-
The prevalence of chronic pain in children and adolescents: a systematic review update and meta-analysis. Pain (IF 7.4) Pub Date : 2024-05-14 Christine T Chambers, Justine Dol, Perri R Tutelman, Charlotte L Langley, Jennifer A Parker, Brittany T Cormier, Gary J Macfarlane, Gareth T Jones, Darlene Chapman, Nicole Proudfoot, Amy Grant, Justina Marianayagam
Chronic pain, defined as persistent or recurring pain or pain lasting longer than 3 months, is a common childhood problem. The objective of this study was to conduct an updated systematic review and meta-analysis on the prevalence of chronic pain (ie, overall, headache, abdominal pain, back pain, musculoskeletal pain, multisite/general pain, and other) in children and adolescents. EMBASE, PubMed, CINAHL
-
Data-driven identification of distinct pain drawing patterns and their association with clinical and psychological factors: a study of 21,123 patients with spinal pain. Pain (IF 7.4) Pub Date : 2024-05-14 Natalie Hong Siu Chang, Casper Nim, Steen Harsted, James J Young, Søren O'Neill
The variability in pain drawing styles and analysis methods has raised concerns about the reliability of pain drawings as a screening tool for nonpain symptoms. In this study, a data-driven approach to pain drawing analysis has been used to enhance the reliability. The aim was to identify distinct clusters of pain patterns by using latent class analysis (LCA) on 46 predefined anatomical areas of a
-
Use of patient-reported global assessment measures in clinical trials of chronic pain treatments: ACTTION systematic review and considerations. Pain (IF 7.4) Pub Date : 2024-05-14 Dale J Langford, Remington P Mark, Fallon O France, Mahd Nishtar, Meghan Park, Sonia Sharma, Isabel C Shklyar, Thomas J Schnitzer, Philip G Conaghan, Dagmar Amtmann, Bryce B Reeve, Dennis C Turk, Robert H Dworkin, Jennifer S Gewandter
Establishing clinically meaningful changes in pain experiences remains important for clinical trials of chronic pain treatments. Regulatory guidance and pain measurement initiatives have recommended including patient-reported global assessment measures (eg, Patient-Global Impression of Change [PGIC]) to aid interpretation of within-patient differences in domain-specific clinical trial outcomes (eg
-
The relationship between traumatic exposure and pain perception in children: the moderating role of posttraumatic symptoms. Pain (IF 7.4) Pub Date : 2024-05-08 Einat Levy Gigi, Moriya Rachmani, Ruth Defrin
Adverse childhood experiences (ACEs) affect approximately half of all children worldwide. These experiences have been linked to increased pain sensitivity in adulthood and a higher likelihood of developing severe chronic pain. However, most studies have assessed the effects of ACEs retrospectively, long after they occurred, leaving room for other factors to influence the observed outcomes. We investigated
-
Probing white matter microstructure in youth with chronic pain and its relation to catastrophizing using neurite orientation dispersion and density imaging. Pain (IF 7.4) Pub Date : 2024-05-08 Inge Timmers, Emma E Biggs, Lisa Bruckert, Alexandra G Tremblay-McGaw, Hui Zhang, David Borsook, Laura E Simons
Chronic pain is common in young people and can have a major life impact. Despite the burden of chronic pain, mechanisms underlying chronic pain development and persistence are still poorly understood. Specifically, white matter (WM) connectivity has remained largely unexplored in pediatric chronic pain. Using diffusion-weighted imaging, this study examined WM microstructure in adolescents (age M =
-
Parental narrative style moderates the relation between pain-related attention and memory biases in youth with chronic pain. Pain (IF 7.4) Pub Date : 2024-05-08 Aline Wauters, Dimitri M L Van Ryckeghem, Melanie Noel, Kendra Mueri, Sabine Soltani, Tine Vervoort
Negatively biased pain memories robustly predict maladaptive pain outcomes in children. Both attention bias to pain and parental narrative style have been linked with the development of these negative biases, with previous studies indicating that how parents talk to their child about the pain might buffer the influence of children's attention bias to pain on the development of such negatively biased
-
Small fibre neuropathy frequently underlies the painful long-COVID syndrome. Pain (IF 7.4) Pub Date : 2024-05-07 Pietro Falco, Daniel Litewczuk, Giulia Di Stefano, Eleonora Galosi, Caterina Leone, Gianfranco De Stefano, Giuseppe Di Pietro, Lorenzo Tramontana, Maria Rosa Ciardi, Patrizia Pasculli, Maria Antonella Zingaropoli, Lars Arendt-Nielsen, Andrea Truini
Approximately 10% to 20% of individuals with previous SARS-CoV-2 infection may develop long-COVID syndrome, characterized by various physical and mental health issues, including pain. Previous studies suggested an association between small fibre neuropathy and pain in long-COVID cases. In this case-control study, our aim was to identify small fibre neuropathy in patients experiencing painful long-COVID
-
Statistical modeling of acute and chronic pain patient-reported outcomes obtained from ecological momentary assessment. Pain (IF 7.4) Pub Date : 2024-05-07 Andrew Leroux, Ciprian Crainiceanu, Scott Zeger, Margaret Taub, Briha Ansari, Tor D Wager, Emine Bayman, Christopher Coffey, Carl Langefeld, Robert McCarthy, Alex Tsodikov, Chad Brummet, Daniel J Clauw, Robert R Edwards, Martin A Lindquist
