T cells with high BCL-2 expression induced by venetoclax impact anti-leukemic immunity “graft-versus-leukemia effects”
Blood Cancer J.
(IF 12.8 )
Pub Date : 2024-05-14
Joji Nagasaki, Mitsutaka Nishimoto, Hideo Koh, Hiroshi Okamura, Mika Nakamae, Kazuki Sakatoku, Kentaro Ido, Masatomo Kuno, Yosuke Makuuchi, Teruhito Takakuwa, Yasuhiro Nakashima, Masayuki Hino, Hirohisa Nakamae
A comprehensive approach to evaluate genetic abnormalities in multiple myeloma using optical genome mapping
Blood Cancer J.
(IF 12.8 )
Pub Date : 2024-05-03
Ying S. Zou, Melanie Klausner, Jen Ghabrial, Victoria Stinnett, Patty Long, Laura Morsberger, Jaclyn B. Murry, Katie Beierl, Christopher D. Gocke, Rena R. Xian, Kevin H. Toomer, Jing Christine Ye, Robert Z. Orlowski, Carol Ann Huff, Syed Abbas Ali, Philip H. Imus, Christian B. Gocke, Guilin Tang
Similar efficacy of ibrutinib arms across ALPINE and ELEVATE-RR trials in relapsed/refractory chronic lymphocytic leukemia: a matching-adjusted indirect comparison
Blood Cancer J.
(IF 12.8 )
Pub Date : 2024-05-02
Mazyar Shadman, Alessandra Tedeschi, Leyla Mohseninejad, Keri Yang, Nicole Lamanna, Sheng Xu, Aileen Cohen, Swetha Challagulla, Mei Xue, Rhys Williams, Susan M. O’Brien, Jennifer R. Brown, Constantine Tam
Patient-derived follicular lymphoma spheroids recapitulate lymph node signaling and immune profile uncovering galectin-9 as a novel immunotherapeutic target
Blood Cancer J.
(IF 12.8 )
Pub Date : 2024-05-02
Cèlia Dobaño-López, Juan García Valero, Ferran Araujo-Ayala, Ferran Nadeu, Fabien Gava, Carla Faria, Marine Norlund, Renaud Morin, Pascale Bernes-Lasserre, Fabian Arenas, Marta Grau, Cristina López, Irene López-Oreja, Neus Serrat, Ares Martínez-Farran, Lluís Hernández, Heribert Playa-Albinyana, Rubén Giménez, Silvia Beà, Elías Campo, Jean-Michel Lagarde, Armando López-Guillermo, Laura Magnano, Dolors
Continuously improving outcome over time after second allogeneic stem cell transplantation in relapsed acute myeloid leukemia: an EBMT registry analysis of 1540 patients
Blood Cancer J.
(IF 12.8 )
Pub Date : 2024-05-02
Ann-Kristin Schmälter, Maud Ngoya, Jacques-Emmanuel Galimard, Ali Bazarbachi, Jürgen Finke, Nicolaus Kröger, Martin Bornhäuser, Matthias Stelljes, Friedrich Stölzel, Johanna Tischer, Thomas Schroeder, Peter Dreger, Igor-Wolfgang Blau, Bipin Savani, Sebastian Giebel, Jordi Esteve, Arnon Nagler, Christoph Schmid, Fabio Ciceri, Mohamad Mohty
The genomic profiling of high-risk smoldering myeloma patients treated with an intensive strategy unveils potential markers of resistance and progression
Blood Cancer J.
(IF 12.8 )
Pub Date : 2024-04-29
A. Medina-Herrera, I. Vazquez, I. Cuenca, J. M. Rosa-Rosa, B. Ariceta, C. Jimenez, M. Fernandez-Mercado, M. J. Larrayoz, N. C. Gutierrez, M. Fernandez-Guijarro, V. Gonzalez-Calle, P. Rodriguez-Otero, A. Oriol, L. Rosiñol, A. Alegre, F. Escalante, J. De La Rubia, A. I. Teruel, F. De Arriba, M. T. Hernandez, J. Lopez-Jimenez, E. M. Ocio, N. Puig, B. Paiva, J. J. Lahuerta, J. Bladé, J. F. San Miguel,
Rapid immune reconstitution following the infusion of autologous, Blinatumomab Expanded T-cells (BET) in patients with B-cell indolent NHL or CLL
Blood Cancer J.
