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Case of the month from the Department of Medical Oncology, Peter MacCallum Cancer Centre, University of Melbourne, Australia: recurrent metastatic spermatocytic tumour successfully treated with salvage systemic chemotherapy BJU Int. (IF 4.5) Pub Date : 2024-05-15 Jane McKenzie, Catherine Mitchell, Jeremy Lewin, Ciara Conduit
Introduction Spermatocytic tumours are a rare subtype of testicular neoplasm and represent less than 1% of all testicular neoplasms. They generally display indolent biology and therefore commonly present as large testicular masses. Despite this, and in contrast to invasive germ cell tumours, spermatocytic tumours are rarely pT2 (i.e., rarely involve the tunica vaginalis or display lymphovascular invasion)
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Targeted microwave ablation for prostate cancer (FOSTINE1b): a prospective ‘ablate-and-resect’ study BJU Int. (IF 4.5) Pub Date : 2024-05-14 Alexandre Peltier, Roland van Velthoven, Arthur Baudewyns, Grégoire Assenmacher, Marc Lemort, Yolene Lefebvre, Nicolas Sirtaine, Romain Diamand
To assess histopathological outcomes, as well as feasibility and safety of targeted microwave ablation (TMA) via the Trinity® system (KOELIS, La Tronche, France).
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Grid-based cognitive diagnostic prostatic biopsy without transrectal ultrasonography BJU Int. (IF 4.5) Pub Date : 2024-05-13 Dhruv Satya Sahni, John Morrison, Hing Y. Leung
Introduction Prostate and colorectal cancers are the second and third most common malignancies affecting men globally [1]. Abdominoperineal resection is the standard of care surgical treatment for patients with malignancy of the distal rectum or anal canal, while pan-proctocolectomy may be indicated for patients with inflammatory bowel disease and familial adenomatous polyposis [2]. Both these procedures
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Chromosome segregation in SCNT oocytes Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-05-14 Louise Lloyd
The possibility of men in same-sex relationships and people who do not have their own eggs having biological children has been advanced by new research into in vitro gametogenesis, in which functional haploid gametes are generated from diploid somatic cells. In previous, proof-of-principle experiments showing that haploidy in somatic cell genomes can be induced experimentally by premature cell division
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A review of vitamin use for the prevention or treatment of prostate cancer BJU Int. (IF 4.5) Pub Date : 2024-05-14 David J. Benjamin, Omid Yazdanpanah, Arash Rezazadeh Kalebasty
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Overcoming barriers in cancer care for gender minorities Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-05-13 David J. Benjamin, Omid Yazdanpanah, Arash Rezazadeh Kalebasty
As the population of gender minorities grows in the setting of rising incidence of cancers globally, health-care professionals and institutions must be prepared to provide inclusive care. Individual-level training as well as institutional-level efforts on gender identity data collection and creation of inclusive clinical spaces could help mitigate health-care disparities.
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Transnational telesurgery performed with the new robot‐assisted flexible ureteroscopy system BJU Int. (IF 4.5) Pub Date : 2024-05-11 Guangdi Chu, Xuecheng Yang, Wei Jiao, Jianchang Zhao, Bo Guan, Yuan Gao, Shuxin Wang, Jianmin Li, Haitao Niu
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Female non‐obstetric urogenital fistula repair: long‐term patient‐reported outcomes and a scoping literature review BJU Int. (IF 4.5) Pub Date : 2024-05-11 Jakob Klemm, Daniel R. Stelzl, Robert J. Schulz, Phillip Marks, Shahrokh F. Shariat, Margit Fisch, Roland Dahlem, Malte W. Vetterlein
ObjectiveTo investigate long‐term and patient‐reported outcomes, including sexual function, in women undergoing urogenital fistula (UGF) repair, addressing the lack of such data in Western countries, where fistulas often result from iatrogenic causes.Patients and MethodsWe conducted a retrospective analysis at a tertiary referral centre (2010–2023), classifying fistulas based on World Health Organisation
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High Prevalence of Psychological Comorbidities and Functional Neurological Symptoms in Women With Urinary Retention. J. Urol. (IF 6.6) Pub Date : 2024-05-10 Caroline Selai, Cheng-Hung Lee, Sara Simeoni, Mahreen Pakzad, Eileen Joyce, Pany Petrochilos, Khadija Rehrou Rantell, Vasile Boico, Jalesh N Panicker
Chronic idiopathic urinary retention (CIUR) in young women is poorly understood and a probable etiology is established only in around 40%, most commonly a primary disorder of external urethral sphincter relaxation, sometimes referred to as Fowler's syndrome. A high prevalence of psychological and functional comorbidities is reported, however these have been poorly characterized.
