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Response to: You et al., ‘Comment on: How effective are exercises delivered digitally (requiring internet), amongst patients with hip or knee osteoarthritis? A systematic review and meta-analysis’ Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-05-09 Matthew G. King, Mark J. Scholes, Iryoung Fan, Dhruv Govil, Adam I. Semciw
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Clinical practice guidelines for osteoarthritis: Caveats related to discrepancies in recommendations Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-05-09 Robin Christensen, Amanda E. Nelson
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Collaborative model of care between orthopaedics and allied healthcare professionals (CONNACT) in knee osteoarthritis: Effectiveness-implementation hybrid randomized controlled trial of a community-based, multidisciplinary, stratified intervention Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-05-06 Bryan Y. TAN, Yang Su-Yin, Michelle J. Pereira, Tan C. Yue, LIM C. Joo, NG Julia Poh-Hwee, Lee K. Thiam, Pua Y. Hao, Andrew M. Briggs, David J. Hunter, Soren T. Skou, Julian Thumboo, Josip Car
To compare the clinical and cost effectiveness of the Collaborative Model of Care between Orthopaedics and Allied Healthcare Professionals (CONNACT), a community-based, stratified, multidisciplinary intervention consisting of exercise, education, psychological and nutrition delivered through a chronic care model to usual hospital care in adults with knee osteoarthritis (OA). Pragmatic, parallel-arm
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DDIT3 aggravates TMJOA cartilage degradation via Nrf2/HO-1/NLRP3-mediated autophagy Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-05-06 Chang Yang, Wei Dong, Yan Wang, Xiaofei Dong, Xiaoxiao Xu, Xijie Yu, Jiawei Wang
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Impact of depressive symptoms on direct medical cost among medicare recipients with knee osteoarthritis Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-05-06 Heidi Y. Yang, Zoey S. Song, Jamie E. Collins, Elena Losina
Depressive symptoms are prevalent among knee osteoarthritis (KOA) patients and may lead to additional medical costs. We compared medical costs in Medicare Current Beneficiary Survey (MCBS) respondents with KOA with and without self-reported depressive symptoms. We identified a KOA cohort using ICD-9/10 diagnostic codes in both Part A and Part B claims among community-dwelling MCBS respondents from
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Unraveling sex-specific risks of knee osteoarthritis before menopause: Do sex differences start early in life? Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-05-02 Paula A. Hernandez, John Churchill Bradford, Priyanka Brahmachary, Sophia Ulman, Jennifer L. Robinson, Ronald K. June, Magali Cucchiarini
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Surgical restabilization reduces the progression of post-traumatic osteoarthritis initiated by ACL rupture in mice Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-30 Yu-Yang Lin, Elias H. Jbeily, Priscilla M. Tjandra, Michael C. Pride, Michael Lopez-Torres, Seif B. Elmankabadi, Connor M. Delman, Kristin K. Biris, Heejung Bang, Jill L. Silverman, Cassandra A. Lee, Blaine A. Christiansen
People who sustain joint injuries such as anterior cruciate ligament (ACL) rupture often develop post-traumatic osteoarthritis (PTOA). In human patients, ACL injuries are often treated with ACL reconstruction. However, it is still unclear how effective joint restabilization is for reducing the progression of PTOA. The goal of this study was to determine how surgical restabilization of a mouse knee
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Hand osteoarthritis phenotypes based on a biopsychosocial approach, and their associations with cross-sectional and longitudinal pain Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-30 Elisabeth Mulrooney, Tuhina Neogi, Hanne Dagfinrud, Hilde B. Hammer, Pernille S. Pettersen, Tore K. Kvien, Karin Magnusson, Ida K. Haugen
Hand osteoarthritis (OA) pain is characterized as heterogeneous and multifactorial. Differences in pain may be explained by underlying phenotypes, which have not been previously explored Latent class analysis determined classes of participants with hand OA from the Nor-Hand study baseline examination (2016–17) based on a biopsychosocial framework. Outcomes were hand and overall bodily pain intensity