(IF 12.8 )
Pub Date : 2024-04-26
Giuseppe Gritti, Silvia Ferrari, Federico Lussana, Anna Maria Barbui, Francesco Landi, Monica Rondi, Alessandro Putelli, Francesco Ballardini, Giulia Quaresmini, Muriel Paganessi, Chiara Pavoni, Arianna Ghirardi, Elisa Gotti, Chiara Capelli, Josée Golay, Martino Introna, Alessandro Rambaldi
Combined emapalumab and ruxolitinib in patients with haemophagocytic Lymphohistiocytosis
Blood Cancer J.
(IF 12.8 )
Pub Date : 2024-04-24
Yue Song, Fei Zhou, Feng Du, Ziyan Wang, Liyun Bai, Yifang Yao, Limin Liu, Xiao Ma, Suning Chen, Depei Wu, Xuefeng He
Refined risk stratification helps guiding transplantation choice in adult BCR::ABL1-positive acute lymphoblastic leukemia
Blood Cancer J.
(IF 12.8 )
Pub Date : 2024-04-24
Cheng Wang, Jianfeng Li, Weiyang Liu, Lingling Zhao, Han Yan, Yuchen Yan, Jiayi Ren, Lijun Peng, Jiaojiao Zhang, Yuanfang Liu, Xiangqin Weng, Yongmei Zhu, Duohui Jing, Jian-Qing Mi, Jin Wang
Daratumumab-based quadruplet therapy for transplant-eligible newly diagnosed multiple myeloma with high cytogenetic risk
Blood Cancer J.
(IF 12.8 )
Pub Date : 2024-04-22
Natalie S. Callander, Rebecca Silbermann, Jonathan L. Kaufman, Kelly N. Godby, Jacob Laubach, Timothy M. Schmidt, Douglas W. Sborov, Eva Medvedova, Brandi Reeves, Binod Dhakal, Cesar Rodriguez, Saurabh Chhabra, Ajai Chari, Susan Bal, Larry D. Anderson, Bhagirathbhai R. Dholaria, Nitya Nathwani, Parameswaran Hari, Nina Shah, Naresh Bumma, Sarah A. Holstein, Caitlin Costello, Andrzej Jakubowiak, Tanya
In multiple myeloma, monthly treatment with zoledronic acid beyond two years offers sustained protection against progressive bone disease
Blood Cancer J.
(IF 12.8 )
Pub Date : 2024-04-15
Thomas Lund, Michael Tveden Gundesen, Annette Juul Vangsted, Carsten Helleberg, Einar Haukås, Trine Silkjær, Jon Thor Asmussen, Elena Manuela Teodorescu, Bo Amdi Jensen, Tobias Schmidt Slørdahl, Hareth Nahi, Anders Waage, Niels Abildgaard, Fredrik Schjesvold
Intention-to-treat outcomes utilising a stringent event definition in children and young people treated with tisagenlecleucel for r/r ALL through a national access scheme
Blood Cancer J.
(IF 12.8 )
Pub Date : 2024-04-15
Macarena Oporto Espuelas, Saskia Burridge, Amy A. Kirkwood, Denise Bonney, Kelly Watts, Geoff Shenton, Katarzyna A. Jalowiec, Maeve A. O’Reilly, Claire Roddie, Anna Castleton, Katherine Clesham, Emma Nicholson, Rajesh Alajangi, Shilpa Prabhu, Lindsay George, Ben Uttenthal, Maria Gabelli, Lorna Neill, Caroline Besley, Sridhar Chaganti, Robert F. Wynn, Jack Bartram, Robert Chiesa, Giovanna Lucchini,
Real-world impact of bridging therapy on outcomes of ide-cel for myeloma in the U.S. Myeloma Immunotherapy Consortium
Blood Cancer J.
(IF 12.8 )
Pub Date : 2024-04-12
Aimaz Afrough, Hamza Hashmi, Doris K. Hansen, Surbhi Sidana, Chul Ahn, Lauren C. Peres, Danai Dima, Ciara L. Freeman, Omar Castaneda Puglianini, Mehmet H. Kocoglu, Shebli Atrash, Peter M. Voorhees, Leyla Shune, Joseph P. McGuirk, Gary Simmons, Douglas W. Sborov, James A. Davis, Gurbakhash Kaur, Aishwarya Sannareddy, Christopher J. Ferreri, Mahmoud R. Gaballa, Scott Goldsmith, Omar Nadeem, Shonali Midha
A novel small molecule inhibitor of CD73 triggers immune-mediated multiple myeloma cell death
Blood Cancer J.
