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Effectiveness of Bariatric Metabolic Surgery versus Glucagon-Like Peptide-1 Receptor Agonists for prevention of Congestive Heart Failure Nat. Med. (IF 82.9) Pub Date : 2024-05-15 Yael Wolff Sagy, Gil Lavie, Noga Ramot, Erez Battat, Ronen Arbel, Orna Reges, Dror Dicker
Comparative evidence for the effects of bariatric metabolic surgery (BMS) and glucagon-like peptide-1 receptor agonists (GLP1-RA) on cardiovascular outcomes is limited. Here, in an observational, retrospective cohort study, we compared the incidence of Congestive Heart Failure (CHF) in adults living with obesity and diabetes without history of CHF (primary CHF) treated with BMS versus GLP-1RA. The
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The evolution of personalized nutrition Nat. Med. (IF 82.9) Pub Date : 2024-05-15 Josef Neu
Data from a large randomized trial show that a personalized diet can improve cardiometabolic health, providing support for a ‘food as medicine’ concept that, although centuries old, still lacks robust evidence.
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Heat exposure induced risks of preterm birth mediated by maternal hypertension Nat. Med. (IF 82.9) Pub Date : 2024-05-15 Liyun Wang, Jiangli Di, Qiong Wang, Huanhuan Zhang, Wei Zhao, Xiaoming Shi, Qian Di, John S. Ji, Wannian Liang, Cunrui Huang
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Senaparib as first-line maintenance therapy in advanced ovarian cancer: a randomized phase 3 trial Nat. Med. (IF 82.9) Pub Date : 2024-05-15 Xiaohua Wu, Jihong Liu, Jing Wang, Li Wang, Zhongqiu Lin, Xiaobin Wang, Jianqing Zhu, Beihua Kong, Junwei Fei, Ying Tang, Bairong Xia, Zhiqing Liang, Ke Wang, Yi Huang, Hong Zheng, An Lin, Kui Jiang, Wei Wang, Xin Wang, Ge Lou, Hongming Pan, Shuzhong Yao, Guiling Li, Min Hao, Yunlang Cai, Xuejun Chen, Zhijun Yang, Youguo Chen, Hongwu Wen, Pengpeng Qu, Cong Xu, Chih-Yi Hsieh
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Long acting progestogens versus combined oral contraceptive pill for preventing recurrence of endometriosis related pain: the PRE-EMPT pragmatic, parallel group, open label, randomised controlled trial BMJ (IF 105.7) Pub Date : 2024-05-15 Kevin G Cooper, Siladitya Bhattacharya, Jane P Daniels, Andrew W Horne, T Justin Clark, Ertan Saridogan, Versha Cheed, Danielle Pirie, Melyda Melyda, Mark Monahan, Tracy E Roberts, Emma Cox, Clive Stubbs, Lee J Middleton
Objectives To evaluate the clinical effectiveness of long acting progestogens compared with the combined oral contraceptive pill in preventing recurrence of endometriosis related pain. Design The PRE-EMPT (preventing recurrence of endometriosis) pragmatic, parallel group, open label, randomised controlled trial. Setting 34 UK hospitals. Participants 405 women of reproductive age undergoing conservative
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Equity in medical devices: trainers and educators play a vital role BMJ (IF 105.7) Pub Date : 2024-05-15 Margaret Whitehead, Enitan Carrol, Frank Kee, Raghib Ali, Chris Holmes
Education and training of healthcare professionals is essential to improve the systemwide problem of inequity in medical devices, say Margaret Whitehead and colleagues The impact of racial bias on the performance of medical devices used in the NHS gained public and political attention during the covid pandemic, with the recognition that patients with darker skin tones may be put at increased risk of
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John Launer: Seeing the big picture—the distinctive value of generalism BMJ (IF 105.7) Pub Date : 2024-05-15 John Launer
Patients are often the beneficiaries of medicine, but they can be its victims too. Most people in the western world are likely to know by their 60s that they have at least one chronic condition or risk factor, if not several. As they age further the number of these will almost certainly increase, along with regular check-ups, investigations, and an escalating amount of treatment. Some of the effects
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What do we know about covid-19’s effects on the brain? BMJ (IF 105.7) Pub Date : 2024-05-15 Katharine Lang
