrzej Grzybowski
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Regulation of Ophthalmic Ocular Hypotensive Drug Approval in the United States Over the Past 140 Years Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-27 Gary D. Novack
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Risk of Corneal Graft Rejection and Vaccination: A Matched Case-Control Study From a United States Integrated Health Care System Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-27 JENNIFER H. KU, AFSHAN A. NANJI, JULIA E. TUBERT, CYNTHIA JOE, DIVYA SRIKUMARAN, KEVIN L. WINTHROP, AMANDA E. BRUNTON, ANA FLOREA, FREDERICK FRAUNFELDER, TSAIYU TSENG, YI LUO
Data on vaccine-associated corneal transplant rejections are limited. We examined the association between graft rejection and vaccination. Matched case-control We used electronic health records to identify corneal transplant recipients between January 2008 and August 2022 at Kaiser Permanente Southern California. Cases were transplant recipients who experienced a graft rejection (outcome) during the
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Patterns and Disparities in Recorded Gonioscopy During Initial Glaucoma Evaluations in the United States Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-27 Jun Hui Lee, Kristy Yoo, Khristina Lung, Galo Apolo, Brian Toy, Carina Sanvicente, Benjamin Xu
To assess patterns in gonioscopy during initial glaucoma evaluations in the United States. Retrospective, case-control study. Patients undergoing initial glaucoma evaluation between 2009-2020 were identified in the Optum Clinformatics DataMart. Initial evaluation was defined as follows: (1) glaucoma suspect, anatomical narrow angle (ANA), or primary/secondary glaucoma diagnosed by an ophthalmologist;
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Effect of a Patient Portal Reminder Message After No-Show on Appointment Reattendance in Ophthalmology: A Randomized Clinical Trial Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-23 SARAH ATTA, RICHARD B. BROWN, LAUREN M. WASSER, NATASHA MAYER, JULIE CASSIDY, PEGGY J. LIU, ANDREW M. WILLIAMS
To assess the efficacy of electronic health record (EHR) messaging for re-engaging patients with ophthalmology care after a missed appointment. Prospective, randomized clinical trial. The study setting was an academic ophthalmology department. The patient population comprised of return patients age 18 years or older with an appointment “no show,” or missed appointment. Over 2 phases of recruitment
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Corneal Guttae Alone Do Not Make a Diagnosis of Fuchs’ Endothelial Corneal Dystrophy Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-23 Jayne S. Weiss, Natalie A. Afshari
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Effects of Deep Optic Nerve Head Structures on Bruch's Membrane Opening- Minimum Rim Width and Peripapillary Retinal Nerve Fiber Layer Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-23 Mitsuki Kambayashi, Hitomi Saito, Makoto Araie, Nobuko Enomoto, Hiroshi Murata, Tsutomu Kikawa, Kazuhisa Sugiyama, Tomomi Higashide, Atsuya Miki, Aiko Iwase, Goji Tomita, Toru Nakazawa, Makoto Aihara, Kyoko Ohno-Matsui, Tae-Woo Kim, Christopher Kai Shun Leung, Linda M. Zangwill, Robert N. Weinreb
To explore the effects of deep optic nerve head (ONH) structures on Bruch's membrane opening (BMO)-minimum rim width (MRW) and peripapillary retinal nerve fiber layer thickness (pRNFLT) in healthy eyes. Prospective cross-sectional study. Two hundred five healthy eyes of 141 subjects (mean ± standard deviation of age and axial length (AXL): 46.9 ± 10.0 years and 24.79 ± 1.15 mm) were enrolled. Best
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Association of Ocular Manifestations of Marfan Syndrome With Cardiovascular Complications Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-23 Elaine M. Tran, Karen M. Wai, Andrea L. Kossler, Prithvi Mruthyunjaya, Ehsan Rahimy, Euna B. Koo
To evaluate associations between ocular manifestations of Marfan syndrome and cardiovascular complications. Retrospective cohort study. The TriNetX Analytics platform, a federated health research network of aggregated deidentified electronic health record data of more than 119 million patients, was used to identify patients diagnosed with Marfan syndrome. Univariate logistic regression models were
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Ultra-Wide-Field Optical Coherence Tomography and Gaussian Curvature to Assess Macular and Paravascular Retinoschisis in High Myopia Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-23 QING ZHAO, XINYU ZHAO, YAN LUO, ZHIKUN YANG