Ecological momentary assessment (EMA) allows for the collection of participant-reported outcomes (PROs), including pain, in the normal environment at high resolution and with reduced recall bias. Ecological momentary assessment is an important component in studies of pain, providing detailed information about the frequency, intensity, and degree of interference of individuals' pain. However, there
-
Pain reflects the informational value of nociceptive inputs. Pain (IF 7.4) Pub Date : 2024-05-07 Michel-Pierre Coll, Zoey Walden, Pierre-Alexandre Bourgoin, Veronique Taylor, Pierre Rainville, Manon Robert, Dang Khoa Nguyen, Pierre Jolicoeur, Mathieu Roy
Pain perception and its modulation are fundamental to human learning and adaptive behavior. This study investigated the hypothesis that pain perception is tied to pain's learning function. Thirty-one participants performed a threat conditioning task where certain cues were associated with a possibility of receiving a painful electric shock. The cues that signaled potential pain or safety were regularly
-
Longitudinal examination of associations with the onset of pediatric chronic pain at different pain locations. Pain (IF 7.4) Pub Date : 2024-05-07 Lisa-Marie Rau, Clarissa Humberg, Anna Könning, Nicola Rosenthal, Lorin Stahlschmidt, Julia Wager
Chronic pain is a frequent phenomenon in pediatrics. Little research explores whether there are factors that uniquely predict or accompany the onset of new chronic pain in different locations of the body. In this study, we report pediatric pain data for 3 location subsamples-headache, abdominal pain, and musculoskeletal pain-of a large secondary school sample (N = 2280). We distinguished between participants
-
Recent developments and challenges in positron emission tomography imaging of gliosis in chronic neuropathic pain. Pain (IF 7.4) Pub Date : 2024-05-07 Gaelle M Emvalomenos, James W M Kang, Bianca Jupp, Richelle Mychasiuk, Kevin A Keay, Luke A Henderson
Understanding the mechanisms that underpin the transition from acute to chronic pain is critical for the development of more effective and targeted treatments. There is growing interest in the contribution of glial cells to this process, with cross-sectional preclinical studies demonstrating specific changes in these cell types capturing targeted timepoints from the acute phase and the chronic phase
-
Methods for pragmatic randomized clinical trials of pain therapies: IMMPACT statement. Pain (IF 7.4) Pub Date : 2024-05-03 David Hohenschurz-Schmidt, Dan Cherkin, Andrew S C Rice, Robert H Dworkin, Dennis C Turk, Michael P McDermott, Matthew J Bair, Lynn L DeBar, Robert R Edwards, Scott R Evans, John T Farrar, Robert D Kerns, Michael C Rowbotham, Ajay D Wasan, Penney Cowan, McKenzie Ferguson, Roy Freeman, Jennifer S Gewandter, Ian Gilron, Hanna Grol-Prokopczyk, Smriti Iyengar, Cornelia Kamp, Barbara I Karp, Bethea A Kleykamp
Pragmatic, randomized, controlled trials hold the potential to directly inform clinical decision making and health policy regarding the treatment of people experiencing pain. Pragmatic trials are designed to replicate or are embedded within routine clinical care and are increasingly valued to bridge the gap between trial research and clinical practice, especially in multidimensional conditions, such
-
Translation of paclitaxel-induced peripheral neurotoxicity from mice to patients: the importance of model selection. Pain (IF 7.4) Pub Date : 2024-05-02 Guido Cavaletti, Paola Alberti, Annalisa Canta, Valentina Carozzi, Laura Cherchi, Alessia Chiorazzi, Luca Crippa, Paola Marmiroli, Cristina Meregalli, Eleonora Pozzi, Virginia Rodriguez-Menendez, Christian Steinkühler, Simonetta Andrea Licandro
Paclitaxel-induced peripheral neurotoxicity (PIPN) is a potentially dose-limiting side effect in anticancer chemotherapy. Several animal models of PIPN exist, but their results are sometimes difficult to be translated into the clinical setting. We compared 2 widely used PIPN models characterized by marked differences in their methodologies. Female C57BL/6JOlaHsd mice were used, and they received only
-
Patients' perspective on the chronic pain classification in the 11th revision of the International Classification of Diseases (ICD-11): results from an international web-based survey. Pain (IF 7.4) Pub Date : 2024-05-02 Beatrice Korwisi, Ginea Hay, Patrice Forget, Deirdre Ryan, Rolf-Detlef Treede, Winfried Rief, Antonia Barke
The 11th revision of the International Classification of Diseases and Related Health Problems (ICD-11) aims at improving the lives of persons with the lived experience of chronic pain by providing clearly defined and clinically useful diagnoses that can reduce stigma, facilitate communication, and improve access to pain management, among others. The aim of this study was to assess the perspective of
-
Terpenes from Cannabis sativa induce antinociception in a mouse model of chronic neuropathic pain via activation of adenosine A2A receptors. Pain (IF 7.4) Pub Date : 2024-05-02 Abigail M Schwarz, Attila Keresztes, Thai Bui, Ryan Hecksel, Adrian Peña, Brianna Lent, Zhan-Guo Gao, Martín Gamez-Rivera, Caleb A Seekins, Kerry Chou, Taylor L Appel, Kenneth A Jacobson, Fahad A Al-Obeidi, John M Streicher