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Prostate cancer: To screen, or not to screen? That is the question BJU Int. (IF 4.5) Pub Date : 2024-05-10
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Which men benefit from prostate cancer screening? Prostate cancer mortality by subgroup in the European Randomised Study of Screening for Prostate Cancer BJU Int. (IF 4.5) Pub Date : 2024-05-10 Niko Pasanen, Kirsi Talala, Sebastiaan Remmers, Teuvo L. J. Tammela, Jonas Hugosson, Monique J. Roobol, Kimmo Taari, Rebecka Arnsrud Godtman, Chris Bangma, Anssi Auvinen
ObjectiveTo evaluate whether a subgroup of men can be identified that would benefit more from screening than others.Materials and MethodsThis retrospective cohort study was based on three European Randomised Study of Screening for Prostate Cancer (ERSPC) centres, Finland, the Netherlands and Sweden. We identified 126 827 men aged 55–69 years in the study who were followed for maximum of 16 years after
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We all get erections — de-gendering sexual arousal dysfunction in the ICD Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-05-08 Lucy Greenwald, Daniel R. Dickstein, Barbara Chubak, Deborah C. Marshall
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The Efficacy and Safety of Radiation-Free Retrograde Intrarenal Surgery: A Prospective Multicenter-Based, Randomized, Controlled Trial. J. Urol. (IF 6.6) Pub Date : 2024-05-09 Jae-Wook Chung, Jun-Koo Kang, Wonho Jung, Kyung Jin Oh, Hyeon Woo Kim, Dong Gil Shin, Bum Soo Kim
Fluoroscopy is usually required during retrograde intrarenal surgery (RIRS). Although fluoroscopy is considered necessary for effective and safe RIRS, there is growing awareness regarding radiation exposure risk to patients and surgeons. We conducted a multicenter-based, randomized, controlled trial to compare the safety and effectiveness of radiation-free (RF) RIRS with radiation-usage (RU) RIRS for
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Perioperative, Oncological and Functional Outcomes Between Robot-Assisted Laparoscopic Prostatectomy and Open Radical Retropubic Prostatectomy: A Randomized Clinical Trial. J. Urol. (IF 6.6) Pub Date : 2024-05-09 William Carlos Nahas, Gilberto José Rodrigues, Fabio Augusto Rodrigues Gonçalves, Guilherme Vinícius Sawczyn, Guilherme Garcia Barros, Leonardo Cardili, Giuliano Betoni Guglielmetti, Arnaldo José De Carvalho Fazoli, Maurício Dener Cordeiro, Valter Dell Acqua Cassão, Daher Cesar Chade, Luiz Carlos Neves De Oliveira, Cláudio Bovolenta Murta, José Pontes Júnior, Evelinda Marramon Trindade, Diogo Assed
Limited high-quality studies compared robot-assisted laparoscopic prostatectomy (RALP) versus open retropubic radical prostatectomy (RRP). We sought to compare their postoperative outcomes in a randomized setting.
