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Quantitative imaging reveals steatosis and fibro-inflammation in multiple organs in people with type 2 diabetes: a real-world study. Diabetes (IF 7.7) Pub Date : 2024-05-15 Charlie Diamond, Michele Pansini, Azlinda Hamid, Nicole Eichert, Prashant Pandya, Sarah N Ali, Graham J Kemp, Gaya Thanabalasingham, Helena Thomaides Brears, Daniel J Cuthbertson
We aimed to determine the extent of multi-organ fat accumulation and fibro-inflammation in individuals living with type 2 diabetes. We deeply phenotyped individuals with type 2 diabetes (134 from secondary care, 69 from primary care) with multi-organ, quantitative multi-parametric MRI and compared with 134 matched controls and 92 normal weight controls. We examined the impact of diabetes duration,
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The role of automated insulin delivery technology in diabetes Diabetol. (IF 8.2) Pub Date : 2024-05-13 Charlotte K. Boughton, Roman Hovorka
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RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function Diabetol. (IF 8.2) Pub Date : 2024-05-14 Hazem Ibrahim, Diego Balboa, Jonna Saarimäki-Vire, Hossam Montaser, Oleg Dyachok, Per-Eric Lund, Muhmmad Omar-Hmeadi, Jouni Kvist, Om P. Dwivedi, Väinö Lithovius, Tom Barsby, Vikash Chandra, Solja Eurola, Jarkko Ustinov, Tiinamaija Tuomi, Päivi J. Miettinen, Sebastian Barg, Anders Tengholm, Timo Otonkoski
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The role of brown adipose tissue in metabolic health Nat. Rev. Endocrinol. (IF 40.5) Pub Date : 2024-05-14 Claire Greenhill
It is very well known that brown adipose tissue (BAT) is involved in thermogenesis, particularly in rodents. However, whether and how BAT affects the metabolic health of adult humans has been unclear. A new study addresses this issue. In this study, the researchers generated mice with BAT-specific knockout of the mitochondrial BCAA carrier (MBC, encoded by Slc25a44), which meant that mitochondrial
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Epoxygenase Cyp2c44 regulates hepatic lipid metabolism and insulin signaling by controlling FATP2 localization and activation of the DAG/PKCδ axis Diabetes (IF 7.7) Pub Date : 2024-05-14 Kakali Ghoshal, James M. Luther, Suman B. Pakala, Sergei Chetyrkin, John R. Falck, Roy Zent, David H. Wasserman, Ambra Pozzi
Cytochrome P450 epoxygenase Cyp2c44, a murine epoxyeicosatrienoic acid (EET) producing enzyme, promotes insulin sensitivity and Cyp2c44(−/−) mice show hepatic insulin resistance. Because insulin resistance leads to hepatic lipid accumulation and hyperlipidemia, we hypothesized that Cyp2c44 regulates hepatic lipid metabolism. Standard chow diet (SD) fed male Cyp2c44(−/−) mice had significantly decreased
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Hearing abnormalities in patients treated with teprotumumab Nat. Rev. Endocrinol. (IF 40.5) Pub Date : 2024-05-13 Jason A. Brant, Don O. Kikkawa, Terry J. Smith
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Advances in the management of achondroplasia Nat. Rev. Endocrinol. (IF 40.5) Pub Date : 2024-05-13 Ravi Savarirayan
The first precision therapy for children with achondroplasia, vosoritide, is now approved in many regions, including Australia, the USA, the European Union and Japan. This article discusses the recent trial results for this therapy regarding growth and the co-morbidities associated with achondroplasia and considers the rationale for its clinical use.