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The efficacy and safety of a fixed-dose combination of apocynin and paeonol, APPA, in symptomatic knee OA: A double-blind, randomized, placebo-controlled, clinical trial Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-30 Asger R. Bihlet, Inger Byrjalsen, Jeppe R. Andersen, Alan Reynolds, Nicholas Larkins, Peter Alexandersen, Helene Rovsing, Robert Moots, Philip G. Conaghan
Apocynin (AP) and paeonol (PA) are low molecular weight phenolic compounds with a broad array of anti-inflammatory and immunoregulatory effects. This study assessed of a fixed-dose combination of APPA in people with symptomatic knee osteoarthritis (OA). A multi-center, randomized, placebo-controlled, double-blind phase 2a trial enrolled participants with radiographic knee OA (Kellgren-Lawrence, KL
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Gender differences in patterns of cartilage loss: Data from the Osteoarthritis Initiative Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-29 Rebecca Amesbury, Hedieh Ragati-Haghi, Alexander Mathiessen, Todd Laffaye, Rebekkah I. Stein, Jamie E. Collins, C. Kent Kwoh, Jeffrey Duryea
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HSP70—A key regulator in chondrocyte homeostasis under naturally coupled hydrostatic pressure-thermal stimuli Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-26 Yanheng Guo, Theofanis Stampoultzis, Peyman Karami, Naser Nasrollahzadeh, Vijay K. Rana, Dominique P. Pioletti
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Non-invasive electroarthrography measures cartilage in live horses and correlates to direct measurements of cartilage streaming potentials in weight bearing regions of equine metacarpophalangeal joints Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-26 Adele Changoor, Martin Garon, Eric Quenneville, Pierre Savard, Michael D. Buschmann, Mark B. Hurtig
To perform non-invasive Electroarthrography (EAG) on live horses and establish relationships between EAG and direct measurements of cartilage streaming potentials in weight bearing areas of the equine metacarpophalangeal joint. EAG was performed bilaterally on the metacarpophalangeal joints of live horses (n = 3). Separate experiments used metacarpophalangeal joint explants (n = 11) to measure EAG
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Comparative effectiveness of different placebos and comparator groups for hand osteoarthritis exploring the impact of contextual factors: A systematic review and meta-analysis of randomised trials Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-26 Ida Maria Balsby, Sabrina M. Nielsen, Robin Christensen, Marius Henriksen, Louise Ulff-Møller Dahl, Johannes Iuel Berg, Simon Tarp, Féline Kroon, Margreet Kloppenburg, Weiya Zhang, David J. Hunter, Henning Bliddal, Anna Døssing
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Comment on: How effective are exercises delivered digitally (requiring internet), amongst patients with hip or knee osteoarthritis? A systematic review and meta-analysis Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-25 Yingang You, Qiufang Wei, Yuepeng Teng, Miaomiao Miao
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Corrigendum to ‘Advances in organ-on-a-chip systems for modelling joint tissue and osteoarthritic diseases’ Osteoarthritis Cartilage 30 (2022) 1050-1061 Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-21 L. Banh, K.K. Cheung, M.W.Y. Chan, E.W.K. Young, S. Viswanathan
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Association between hip muscle strength/function and hip cartilage defects in sub-elite football players with hip/groin pain Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-20 S.L. Coburn, K.M. Crossley, J.L. Kemp, F. Gassert, J. Luitjens, S.J. Warden, A.G. Culvenor, M.J. Scholes, M.G. King, P. Lawrenson, T.M. Link, J.J. Heerey
To explore associations between hip muscle strength and cartilage defects (presence and severity) on magnetic resonance imaging (MRI) in young adults with hip/groin pain participating in sub-elite football. Sub-elite football players with hip/groin pain (>6 months) completed assessments of isometric hip strength and functional task performance. Hip cartilage defects were assessed using the Scoring
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Serum levels of hydroxylated metabolites of arachidonic acid cross-sectionally and longitudinally predict knee pain progression: an observational cohort study Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-20 James Turnbull, Rakesh R. Jha, Peter R.W. Gowler, Rose Ferrands-Bentley, Dong-Hyun Kim, David A. Barrett, Aliya Sarmanova, Gwen S. Fernandes, Michael Doherty, Weiya Zhang, David A. Walsh, Ana M. Valdes, Victoria Chapman