Katharine Lang investigates how SARS-CoV-2 infection can affect the brain, how it might have these effects, and what can be done to minimise the risk Covid may be primarily a respiratory infection, but a common symptom is “brain fog”—problems with memory or concentration—which can persist for weeks or months as part of long covid.1 And it’s not the only neurological effect. Giovanni Schifitto, professor
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Cardiovascular toxicity of immune therapies for cancer BMJ (IF 105.7) Pub Date : 2024-05-15 Nicolas L Palaskas, Hyeon-Ju Ali, Efstratios Koutroumpakis, Sarju Ganatra, Anita Deswal
In addition to conventional chemoradiation and targeted cancer therapy, the use of immune based therapies, specifically immune checkpoint inhibitors (ICIs) and chimeric antigen receptor T cell therapy (CAR-T), has increased exponentially across a wide spectrum of cancers. This has been paralleled by recognition of off-target immune related adverse events that can affect almost any organ system including
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Trastuzumab deruxtecan in HER2-positive advanced gastric cancer: exploratory biomarker analysis of the randomized, phase 2 DESTINY-Gastric01 trial Nat. Med. (IF 82.9) Pub Date : 2024-05-14 Kohei Shitara, Yung-Jue Bang, Satoru Iwasa, Naotoshi Sugimoto, Min-Hee Ryu, Daisuke Sakai, Hyun Cheol Chung, Hisato Kawakami, Hiroshi Yabusaki, Yasuhiro Sakamoto, Tomohiro Nishina, Koichiro Inaki, Yusuke Kuwahara, Naoya Wada, Fumitaka Suto, Takeo Arita, Masahiro Sugihara, Zenta Tsuchihashi, Kaku Saito, Akihito Kojima, Kensei Yamaguchi
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Prevalence of comorbidities in individuals with neurodevelopmental disorders from the aggregated phenomics data of 51,227 pediatric individuals Nat. Med. (IF 82.9) Pub Date : 2024-05-14 Alexander J. M. Dingemans, Sandra Jansen, Jeroen van Reeuwijk, Nicole de Leeuw, Rolph Pfundt, Janneke Schuurs-Hoeijmakers, Bregje W. van Bon, Carlo Marcelis, Charlotte W. Ockeloen, Marjolein Willemsen, Pleuntje J. van der Sluijs, Gijs W. E. Santen, R. Frank Kooy, Anneke T. Vulto-van Silfhout, Tjitske Kleefstra, David A. Koolen, Lisenka E. L. M. Vissers, Bert B. A. de Vries
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Dynamics of cognitive variability with age and its genetic underpinning in NIHR BioResource Genes and Cognition cohort participants Nat. Med. (IF 82.9) Pub Date : 2024-05-14 Md Shafiqur Rahman, Emma Harrison, Heather Biggs, Chloe Seikus, Paul Elliott, Gerome Breen, Nathalie Kingston, John R. Bradley, Steven M. Hill, Brian D. M. Tom, Patrick F. Chinnery
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Progranulin AAV gene therapy for frontotemporal dementia: translational studies and phase 1/2 trial interim results Nat. Med. (IF 82.9) Pub Date : 2024-05-14 Jeffrey Sevigny, Olga Uspenskaya, Laura Dean Heckman, Li Chin Wong, Daniel A. Hatch, Ambika Tewari, Rik Vandenberghe, David J. Irwin, Dario Saracino, Isabelle Le Ber, Rebekah Ahmed, Jonathan D. Rohrer, Adam L. Boxer, Sebastian Boland, Patricia Sheehan, Alissa Brandes, Suzanne R. Burstein, Benjamin M. Shykind, Sitharthan Kamalakaran, Carter W. Daniels, E. David Litwack, Erin Mahoney, Jenny Velaga, Ilan
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The efficacy of dapagliflozin in a hierarchical kidney outcome in heart failure Nat. Med. (IF 82.9) Pub Date : 2024-05-13
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Long-term weight loss effects of semaglutide in obesity without diabetes in the SELECT trial Nat. Med. (IF 82.9) Pub Date : 2024-05-13 Donna H. Ryan, Ildiko Lingvay, John Deanfield, Steven E. Kahn, Eric Barros, Bartolome Burguera, Helen M. Colhoun, Cintia Cercato, Dror Dicker, Deborah B. Horn, G. Kees Hovingh, Ole Kleist Jeppesen, Alexander Kokkinos, A. Michael Lincoff, Sebastian M. Meyhöfer, Tugce Kalayci Oral, Jorge Plutzky, André P. van Beek, John P. H. Wilding, Robert F. Kushner
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Sixty Years of Hemodynamic Pharmacology in Obstructive Hypertrophic Cardiomyopathy N. Engl. J. Med. (IF 158.5) Pub Date : 2024-05-13 Steve R. Ommen From the Department of Medicine, Mayo Clinic, Rochester, MN.