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Erratum. Identifying Preferred Features of Weight Loss Programs for Adults With or at Risk of Type 2 Diabetes: A Discrete Choice Experiment With 3,960 Adults in the U.K.. Diabetes Care 2024;47:739–746 Diabetes Care (IF 16.2) Pub Date : 2024-05-10 John Buckell, Caroline A. Mitchell, Kate Fryer, Carolyn Newbert, Alan Brennan, Jack Joyce, Susan A. Jebb, Paul Aveyard, Nicola Guess, Elizabeth Morris
In the article cited above, funding information was inadvertently omitted for authors Paul Aveyard and Susan A. Jebb. The following text has been added: “P.A. is an NIHR senior investigator. P.A. and S.A.J. are funded by NIHR Oxford Biomedical Research Centre, NIHR Oxford Health Biomedical Research Centre, and NIHR Oxford and Thames Valley Applied Research Collaboration.” The authors apologize for
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Polygenic Risk Score Modifies the Association of HbA1c With Hearing Loss in Middle-Aged and Older Chinese: The Dongfeng-Tongji Cohort Diabetes Care (IF 16.2) Pub Date : 2024-05-10 Yaling He, Zhichao Wang, Haiqing Zhang, Xuefeng Lai, Miao Liu, Liangle Yang, Yiquan Zheng, Meian He, Weijia Kong, Xiaomin Zhang
OBJECTIVE Evidence regarding the modifying effect of the polygenic risk score (PRS) on the associations between glycemic traits and hearing loss (HL) was lacking. We aimed to examine whether these associations can be influenced by genetic susceptibility. RESEARCH DESIGN AND METHODS This cross-sectional study included 13,275 participants aged 64.9 years from the Dongfeng-Tongji cohort. HL was defined
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Determinants of plasma levels of proglucagon and the metabolic impact of glucagon receptor signalling: a UK Biobank study Diabetol. (IF 8.2) Pub Date : 2024-05-06 Marie Winther-Sørensen, Sara L. Garcia, Andreas Bartholdy, Maud E. Ottenheijm, Karina Banasik, Søren Brunak, Charlotte M. Sørensen, Lise Lotte Gluud, Filip K. Knop, Jens J. Holst, Mette M. Rosenkilde, Majken K. Jensen, Nicolai J. Wewer Albrechtsen
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Impaired Awareness of Hypoglycemia in Older Adults With Type 1 Diabetes: A Post Hoc Analysis of the WISDM Study Diabetes Care (IF 16.2) Pub Date : 2024-05-07 Anika Bilal, Fanchao Yi, Keri Whitaker, Daria Igudesman, Richard Pratley, Anna Casu
OBJECTIVE Up to one-third of older adults with type 1 diabetes experience impaired awareness of hypoglycemia (IAH), yet the factors associated with IAH remain underexplored in older adults. RESEARCH DESIGN AND METHODS This post hoc analysis evaluated the clinical and glycemic correlates of IAH in adults ≥60 years old with type 1 diabetes in the WISDM study. IAH and normal awareness of hypoglycemia
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Hypothalamic Inflammation Improves Through Bariatric Surgery, and Hypothalamic Volume Predicts Short-Term Weight Loss Response in Adults With or Without Type 2 Diabetes Diabetes Care (IF 16.2) Pub Date : 2024-05-07 Adriana Pané, Laura Videla, Àngels Calvet, Judith Viaplana, Lídia Vaqué-Alcázar, Ainitze Ibarzabal, Mateus Rozalem-Aranha, Jordi Pegueroles, Violeta Moize, Josep Vidal, Emilio Ortega, Isabel Barroeta, Valle Camacho, Gemma Chiva-Blanch, Juan Fortea, Amanda Jiménez
OBJECTIVE Preclinical research implicates hypothalamic inflammation (HI) in obesity and type 2 diabetes pathophysiology. However, their pathophysiological relevance and potential reversibility need to be better defined. We sought to evaluate the effect of bariatric surgery (BS) on radiological biomarkers of HI and the association between the severity of such radiological alterations and post-BS weight
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Increasing Medication Use and Polypharmacy in Type 2 Diabetes: The Danish Experience From 2000 to 2020 Diabetes Care (IF 16.2) Pub Date : 2024-05-06 Karl Sebastian Johansson, Espen Jimenez-Solem, Tonny Studsgaard Petersen, Mikkel Bring Christensen
OBJECTIVE Type 2 diabetes often coexists with other conditions that are amenable to pharmacological treatment. We hypothesized that polypharmacy among individuals with type 2 diabetes has increased since 2000. RESEARCH DESIGN AND METHODS Using Danish national registries, we established a cohort of all Danish individuals (aged ≥18 years) with type 2 diabetes between 2000 and 2020. We analyzed their
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Continuous Glucose Monitoring Profiles in Pregnancies With and Without Gestational Diabetes Mellitus Diabetes Care (IF 16.2) Pub Date : 2024-05-03 Celeste Durnwald, Roy W. Beck, Zoey Li, Elizabeth Norton, Richard M. Bergenstal, Mary Johnson, Sean Dunnigan, Matthew Banfield, Katie Krumwiede, Judy Sibayan, Peter Calhoun, Anders L. Carlson