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Breaking the silence: normalizing receptive anal intercourse for patients, for people and for myself Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-05-08 Daniel R. Dickstein
The lack of information and discussion on receptive anal intercourse (RAI) perpetuates the stigma. Normalizing RAI and empowering individuals to embrace their sexuality without shame or judgement requires us to confront biases, foster dialogue and break the silence.
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Centralization of care for rare genetic syndromes associated with cancer: improving outcomes and advancing research on VHL disease Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-05-08 Alessandro Larcher, Federico Belladelli, Francesco Cei, Chiara Re, Isaline Rowe, Francesco Montorsi, Umberto Capitanio, Andrea Salonia
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Asexuality: the invisible orientation Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-05-07 Sarah Cosgriff, Stella Schneckenburger
Asexuality is often neglected in education and conversations around sexuality, making it essentially an ‘invisible orientation’. This lack of knowledge is associated with harmful misconceptions, which need challenging within the medical profession and in the general population to ensure inclusion of people who identify on the asexual spectrum.
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Elevated periprostatic androgens, sneaky testosterone and its implications Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-05-07 Masoud Bitaraf, Ranjith Ramasamy, Sanoj Punnen, Nima Sharifi
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Structural Changes in Brain White Matter Tracts Associated with Overactive Bladder Revealed by Diffusion Tensor MRI: Findings from a LURN Cross-Sectional Case-Control Study. J. Urol. (IF 6.6) Pub Date : 2024-05-08 H Henry Lai, Jerrel Rutlin, Abigail R Smith, Margaret E Helmuth, James A Hokanson, Claire C Yang, J Quentin Clemens, Vincent A Magnotta, C Emi Bretschneider, Kimberly Kenton, John O L DeLancey, Karen John, Ziya Kirkali, Joshua S Shimony
To investigate structural changes in brain white matter tracts using diffusion tensor magnetic resonance imaging (DTI) in patients with overactive bladder (OAB).
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Decisional Conflict Among Patients Newly Diagnosed With Clinical T1 Renal Masses. J. Urol. (IF 6.6) Pub Date : 2024-05-08 Amir Feinberg, Kathryn H Gessner, Allison M Deal, Hillary Heiling, Shannon Myers, Mathew C Raynor, Matthew I Milowsky, Sara E Wobker, Clayton Commander, Allison J Lazard, Marc A Bjurlin, Angela B Smith, David C Johnson, Eric M Wallen, William Y Kim, Hung-Jui Tan
Because multiple management options exist for clinical T1 renal masses, patients may experience a state of uncertainty about the course of action to pursue (ie, decisional conflict). To better support patients, we examined patient, clinical, and decision-making factors associated with decisional conflict among patients newly diagnosed with clinical T1 renal masses suspicious for kidney cancer.
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One‐year outcomes of same‐day‐discharge robot‐assisted radical prostatectomy BJU Int. (IF 4.5) Pub Date : 2024-05-08 Alae Touzani, Daniele D'Agate, Claudia Kesch, Giorgio Calleris, Bogdan Buhas, Rawad Abou‐Zahr, Razvan‐George Rahota, Adil Ouzzane, Benjamin Pradère, Christophe Tollon, Alberto Martini, Guillaume Ploussard
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Improving detection of carcinoma in situ in bladder cancer: urinary cytology vs the Xpert® BC Monitor BJU Int. (IF 4.5) Pub Date : 2024-05-08 Maximilian Haas, Maximilian C. Kriegmair, Johannes Breyer, Danijel Sikic, Felix Wezel, Florian Roghmann, Mirco Brehmer, Ralph M. Wirtz, Jonas Jarczyk, Philipp Erben, Veronika Bahlinger, Franziska Goldschmidt, Guido Fechner, Jack Chen, Ellen Paxinos, Michael Bates, Friedemann Zengerling, Christian Bolenz, Maximilian Burger, Arndt Hartmann, Markus Eckstein