In April 1964, leading cardiologists, cardiovascular surgeons, and pathologists convened in London for a 2-day symposium to discuss a relatively new disease entity that we now know as obstructive h...
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Aficamten for Symptomatic Obstructive Hypertrophic Cardiomyopathy N. Engl. J. Med. (IF 158.5) Pub Date : 2024-05-13 Martin S. Maron, Ahmad Masri, Michael E. Nassif, Roberto Barriales-Villa, Michael Arad, Nuno Cardim, Lubna Choudhury, Brian Claggett, Caroline J. Coats, Hans-Dirk Düngen, Pablo Garcia-Pavia, Albert A. Hagège, James L. Januzzi, Matthew M.Y. Lee, Gregory D. Lewis, Chang-Sheng Ma, Michelle Michels, Iacopo Olivotto, Artur Oreziak, Anjali T. Owens, John A. Spertus, Scott D. Solomon, Jacob Tfelt-Hansen,
One of the major determinants of exercise intolerance and limiting symptoms among patients with obstructive hypertrophic cardiomyopathy (HCM) is an elevated intracardiac pressure resulting from lef...
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To increase public satisfaction in the NHS, we need a new conversation about how to improve it BMJ (IF 105.7) Pub Date : 2024-05-13 Jessie Cunnett, Richard Smith
As satisfaction with the NHS reaches a new low, we should embrace the power of citizens and society to restore public confidence , argue these authors The recent British Social Attitudes Survey found that less than a quarter (24%) of the 3374 respondents sampled in England, Wales, and Scotland were satisfied with the NHS—the lowest in the 41 year history of the survey.1 Since 2020, there has been an
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Matt Morgan: Rekindling the NHS’s foundational flame BMJ (IF 105.7) Pub Date : 2024-05-14 Matt Morgan
One of the joys of writing this column is receiving emails from readers who work across a wide spectrum of medicine, from students to retired professors. I read one such email from a retired, fellow Cardiff alumnus in response to my last column discussing the new play Nye . After I’d watched the play at the National Theatre1—which dramatises the NHS’s origins through the eyes of Aneurin Bevan, former
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The future of NHS primary care should focus on integration not fragmentation BMJ (IF 105.7) Pub Date : 2024-05-14 See Chai Carol Chan, Rebecca Wright, Azeem Majeed
In some parts of England, there are proposals to divide NHS primary care services. NHS England’s strategy aims to separate patients with “same-day” acute care or with “simpler” medical issues from patients with more complex, long term needs. The aim is to allow general practitioners (GPs) to primarily focus on the latter group of patients.12 While this approach appears superficially to be a rational
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Helen Salisbury: Training our replacements BMJ (IF 105.7) Pub Date : 2024-05-14 Helen Salisbury
Are there limits on what people should be allowed to do in the medical or surgical field when they’re not a doctor and not training to be one? We teach someone our skills so that they may one day exercise them independently, and almost from the moment we qualify as doctors we start training our replacements. The time available for this training is finite, so we should think carefully about how we spend
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The end of local clinical excellence awards BMJ (IF 105.7) Pub Date : 2024-05-14 Nick Murphy, Mark Exworthy, Julia Gauly, Jo Parsons, Katlyn Green
The news that consultants have accepted the government’s pay offer marks an important moment in British health policy, signalling the end of local clinical excellence awards (LCEAs) in England and Wales.1 The NHS has had a form of performance related pay for consultants since its inception. The 2003 consultant contract included the provision of locally administered awards for the delivery of “clinical