OBJECTIVE To determine whether continuous glucose monitoring (CGM)-derived glycemic patterns can characterize pregnancies with gestational diabetes mellitus (GDM) as diagnosed by standard oral glucose tolerance test at 24–28 weeks’ gestation compared with those without GDM. RESEARCH DESIGN AND METHODS The analysis includes 768 individuals enrolled from two sites prior to 17 weeks’ gestation between
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Elevated cathepsin S serum levels in new-onset type 1 diabetes and autoantibody-positive siblings Diabetes (IF 7.7) Pub Date : 2024-05-03 Caroline Frørup, Mathias Høj Jensen, Martin Haupt-Jorgensen, Karsten Buschard, Joachim Størling, Flemming Pociot, Tina Fløyel
Accumulating data suggest a role for the lysosomal protease cathepsin S (CTSS) in type 1 diabetes. Circulating CTSS is increased in type 1 diabetes; however, whether CTSS has protective or deleterious effects is unclear. The study’s objectives were to examine the biomarker potential of CTSS in new-onset type 1 diabetes, and to investigate the expression and secretion of CTSS in human islets and β cells
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Excess Intramyocellular Lipid Does Not Affect Muscle Fiber Biophysical Properties in Mice or People with Metabolically Abnormal Obesity Diabetes (IF 7.7) Pub Date : 2024-05-03 Karen C. Shen, Kelsey H. Collins, Jeremie L.A. Ferey, Alan Fappi, Jeremy J. McCormick, Bettina Mittendorfer, Farshid Guilak, Gretchen A. Meyer
Observational studies show correlations between intramyocellular lipid (IMCL) content and muscle strength and contractile function in people with “metabolically abnormal” obesity. However, a clear physiologic mechanism for this association is lacking and causation is debated. We combined immunofluorescent confocal imaging with force measurements on permeabilized muscle fibers from metabolically normal
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Comprehensive clinical and genetic analyses of circulating bile acids and their associations with diabetes and its indices Diabetes (IF 7.7) Pub Date : 2024-05-03 Ibrahim Choucair, Deepthi P. Mallela, James R. Hilser, Jaana A. Hartiala, Ina Nemet, Valentin Gogonea, Lin Li, Aldons J. Lusis, Michael A. Fischbach, W. H. Wilson Tang, Hooman Allayee, Stanley L. Hazen
Bile acids (BAs) are cholesterol-derived compounds that regulate glucose, lipid, and energy metabolism. Despite their significance in glucose homeostasis, the association between specific BA molecular species and their synthetic pathways with diabetes mellitus (DM) is unclear. Here, we used a recently validated stable-isotope dilution highperformance liquid chromatography with tandem mass spectrometry
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Arginine vasopressin deficiency: diagnosis, management and the relevance of oxytocin deficiency Nat. Rev. Endocrinol. (IF 40.5) Pub Date : 2024-05-01 Cihan Atila, Julie Refardt, Mirjam Christ-Crain
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A congress on head and neck paragangliomas: advancing clinical care Nat. Rev. Endocrinol. (IF 40.5) Pub Date : 2024-05-01 Mario Sanna, Karel Pacak, David Taїeb, Renato Mariani-Costantini
The First International Congress on Head and Neck Paragangliomas in 2023 launched a global initiative directed towards improving the management of head and neck paragangliomas (HNPGLs), including prevention, treatment and research. The Congress highlighted a lack of international evidence-based consensuses and guidelines for HNPGLs. The Congress will now convene triennially to foster personalized medicine
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Thyroid function and iodine intake: global recommendations and relevant dietary trends Nat. Rev. Endocrinol. (IF 40.5) Pub Date : 2024-05-01 Sarah C. Bath
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Hypoglycemic Response to Dorzagliatin in a Patient With GCK-MODY Diabetes Care (IF 16.2) Pub Date : 2024-05-01 Yilin Zhao, Yumin Ma, Tianhao Ba, Xueyao Han, Qian Ren, Linong Ji
OBJECTIVE Metformin, insulin, and insulin secretagogues do not alter HbA1c levels in glucokinase-maturity-onset diabetes of the young (GCK-MODY). However, the efficacy of the new hypoglycemic drugs on GCK-MODY remains unclear. RESEARCH DESIGN AND METHODS We describe a case of GCK-MODY with unchanged blood glucose under different therapies during an 8 years’ follow-up. His HbA1c and biochemical indices
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Optimizing the treatment of hypothyroidism Nat. Rev. Endocrinol. (IF 40.5) Pub Date : 2024-04-29 Antonio C. Bianco, Peter N. Taylor
Daily levothyroxine (LT4) is the standard of care for the treatment of hypothyroidism; however, a small number of patients experience residual symptoms of hypothyroidism. Guidelines indicate that a trial with LT4 and liothyronine (LT3) could be attempted once other conditions have been addressed or excluded. Even so, currently, treatment of hypothyroidism can still be suboptimal.