Terpenes are small hydrocarbon compounds that impart aroma and taste to many plants, including Cannabis sativa. A number of studies have shown that terpenes can produce pain relief in various pain states in both humans and animals. However, these studies were methodologically limited and few established mechanisms of action. In our previous work, we showed that the terpenes geraniol, linalool, β-pinene
-
The downside to choice: instrumental control increases conditioned nocebo hyperalgesia. Pain (IF 7.4) Pub Date : 2024-05-02 Biya Tang, Evan Livesey, Ben Colagiuri
Nocebo hyperalgesia is a pervasive problem in which the treatment context triggers negative expectations that exacerbate pain. Thus, developing ethical strategies to mitigate nocebo hyperalgesia is crucial. Emerging research suggests that choice has the capacity to reduce nocebo side effects, but choice effects on nocebo hyperalgesia have not been explored. This study investigated the impact of choice
-
The associations of opioid and benzodiazepine prescriptions with injuries among US military service members. Pain (IF 7.4) Pub Date : 2024-05-02 Marija S Kelber, Derek J Smolenski, Bradley E Belsher, Kevin O'Gallagher, Fuad Issa, Lindsay Thonsen Stewart, Daniel P Evatt
Given the high rates of physical trauma and pain among service members, opioid-prescribing practices and use patterns have significant implications for the well-being of service members and can affect military medicine and personnel readiness. This study measured the association between prescribed opioid and benzodiazepine medications and subsequently reported injuries (accidental, alcohol and drug
-
Analgesic candidate adenosine A3 receptors are expressed by perineuronal peripheral macrophages in human dorsal root ganglion and spinal cord microglia. Pain (IF 7.4) Pub Date : 2024-04-30 Matthew R Sapio, Ellen S Staedtler, Diana M King, Dragan Maric, Jahandar Jahanipour, Andre Ghetti, Kenneth A Jacobson, Andrew J Mannes, Michael J Iadarola
Adenosine receptors are a family of purinergic G protein-coupled receptors that are widely distributed in bodily organs and in the peripheral and central nervous systems. Recently, antihyperalgesic actions have been suggested for the adenosine A3 receptor, and its agonists have been proposed as new neuropathic pain treatments. We hypothesized that these receptors may be expressed in nociceptive primary
-
The rostral ventromedial medulla modulates pain and depression-related behaviors caused by social stress. Pain (IF 7.4) Pub Date : 2024-04-23 Marco Pagliusi, Anna P Amorim-Marques, Mary Kay Lobo, Francisco S Guimarães, Sabrina F Lisboa, Felipe V Gomes
The rostral ventromedial medulla (RVM) is a crucial structure in the descending pain modulatory system, playing a key role as a relay for both the facilitation and inhibition of pain. The chronic social defeat stress (CSDS) model has been widely used to study stress-induced behavioral impairments associated with depression in rodents. Several studies suggest that CSDS also causes changes related to
-
People with painful knee osteoarthritis hold negative implicit attitudes towards activity. Pain (IF 7.4) Pub Date : 2024-04-16 Brian W Pulling, Felicity A Braithwaite, Joanne Mignone, David S Butler, J P Caneiro, Ottmar V Lipp, Tasha R Stanton
Negative attitudes/beliefs surrounding osteoarthritis, pain, and activity contribute to reduced physical activity in people with knee osteoarthritis (KOA). These attitudes/beliefs are assessed using self-report questionnaires, relying on information one is consciously aware of and willing to disclose. Automatic (ie, implicit) assessment of attitudes does not rely on conscious reflection and may identify
-
Painful distortions: people with painful knee osteoarthritis have biased visuospatial perception of the environment. Pain (IF 7.4) Pub Date : 2024-04-16 Erin MacIntyre, Felicity A Braithwaite, Tasha R Stanton
Visuospatial perception is thought to be adaptive-ie, hills are perceived as steeper when capacity is low, or threat is high-guiding appropriate interaction with the environment. Pain (bodily threat) may similarly modulate visuospatial perception, with the extent of modulation influenced by threat magnitude (pain intensity, fear) and associated with behaviour (physical activity). We compared visuospatial
-
Barriers and enablers to exercise adherence in people with nonspecific chronic low back pain: a systematic review of qualitative evidence. Pain (IF 7.4) Pub Date : 2024-04-16 Yannick L Gilanyi, Brishna Shah, Aidan G Cashin, Mitchell T Gibbs, Jessica Bellamy, Richard Day, James H McAuley, Matthew D Jones
Exercise is a first-line treatment for chronic low back pain (CLBP), reducing pain and disability in the short term. However, exercise benefits decrease over time, with a lack of long-term exercise adherence a potential reason for this. This study aimed to synthesize the perceptions and beliefs of individuals with CLBP and identify their barriers and enablers to exercise adherence. We searched CENTRAL
-
Risk of adverse outcomes during gabapentinoid therapy and factors associated with increased risk in UK primary care using the clinical practice research datalink: a cohort study. Pain (IF 7.4) Pub Date : 2024-04-11 Sara Muller, James Bailey, Ram Bajpai, Toby Helliwell, Sarah A Harrisson, Rebecca Whittle, Christian D Mallen, Julie Ashworth