To examine associations between serum oxylipins, which regulate tissue repair and pain signalling, and knee pain/radiographic osteoarthritis (OA) at baseline and knee pain at 3 year follow-up. Baseline, and 3 year follow-up, knee pain phenotypes were assessed from 154 participants in the Knee Pain in the Community (KPIC) cohort study. Serum and radiographic Kellgren and Lawrence (KL) and Nottingham
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Mild exercise expedites joint clearance and slows joint degradation in a joint instability model of osteoarthritis in male rats Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-18 Jarred M. Kaiser, Fabrice C. Bernard, Krishna Pucha, Sarvgna K. Raval, Tracy Eng, Travis Fulton, Shannon E. Anderson, Kyle D. Allen, J. Brandon Dixon, Nick J. Willett
Exercise remains a hallmark treatment for post-traumatic osteoarthritis (PTOA) and may maintain joint homeostasis in part by clearing inflammatory cytokines, cells, and particles. It remains largely unknown whether exercise-induced joint clearance can provide therapeutic relief of PTOA. In this study, we hypothesized that exercise could slow the progression of preclinical PTOA in part by enhancing
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Osteochondral fluid transport in an ex vivo system Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-15 Brady David Hislop, Ara K. Mercer, Alexandria G. Whitley, Erik P. Myers, Marie Mackin, Chelsea M. Heveran, Ronald K. June
Alterations to bone-to-cartilage fluid transport may contribute to the development of osteoarthritis (OA). Larger biological molecules in bone may transport from bone-to-cartilage ( insulin, 5 kDa). However, many questions remain about fluid transport between these tissues. The objectives of this study were to (1) test for diffusion of 3 kDa molecular tracers from bone-to-cartilage and (2) assess potential
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Adiposity and cartilage lesions following ACL reconstruction Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-15 Harvi F. Hart, Kay M. Crossley, Brooke E. Patterson, Ali Guermazi, Trevor B. Birmingham, Chris Koskoletos, Amélie Michaud, Alysha De Livera, Adam G. Culvenor
To determine if global, central, or peripheral adiposity is associated with prevalent and worsening cartilage lesions following anterior cruciate ligament reconstruction (ACLR). In 107 individuals one-year post-ACLR, adiposity was assessed globally (body mass index), centrally (waist circumference), and peripherally (knee subcutaneous adipose tissue thickness) from magnetic resonance imaging (MRI)
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Assessing the efficacy of the Stop OsteoARthritis (SOAR) program: A randomized delayed-controlled trial in persons at increased risk of early onset post-traumatic knee osteoarthritis Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-12 Justin M. Losciale, Linda K. Truong, Kexin Zhang, Trish Silvester-Lee, Maxi Miciak, Andrea Pajkic, Christina Y. Le, Hui Xie, Alison M. Hoens, Amber D. Mosewich, Michael A. Hunt, Linda C. Li, Ewa M. Roos, Jackie L. Whittaker
Assess the efficacy of an 8-week virtual, physiotherapist (PT)-guided knee health program (Stop OsteoARthritis (SOAR)) to improve knee extensor strength in individuals at risk of post-traumatic knee osteoarthritis (PTOA). In this superiority, randomized delayed-control trial, persons aged 16–35 years, 1–4 years after a self-reported knee joint injury were randomly assigned (1:1) to receive the SOAR
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Elevated nutrient availability enhances chondrocyte metabolism and biosynthesis in tissue-engineered cartilage Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-12 Roberto Tarantino, Halie Mei Jensen, Stephen D. Waldman
Chondrocytes, which typically rely on anaerobic metabolism, exhibit upregulated biosynthetic activity when subjected to conditions that elicit mixed aerobic-anaerobic metabolism. Previously, we observed that increasing media volume resulted in the transition from anaerobic to mixed aerobic-anaerobic metabolism. Maximal extracellular matrix (ECM) accumulation occurred at this transition as a result
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Transient receptor potential vanilloid 4 regulates extracellular matrix composition and mediates load-induced intervertebral disc degeneration in a mouse model Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-09 Min Kyu Mark Kim, Matthew Lawrence, Diana Quinonez, Courtney Brooks, Rithwik Ramachandran, Cheryle A. Séguin
Transient receptor potential vanilloid 4 (TRPV4) is a multi-modally activated cation channel that mediates mechanotransduction pathways by which musculoskeletal tissues respond to mechanical load and regulate tissue health. Using conditional knockout mice, we investigated the role of in regulating intervertebral disc (IVD) health and injury-induced IVD degeneration. ( KO) mice were used to knockout