ObjectiveTo investigate and compare the performance of urinary cytology and the Xpert BC Monitor test in the detection of bladder cancer in various clinically significant patient cohorts, including patients with carcinoma in situ (CIS), in a prospective multicentre setting, aiming to identify potential applications in clinical practice.Patients and MethodsA total of 756 patients scheduled for transurethral
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Case of the month from the Desai Sethi Urology Institute, Florida, USA: bladder outlet obstruction‐induced urinothorax after percutaneous nephrolithotomy BJU Int. (IF 4.5) Pub Date : 2024-05-08 Ryan Chen, Joao G. Porto, Ruben Blachman‐Braun, Diana M. Lopategui, Robert Marcovich, Hemendra N. Shah
Introduction Urinothorax, a rare cause of pleural effusion characterised by the presence of urine in the pleural space, typically occurs iatrogenically after urological procedures or spontaneously due to obstructive uropathies. Its diagnosis centres on high clinical suspicion and the biochemical analysis of pleural fluid, with treatment focusing on alleviating urinary obstruction or treating traumatic
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Current and emerging strategies to curb antibiotic-resistant urinary tract infections Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-05-07 Aaron Simoni, Laura Schwartz, Guillermo Yepes Junquera, Christina B. Ching, John David Spencer
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Abstracts from the Caribbean Urological Association 25th Annual International Conference, November 3rd–5th, 2023; Port of Spain, Trinidad, West Indies BJU Int. (IF 4.5) Pub Date : 2024-05-07
Clinicopathological profile of prostate cancer at a tertiary institution in Trinidad J De Gannes, S Mohammed, A Singh, K Gooden Port of Spain General Hospital, Trinidad and Tobago Objectives: To examine the cross sectional clinical and pathological profile of prostate biopsies of all patients attending the Port of Spain General Hospital over a period of 1 year from January 2020 to January 2021. Methodology:
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Author Index BJU Int. (IF 4.5) Pub Date : 2024-05-07
Ahamad, 10 Aji, S, 8 Anwar, A, 9 Bajrangee, G, 14 Bandoo, V, 6, 7 Barker, J, 13 Baron, J, 7 Bayo, O, 13 Bhagaloo, V, 11 Bhagwandeen, B, 12 Burnett, AL, 8, 12 Cathcart, P, 10 Challacombe, B, 6 Clark, C, 9 Cooblal, AS, 8 De Gannes, J, 4 Depeiza, N, 13 Furrer, M, 10 Ghazi, A, 8 Goetz, L, 12, 14 Gooden, K, 4, 12 Goordeen, D, 13 Gosein, S, 9, 14 Guest, K, 9 Hage, O.El, 10 Harrykissoon, K, 14 Hassan, M,
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The evolving treatment landscape of metastatic urothelial cancer Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-05-03 Giandomenico Roviello, Matteo Santoni, Guru P. Sonpavde, Martina Catalano
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Lower Urinary Tract Symptoms in US Women: Contemporary Prevalence Estimates from the RISE FOR HEALTH Study. J. Urol. (IF 6.6) Pub Date : 2024-05-04 Siobhan Sutcliffe, Chloe Falke, Cynthia S Fok, James W Griffith, Bernard L Harlow, Kimberly A Kenton, Cora E Lewis, Lisa Kane Low, Jerry L Lowder, Emily S Lukacz, Alayne D Markland, Gerald McGwin, Melanie R Meister, Elizabeth R Mueller, Diane K Newman, Ratna Pakpahan, Leslie M Rickey, Todd Rockwood, Melissa A Simon, Abigail R Smith, Kyle D Rudser, Ariana L Smith
To estimate the prevalence of a wide range of lower urinary tract symptoms (LUTS) in US women, and to explore associations with bother and discussion with healthcare providers, friends, and family.