(IF 12.8 )
Pub Date : 2024-04-09
Arghya Ray, Ting Du, Xueping Wan, Yan Song, Sindhu C. Pillai, Md. Abu Musa, Teng Fang, Jared Moore, Brian Blank, Xiaohui Du, Xi Chen, Robert Warne, Dena Sutimantanapi, Fang Lui, Tatiana Zavorotinskaya, Christophe Colas, Lori Friedman, Melissa R. Junttila, Dharminder Chauhan, Kenneth C. Anderson
Comparison of the 2022 world health organization classification and international consensus classification in myelodysplastic syndromes/neoplasms
Blood Cancer J.
(IF 12.8 )
Pub Date : 2024-04-09
Wan-Hsuan Lee, Chien-Chin Lin, Cheng-Hong Tsai, Feng-Ming Tien, Min-Yen Lo, Mei-Hsuan Tseng, Yuan-Yeh Kuo, Shan-Chi Yu, Ming-Chih Liu, Chang-Tsu Yuan, Yi-Tsung Yang, Ming-Kai Chuang, Bor-Sheng Ko, Jih-Luh Tang, Hsun-I Sun, Yi-Kuang Chuang, Hwei-Fang Tien, Hsin-An Hou, Wen-Chien Chou
Bayesian interim analysis for prospective randomized studies: reanalysis of the acute myeloid leukemia HOVON 132 clinical trial
Blood Cancer J.
(IF 12.8 )
Pub Date : 2024-03-27
Niek G. van der Maas, Jurjen Versluis, Kazem Nasserinejad, Joost van Rosmalen, Thomas Pabst, Johan Maertens, Dimitri Breems, Markus Manz, Jacqueline Cloos, Gert J. Ossenkoppele, Yngvar Floisand, Patrycja Gradowska, Bob Löwenberg, Gerwin Huls, Douwe Postmus, Francesco Pignatti, Jan J. Cornelissen
A successful treatment-free remission is achievable also by chronic myeloid leukemia patients lacking optimal requirements
Blood Cancer J.
(IF 12.8 )
Pub Date : 2024-03-26
Massimiliano Bonifacio, Luigi Scaffidi, Maria Cristina Miggiano, Davide Facchinelli, Luca Tosoni, Sara Pezone, Davide Griguolo, Giulia Ciotti, Marco Danini, Andrea Bernardelli, Rita Bresciani, Monica Cavraro, Lara Crosera, Elena De March, Michele Dell’Eva, Laura Dorotea, Luca Frison, Lara Furlani, Ilaria Gianesello, Ester Lovato, Elena Marchetti, Gianluca Morelli, Rikard Mullai, Umberto Pizzano, Simone
Outcomes of patients with multiple myeloma refractory to standard dose vs low dose lenalidomide
Blood Cancer J.
(IF 12.8 )
Pub Date : 2024-03-26
Utkarsh Goel, Charalampos Charalampous, Prashant Kapoor, Moritz Binder, Francis K. Buadi, David Dingli, Angela Dispenzieri, Amie Fonder, Morie A. Gertz, Wilson I. Gonsalves, Suzanne R. Hayman, Miriam A. Hobbs, Yi L. Hwa, Taxiarchis Kourelis, Martha Q. Lacy, Nelson Leung, Yi Lin, Rahma M. Warsame, Robert A. Kyle, S. Vincent Rajkumar, Shaji K. Kumar
How comparable are patient outcomes in the “real-world” with populations studied in pivotal AML trials?
Blood Cancer J.