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Sex differences in osteoarthritis prevalence, pain perception, physical function and therapeutics Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-06 Neil A. Segal, Jeannine M. Nilges, Win Min Oo
Women have a higher prevalence of osteoarthritis (OA) and worse clinical courses than men. However, the underlying factors and therapeutic outcomes of these sex-specific differences are incompletely researched. This review examines the current state of knowledge regarding sex differences in OA prevalence, risk factors, pain severity, functional outcomes, and use and response to therapeutics. PubMed
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Pioneering a chick embryo model to explore the intrauterine etiology of developmental dysplasia of the hip in oligohydramnios conditions Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-06 Shaoting Luo, Yufan Chen, Weizheng Zhou, Federico Canavese, Lianyong Li
To explore the impact of oligohydramnios on fetal movement and hip development, given its association with developmental dysplasia of the hip (DDH) but unclear mechanisms. Chick embryos were divided into four groups based on the severity of oligohydramnios induced by amniotic fluid aspiration (control, 0.2 mL, 0.4 mL, 0.6 mL). Fetal movement was assessed by detection of movement and quantification
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Exploring the association of gender role expectations of pain and measures of pain sensitization in people with knee osteoarthritis: A cross-sectional study Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-02 Y.V. Raghava Neelapala, Saurab Sharma, Lisa C. Carlesso
First, we explored the association between Gender Role Expectations of Pain (GREP), and psychophysical measures of sensitization in people with knee osteoarthritis (OA). Second, we explored whether the association differed by level of GREP items (high vs low scores). We conducted secondary analyses of a cohort study. Those who were (i) age of ≥40, English or French speaking, ii) diagnosed with knee
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Post-traumatic and OA-related lesions in the knee at baseline and 2 years after traumatic meniscal injury: Secondary analysis of a randomized controlled trial Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-02 Sabine J.A. van der Graaff, Edwin H.G. Oei, Max Reijman, Lars Steenbekkers, Marienke van Middelkoop, Rianne A. van der Heijden, Duncan E. Meuffels, STARR Study Group
To assess the presence of early degenerative changes on Magnetic Resonance Imaging (MRI) 24 months after a traumatic meniscal tear and to compare these changes in patients treated with arthroscopic partial meniscectomy or physical therapy plus optional delayed arthroscopic partial meniscectomy. We included patients aged 18–45 years with a recent onset, traumatic, MRI verified, isolated meniscal tear
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Studies on postoperative outcome prognostic factors reveal intrinsic nature of osteoarthritis as a systemic disease: Comment on Osteoarthritis and Cartilage 2023;24(1):98–107 Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-29 E.V. Tchetina, E.A. Taskina
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One leg testing in hip and knee osteoarthritis: A comparison with a two-leg oriented functional outcome measure and self-reported functional measures Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-27 R. Bendrik, B. Sundström, K. Bröms, M. Emtner, LV Kallings, M. Peterson
To compare the responsiveness of two unilateral lower-limb performance-based tests, the one-leg rise test and the maximal step-up test, with the bilateral 30-second chair-stand test and the self-reported measure of physical function (HOOS/KOOS). Specific aims were to evaluate responsiveness, floor/ceiling effect and association between the instruments. Data was included from 111 participants, mean
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Sex-specific effects of injury and beta-adrenergic activation on metabolic and inflammatory mediators in a murine model of post-traumatic osteoarthritis Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-26 Ravi K. Komaravolu, Padmaja Mehta-D’souza, Taylor Conner, Madeline Allen, Jessica Lumry, Albert Batushansky, Nathan P. Pezant, Courtney G. Montgomery, Timothy M. Griffin