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Incretin-Based Weight Loss Pharmacotherapy: Can Resistance Exercise Optimize Changes in Body Composition? Diabetes Care (IF 16.2) Pub Date : 2024-04-30 João Carlos Locatelli, Juliene Gonçalves Costa, Andrew Haynes, Louise H. Naylor, P. Gerry Fegan, Bu B. Yeap, Daniel J. Green
This narrative review highlights the degree to which new antiobesity medications based on gut-derived nutrient-stimulated hormones (incretins) cause loss of lean mass, and the importance of resistance exercise to preserve muscle. Glucagon-like peptide 1 receptor agonists (GLP-1RA) induce substantial weight loss in randomized trials, effects that may be enhanced in combination with glucose-dependent
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Nutritional Status, Dietary Intake, and Nutrition-Related Interventions Among Older Adults With Type 1 Diabetes: A Systematic Review and Call for More Evidence Toward Clinical Guidelines Diabetes Care (IF 16.2) Pub Date : 2024-04-30 Angelica Cristello Sarteau, Gabriella Ercolino, Rashmi Muthukkumar, Angela Fruik, Elizabeth J. Mayer-Davis, Anna R. Kahkoska
There is an emerging population of older adults (≥65 years) living with type 1 diabetes. Optimizing health through nutrition during this life stage is challenged by multiple and ongoing changes in diabetes management, comorbidities, and lifestyle factors. There is a need to understand nutritional status, dietary intake, and nutrition-related interventions that may maximize well-being throughout the
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Glycemic Control, Cognitive Aging, and Impairment Among Diverse Hispanics/Latinos: Study of Latinos–Investigation of Neurocognitive Aging (Hispanic Community Health Study/Study of Latinos) Diabetes Care (IF 16.2) Pub Date : 2024-04-30 Hector M. González, Wassim Tarraf, Ariana M. Stickel, Alejandra Morlett, Kevin A. González, Alberto R. Ramos, Tatjana Rundek, Linda C. Gallo, Gregory A. Talavera, Martha L. Daviglus, Richard B. Lipton, Carmen Isasi, Melissa Lamar, Donglin Zeng, Charles DeCarli
OBJECTIVE Hispanics/Latinos in the United States have the highest prevalence of undiagnosed and untreated diabetes and are at increased risk for cognitive impairment. In this study, we examine glycemic control in relation to cognitive aging and impairment in a large prospective cohort of middle-aged and older Hispanics/Latinos of diverse heritages. RESEARCH DESIGN AND METHODS Study of Latinos–Investigation
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Once-weekly insulins: a promising approach to reduce the treatment burden in people with diabetes Diabetol. (IF 8.2) Pub Date : 2024-04-29 Roberto Trevisan, Matteo Conti, Stefano Ciardullo
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ACSF2 and lysine lactylation contribute to renal tubule injury in diabetes Diabetol. (IF 8.2) Pub Date : 2024-04-27 Jingfang Chen, Qi Feng, Yingjin Qiao, Shaokang Pan, Lulu Liang, Yong Liu, Xiaonan Zhang, Dongwei Liu, Zhihong Liu, Zhangsuo Liu
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Discordance between mean glucose and time in range in relation to HbA1c in individuals with type 1 diabetes: results from the GOLD and SILVER trials Diabetol. (IF 8.2) Pub Date : 2024-04-26 Sofia Sterner Isaksson, Henrik Imberg, Irl B. Hirsch, Erik Schwarcz, Jarl Hellman, Magnus Wijkman, Jan Bolinder, Thomas Nyström, Helene Holmer, Sara Hallström, Arndís F. Ólafsdóttir, Sofia Pekkari, William Polonsky, Marcus Lind
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The metabolome as a diagnostic for maximal aerobic capacity during exercise in type 1 diabetes Diabetol. (IF 8.2) Pub Date : 2024-04-25 Guy S. Taylor, Kieran Smith, Jadine Scragg, Timothy J. McDonald, James A. Shaw, Daniel J. West, Lee D. Roberts