Growing evidence from pharmacovigilance data and postmortem toxicology reports highlights the misuse potential of gabapentinoids. This study aimed to investigate the risk of serious adverse outcomes (drug misuse, overdose, major trauma), and their risk factors, in primary care patients who are prescribed gabapentinoids. Using the UK Clinical Practice Research Datalink, a matched cohort study calculated
-
Blocking proteinase-activated receptor 2 signaling relieves pain, suppresses nerve sprouting, improves tissue repair, and enhances analgesic effect of B vitamins in rats with Achilles tendon injury. Pain (IF 7.4) Pub Date : 2024-04-09 Lihui Li, Hongyu Yao, Rufan Mo, Lihong Xu, Peng Chen, Yuchen Chen, Jiang-Jian Hu, Wei Xie, Xue-Jun Song
Tendon injury produces intractable pain and disability in movement, but the medications for analgesia and restoring functional integrity of tendon are still limited. In this study, we report that proteinase-activated receptor 2 (PAR2) activation in dorsal root ganglion (DRG) neurons contributes to chronic pain and tendon histopathological changes produced by Achilles tendon partial transection injury
-
Pediatric chronic pain grading-a revised classification of the severity of pediatric chronic pain. Pain (IF 7.4) Pub Date : 2024-04-05 Susanne Grothus, Ariane Sommer, Lorin Stahlschmidt, Gerrit Hirschfeld, Lea Höfel, Roland Linder, Boris Zernikow, Julia Wager
In this study, we describe the development and validation of a revised Pediatric Chronic Pain Grading (P-CPG) for children aged 8 to 17 years that adds emotional impairment to previously used measures of pain intensity and functional impairment. Such a measure enables the assessment of chronic pain severity in different epidemiological and clinical populations, the stratification of treatment according
-
Nociplastic pain mechanisms and toll-like receptors as promising targets for its management. Pain (IF 7.4) Pub Date : 2024-04-05 Erick J Rodríguez-Palma, Saul Huerta de la Cruz, Ana M Islas-Espinoza, Gabriela Castañeda-Corral, Vinicio Granados-Soto, Rajesh Khanna
Nociplastic pain, characterized by abnormal pain processing without an identifiable organic cause, affects a significant portion of the global population. Unfortunately, current pharmacological treatments for this condition often prove ineffective, prompting the need to explore new potential targets for inducing analgesic effects in patients with nociplastic pain. In this context, toll-like receptors
-
Top-down attention does not modulate mechanical hypersensitivity consecutive to central sensitization: insights from an experimental analysis. Pain (IF 7.4) Pub Date : 2024-04-03 Delia Della Porta, Eléonore Scheirman, Valéry Legrain
According to the neurocognitive model of attention to pain, when the attentional resources invested in a task unrelated to pain are high, limited cognitive resources can be directed toward the pain. This is supported by experimental studies showing that diverting people's attention away from acute pain leads to experiencing less pain. Theoretical work has suggested that this phenomenon may present
-
Patterns of physiotherapy attendance in compensated Australian workers with low back pain: a retrospective cohort study. Pain (IF 7.4) Pub Date : 2024-04-02 Michael Di Donato, Luke R Sheehan, Ross Iles, Shannon Gray, Rachelle Buchbinder, Alex Collie
Workers with low back pain (LBP) frequently seek care from physiotherapists. We sought to identify patterns of physiotherapy attendance and factors associated with these patterns in Australian workers with accepted compensation claims for LBP. We included workers with accepted workers' compensation claims for LBP from 4 Australian states between 2011 and 2015. We used trajectory modelling to identify
-
Subgroups of pelvic pain are differentially associated with endometriosis and inflammatory comorbidities: a latent class analysis. Pain (IF 7.4) Pub Date : 2024-04-02 Marzieh Ghiasi, Chi Chang, Amy L Shafrir, Allison F Vitonis, Naoko Sasamoto, Ana I Vazquez, Amy D DiVasta, Kristen Upson, Christine B Sieberg, Kathryn L Terry, Claudia B Holzman, Stacey A Missmer
Chronic pelvic pain is heterogeneous with potentially clinically informative subgroups. We aimed to identify subgroups of pelvic pain based on symptom patterns and investigate their associations with inflammatory and chronic pain-related comorbidities. Latent class analysis (LCA) identified subgroups of participants (n = 1255) from the Adolescence to Adulthood (A2A) cohort. Six participant characteristics
-
Uncovering moderators of pain perception by women with endometriosis from Latin America and Spain: the roles of sociodemographics, racial self-identity, and pain catastrophizing. Pain (IF 7.4) Pub Date : 2024-04-02 Idhaliz Flores, Annelyn Torres-Reverón, Eduardo Navarro, Cristina I Nieves-Vázquez, Ariana C Cotto-Vázquez, Joanne M Alonso-Díaz, Nabal J Bracero, Katy Vincent
A cross-sectional multinational collaborative study on women with endometriosis from Latin America and Spain uncovered high levels of painful symptomatology and high pain catastrophizing scores. Associations between pain perception/catastrophizing and race/ethnicity have been documented. This study was conducted to uncover factors moderating pelvic pain severity, including socioeconomic variables,