(IF 12.8 )
Pub Date : 2024-03-26
Ing Soo Tiong, Meaghan Wall, Ashish Bajel, Akash Kalro, Shaun Fleming, Andrew W. Roberts, Nisha Thiagarajah, Chong Chyn Chua, Maya Latimer, David Yeung, Paula Marlton, Amanda Johnston, Anoop Enjeti, Chun Yew Fong, Gavin Cull, Stephen Larsen, Glen Kennedy, Anthony Schwarer, David Kipp, Sundra Ramanathan, Emma Verner, Campbell Tiley, Edward Morris, Uwe Hahn, John Moore, John Taper, Duncan Purtill, Pauline
Once-weekly versus twice-weekly bortezomib in newly diagnosed multiple myeloma: a real-world analysis
Blood Cancer J.
(IF 12.8 )
Pub Date : 2024-03-22
Fieke W. Hoff, Rahul Banerjee, Adeel M. Khan, Georgia McCaughan, Bo Wang, Xiaoliang Wang, James Roose, Larry D. Anderson, Andrew J. Cowan, S. Vincent Rajkumar, Gurbakhash Kaur
Genetically determined telomere length and risk for haematologic diseases: results from large prospective cohorts and Mendelian Randomization analysis
Blood Cancer J.
(IF 12.8 )
Pub Date : 2024-03-18
Yang Li, Jia Chen, Ting Sun, Yunfei Chen, Rongfeng Fu, Xiaofan Liu, Feng Xue, Wei Liu, Mankai Ju, Xinyue Dai, Huan Dong, Huiyuan Li, Wentian Wang, Ying Chi, Lei Zhang
Progression free survival of myeloma patients who become IFE-negative correlates with the detection of residual monoclonal free light chain (FLC) by mass spectrometry
Blood Cancer J.
(IF 12.8 )
Pub Date : 2024-03-18
H. V. Giles, M. T. Drayson, B. Kishore, C. Pawlyn, M. Kaiser, G. Cook, R. de Tute, R. G. Owen, D. Cairns, T. Menzies, F. E. Davies, G. J. Morgan, G. Pratt, G. H. Jackson
PTCy versus ATG as graft-versus-host disease prophylaxis in mismatched unrelated stem cell transplantation
Blood Cancer J.
(IF 12.8 )
Pub Date : 2024-03-15
Olaf Penack, Mouad Abouqateb, Christophe Peczynski, William Boreland, Zafer Gülbas, Tobias Gedde-Dahl, Cristina Castilla-Llorente, Nicolaus Kröger, Mathias Eder, Alessandro Rambaldi, Francesca Bonifazi, Igor Wolfgang Blau, Matthias Stelljes, Peter Dreger, Ivan Moiseev, Hélène Schoemans, Christian Koenecke, Zinaida Peric
Clinical outcomes of patients with lymphoid blastic phase of chronic myeloid leukemia treated with CAR T-cell therapy
Blood Cancer J.
(IF 12.8 )
Pub Date : 2024-03-06
Yujie Liu, Yuqing Tu, Jinyan Xiao, Yifan Shen, Biqi Zhou, Qiannan Yang, Lei Yu, Lijuan Qi, Jia Chen, Tianhui Liu, Depei Wu, Yang Xu
Enhancing prognostic power in multiple myeloma using a plasma cell signature derived from single-cell RNA sequencing
Blood Cancer J.
(IF 12.8 )
Pub Date : 2024-03-06
Jian-rong Li, Shahram Arsang-Jang, Yan Cheng, Fumou Sun, Anita D’Souza, Binod Dhakal, Parameswaran Hari, Quillan Huang, Paul Auer, Yong Li, Raul Urrutia, Fenghuang Zhan, John D. Shaughnessy, Siegfried Janz, Jing Dong, Chao Cheng
Adverse effects and non-relapse mortality of BCMA directed T cell therapies in multiple myeloma: an FAERS database study
Blood Cancer J.
(IF 12.8 )
Pub Date : 2024-03-05
Zimu Gong, Godsfavour Umoru, Jorge Monge, Nishi Shah, Ghulam Rehman Mohyuddin, Sabarinath Venniyil Radhakrishnan, Rajshekhar Chakraborty, Leo Rasche, Carolina Schinke, Anita D’Souza, Meera Mohan
Unrelated donor hematopoietic stem cell transplantation compared to immunosuppressive therapy plus eltrombopag as first-line treatment for adults with severe aplastic anemia
Blood Cancer J.