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A lack of quality statistics is hiding the real heatwave death toll BMJ (IF 105.7) Pub Date : 2024-05-14 Disha Shetty
Heatwaves are intensifying but gaps in the data mean that the number of people who have died from rising temperatures is unclear. Disha Shetty reports on why—and why it matters Malaysia’s capital Kuala Lumpur is hot and humid throughout the year but this April temperatures rose to over 37°C compared with the usual low 30s. The tropical country’s meteorology department published a heatwave warning for
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Text Messages With Financial Incentives for Men With Obesity JAMA (IF 120.7) Pub Date : 2024-05-14 Pat Hoddinott, Catriona O’Dolan, Lisa Macaulay, Stephan U. Dombrowski, James Swingler, Seonaidh Cotton, Alison Avenell, Abraham M. Getaneh, Cindy Gray, Kate Hunt, Frank Kee, Alice MacLean, Michelle McKinley, Claire Torrens, Katrina Turner, Marjon van der Pol, Graeme MacLennan
ImportanceEffective weight loss interventions are needed for men with obesity.ObjectiveTo determine whether an intervention that combined text messaging with financial incentives attained significant weight loss at the 12-month follow-up compared with the control group and whether an intervention of text messaging alone attained significant weight loss at the 12-month follow-up compared with the control
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An Adaptive Behavioral Intervention for Weight Loss Management JAMA (IF 120.7) Pub Date : 2024-05-14 Bonnie Spring, Angela F. Pfammatter, Laura Scanlan, Elyse Daly, Jean Reading, Sam Battalio, H. Gene McFadden, Don Hedeker, Juned Siddique, Inbal Nahum-Shani
ImportanceLifestyle interventions for weight loss are difficult to implement in clinical practice. Self-managed mobile health implementations without or with added support after unsuccessful weight loss attempts could offer effective population-level obesity management.ObjectiveTo test whether a wireless feedback system (WFS) yields noninferior weight loss vs WFS plus telephone coaching and whether
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Refining neoadjuvant immunotherapy for resectable lung cancer Nat. Med. (IF 82.9) Pub Date : 2024-05-13 Misty D. Shields, Christine M. Lovly
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Gut bacteria switch A and B blood types to ‘universal’ Nat. Med. (IF 82.9) Pub Date : 2024-05-13
Enzymes produced by Akkermansia muciniphila generated group O blood by degrading A and B antigens, which could help solve blood donor shortages in the future.
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Screening and diagnosis of cardiovascular disease using artificial intelligence-enabled cardiac magnetic resonance imaging Nat. Med. (IF 82.9) Pub Date : 2024-05-13 Yan-Ran (Joyce) Wang, Kai Yang, Yi Wen, Pengcheng Wang, Yuepeng Hu, Yongfan Lai, Yufeng Wang, Kankan Zhao, Siyi Tang, Angela Zhang, Huayi Zhan, Minjie Lu, Xiuyu Chen, Shujuan Yang, Zhixiang Dong, Yining Wang, Hui Liu, Lei Zhao, Lu Huang, Yunling Li, Lianming Wu, Zixian Chen, Yi Luo, Dongbo Liu, Pengbo Zhao, Keldon Lin, Joseph C. Wu, Shihua Zhao
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Association between pretreatment emotional distress and immune checkpoint inhibitor response in non-small-cell lung cancer Nat. Med. (IF 82.9) Pub Date : 2024-05-13 Yue Zeng, Chun-Hong Hu, Yi-Zheng Li, Jian-Song Zhou, Shu-Xing Wang, Meng-Dong Liu, Zhen-Hua Qiu, Chao Deng, Fang Ma, Chun-Fang Xia, Fei Liang, Yu-Rong Peng, Ao-Xi Liang, Sheng-Hao Shi, Shi-Jiao Yao, Jun-Qi Liu, Wen-Jie Xiao, Xiao-Qiao Lin, Xin-Yu Tian, Ying-Zhe Zhang, Zhuo-Ying Tian, Ji-An Zou, Yun-Shu Li, Chao-Yue Xiao, Tian Xu, Xiao-Jie Zhang, Xiao-Ping Wang, Xian-Ling Liu, Fang Wu