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Von Hippel–Lindau protein signalling in clear cell renal cell carcinoma Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-05-02 Chengheng Liao, Lianxin Hu, Qing Zhang
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A Multicenter Prospective Randomized Controlled Trial Comparing Cxbladder Triage to Cystoscopy in Patients With Microhematuria. The Safe Testing of Risk for Asymptomatic Microhematuria Trial. J. Urol. (IF 6.6) Pub Date : 2024-05-03 Yair Lotan, Siamak Daneshmand, Neal Shore, Peter Black, Kristen R Scarpato, Amit Patel, Tony Lough, Daniel A Shoskes, Jay D Raman
AUA guidelines for patients with microhematuria (≥3 red blood cells [RBC]/high-power field [hpf]) include cystoscopy for most over age 40 due to risk of urothelial cancer (UC). Cxbladder Triage (CxbT) is a urinary genomic test with UC negative predictive value of 99%. In this prospective randomized controlled trial, we compared cystoscopy use in a standard of care (SOC) arm vs a marker-based approach
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Clinically Significant Prostate Cancer Detection Following Transrectal and Transperineal Biopsy: Results of the Prostate Biopsy Efficacy and Complications Randomized Clinical Trial. J. Urol. (IF 6.6) Pub Date : 2024-05-03 Badar M Mian, Paul J Feustel, Asef Aziz, Ronald P Kaufman, Adrien Bernstein, Hugh A G Fisher
The comparative effectiveness of transrectal and transperineal prostate biopsy in detecting clinically significant prostate cancer is not well understood. We conducted a randomized clinical trial to determine whether transperineal biopsy improves the detection of clinically significant prostate cancer.
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Quality of Life and Bladder Symptoms in Adolescents and Young Adults With Spina Bifida Who Catheterize via Urethra Versus Catheterizable Channel. J. Urol. (IF 6.6) Pub Date : 2024-05-03 Josephine Hirsch, N Valeska Halstead, Theresa Meyer, James T Rague, Soojin Kim, Ilina Rosoklija, Stephanie Kielb, Jill E Larson, Vineeta T Swaroop, Robin M Bowman, Earl Y Cheng, Diana K Bowen, Elizabeth B Yerkes, David I Chu
To assess associations between health-related quality of life (HRQOL), bladder-related QOL, bladder symptoms, and bladder catheterization route among adolescents and young adults (AYA) with spina bifida (SB).
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Strengthening preclinical testing to increase safety in surgical mesh Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-05-01 Nicholas T. H. Farr, Victoria L. Workman, Christopher R. Chapple, Sheila MacNeil, Cornelia Rodenburg
Inflammatory and fibrotic responses to polypropylene mesh led to the withdrawal of this practice for treatment of stress urinary incontinence and pelvic organ prolapse in women in some countries. Improved material testing has been urged. We report poor responses of polypropylene mesh to repeated mechanical distension and macrophage interrogation. These results from preclinical in vitro testing show
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Evaluation of radiation exposure to the gonads of urologists during seated lithotripsy procedures BJU Int. (IF 4.5) Pub Date : 2024-05-01 Duncan Self, Jennifer Diffey, Anders Bergersen, Nicholas McLeod, Avi Raman
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Case of the month from the Department of Urology, Addenbrookes Hospital, Cambridge, UK: clinical perinephric haematoma after shock wave lithotripsy: a rare but significant complication BJU Int. (IF 4.5) Pub Date : 2024-04-30 Sindhu Sankaran, Andrew Winterbottom, Oliver Wiseman
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Racial disparities in stage at bladder cancer diagnosis in the US Veterans Affairs healthcare system BJU Int. (IF 4.5) Pub Date : 2024-04-29 Kelly K. Bree, Jessica L. Janes, Patrick J. Hensley, Aditya Srinivasan, Amanda M. De Hoedt, Sanjay Das, Stephen J. Freedland, Stephen B. Williams
ObjectiveTo describe patient characteristics and pathological stage at bladder cancer (BCa) diagnosis in a diverse population within a national, equal‐access healthcare system.MethodsThis retrospective cohort study identified 15 966 men diagnosed with BCa in the Veterans Affairs (VA) healthcare system from 2000 to 2020. The primary outcome was pathological stage at diagnosis, determined by index transurethral