-
Mechanical pain sensitivity is associated with hippocampal structural integrity. Pain (IF 7.4) Pub Date : 2024-03-28 Lizbeth J Ayoub, Liat Honigman, Alexander J Barnett, Mary Pat McAndrews, Massieh Moayedi
Rodents and human studies indicate that the hippocampus, a brain region necessary for memory processing, responds to noxious stimuli. However, the hippocampus has yet to be considered a key brain region directly involved in the human pain experience. One approach to answer this question is to perform quantitative sensory testing on patients with hippocampal damage-ie, medial temporal lobe epilepsy
-
The sociocultural context of adolescent pain: portrayals of pain in popular adolescent media. Pain (IF 7.4) Pub Date : 2024-03-27 Allison Cormier, Kendra Mueri, Maria Pavlova, Anna Hood, Queenie Li, Idia Thurston, Abbie Jordan, Melanie Noel
Research has consistently suggested that media consumption plays a vital role in children's socialization, including the socialization of painful experiences. Past research examining young children's popular media revealed worrisome trends in media depictions of pain; it consisted of narrow depictions of pain, gender stereotypes, and an overwhelming lack of empathy from observers, which could contribute
-
Characterizing the opioidergic mechanisms of repetitive transcranial magnetic stimulation-induced analgesia: a randomized controlled trial. Pain (IF 7.4) Pub Date : 2024-03-26 Ying Liu, Junfeng Sun, Chaomin Wu, Jinxuan Ren, Yanni He, Na Sun, Hao Huang, QunShan Chen, Dan Liu, Yangyuxin Huang, Feng Xu, Lina Yu, Bernadette M Fitzgibbon, Robin F H Cash, Paul B Fitzgerald, Min Yan, Xianwei Che
Repetitive transcranial magnetic stimulation (rTMS) is a promising technology to reduce chronic pain. Investigating the mechanisms of rTMS analgesia holds the potential to improve treatment efficacy. Using a double-blind and placebo-controlled design at both stimulation and pharmacologic ends, this study investigated the opioidergic mechanisms of rTMS analgesia by abolishing and recovering analgesia
-
Asymmetrical atrophy of the paraspinal muscles in patients undergoing unilateral lumbar medial branch radiofrequency neurotomy. Pain (IF 7.4) Pub Date : 2024-03-22 Ali E Guven, Gisberto Evangelisti, Marco D Burkhard, Paul Köhli, Jan Hambrecht, Jiaqi Zhu, Erika Chiapparelli, Michael Kelly, Koki Tsuchiya, Krizia Amoroso, Arman Zadeh, Jennifer Shue, Ek Tsoon Tan, Andrew A Sama, Federico P Girardi, Frank P Cammisa, Alexander P Hughes
Lumbar medial branch radiofrequency neurotomy (RFN), a common treatment for chronic low back pain due to facet joint osteoarthritis (FJOA), may amplify paraspinal muscle atrophy due to denervation. This study aimed to investigate the asymmetry of paraspinal muscle morphology change in patients undergoing unilateral lumbar medial branch RFN. Data from patients who underwent RFN between March 2016 and
-
The effects of virtual reality neuroscience-based therapy on clinical and neuroimaging outcomes in patients with chronic back pain: a randomized clinical trial. Pain (IF 7.4) Pub Date : 2024-03-08 Marta Čeko, Tassilo Baeuerle, Lynn Webster, Tor D Wager, Mark A Lumley
Chronic pain remains poorly managed. The integration of immersive technologies (ie, virtual reality [VR]) with neuroscience-based principles may provide effective pain treatment by targeting cognitive and affective neural processes that maintain pain and therefore potentially changing neurobiological circuits associated with pain chronification and amplification. We tested the effectiveness of a novel
-
Ketogenic diet mitigates opioid-induced hyperalgesia by restoring short-chain fatty acids-producing bacteria in the gut. Pain (IF 7.4) Pub Date : 2024-03-06 Joshua Crawford, Sufang Liu, Ran Tao, Phillip Kramer, Steven Bender, Feng Tao
Opioids are commonly prescribed to patients with chronic pain. Chronic opioid usage comes with a slew of serious side effects, including opioid-induced hyperalgesia (OIH). The patients with long-term opioid treatment experience paradoxical increases in nociceptive hypersensitivity, namely, OIH. Currently, treatment options for OIH are extremely lacking. In this study, we show that the ketogenic diet
-
"I wish I knew then what I know now" - pain science education concepts important for female persistent pelvic pain: a reflexive thematic analysis. Pain (IF 7.4) Pub Date : 2024-03-06 Amelia K Mardon, K Jane Chalmers, Lauren C Heathcote, Lee-Anne Curtis, Lesley Freedman, Rinkle Malani, Romy Parker, Patricia B Neumann, G Lorimer Moseley, Hayley B Leake
Pain science education (PSE) provides people with an understanding of "how pain works" grounded in the biopsychosocial model of pain; it has been demonstrated to improve outcomes in musculoskeletal pain conditions. Preliminary evidence suggests PSE may be effective for female individuals with persistent pelvic pain, but how the content of PSE needs to be modified for this group remains to be determined
-
MicroRNA let-7b enhances spinal cord nociceptive synaptic transmission and induces acute and persistent pain through neuronal and microglial signaling. Pain (IF 7.4) Pub Date : 2024-03-06 Ouyang Chen, Changyu Jiang, Temugin Berta, Bethany Powell Gray, Kenta Furutani, Bruce A Sullenger, Ru-Rong Ji