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High-resolution African HLA resource uncovers HLA-DRB1 expression effects underlying vaccine response Nat. Med. (IF 82.9) Pub Date : 2024-05-13 Alexander J. Mentzer, Alexander T. Dilthey, Martin Pollard, Deepti Gurdasani, Emre Karakoc, Tommy Carstensen, Allan Muhwezi, Clare Cutland, Amidou Diarra, Ricardo da Silva Antunes, Sinu Paul, Gaby Smits, Susan Wareing, HwaRan Kim, Cristina Pomilla, Amanda Y. Chong, Debora Y. C. Brandt, Rasmus Nielsen, Samuel Neaves, Nicolas Timpson, Austin Crinklaw, Cecilia S. Lindestam Arlehamn, Anna Rautanen, Dennison
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Artificial intelligence in surgery Nat. Med. (IF 82.9) Pub Date : 2024-05-13 Chris Varghese, Ewen M. Harrison, Greg O’Grady, Eric J. Topol
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David Oliver: The risk assessment for NHS England’s long term workforce plan should worry doctors BMJ (IF 105.7) Pub Date : 2024-05-13 David Oliver
In June 2023 NHS England (NHSE) published its long awaited and serially delayed long term workforce plan for the NHS.1 In the 10 months since then we’ve seen pay disputes, difficult contract negotiations, strike action, and ballots of clinical staff.234 While the BMA’s Consultants Committee has now settled a long running contract dispute with the government,5 its Junior Doctors Committee seems no closer
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How can we support staff after the death by suicide of a colleague? BMJ (IF 105.7) Pub Date : 2024-05-13 Abi Rimmer
Losing a colleague to suicide can have a huge impact on a team. There are measures that can be put in place to support them, Abi Rimmer hears Gail Kinman, professor of occupational health psychology, Birkbeck Business School, says, “The sudden death of a colleague can be shocking, distressing, and destabilising. For a death by suicide, emotional responses can be intense, with wide ranging consequences
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Diagnosing cancer in English community pharmacies BMJ (IF 105.7) Pub Date : 2024-05-13 Stephen H Bradley, Daniel Jones, Su Wood, Meena Rafiq, Carolyn Bradley, William T Hamilton
Stephen Bradley and colleagues argue that plans to involve community pharmacies in diagnosing cancer are unlikely to transform cancer detection in primary care Cancer is diagnosed at more advanced stages, and consequently with poorer outcomes, in the UK than in many other high income countries.1234 Although these disparities have been observed over decades, worsening access to general practice appointments
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Prognostic Value of Cardiovascular Biomarkers in the Population JAMA (IF 120.7) Pub Date : 2024-05-13 Johannes Tobias Neumann, Raphael Twerenbold, Jessica Weimann, Christie M. Ballantyne, Emelia J. Benjamin, Simona Costanzo, James A. de Lemos, Christopher R. deFilippi, Augusto Di Castelnuovo, Chiara Donfrancesco, Marcus Dörr, Kai M. Eggers, Gunnar Engström, Stephan B. Felix, Marco M. Ferrario, Ron T. Gansevoort, Simona Giampaoli, Vilmantas Giedraitis, Pär Hedberg, Licia Iacoviello, Torben Jørgensen
ImportanceIdentification of individuals at high risk for atherosclerotic cardiovascular disease within the population is important to inform primary prevention strategies.ObjectiveTo evaluate the prognostic value of routinely available cardiovascular biomarkers when added to established risk factors.Design, Setting, and ParticipantsIndividual-level analysis including data on cardiovascular biomarkers
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Keep Your Eyes on the Prize — Focusing on Health Care Equity N. Engl. J. Med. (IF 158.5) Pub Date : 2024-05-11 Alicia Fernandez, and Marshall H. Chin From the Department of Medicine, University of California, San Francisco (A.F.), and the Department of Medicine, University of Chicago, Chicago (M.H.C.).
Prioritization of individual social-needs screening in health care may strip energy, attention, and resources from the goal of advancing equity in patient experience and clinical outcomes.