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Exercise-induced increase in muscle insulin sensitivity in men is amplified when assessed using a meal test Diabetol. (IF 8.2) Pub Date : 2024-04-25 Christian T. Voldstedlund, Kim A. Sjøberg, Farina L. Schlabs, Casper M. Sigvardsen, Nicoline R. Andersen, Jens J. Holst, Bolette Hartmann, Jørgen F. P. Wojtaszewski, Bente Kiens, Glenn K. McConell, Erik A. Richter
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Bo Hellman, 19 June 1930–4 December 2023 Diabetol. (IF 8.2) Pub Date : 2024-04-25 Erik Gylfe, Anders Tengholm
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New genes associated with adult-onset obesity Nat. Rev. Endocrinol. (IF 40.5) Pub Date : 2024-04-24 Claire Greenhill
The factors that determine an individual’s body weight are highly complex and incompletely understood. Currently, >1,000 genes that are associated with body weight have been identified; however, these variants explain only a small fraction of the population variance in BMI. Over the past few years, whole-exome sequencing has been applied at the population scale, in exome-wide association studies. Now
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Early-Onset Hypertension and Sex-Specific Residual Risk for Cardiovascular Disease in Type 2 Diabetes Diabetes Care (IF 16.2) Pub Date : 2024-04-24 Hongwei Ji, Joseph E. Ebinger, Alan C. Kwan, Karen Reue, Jennifer C. Sullivan, John Shyy, Susan Cheng
OBJECTIVE To investigate whether the sex disparities in type 2 diabetes–associated cardiovascular disease (CVD) risks may be related to early-onset hypertension that could benefit from intensive blood pressure (BP) control. RESEARCH DESIGN AND METHODS We analyzed intensive versus standard BP control in relation to incident CVD events in women and men with type 2 diabetes, based on their age of hypertension
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Association of Water Arsenic With Incident Diabetes in U.S. Adults: The Multi-Ethnic Study of Atherosclerosis and the Strong Heart Study Diabetes Care (IF 16.2) Pub Date : 2024-04-24 Maya Spaur, Marta Galvez-Fernandez, Qixuan Chen, Melissa A. Lombard, Benjamin C. Bostick, Pam Factor-Litvak, Amanda M. Fretts, Steven J. Shea, Ana Navas-Acien, Anne E. Nigra
OBJECTIVE We examined the association of arsenic in federally regulated community water systems (CWSs) and unregulated private wells with type 2 diabetes (T2D) incidence in the Strong Heart Family Study (SHFS), a prospective study of American Indian communities, and the Multi-Ethnic Study of Atherosclerosis (MESA), a prospective study of racially and ethnically diverse urban U.S. communities. RESEARCH
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Short-term effects of obesity surgery versus low-energy diet on body composition and tissue-specific glucose uptake: a randomised clinical study using whole-body integrated 18F-FDG-PET/MRI Diabetol. (IF 8.2) Pub Date : 2024-04-24 Jan W. Eriksson, Maria J. Pereira, Christakis Kagios, Sofia Kvernby, Elin Lundström, Giovanni Fanni, Martin H. Lundqvist, Björn C. L. Carlsson, Magnus Sundbom, Sambit Tarai, Mark Lubberink, Joel Kullberg, Ulf Risérus, Håkan Ahlström
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Associations of 24 h time-use compositions of sitting, standing, physical activity and sleeping with optimal cardiometabolic risk and glycaemic control: The Maastricht Study Diabetol. (IF 8.2) Pub Date : 2024-04-24 Christian J. Brakenridge, Annemarie Koster, Bastiaan E. de Galan, Alison Carver, Dorothea Dumuid, Francis Q. S. Dzakpasu, Simone J. P. M. Eussen, Hans H. C. M. Savelberg, Hans Bosma, Neville Owen, Nicolaas C. Schaper, Genevieve N. Healy, David W. Dunstan