(IF 12.8 )
Pub Date : 2024-03-06
Liangliang Wu, Limin Liu, Xin Zhao, Ming Zhou, Andie Fu, Yuping Zhang, Wenrui Yang, Xiaowei Chen, Wenjian Mo, Caixia Wang, Yumiao Li, Shilin Xu, Shiyi Pan, Ruiqing Zhou, Fankai Meng, Fengkui Zhang, Depei Wu, Shunqing Wang
Teclistamab in relapsed refractory multiple myeloma: multi-institutional real-world study
Blood Cancer J.
(IF 12.8 )
Pub Date : 2024-03-05
Meera Mohan, Jorge Monge, Nishi Shah, Danny Luan, Mark Forsberg, Vineel Bhatlapenumarthi, Metodi Balev, Anannya Patwari, Heloise Cheruvalath, Divaya Bhutani, Sharmilan Thanendrarajan, Binod Dhakal, Maurizio Zangari, Samer Al-Hadidi, Dennis Cooper, Suzanne Lentzsch, Frits van Rhee, Anita D’Souza, Aniko Szabo, Carolina Schinke, Rajshekhar Chakraborty
Dual T-cell constant β chain (TRBC)1 and TRBC2 staining for the identification of T-cell neoplasms by flow cytometry
Blood Cancer J.
(IF 12.8 )
Pub Date : 2024-02-29
Pedro Horna, Matthew J. Weybright, Mathieu Ferrari, Dennis Jungherz, YaYi Peng, Zulaikha Akbar, F. Tudor Ilca, Gregory E. Otteson, Jansen N. Seheult, Janosch Ortmann, Min Shi, Paul M. Maciocia, Marco Herling, Martin A. Pule, Horatiu Olteanu
Comparing venetoclax in combination with hypomethylating agents to hypomethylating agent-based therapies for treatment naive TP53-mutated acute myeloid leukemia: results from the Consortium on Myeloid Malignancies and Neoplastic Diseases (COMMAND)
Blood Cancer J.
(IF 12.8 )
Pub Date : 2024-02-20
Talha Badar, Ahmad Nanaa, Ehab Atallah, Rory M. Shallis, Sacchi de Camargo Correia Guilherme, Aaron D. Goldberg, Antoine N. Saliba, Anand Patel, Jan P. Bewersdorf, Adam S. DuVall, Danielle Bradshaw, Yasmin Abaza, Guru Subramanian Guru Murthy, Neil Palmisiano, Amer M. Zeidan, Vamsi Kota, Mark R. Litzow
Post-transplant cyclophosphamide versus anti-thymocyte globulin after reduced intensity peripheral blood allogeneic cell transplantation in recipients of matched sibling or 10/10 HLA matched unrelated donors: final analysis of a randomized, open-label, multicenter, phase 2 trial
Blood Cancer J.
(IF 12.8 )
Pub Date : 2024-02-19
Eolia Brissot, Myriam Labopin, Helene Labussière, Gaelle Fossard, Patrice Chevallier, Thierry Guillaume, Ibrahim Yakoub-Agha, Micha Srour, Claude-Eric Bulabois, Anne Huynh, Sylvain Chantepie, Anne-Lise Menard, Marie-Therese Rubio, Patrice Ceballos, Rémy Dulery, Sabine Furst, Florent Malard, Didier Blaise, Mohamad Mohty
Prognostic value of ferritin in ASCT MM patients: integration with GEP models and ISS series systems
Blood Cancer J.
(IF 12.8 )
Pub Date : 2024-02-14
Wancheng Guo, Yihao Zhan, David Mery, Eric R. Siegel, Fumou Sun, Yan Cheng, Timothy Cody Ashby, Zijun Zhang, Clyde Bailey, Daisy V. Alapat, Hongling Peng, Samer Al Hadidi, Sharmilan Thanendrarajan, Carolina Schinke, Maurizio Zangari, Frits van Rhee, Guido Tricot, John D. Shaughnessy, Fenghuang Zhan
Neutrophil-to-lymphocyte ratio and all-cause mortality with and without myeloproliferative neoplasms—a Danish longitudinal study
Blood Cancer J.