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Chronic Silicosis N. Engl. J. Med. (IF 158.5) Pub Date : 2024-05-11 Shan Kai Ing Sibu General Hospital, Sibu, Malaysia, Sze Shyang Kho Sarawak General Hospital, Kuching, Malaysia
A 47-year-old man was incidentally found to have diffuse nodular opacities on chest radiography. He had worked in a quarry for more than 30 years.
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Cardiovascular Burden of the V142I Transthyretin Variant JAMA (IF 120.7) Pub Date : 2024-05-12 Senthil Selvaraj, Brian Claggett, Svati H. Shah, Robert J. Mentz, Michel G. Khouri, Ani W. Manichaikul, Sadiya S. Khan, Stephen S. Rich, Thomas H. Mosley, Emily B. Levitan, Pankaj Arora, Parag Goyal, Bernhard Haring, Charles B. Eaton, Richard K. Cheng, Gretchen L. Wells, JoAnn E. Manson, Marianna Fontana, Scott D. Solomon
ImportanceIndividual cohort studies concur that the amyloidogenic V142I variant of the transthyretin (TTR) gene, present in 3% to 4% of US Black individuals, increases heart failure (HF) and mortality risk. Precisely defining carrier risk across relevant clinical outcomes and estimating population burden of disease are important given established and emerging targeted treatments.ObjectivesTo better
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The UK doesn’t have a “sick note culture,” but it does have a broken benefits system BMJ (IF 105.7) Pub Date : 2024-05-10 James Taylor
The government needs to stop demonising disabled people and tackle the barriers that prevent them from accessing work, says James Taylor The government claims it’s planning to tackle the rise in economic inactivity in the UK by cracking down on Britain’s “sick note culture.”1 But for charities like Scope, who support disabled people to find suitable jobs, this assessment is entirely and infuriatingly
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Work and vocational rehabilitation for people living with long covid BMJ (IF 105.7) Pub Date : 2024-05-10 Rory J O’Connor, Amy Parkin, Ghazala Mir, Jordan Mullard, Sareeta Baley, Jenny Ceolta-Smith, Clare Rayner
### What you need to know Long covid is a complex, highly variable, and sometimes relapsing-remitting condition that may have profound impacts on a patient’s wellbeing and ability to work.1 Many people living with long covid are attempting to return to work, or stay in work, while learning to manage an emerging long term condition.2 These challenges may be compounded by workplace burnout, fuelled by
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When I use a word . . . The languages of medicines—generics and bioavailability BMJ (IF 105.7) Pub Date : 2024-05-10 Jeffrey K Aronson
The term “generic” derives from an IndoEuropean linguistic root, GN, which implies both knowing and begetting, and comes down to us via the Latin noun genus, a class or type. Generic drug names are names like British Approved Names and International Nonproprietary Names, which are simpler than the full chemical names that drugs have. Furthermore, they dissociate the drug from its original manufacturer
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Caring for a loved one can make you a better clinician BMJ (IF 105.7) Pub Date : 2024-05-10 Shibley Rahman
I looked after my mum at home, from the point of her clinical diagnosis by her GP to her death (alone in hospital) last year. Kaviraj conveys well how the role of carer is equal in intensity to a full time job.1 For me it was like being a …
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Engaging men and boys in sexual and reproductive health and rights BMJ (IF 105.7) Pub Date : 2024-05-10 Maria Lohan, Avni Amin, Magaly Marques, Mark Tomlinson
Men and boys are critical to meaningful progress in gender equality Two of the UN’s sustainable development goals (on good health and wellbeing and on gender equality) emphasise improving sexual and reproductive health and rights.1 Given the centrality of unequal gender and power relations to this issue, we need to work with men and boys, alongside women and girls, to make meaningful progress.23456
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Expression of concern about content of which Dr Paul McCrory is a single author BMJ (IF 105.7) Pub Date : 2024-05-09 British Medical Journal Publishing Group
This editorial ( BMJ 2007;335:781, doi:10.1136/bmj.39352.454792.80) is authored by Dr Paul McCrory. During 2021 and 2022 there was an …
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Expression of concern about content of which Dr Paul McCrory is a single author BMJ (IF 105.7) Pub Date : 2024-05-09 British Medical Journal Publishing Group
This editorial ( BMJ 2003;327:351, doi:10.1136/bmj.327.7411.351) is authored by Dr Paul McCrory. During 2021 and 2022 there was an …
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Issue Information CA: Cancer J. Clin. (IF 254.7) Pub Date : 2024-05-08
No abstract is available for this article.