Secreted microRNAs (miRNAs) have been detected in various body fluids including the cerebrospinal fluid, yet their direct role in regulating synaptic transmission remains uncertain. We found that intrathecal injection of low dose of let-7b (1 μg) induced short-term (<24 hours) mechanical allodynia and heat hyperalgesia, a response that is compromised in Tlr7-/- or Trpa1-/- mice. Ex vivo and in vivo
-
Defining suffering in pain. A systematic review on pain-related suffering using natural language processing. Pain (IF 7.4) Pub Date : 2024-03-05 Niklas Noe-Steinmüller, Dmitry Scherbakov, Alexandra Zhuravlyova, Tor D Wager, Pavel Goldstein, Jonas Tesarz
Understanding, measuring, and mitigating pain-related suffering is a key challenge for both clinical care and pain research. However, there is no consensus on what exactly the concept of pain-related suffering includes, and it is often not precisely operationalized in empirical studies. Here, we (1) systematically review the conceptualization of pain-related suffering in the existing literature, (2)
-
Digging deeper into pain: an ethological behavior assay correlating well-being in mice with human pain experience. Pain (IF 7.4) Pub Date : 2024-03-05 Luke A Pattison, Alexander Cloake, Sampurna Chakrabarti, Helen Hilton, Rebecca H Rickman, James P Higham, Michelle Y Meng, Luke W Paine, Maya Dannawi, Lanhui Qiu, Anne Ritoux, David C Bulmer, Gerard Callejo, Ewan St John Smith
The pressing need for safer, more efficacious analgesics is felt worldwide. Preclinical tests in animal models of painful conditions represent one of the earliest checkpoints novel therapeutics must negotiate before consideration for human use. Traditionally, the pain status of laboratory animals has been inferred from evoked nociceptive assays that measure their responses to noxious stimuli. The disconnect
-
Peripheral and central neurobiological effects of botulinum toxin A (BoNT/A) in neuropathic pain: a systematic review. Pain (IF 7.4) Pub Date : 2024-03-05 Nathan Moreau, Sohaib Ali Korai, Giovanna Sepe, Fivos Panetsos, Michele Papa, Giovanni Cirillo
Botulinum toxin (BoNT), a presynaptic inhibitor of acetylcholine (Ach) release at the neuromuscular junction (NMJ), is a successful and safe drug for the treatment of several neurological disorders. However, a wide and recent literature review has demonstrated that BoNT exerts its effects not only at the "periphery" but also within the central nervous system (CNS). Studies from animal models, in fact
-
Characterizing high-cost healthcare users among adults with back pain in Ontario, Canada: a population-based cohort study. Pain (IF 7.4) Pub Date : 2024-03-05 Jessica J Wong, Pierre Côté, Andrea C Tricco, Tristan Watson, Laura C Rosella
Some patients with back pain contribute disproportionately to high healthcare costs; however, characteristics of high-cost users with back pain are not well defined. We described high-cost healthcare users based on total costs among a population-based cohort of adults with back pain within the Ontario government's single-payer health system across sociodemographic, health, and behavioural characteristics
-
Does pain tolerance mediate the effect of physical activity on chronic pain in the general population? The Tromsø Study. Pain (IF 7.4) Pub Date : 2024-03-05 Anders Pedersen Årnes, Mats Kirkeby Fjeld, Hein Stigum, Christopher Sivert Nielsen, Audun Stubhaug, Aslak Johansen, Laila Arnesdatter Hopstock, Bente Morseth, Tom Wilsgaard, Ólöf Anna Steingrímsdóttir
Knowledge is needed regarding mechanisms acting between physical activity (PA) and chronic pain. We investigated whether cold pain tolerance mediates an effect of leisure-time physical activity on the risk of chronic pain 7 to 8 years later using consecutive surveys of the population-based Tromsø Study. We included participants with information on baseline leisure-time PA (LTPA) and the level of cold
-
The effect of unpredictability on the perception of pain: a systematic review and meta-analysis. Pain (IF 7.4) Pub Date : 2024-02-28 Fabien Pavy, Jonas Zaman, Wim Van den Noortgate, Aurelia Scarpa, Andreas von Leupoldt, Diana M Torta
Despite being widely assumed, the worsening impact of unpredictability on pain perception remains unclear because of conflicting empirical evidence, and a lack of systematic integration of past research findings. To fill this gap, we conducted a systematic review and meta-analysis focusing on the effect of unpredictability on pain perception. We also conducted meta-regression analyses to examine the
-
ATF4 inhibits TRPV4 function and controls itch perception in rodents and nonhuman primates. Pain (IF 7.4) Pub Date : 2024-02-28 Man-Xiu Xie, Jun-Hua Rao, Xiao-Yu Tian, Jin-Kun Liu, Xiao Li, Zi-Yi Chen, Yan Cao, An-Nan Chen, Hai-Hua Shu, Xiao-Long Zhang
Acute and chronic itch are prevalent and incapacitating, yet the neural mechanisms underlying both acute and chronic itch are just starting to be unraveled. Activated transcription factor 4 (ATF4) belongs to the ATF/CREB transcription factor family and primarily participates in the regulation of gene transcription. Our previous study has demonstrated that ATF4 is expressed in sensory neurons. Nevertheless