Metabolic processes are intricately linked to the resolution of innate inflammation and tissue repair, two critical steps for treating post-traumatic osteoarthritis (PTOA). Based on lipolytic and immunoregulatory actions of norepinephrine, we hypothesized that intra-articular β-adrenergic receptor (βAR) stimulation would suppress PTOA-associated inflammation in the infrapatellar fat pad (IFP) and synovium
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In response to comment from E. V. Tchetina and E. A. Taskina re. ‘Association of synovial fluid and urinary C2C-HUSA levels with surgical outcomes post-total knee arthroplasty’ Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-26 Jason S. Rockel, Amit Sandhu, Osvaldo Espin-Garcia, A. Robin Poole, Mohit Kapoor
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Response to commentary by Dvir-Ginzberg et al. Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-26 Paula A. Hernandez
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Do we understand sex-related differences governing dimorphic disease mechanisms in preclinical animal models of osteoarthritis? Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-24 Mona Dvir-Ginzberg, Yonathan H. Maatuf, Ali Mobasheri
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Mechanical loading rescues mechanoresponsiveness in a human osteoarthritis explant model despite Wnt activation Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-15 R. Castro-Viñuelas, N. Viudes-Sarrión, A.V. Rojo-García, S. Monteagudo, R.J. Lories, I. Jonkers
Optimizing rehabilitation strategies for osteoarthritis necessitates a comprehensive understanding of chondrocytes’ mechanoresponse in both health and disease, especially in the context of the interplay between loading and key pathways involved in osteoarthritis (OA) development, like canonical Wnt signaling. This study aims to elucidate the role of Wnt signaling in the mechanoresponsiveness of healthy
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Exercise for knee osteoarthritis pain: Association or causation? Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-13 Marius Henriksen, Jos Runhaar, Aleksandra Turkiewicz, Martin Englund
Exercise is universally recommended as a primary strategy for the management of knee osteoarthritis (OA) pain. The recommendations are based on results from more than 100 randomized controlled trials (RCTs) that compare exercise to no-attention control groups. However, due to the inherent difficulties with adequate placebo control, participant blinding and the use of patient-reported outcomes, the
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Appraisal of quality and analysis of the similarities and differences between osteoarthritis Clinical Practice Guideline recommendations: A systematic review Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-05 Bimbi Gray, Alison Gibbs, Jocelyn L. Bowden, Jillian P. Eyles, Sandra Grace, Kim Bennell, Rinie Geenen, Sharon Kolasinski, Christian Barton, Philip G. Conaghan, Timothy McAlindon, Olivier Bruyere, Quentin Géczy, David J. Hunter
Clinical Practice Guidelines (CPGs) aim to support management of hip and knee osteoarthritis (OA), but recommendations are often conflicting and implementation is poor, contributing to evidence-to-practice gaps. This systematic review investigated the contextual and methodological factors contributing to conflicting recommendations for hip and knee OA. Our systematic review appraised CPGs for managing
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Exploratory neutron tomography of articular cartilage Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-04 E. Tobias B. Wrammerfors, Elin Törnquist, Maria Pierantoni, Amanda Sjögren, Alessandro Tengattini, Anders Kaestner, René in ’t Zandt, Martin Englund, Hanna Isaksson
To investigate the feasibility of using neutron tomography to gain new knowledge of human articular cartilage degeneration in osteoarthritis (OA). Different sample preparation techniques were evaluated to identify maximum intra-tissue contrast. Human articular cartilage samples from 14 deceased donors (18–75 years, 9 males, 5 females) and 4 patients undergoing total knee replacement due to known OA
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Hip contact forces can be predicted with a neural network using only synthesised key points and electromyography in people with hip osteoarthritis Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-03 Bradley M. Cornish, Claudio Pizzolato, David J. Saxby, Zhengliang Xia, Daniel Devaprakash, Laura E. Diamond
To develop and validate a neural network to estimate hip contact forces (HCF), and lower body kinematics and kinetics during walking in individuals with hip osteoarthritis (OA) using synthesised anatomical key points and electromyography. To assess the capability of the neural network to detect directional changes in HCF resulting from prescribed gait modifications. A calibrated electromyography-informed