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Non‐infectious adverse events of transperineal prostate biopsies performed under local anaesthesia BJU Int. (IF 4.5) Pub Date : 2024-04-28 Maciej Jacewicz, Erik Rud, Peter Lauritzen, Eduard Baco
ObjectiveTo report non‐infectious adverse events associated with transperineal prostate biopsy (TPBx) performed under local anaesthesia (LA) in an outpatient setting.Patients and methodsThis study reports secondary outcomes from the Norwegian arm of the prospective NORAPP study (ClinicalTrials.gov identifier NCT04146142) and included all patients referred for prostate biopsy from November 2019 to February
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From biology to the clinic — exploring liver metastasis in prostate cancer Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-04-26 Xudong Ni, Yu Wei, Xiaomeng Li, Jian Pan, Bangwei Fang, Tingwei Zhang, Ying Lu, Dingwei Ye, Yao Zhu
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‘Igloo’ technique for robot‐assisted radical prostatectomy – maximum nerve sparing for early recovery of continence and sexual function BJU Int. (IF 4.5) Pub Date : 2024-04-26 Christian D. Fankhauser, Christian Malkmus, Fabian Aschwanden, Philipp Baumeister, Agostino Mattei
Introduction Robot-assisted radical prostatectomy (RARP) is a treatment option for men with localised prostate cancer. The challenge of RARP consists in competing oncological and functional goals. The most common side effects following RARP are urinary incontinence and erectile dysfunction, occurring in 74% and 79%, respectively, of participants in the PROTECT study, a prospective randomised trial
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Influence of substance use on male reproductive health and offspring outcomes Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-04-25 Jamie O. Lo, Jason C. Hedges, Wesley H. Chou, Kylie R. Tager, Ian D. Bachli, Olivia L. Hagen, Susan K. Murphy, Carol B. Hanna, Charles A. Easley
The prevalence of substance use globally is rising and is highest among men of reproductive age. In Africa, and South and Central America, cannabis use disorder is most prevalent and in Eastern and South-Eastern Europe, Central America, Canada and the USA, opioid use disorder predominates. Substance use might be contributing to the ongoing global decline in male fertility, and emerging evidence has
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First‐line immunotherapy of metastatic renal cell carcinoma: an updated network meta‐analysis including triplet therapy BJU Int. (IF 4.5) Pub Date : 2024-04-25 Takafumi Yanagisawa, Tatsushi Kawada, Kensuke Bekku, Ekaterina Laukhtina, Pawel Rajwa, Markus von Deimling, Marcin Chlosta, Fahad Quhal, Benjamin Pradere, Pierre I. Karakiewicz, Keiichiro Mori, Takahiro Kimura, Shahrokh F. Shariat, Manuela Schmidinger
ObjectiveTo compare the differential efficacy of first‐line immune checkpoint inhibitor (ICI)‐based combined therapies among patients with intermediate‐ and poor‐risk metastatic renal cell carcinoma (mRCC), as recently, the efficacy of triplet therapy comprising nivolumab plus ipilimumab plus cabozantinib has been published.Patients and MethodsThree databases were searched in December 2022 for randomised
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Surveillance of non‐muscle‐invasive bladder cancer with blue‐light cystoscopy: a meta‐analysis BJU Int. (IF 4.5) Pub Date : 2024-04-25 Reza Sari Motlagh, Alireza Ghoreifi, Takafumi Yanagisawa, Tatsushi Kawada, Sascha Ahyai, Axel S. Merseburger, Mohammad Abufaraj, Michael Abern, Hooman Djaladat, Siamak Daneshmand, Shahrokh F. Shariat
ObjectiveTo compare the value of flexible blue‐light cystoscopy (BLC) vs flexible white‐light cystoscopy (WLC) in the surveillance setting of non‐muscle‐invasive bladder cancer (NMIBC).MethodsAll major databases were searched for articles published before May 2023 according to the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) statement. The primary outcome was the accuracy
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Fluorescence‐guided surgery using cetuximab‐800CW in patients with penile carcinoma BJU Int. (IF 4.5) Pub Date : 2024-04-25 Thomas S. Nijboer, Christa A. M. van der Fels, Jaron G. de Wit, Bas Keizers, Henrik K. Huizinga, Floris J. Voskuil, Maarten J. H. Voskamp, Marius C. van den Heuvel, Max J. H. Witjes, Igle Jan de Jong