(IF 12.8 )
Pub Date : 2024-02-09
Morten Kranker Larsen, Vibe Skov, Lasse Kjær, Christina Schjellerup Eickhardt-Dalbøge, Trine Alma Knudsen, Marie Hvelplund Kristiansen, Anders Lindholm Sørensen, Troels Wienecke, Morten Andersen, Johnny T. Ottesen, Johanne Gudmand-Høyer, Jordan Andrew Snyder, Mikkel Porsborg Andersen, Christian Torp-Pedersen, Henrik Enghusen Poulsen, Thomas Stiehl, Hans Carl Hasselbalch, Christina Ellervik
Efficacy and immune modulation associated with the addition of IMiDs to Daratumumab backbone in multiple myeloma patients refractory to both drug classes: resetting synergistic activity
Blood Cancer J.
(IF 12.8 )
Pub Date : 2024-02-06
Ioannis V. Kostopoulos, Despina Fotiou, Maria Gavriatopoulou, Pantelis Rousakis, Ioannis Ntanasis-Stathopoulos, Chrysanthi Panteli, Panagiotis Malandrakis, Magdalini Migkou, Nikolaos Angelis, Nikolaos Kanellias, Evangelos Eleutherakis-Papaiakovou, Foteini Theodorakakou, Maria Krevvata, Evangelos Terpos, Meletios-Athanasios Dimopoulos, Ourania Tsitsilonis, Efstathios Kastritis
Efficacy of novel agents against cellular models of familial platelet disorder with myeloid malignancy (FPD-MM)
Blood Cancer J.
(IF 12.8 )
Pub Date : 2024-02-05
Christopher P. Mill, Warren C. Fiskus, Courtney D. DiNardo, Patrick Reville, John A. Davis, Christine E. Birdwell, Kaberi Das, Hanxi Hou, Koichi Takahashi, Lauren Flores, Xinjia Ruan, Xiaoping Su, Sanam Loghavi, Joseph D. Khoury, Kapil N. Bhalla
GPRC5D as a novel target for the treatment of multiple myeloma: a narrative review
Blood Cancer J.
(IF 12.8 )
Pub Date : 2024-02-02
Paula Rodriguez-Otero, Niels W. C. J. van de Donk, Kodandaram Pillarisetti, Ingrid Cornax, Deeksha Vishwamitra, Kathleen Gray, Brandi Hilder, Jaszianne Tolbert, Thomas Renaud, Tara Masterson, Christoph Heuck, Colleen Kane, Raluca Verona, Philippe Moreau, Nizar Bahlis, Ajai Chari
Enhancement of Omicron-specific immune responses following bivalent COVID-19 booster vaccination in patients with chronic lymphocytic leukaemia
Blood Cancer J.
(IF 12.8 )
Pub Date : 2024-01-25
Thomas Roberts, Grace Uwenedi, Rachel Bruton, Graham McIlroy, Sarah Damery, Panagiota Sylla, Nicola Logan, Sam Scott, May Lau, Ahmed Elzaidi, Siobhan Plass, Soumyajit Mallick, Katie Spencer, Christine Stephens, Christopher Bentley, Guy Pratt, Jianmin Zuo, Shankara Paneesha, Brian Willett, Paul Moss, Helen Parry
Genetics and pathologic landscape of lineage switch of acute leukemia during therapy
Blood Cancer J.
(IF 12.8 )
Pub Date : 2024-01-25
Ting Zhou, Choladda V. Curry, Mahsa Khanlari, Min Shi, Wei Cui, Deniz Peker, Weina Chen, Endi Wang, Juehua Gao, Qi Shen, Wei Xie, Fatima Z. Jelloul, Rebecca L. King, Ji Yuan, Xiaoqiong Wang, Chen Zhao, Ifeyinwa E. Obiorah, Elizabeth L. Courville, Eric Nomura, Sindhu Cherian, Mina L. Xu, W. Richard Burack, Hong-xing Liu, Elias J. Jabbour, Koichi Takahashi, Wei Wang, Sa A. Wang, Joseph D. Khoury, L.
Alterations in chromosome 1q in multiple myeloma randomized clinical trials: a systematic review
Blood Cancer J.
(IF 12.8 )
Pub Date : 2024-01-25
Karun Neupane, Gliceida Galarza Fortuna, Riyasha Dahal, Timothy Schmidt, Rafael Fonseca, Rajshekhar Chakraborty, Kelly Ann Koehn, Meera Mohan, Hira Mian, Luciano J. Costa, Douglas Sborov, Ghulam Rehman Mohyuddin
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