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Modulation of early osteoarthritis by tibiofemoral re-alignment in sheep Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-03 Jan Reinhard, Tamás Oláh, Matthias W. Laschke, Lars K.H. Goebel, Gertrud Schmitt, Susanne Speicher-Mentges, Michael D. Menger, Magali Cucchiarini, Dietrich Pape, Henning Madry
To investigate whether tibiofemoral alignment influences early knee osteoarthritis (OA). We hypothesized that varus overload exacerbates early degenerative osteochondral changes, and that valgus underload diminishes early OA. Normal, over- and underload were induced by altering alignment via high tibial osteotomy in adult sheep (n = 8 each). Simultaneously, OA was induced by partial medial anterior
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Timing is everything: Towards classification criteria for early-stage symptomatic knee osteoarthritis Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-02 Armaghan Mahmoudian, Lauren K. King, Jean W. Liew, Qiuke Wang, C. Thomas Appleton, Martin Englund, Ida K. Haugen, L. Stefan Lohmander, Jos Runhaar, Aleksandra Turkiewicz, Tuhina Neogi, Gillian A. Hawker, on behalf of the OARSI Early-stage Symptomatic Knee Osteoarthritis Initiative
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Inhibition of Phlpp1 preserves the mechanical integrity of articular cartilage in a murine model of post-traumatic osteoarthritis Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-01 Katherine M. Arnold, Samantha R. Weaver, Elizabeth L. Zars, Daniel J. Tschumperlin, Jennifer J. Westendorf
Phlpp1 inhibition is a potential therapeutic strategy for cartilage regeneration and prevention of post-traumatic osteoarthritis (PTOA). To understand how Phlpp1 loss affects cartilage structure, cartilage elastic modulus was measured with atomic force microscopy (AFM) in male and female mice after injury. Osteoarthritis was induced in male and female Wildtype (WT) and Phlpp1 mice by destabilization
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Evolution and advancements in genomics and epigenomics in OA research: How far we have come Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-28 Yolande F.M. Ramos, Sarah J. Rice, Shabana Amanda Ali, Chiara Pastrello, Igor Jurisica, Muhammad Farooq Rai, Kelsey H. Collins, Annemarie Lang, Tristan Maerz, Jeroen Geurts, Cristina Ruiz-Romero, Ronald K. June, C. Thomas Appleton, Jason S. Rockel, Mohit Kapoor
Osteoarthritis (OA) is the most prevalent musculoskeletal disease affecting articulating joint tissues, resulting in local and systemic changes that contribute to increased pain and reduced function. Diverse technological advancements have culminated in the advent of high throughput “omic” technologies, enabling identification of comprehensive changes in molecular mediators associated with the disease
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A missed opportunity: A scoping review of the effect of sex and age on osteoarthritis using large animal models Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-24 Holly L. Stewart, Derek Gilbert, Darko Stefanovski, Zoe Garman, Michael B. Albro, Manish Bais, Mark W. Grinstaff, Brian D. Snyder, Thomas P. Schaer
The objective was to critically analyze the published literature accounting for sex differences and skeletal age (open vs. closed physis) in preclinical animal models of OA, including the disaggregation of data by sex and skeletal maturity when data is generated from combined sex and/or multi-aged cohorts without proper confounding. A scoping literature review of PubMed, Web of Science, EMBASE, and
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Reflections on 30 years of publishing osteoarthritis research: Where we’ve been and where we’re going Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-23 Michelle S. Yau, Stephanie R. Filbay, Joel A. Block, L. Stefan Lohmander
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miR-708–5p deficiency involves the degeneration of mandibular condylar chondrocytes via the TLR4/NF-κB pathway Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-23 Lingfeng Xu, Yuejiao Zhang, Jia Yu, Wanqiu Huo, Jiali Xu, Hongxu Yang, Mian Zhang, Shibing Yu, Yaoping Wu, Meiqing Wang
Ageing and aberrant biomechanical stimulation are two major risk factors for osteoarthritis (OA). One of the main characteristics of aged cartilage is cellular senescence. One of the main characteristics of osteoarthritic joints is cartilage degeneration. The cells in the temporomandibular joint (TMJ) cartilage are zonally arranged. The deep zone cells are differentiated from the superficial zone cells