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Inhibitory regulation of FoxO1 in PPARδ expression drives mitochondria dysfunction and insulin resistance Diabetes (IF 7.7) Pub Date : 2024-04-24 Soyoung Park, Hye-Na Cha, Min-Gyeong Shin, Sanghee Park, Yeongmin Kim, Min-Seob Kim, Kyung-Hoon Shin, Themis Thoudam, Eun Ju Lee, Robert R. Wolfe, Jinmyoung Dan, Jin-Ho Koh, Il-Young Kim, Inho Choi, In-kyu Lee, Hoon-Ki Sung, So-Young Park
Forkhead box protein O1 (FoxO1) regulates muscle growth, but the metabolic role of FoxO1 in skeletal muscle and its mechanisms remain unclear. To explore the metabolic role of FoxO1 in skeletal muscle, we generated skeletal muscle-specific FoxO1 inducible knockout (mFoxO1 iKO) mice and fed them a high-fat diet to induce obesity. We measured insulin sensitivity, fatty acid oxidation, mitochondrial function
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Interrelationships among accumulations of intra- and peri-organ fat, visceral fat, and subcutaneous fat Diabetes (IF 7.7) Pub Date : 2024-04-24 Kento Mitsushio, Megu Y Baden, Takuya Kagisaki, Sarasa Kato, Akiko Niki, Risa Takayama, Tomomi Horii, Harutoshi Ozawa, Chisaki Ishibashi, Yoshiya Hosokawa, Yukari Fujita, Junji Kozawa, Iichiro Shimomura
We aimed to clarify the relationship between intra- and peri-organ fat, visceral fat, and subcutaneous fat. We used abdominal CT to evaluate intra- and peri-organ fat accumulations in the pancreas, liver, spleen, renal parenchyma, renal sinus, and skeletal muscle. The relationships between these fats, visceral fat, and subcutaneous fat were examined by using the partial correlation and covariance analysis
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Immunometabolic Signatures of Circulating Monocytes in Humans with Obesity and Insulin Resistance Diabetes (IF 7.7) Pub Date : 2024-04-24 Lisa Smeehuijzen, Anouk Gijbels, Joline P. Nugteren-Boogaard, Frank Vrieling, Mehdi Boutagouga Boudjadja, Inez Trouwborst, Kelly M. Jardon, Gabby B. Hul, Edith J.M. Feskens, Ellen E. Blaak, Gijs H. Goossens, Lydia A. Afman, Rinke Stienstra
Obesity is associated with chronic inflammation and metabolic complications, including insulin resistance (IR). Immune cells drive inflammation through the rewiring of intracellular metabolism. However, the impact of obesity-related IR on the metabolism and functionality of circulating immune cells, like monocytes, remains poorly understood. To increase insight into the inter-individual variation of
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Female protection against diabetic kidney disease is regulated by kidney-specific AMPK activity Diabetes (IF 7.7) Pub Date : 2024-04-24 Hak Joo Lee, Liang Min, Jingli Gao, Shane Matta, Viktor Drel, Afaf Saliba, Ian Tamayo, Richard Montellano, Leila Hejazi, Soumya Maity, Guogang Xu, Brian I. Grajeda, Sourav Roy, Kenneth R. Hallows, Goutam Ghosh Choudhury, Balakuntalam S. Kasinath, Kumar Sharma
Reduced kidney AMPK activity is associated with nutrient stress-induced chronic kidney disease (CKD) in male mice. In contrast, female mice resist nutrient stress-induced CKD. The role of kidney AMPK in sex-related organ protection against nutrient stress and metabolite changes were evaluated in diabetic kidney tubule-specific AMPKγ2KO (KTAMPKγ2KO) male and female mice. In WT males, diabetes increased
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Mild autonomous cortisol secretion: pathophysiology, comorbidities and management approaches Nat. Rev. Endocrinol. (IF 40.5) Pub Date : 2024-04-22 Alessandro Prete, Irina Bancos
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Anand Hardikar: a scientific nomad searching for the truth Lancet Diabetes Endocrinol. (IF 44.5) Pub Date : 2024-04-23 Susan Rahimi, Marta Koch