-
Low-frequency (5-Hz) stimulation of ventrolateral periaqueductal gray modulates the descending serotonergic system in the peripheral neuropathic pain. Pain (IF 7.4) Pub Date : 2024-02-28 Minkyung Park, Chin Su Koh, Heesue Chang, Tae Jun Kim, Wonki Mun, Jin Woo Chang, Hyun Ho Jung
Neuropathic pain is a type of chronic pain that entails severe prolonged sensory dysfunctions caused by a lesion of the somatosensory system. Many of those suffering from the condition do not experience significant improvement with existing medications, resulting in various side effects. In this study, Sprague-Dawley male rats were used, and long-term deep brain stimulation of the ventrolateral periaqueductal
-
Vagus nerve stimulation rescues persistent pain following orthopedic surgery in adult mice. Pain (IF 7.4) Pub Date : 2024-02-27 Pau Yen Wu, Ana Isabel Caceres, Jiegen Chen, Jamie Sokoloff, Mingjian Huang, Gurpreet Singh Baht, Andrea G Nackley, Sven-Eric Jordt, Niccolò Terrando
Postoperative pain is a major clinical problem imposing a significant burden on patients and society. In a survey 2 years after orthopedic surgery, 57% of patients reported persisting postoperative pain. However, only limited progress has been made in the development of safe and effective therapies to prevent the onset and chronification of pain after orthopedic surgery. We established a tibial fracture
-
Aged females unilaterally hypersensitize, lack descending inhibition, and overexpress alpha1D adrenergic receptors in a murine posttraumatic chronic pain model. Pain (IF 7.4) Pub Date : 2024-02-27 Silke J Hirsch, Alexandra Budig, Sanar Husam, Frank Birklein
Vulnerability to chronic pain is found to depend on age and sex. Most patients with chronic pain are elderly women, especially with posttraumatic pain after bone fracture that prevails beyond the usual recovery period and develops into a complex regional pain syndrome (CRPS). There, a distal bone fracture seems to initiate a pathophysiological process with unknown mechanism. To investigate whether
-
Chemotherapy-induced peripheral neuropathy models constructed from human induced pluripotent stem cells and directly converted cells: a systematic review. Pain (IF 7.4) Pub Date : 2024-02-21 Pascal S H Smulders, Kim Heikamp, Jeroen Hermanides, Markus W Hollmann, Werner Ten Hoope, Nina C Weber
Developments in human cellular reprogramming now allow for the generation of human neurons for in vitro disease modelling. This technique has since been used for chemotherapy-induced peripheral neuropathy (CIPN) research, resulting in the description of numerous CIPN models constructed from human neurons. This systematic review provides a critical analysis of available models and their methodological
-
Quantitative sensory testing, psychological factors, and quality of life as predictors of current and future pain in patients with knee osteoarthritis. Pain (IF 7.4) Pub Date : 2024-02-20 Emma Hertel, Lars Arendt-Nielsen, Anne Estrup Olesen, Michael Skipper Andersen, Kristian Kjær-Staal Petersen
Substantial interindividual variability characterizes osteoarthritis (OA) pain. Previous findings identify quantitative sensory testing (QST), psychological factors, and health-related quality of life as contributors to OA pain and predictors of treatment outcomes. This exploratory study aimed to explain baseline OA pain intensity and predict OA pain after administration of a nonsteroidal anti-inflammatory
-
Do current methods of measuring the impact of chronic pain on work reflect the experience of working-age adults? An integrated mixed-methods systematic narrative review. Pain (IF 7.4) Pub Date : 2024-02-20 Anne L Stagg, Ira Madan, Nicola Fear, Martin J Stevens, Elaine Wainwright, Jan L Hoving, Gary J Macfarlane, Rosemary Hollick, LaKrista Morton
Chronic pain affects individuals' work participation. The impact of chronic pain on work has historically been measured through sickness absence, though it is now appreciated that the impacts on work are far wider. This mixed-methods review aimed to identify the full range of impacts of pain on work in addition to impacts that are currently measured quantitatively to inform the development of a new
-
Causal associations of central and peripheral risk factors with knee osteoarthritis: a longitudinal and Mendelian Randomisation study using UK Biobank data. Pain (IF 7.4) Pub Date : 2024-02-13 William David Thompson, Subhashisa Swain, Sizheng Steven Zhao, Carol Coupland, Changfu Kuo, Michael Doherty, Weiya Zhang
Our aim was to investigate relative contributions of central and peripheral mechanisms to knee osteoarthritis (OA) diagnosis and their independent causal association with knee OA. We performed longitudinal analysis using data from UK-Biobank participants. Knee OA was defined using International Classification of Diseases manual 10 codes from participants' hospital records. Central mechanisms were proxied
-
Development of PainFace software to simplify, standardize, and scale up mouse grimace analyses. Pain (IF 7.4) Pub Date : 2024-02-13 Eric S McCoy, Sang Kyoon Park, Rahul P Patel, Dan F Ryan, Zachary J Mullen, Jacob J Nesbitt, Josh E Lopez, Bonnie Taylor-Blake, Kelly A Vanden, James L Krantz, Wenxin Hu, Rosanna L Garris, Magdalyn G Snyder, Lucas V Lima, Susana G Sotocinal, Jean-Sebastien Austin, Adam D Kashlan, Sanya Shah, Abigail K Trocinski, Samhitha S Pudipeddi, Rami M Major, Hannah O Bazick, Morgan R Klein, Jeffrey S Mogil, Guorong