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Alterations in compositional and cellular properties of the subchondral bone are linked to cartilage degeneration in hip osteoarthritis Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-23 Julian Delsmann, Julian Eissele, Alexander Simon, Assil-Ramin Alimy, Simon von Kroge, Herbert Mushumba, Klaus Püschel, Björn Busse, Christian Ries, Michael Amling, Frank Timo Beil, Tim Rolvien
The subchondral bone is an emerging regulator of osteoarthritis (OA). However, knowledge of how specific subchondral alterations relate to cartilage degeneration remains incomplete. Femoral heads were obtained from 44 patients with primary OA during total hip arthroplasty and from 30 non-OA controls during autopsy. A multiscale assessment of the central subchondral bone region comprising histomorphometry
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Assessing the degree to which randomized control trials align with the core outcome set for osteoarthritis of knee and hip: A cross-sectional analysis Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-23 Trevon Jelinek, Alec Young, Garrett Jones, Kimberly Magana, Trevor Magee, Shaelyn Ward, Jay Modi, Kyle Fitzgerald, Griffin Hughes, Alicia Ito Ford, Matt Vassar
To assess the degree of core outcome set alignment and identify issues with alignment to the 2019 COS among clinical trial registrations focused on knee and/or hip osteoarthritis (OA). Our search was performed on registered knee and hip OA randomized controlled trials (RCTs) available on ClinicalTrials.gov and WHO International Clinical Trials Registry Platform. The screening process considered trials
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Importance of IL-6 trans-signaling and high autocrine IL-6 production in human osteoarthritic chondrocyte metabolism Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-16 Annett Eitner, Christian König, Felix C. Kohler, Gunther O. Hofmann, Britt Wildemann, Matthias Aurich, Hans-Georg Schaible
Neutralization of Interleukin (IL)-6-signaling by antibodies is considered a promising tool for the treatment of osteoarthritis (OA). To gain further insight into this potential treatment, this study investigated the effects of IL-6-signaling and IL-6 neutralization on chondrocyte metabolism and the release of IL-6-signaling-related mediators by human chondrocytes. Chondrocytes were collected from
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Progress in rehabilitation-related exercise for knee OA at OARSI over the past 30 years Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-13 Daniel K. White, Louise M. Thoma
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Obesity and body mass index: Past and future considerations in osteoarthritis research Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-12 Kristine Godziuk, Gillian A. Hawker
Obesity is an important topic for the osteoarthritis (OA) scientific community. However, the predominant use of body mass index (BMI) to define obesity in OA research is associated with uncertainties and limitations. These include an inability to discern fat and muscle mass, account for sex-differences in fat distribution, or identify adiposity-related health impairments. A focus on BMI in OA research
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Changing the narrative on osteoarthritis: A call for global action Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-12 Clare Jinks, Angie Botto-van Bemden, Samantha Bunzli, Jocelyn Bowden, Thorlene Egerton, Jillian Eyles, Nadine Foster, Emma L. Healey, John Maddison, Daniel O’Brien, Jonathan G. Quicke, Dieuwke Schiphof, Emma Parry, Martin J. Thomas, Melanie A. Holden, Change OA Narrative (COAN) Initiative, Kelli Allen, Opeyemi O Babatunde, Kim L Bennel, Alice Berry, Sita Bierma-Zeinstra, Leigh Callahan, Laura Campbell
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30 Years of MRI-based cartilage & bone morphometry in knee osteoarthritis: From correlation to clinical trials Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-06 Felix Eckstein, Anita E. Wluka, Wolfgang Wirth, Flavia Cicuttini
The first publication on morphometric analysis of articular cartilage using magnetic resonance imaging (MRI) in 1994 set the scene for a game change in osteoarthritis (OA) research. The current review highlights milestones in cartilage and bone morphometry, summarizing the rapid progress made in imaging, its application to understanding joint (patho-)physiology, and its use in interventional clinical