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Better communication is key for quality-of-life improvement in low-income and minority patients CA: Cancer J. Clin. (IF 254.7) Pub Date : 2024-05-08 Mike Fillon
Although approximately half of patients with cancer receive symptom management and advance care planning (ACP), a new study reports that the percentage is much worse—only approximately 20%—for low-income and minority patients. The researchers note that this disparity results in not just reduced quality of life for the patients but also increased costs of care for individuals and overall. The study
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The association between menopausal hormone therapy and breast cancer remains unsettled CA: Cancer J. Clin. (IF 254.7) Pub Date : 2024-05-08 Mike Fillon
“Too often, we have patients who are told concretely—by their physicians—that HT therapy is bad—it increases your breast cancer risk; this doesn‘t account for all of the other medical benefits of HRT and quality-of-life factors that impact women during menopause.” —Ellie Proussaloglou, MD It has been more than 2 decades since the Women’s Health Initiative (WHI; https://www.whi.org/) alarmed clinicians
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Studying paired patient tissue and blood enables insights into immunotherapy toxicity Nat. Med. (IF 82.9) Pub Date : 2024-05-09
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Gene therapy trials deliver double win Nat. Med. (IF 82.9) Pub Date : 2024-05-09
Final results of two studies — whose preliminary data led to regulatory approval of the gene therapy exagamglogene autotemcel — describe highly effective treatment of sickle-cell disease and transfusion-dependent β-thalassemia.
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Single-cell transcriptomic analyses reveal distinct immune cell contributions to epithelial barrier dysfunction in checkpoint inhibitor colitis Nat. Med. (IF 82.9) Pub Date : 2024-05-09 Molly Fisher Thomas, Kamil Slowikowski, Kasidet Manakongtreecheep, Pritha Sen, Nandini Samanta, Jessica Tantivit, Mazen Nasrallah, Leyre Zubiri, Neal P. Smith, Alice Tirard, Swetha Ramesh, Benjamin Y. Arnold, Linda T. Nieman, Jonathan H. Chen, Thomas Eisenhaure, Karin Pelka, Yuhui Song, Katherine H. Xu, Vjola Jorgji, Christopher J. Pinto, Tatyana Sharova, Rachel Glasser, PuiYee Chan, Ryan J. Sullivan
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Global Health Law for a Safer and Fairer World N. Engl. J. Med. (IF 158.5) Pub Date : 2024-05-08 Debra Malina, Sam Halabi, Lawrence O. Gostin, Olohikhuae Egbokhare, and Matthew M. Kavanagh From the O’Neill Institute for National and Global Health Law, Georgetown University Law Center and Georgetown University School of Health, Washington, DC.
After Covid-19, the global health community must address major gaps in global preparedness, critical capacities needed for a safer and fairer world, and international instruments required for reali...
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Case 14-2024: A 30-Year-Old Woman with Back Pain, Leg Stiffness, and Falls N. Engl. J. Med. (IF 158.5) Pub Date : 2024-05-09 Richard C. Cabot, Eric S. Rosenberg, David M. Dudzinski, Meridale V. Baggett, Kathy M. Tran, Dennis C. Sgroi, Jo-Anne O. Shepard, Emily K. McDonald, and Tara Corpuz, Christopher T. Doughty, Pamela W. Schaefer, Kate Brizzi, and Jenny J. Linnoila From the Department of Neurology, Brigham and Women’s Hospital (C.T.D.), the Departments of Radiology (P.W.S.), Medicine (K.B.), and Neurology (K.B., J.J.L
A 30-year-old woman was evaluated because of back pain, leg stiffness, and falling. Tone was increased in the legs. Exaggeration of the normal lumbar lordosis was seen on MRI. A diagnosis was made.
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Microplastics and Nanoplastics in Atheromas N. Engl. J. Med. (IF 158.5) Pub Date : 2024-05-09
To the Editor: Marfella et al. (March 7 issue)1 found the presence of microplastics and nanoplastics (MNPs) in carotid artery plaque and linked it with a higher risk of cardiovascular events. Howev...