To evaluate the severity and related factors of macular retinoschisis (MRS) and paravascular retinoschisis (PVRS) in high myopia (HM) using ultra-wide-field optical coherence tomography (UWF-OCT) and a novel Gaussian curvature (K). A cross-sectional study. Patients diagnosed with HM in Peking Union Medical College Hospital were recruited between January 2022 and November 2022. The presence and severity
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Comment on Large Language Models in Ophthalmology Scientific Writing: Ethical Considerations, Blurred Lines or Not at All?1 Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-22 Dr Alexander James Cameron Jessup, Professor Minas Theodore Coroneo
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Clinical Course and Visual Outcomes of Papilledema in Pediatric Cerebral Venous Sinus Thrombosis Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-22 Jessica A. Sun, Tais Estrela, Ryan Gise
Cerebral venous sinus thrombosis (CVST) is a rare but life-threatening event with significant neurologic and visual morbidity. In this study, we report on the natural history and visual outcomes of papilledema in children with CVST. Retrospective case series. Patients with CVST evaluated by the Department of Ophthalmology between 2000 and 2023 were included. Records were reviewed for presence and course
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Socioeconomic Disparities in Glaucoma Severity at Initial Diagnosis: A Nationwide Electronic Health Record Cohort Analysis Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-22 SWARUP S. SWAMINATHAN, FELIPE A. MEDEIROS
To assess disparities in initial disease severity among open-angle glaucoma (OAG) patients. Cross-sectional study. In this analysis of Epic Cosmos, an aggregated electronic health record dataset encompassing >213 million patients, OAG patients examined in ophthalmology or optometry clinics between January 1, 2013, and June 1, 2023, were evaluated. OAG severity at presentation was classified as mild
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Comparison of the biometric characteristics after long term implantation of iris-fixated phakic intraocular lens in explanted and non-explanted groups of eyes Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-22 Luis Izquierdo, Fiorella Casanova Imken, Pablo Larco, Jose Chauca, Maria A. Henriquez
To evaluate and compare the biometric characteristics of the anterior chamber of a group of patients with significant endothelial cell loss (ECL) that required phakic IOL (pIOL) explantation and a group of patients who did not fulfill the explantation criteria related to corneal decompensation. Retrospective consecutive interventional case series The study included all consecutive patients implanted
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Drug Approval for the Treatment of Geographic Atrophy: How We Got Here and Where We Need to Go Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-21 Karl G. Csaky, Jason M.L. Miller, Daniel F. Martin, Mark W. Johnson
To discuss the clinical trial results leading to the US Food and Drug Administration (FDA) approval of anti-complement therapies for geographic atrophy (GA), perspectives on functional data from the GA clinical trials, and how lessons from the FDA approval may guide future directions for basic and clinical research in AMD. Selected literature review with analysis and perspective We performed a targeted
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Clinical Significance of Optic Disc Hemorrhage Size in Visual Field Progression in Glaucoma Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-21 YOON JEONG, EUNOO BAK, MIRINAE JANG, AHNUL HA, YOUNG IN SHIN, MIN GU HUH, YOUNG KOOK KIM, JIN WOOK JEOUNG, KI HO PARK
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Omidenepag Isopropyl Versus Timolol in Patients With Glaucoma or Ocular Hypertension: Two Randomized Phase 3 Trials (SPECTRUM 4 and 3) Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-21 JASON BACHARACH, JACOB W. BRUBAKER, DAVID G. EVANS, FENGHE LU, NORIKO ODANI-KAWABATA, TAKAHARU YAMABE, DAVID L. WIRTA
The SPECTRUM 4 and 3 studies assessed the intraocular pressure (IOP)-lowering efficacy and safety of omidenepag isopropyl (OMDI) 0.002% vs timolol 0.5% in patients with glaucoma or ocular hypertension (OHT). Phase 3, randomized, controlled, double-masked, noninferiority studies. Multicenter studies in the US. Inclusion criteria for adults ≥ 18 years (SPECTRUM 4 [ = 409] and 3 [ = 413]) were open-angle
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Comment on: Large Language Models in Ophthalmology Scientific Writing: Ethical Considerations Blurred Lines or Not at All? Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-21 Konradin Metze, Irene Lorand-Metze, Rosana C. Morandin-Reis, João B. Florindo