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Adoption of core outcome sets in osteoarthritis clinical trials: Still a long way to go Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-05 Toby O. Smith
Abstract not available
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Associations of inflammatory and metabolic biomarkers with incident erosive hand osteoarthritis in the osteoarthritis initiative cohort Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-03 Timothy E. McAlindon, Jennifer L. Hunnicutt, Mary B. Roberts, Ida K. Haugen, Lena F. Schaefer, Jeffrey B. Driban, Bing Lu, Jeffrey Duryea, Stacy E. Smith, Sarah L. Booth, Gayle A. Petty, Alexander Mathiessen, Li Zeng, Charles Eaton
Erosive hand osteoarthritis (eHOA) is a subtype of hand osteoarthritis (OA) that develops in finger joints with pre-existing OA and is differentiated by clinical characteristics (hand pain/disability, inflammation, and erosions) that suggest inflammatory or metabolic processes. This was a longitudinal nested case-cohort design among Osteoarthritis Initiative participants who had hand radiographs at
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Molecular pathogenesis of OA pain: Past, present, and future Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-01-18 Tonia L. Vincent, Rachel E. Miller
To provide a historical perspective and narrative review on research into the molecular pathogenesis of osteoarthritis pain. PubMed databases were searched for combinations of “osteoarthritis”, “pain” and “animal models” for papers that represented key phases in the history of osteoarthritis pain discovery research including epidemiology, pathology, imaging, preclinical modeling and clinical trials
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Assessing the association of epigenetic age acceleration with osteoarthritis in the Multicenter Osteoarthritis Study (MOST) Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-01-17 Michelle S. Yau, Paul C. Okoro, Ida K. Haugen, John A. Lynch, Michael C. Nevitt, Cora E. Lewis, James C. Torner, David T. Felson
Advancing age is one of the strongest risk factors for osteoarthritis (OA). DNA methylation-based measures of epigenetic age acceleration may provide insights into mechanisms underlying OA. We analyzed data from the Multicenter Osteoarthritis Study in a subset of 671 participants ages 45–69 years with no or mild radiographic knee OA. DNA methylation was assessed with the Illumina Infinium MethylationEPIC
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Anaphylatoxins and their corresponding receptors as potential drivers in cartilage calcification during osteoarthritis progression Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-01-17 Leonie Ruths, Markus Huber-Lang, Gundula Schulze-Tanzil, Jana Riegger
The complement cascade as major fluid phase innate immune system is activated during progression of osteoarthritis (OA). Generated anaphylatoxins and the corresponding receptors C3aR and C5aR1 are associated with the calcification of blood vessels and involved in osteogenic differentiation. This study aims on elucidating whether complement activation products contribute to cartilage calcification of
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Looking back on 30+ years of the Johnston County Osteoarthritis Project while looking forward with the Johnston County Health Study: A narrative review Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-01-17 Yvonne M. Golightly, Jordan B. Renner, Charles G. Helmick, Joanne M. Jordan, Amanda E. Nelson
Over the last 30 years, knowledge of the epidemiology of osteoarthritis (OA) has dramatically advanced, and has been on the forefront of disseminating research findings from large OA cohort studies, including the Johnston County OA Project (JoCoOA). The JoCoOA is a population-based, prospective longitudinal cohort that began roughly 30 years ago with a key focus on understanding prevalence, incidence
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Optimising the implementation of evidence-based osteoarthritis guidelines in primary care: Development of a Knowledge Mobilisation Toolkit Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-01-17 Laura Swaithes, Zoe Paskins, Andrew Finney, Nicola Walsh, Magdalena Skrybant, Christian Mallen, Krysia Dziedzic
Implementing clinical guidelines for osteoarthritis (OA) in primary care is complex. Whilst international guidelines detail best practice for OA looks like, little is known about this is best implemented. Limited resources are available to guideline developers, practitioners, researchers, or the public to facilitate implementation. Set in the context of a larger research project which sought to understand