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Physiological Integration of Taste and Metabolism N. Engl. J. Med. (IF 158.5) Pub Date : 2024-05-09 Dan L. Longo, Josephine M. Egan From the Diabetes Section, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore.
Much of what we learned in school about how we taste is wrong. Progress in understanding how taste works is providing insights that may help in the management of obesity, diabetes, and other illnesses.
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Recombinant ADAMTS13 for Immune Thrombotic Thrombocytopenic Purpura N. Engl. J. Med. (IF 158.5) Pub Date : 2024-05-09 Pavan K. Bendapudi, Brody H. Foy, Sarah B. Mueller, Jun Liu, Louis M. Feingold, Kristen E. Burke, Wendy Cruz, Maria Y. Chen, Emily S. Lau, Rachel L. Goldberg, Ishan Tatake, Shelby C. Wilkinson, Brian J. Carney, James R. Stone, Doyun Park, Alzira R. Avelino, Sajjad Hassan, Chester Andrzejewski, Kristen N. Ruby, Kenneth D. Friedman, Patricia A.R. Brunker, Rebecca K. Leaf, John Higgins, Walter H. Dzik
In patients with immune thrombotic thrombocytopenic purpura (iTTP), autoantibodies against the metalloprotease ADAMTS13 lead to catastrophic microvascular thrombosis. However, the potential benefit...
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Trial of Thrombectomy for Stroke with a Large Infarct of Unrestricted Size N. Engl. J. Med. (IF 158.5) Pub Date : 2024-05-09 Vincent Costalat, Tudor G. Jovin, J.F. Albucher, Christophe Cognard, Hilde Henon, Nasreddine Nouri, Benjamin Gory, Sebastien Richard, Gaultier Marnat, Igor Sibon, Federico Di Maria, Mariam Annan, Grégoire Boulouis, Pere Cardona, Michael Obadia, Michel Piotin, Romain Bourcier, Benoit Guillon, Sophie Godard, Anne Pasco-Papon, Omer F. Eker, Tae-Hee Cho, Guillaume Turc, Olivier Naggara, Stéphane Velasco
The use of thrombectomy in patients with acute stroke and a large infarct of unrestricted size has not been well studied.We assigned, in a 1:1 ratio, patients with proximal cerebral vessel occlusio...
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Guidance on terminology, application, and reporting of citation searching: the TARCiS statement BMJ (IF 105.7) Pub Date : 2024-05-09 Julian Hirt, Thomas Nordhausen, Thomas Fuerst, Hannah Ewald, Christian Appenzeller-Herzog
Evidence syntheses adhering to systematic literature searching techniques are a cornerstone of evidence based healthcare. Beyond term based searching in electronic databases, citation searching is a prevalent search technique to identify relevant sources of evidence. However, for decades, citation searching methodology and terminology has not been standardised. An evidence guided, four round Delphi
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Association of ultra-processed food consumption with all cause and cause specific mortality: population based cohort study BMJ (IF 105.7) Pub Date : 2024-05-08 Zhe Fang, Sinara Laurini Rossato, Dong Hang, Neha Khandpur, Kai Wang, Chun-Han Lo, Walter C Willett, Edward L Giovannucci, Mingyang Song
Objective To examine the association of ultra-processed food consumption with all cause mortality and cause specific mortality. Design Population based cohort study. Setting Female registered nurses from 11 US states in the Nurses’ Health Study (1984-2018) and male health professionals from all 50 US states in the Health Professionals Follow-up Study (1986-2018). Participants 74 563 women and 39 501
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Ovarian cancer: identifying and managing familial and genetic risk—summary of new NICE guidance BMJ (IF 105.7) Pub Date : 2024-05-09 Eric Slade, Laura Berg, Katharina Dworzynski, Ranjit Manchanda
### What you need to know In the UK, around 7500 women are diagnosed with ovarian cancer annually. Approximately 340 000 to 440 000 UK women carry a pathogenic variant in a high risk gene that increases their risk of developing the disease.1 However, only around 3% of people with a high risk gene know that they carry it.2 Most ovarian cancers associated with high risk genes are diagnosed at advanced