ObjectiveTo investigate the feasibility of fluorescence molecular imaging (FMI), using cetuximab‐800CW, as an intraoperative tool to determine surgical margins in penile squamous cell carcinoma (PSCC).Patients and methodsA total of 11 patients with PSCC received 75 mg cetuximab followed by 15 mg cetuximab‐800CW 2 days before surgery. FMI of the whole excision specimen and tissue slices was performed
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Immunotherapy for advanced or metastatic urothelial carcinoma: an abridged Cochrane review BJU Int. (IF 4.5) Pub Date : 2024-04-25 Philipp Maisch, Eu Chang Hwang, Kwangmin Kim, Vikram M. Narayan, Caitlin Bakker, Frank Kunath, Philipp Dahm
ObjectivesTo assess the effects of immunotherapy compared to chemotherapy as first‐ and second‐line treatment of advanced or metastatic urothelial carcinoma.MethodsBased on a published protocol, we performed a systematic search of multiple databases. Two review authors independently performed the literature selection, identified relevant studies, assessed the eligibility of studies for inclusion, and
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Physiotherapy for continence and muscle function in prostatectomy: a randomised controlled trial BJU Int. (IF 4.5) Pub Date : 2024-04-25 Mifuka Ouchi, Takeya Kitta, Hiroki Chiba, Madoka Higuchi, Yui Abe‐Takahashi, Mio Togo, Naohisa Kusakabe, Sachiyo Murai, Hiroshi Kikuchi, Ryuji Matsumoto, Takahiro Osawa, Takashige Abe, Nobuo Shinohara
ObjectiveTo assess the effectiveness of pre‐ and postoperative supervised pelvic floor muscle training (PFMT) on the recovery of continence and pelvic floor muscle (PFM) function after robot‐assisted laparoscopic radical prostatectomy (RARP).Patients and MethodsWe carried out a single‐blind randomised controlled trial involving 54 male patients scheduled to undergo RARP. The intervention group started
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Peri‐operative outcomes following radical prostatectomy in the setting of advanced prostate cancer BJU Int. (IF 4.5) Pub Date : 2024-04-24 Rishabh K. Simhal, Kerith R. Wang, Yash B. Shah, Costas D. Lallas, Mihir S. Shah, Thenappan Chandrasekar
ObjectiveTo compare the peri‐operative outcomes of radical prostatectomy (RP) for locally advanced, node‐positive, and metastatic prostate cancer (PCa), as determined through pathological staging, using the American College of Surgeons National Surgical Quality Improvement Project.MethodsWe identified RP procedures performed between 2019 and 2021. Patients were stratified by pathological staging to
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The AUA/SUFU Guideline on the Diagnosis and Treatment of Idiopathic Overactive Bladder. J. Urol. (IF 6.6) Pub Date : 2024-04-23 Anne Pelletier Cameron, Doreen E Chung, Elodi J Dielubanza, Ekene Enemchukwu, David A Ginsberg, Brian T Helfand, Penny Holland, Brian J Linder, Leila Rahimi, W Stuart Reynolds, Eric S Rovner, Lesley Souter, Anne M Suskind, Elizabeth Takacs, Blayne Welk, Ariana L Smith
The purpose of this guideline is to provide evidence-based guidance to clinicians of all specialties on the evaluation, management, and treatment of idiopathic overactive bladder (OAB). The guideline informs the reader on valid diagnostic processes and provides an approach to selecting treatment options for patients with OAB through the shared decision-making process that will maximize symptom control
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A Phase II Trial of Intravesical Gemcitabine and Docetaxel in the Treatment of Bacillus Calmette-Guérin‒Naïve Nonmuscle-Invasive Urothelial Carcinoma of the Bladder. J. Urol. (IF 6.6) Pub Date : 2024-04-23 Sunil H Patel, Andrew T Gabrielson, Sin Chan, Deborah Schwartz, Connie Collins, Nirmish Singla, Bruce Trock, Trinity J Bivalacqua, Noah Hahn, Max R Kates
Combination intravesical gemcitabine and docetaxel (GemDoce) has demonstrated efficacy as second-line therapy for patients with bacillus Calmette-Guérin (BCG)‒unresponsive nonmuscle-invasive urothelial carcinoma of the bladder (NMIBC). In the context of widespread BCG shortages, we performed a phase 2 prospective trial to assess GemDoce for BCG-naïve NMIBC.