Facial grimacing is used to quantify spontaneous pain in mice and other mammals, but scoring relies on humans with different levels of proficiency. Here, we developed a cloud-based software platform called PainFace (http://painface.net) that uses machine learning to detect 4 facial action units of the mouse grimace scale (orbitals, nose, ears, whiskers) and score facial grimaces of black-coated C57BL/6
-
Musculoskeletal pain in 13-year-old children: the generation R study. Pain (IF 7.4) Pub Date : 2024-02-07 Guido J van Leeuwen, Marleen M van den Heuvel, Patrick J E Bindels, Sita M A Bierma-Zeinstra, Marienke van Middelkoop
Musculoskeletal (MSK) pain is a common reason for consultation in general practice and frequently reported in children and adolescents. This study examined the prevalence of MSK pain in 13-year-old children and assessed associations with physical and psychosocial factors. Data from the Generation R Study, a population-based birth cohort, was used. Prevalence and characteristics of MSK pain were assessed
-
Concurrent and lagged associations among pain medication use, pain, and negative affect: a daily diary study of people with chronic low back pain. Pain (IF 7.4) Pub Date : 2024-02-07 John W Burns, James Gerhart, David A Smith, Laura Porter, Bonny Rye, Francis Keefe
People with chronic pain often attempt to manage pain and concurrent emotional distress with analgesic substances. Habitual use of such substances-even when not opioid-based-can pose side effect risks. A negative reinforcement model has been proposed whereby relief of pain and emotional distress following medication consumption increases the likelihood that the experience of elevated pain and distress
-
Sex differences in facial expressions of pain: results from a combined sample. Pain (IF 7.4) Pub Date : 2024-02-07 Pia Schneider, Stefan Lautenbacher, Miriam Kunz
Facial expressions of pain play an important role in pain diagnostics and social interactions. Given the prominent impact of sex on various aspects of pain, it is not surprising that sex differences have also been explored regarding facial expressions of pain; however, with inconclusive findings. We aim to further investigate sex differences in facial expressions of pain by using a large, combined
-
Bilateral deficiency of Meissner corpuscles and papillary microvessels in patients with acute complex regional pain syndrome. Pain (IF 7.4) Pub Date : 2024-02-07 Katharina Mehling, Juliane Becker, Jeremy Chen, Sabrina Scriba, Gudrun Kindl, Rafael Jakubietz, Claudia Sommer, Beate Hartmannsberger, Heike L Rittner
Complex regional pain syndrome (CRPS) presents postinjury with disproportionate pain and neuropathic, autonomic, motor symptoms, and skin texture affection. However, the origin of these multiplex changes is unclear. Skin biopsies offer a window to analyze the somatosensory and vascular system as well as skin trophicity with their protecting barriers. In previous studies, barrier-protective exosomal
-
Race-specific associations: inflammatory mediators and chronic low back pain. Pain (IF 7.4) Pub Date : 2024-02-06 Demario S Overstreet, Larissa J Strath, Robert E Sorge, Pavithra A Thomas, Jingui He, Asia M Wiggins, Joanna Hobson, D Leann Long, Samantha M Meints, Edwin N Aroke, Burel R Goodin
Chronic low back pain (cLBP) is a global health crisis that disproportionately burdens non-Hispanic Black (NHB) individuals, compared with those who identify as non-Hispanic White (NHW). Despite the growing personal and societal impact of cLBP, its biological underpinnings remain poorly understood. To elucidate the biological factors that underlie the racial disparities in cLBP, this study sought to
-
Productivity outcomes from chronic pain management interventions in the working age population; a systematic review. Pain (IF 7.4) Pub Date : 2024-02-06 Anonnya Rizwana Chowdhury, Petra L Graham, Deborah Schofield, Daniel S J Costa, Michael Nicholas
Productivity loss because of chronic pain in the working age population is a widespread concern internationally. Interventions for chronic pain in working age adults might be expected to achieve enhanced productivity in terms of reduced costs of workers' compensation insurance, reduced disability support, and improved rates of return to work for injured workers. This would require the use of measures
-
High-speed imaging of evoked rodent mechanical behaviors yields variable results that are not predictive of inflammatory injury. Pain (IF 7.4) Pub Date : 2024-02-02 Dianise M Rodríguez García, Aniko Szabo, Alexander R Mikesell, Samuel J Zorn, Ulrich Kemmo Tsafack, Anvitha Sriram, Tyler B Waltz, Jonathan D Enders, Christina M Mecca, Cheryl L Stucky, Katelyn E Sadler
Few analgesics identified using preclinical models have successfully translated to clinical use. These translational limitations may be due to the unidimensional nature of behavioral response measures used to assess rodent nociception. Advances in high-speed videography for pain behavior allow for objective quantification of nuanced aspects of evoked paw withdrawal responses. However, whether videography-based