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Robot-assisted retrograde intrarenal surgery: first clinical experience with the ILY® system BJU Int. (IF 4.5) Pub Date : 2024-04-23 Alba Farré, Oriol Angerri, Andrés Kanashiro, Marta Casadevall, Alessandro Uleri, Josep Balañà, Francisco Sánchez Martin, Félix Millan, Joan Palou, Esteban Emiliani
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Bladder cancer variants — one disease with many faces Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-04-22 Bogdan Czerniak
Bladder cancer progression to microscopically distinct variants such as sarcomatoid, small cell, micropapillary and plasmacytoid is associated with more aggressive clinical behaviour than conventional carcinoma. Advances in molecular profiling led to the identification of molecular subtypes of bladder cancer and provided insights into disease progression to aggressive variants.
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Advances in cancer and a new antibiotic to treat complex UTIs BJU Int. (IF 4.5) Pub Date : 2024-04-22
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‘Case of the Month’ from the Department of Urology, Oxford University Hospitals, Oxford, UK: stereotactic radiotherapy to the vas deferens for PSMA-PET CT detected local recurrence 10 years after radical prostatectomy BJU Int. (IF 4.5) Pub Date : 2024-04-22 Anthony S. Bates, Abhishek D. Sharma, Philip Camilleri, Lisa Browning, Clare Verrill, Freddie C. Hamdy
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The Getting It right First Time (GIRFT) programme in urology; rationale and methodology BJU Int. (IF 4.5) Pub Date : 2024-04-18 Joseph B. John, William K. Gray, Kieran O'Flynn, Tim W.R. Briggs, John S. McGrath
The Getting It Right First Time (GIRFT) programme is a quality improvement initiative covering the National Health Service in England. The programme aims to standardise clinical practices and improve patient and system level outcomes by utilising data-driven insights and clinically-led recommendations. There are GIRFT workstreams for every medical and surgical specialty, including urology. Defining
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EAU à la mode Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-04-17 Louise Lloyd
Urologists from around the world congregated at the 39th Annual Congress of the European Association of Urology (EAU), which took place in Paris, France, between 5 and 8 April 2024. In the Olympic host city, the Olympian efforts of clinicians and researchers in the field to improve knowledge and understanding and, ultimately, patient outcomes were evident around the convention centre. Day 1 of the
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The evolving landscape of monogenic nephrolithiasis and therapeutic innovations Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-04-17 Chen-Han Wilfred Wu, Yu-Ren Huang, Donald Bodner, Fredrick R. Schumacher, Michelle Baum, Friedhelm Hildebrandt
Monogenic causes account for up to 20% of nephrolithiasis instances and are crucial for developing targeted treatments. Whole-exome sequencing, genome-wide association, candidate gene, and in vitro and animal functional studies are crucial to identify these mutations. Therapies targeting monogenic variants, such as RNA-interference-based treatments, have been successfully used to treat monogenic disorders