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Endpoints for clinical trials in type 1 diabetes drug development Lancet Diabetes Endocrinol. (IF 44.5) Pub Date : 2024-04-23 Alfonso Galderisi, Brynn E Marks, Linda A DiMeglio, Carine de Beaufort
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Food additive emulsifiers: a new risk factor for type 2 diabetes? Lancet Diabetes Endocrinol. (IF 44.5) Pub Date : 2024-04-23 Mengxi Du, Frank B Hu
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The Human Insulin Thermal Solution project—a private sector initiative to address the thermostability of insulin Lancet Diabetes Endocrinol. (IF 44.5) Pub Date : 2024-04-23 Mats Rasmussen, Morten Hach, Jørgen Iwersen, Gayathri Anil, Henrik Rosborg, Jens Larsen, Lise Camilla Hoffmann, Peter Kurtzhals
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Environmental chemical obesogens, what can we do? Lancet Diabetes Endocrinol. (IF 44.5) Pub Date : 2024-04-23 Tim Lobstein
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Food additive emulsifiers and the risk of type 2 diabetes: analysis of data from the NutriNet-Santé prospective cohort study Lancet Diabetes Endocrinol. (IF 44.5) Pub Date : 2024-04-23 Clara Salame PhD, Guillaume Javaux MSc, Laury Sellem PhD, Emilie Viennois PhD, Fabien Szabo de Edelenyi PhD, Cédric Agaësse RD, Alexandre De Sa RD, Inge Huybrechts PhD, Fabrice Pierre PhD, Prof Xavier Coumoul PhD, Prof Chantal Julia PhD, Emmanuelle Kesse-Guyot PhD, Benjamin Allès PhD, Léopold K Fezeu PhD, Prof Serge Hercberg PhD, Mélanie Deschasaux-Tanguy PhD, Prof Emmanuel Cosson MD, Sopio Tatulashvili
Experimental studies have suggested potential detrimental effects of emulsifiers on gut microbiota, inflammation, and metabolic perturbations. We aimed to investigate the associations between exposures to food additive emulsifiers and the risk of type 2 diabetes in a large prospective cohort of French adults. We analysed data from 104 139 adults enrolled in the French NutriNet-Santé prospective cohort
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Rethinking the label anti-obesity medication Lancet Diabetes Endocrinol. (IF 44.5) Pub Date : 2024-04-23 Stuart W Flint
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Vitamin D supplements and future fracture risk among Mongolian schoolchildren Lancet Diabetes Endocrinol. (IF 44.5) Pub Date : 2024-04-23 Ning Ma, Xia Cui, Wenquan Niu
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Vitamin D supplements and future fracture risk among Mongolian schoolchildren – Author's reply Lancet Diabetes Endocrinol. (IF 44.5) Pub Date : 2024-04-23 Adrian R Martineau, Polyna Khudyakov, Davaasambuu Ganmaa
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β-Cell Function, Incretin Effect, and Glucose Kinetics in Response to a Mixed Meal in Patients With Type 2 Diabetes Treated With Dapagliflozin Plus Saxagliptin Diabetes Care (IF 16.2) Pub Date : 2024-04-23 Giuseppe Daniele, Andrea Tura, Alex Brocchi, Alessandro Saba, Beatrice Campi, Veronica Sancho-Bornez, Angela Dardano, Stefano Del Prato
OBJECTIVE To explore the complementary effects of a combination of dipeptidyl peptidase 4 and sodium–glucose cotransporter 2 inhibitors added to metformin on hormonal and metabolic responses to meal ingestion. RESEARCH DESIGN AND METHODS Forty-five patients (age 58 ± 8 years; HbA1c 58 ± 6 mmol/mol; BMI 30.7 ± 3.2 kg/m2) with type 2 diabetes uncontrolled with metformin were evaluated at baseline and
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Erratum. Liraglutide and Exercise Synergistically Attenuate Vascular Inflammation and Enhance Metabolic Insulin Action in Early Diet-Induced Obesity. Diabetes 2023;72:918–931 Diabetes (IF 7.7) Pub Date : 2024-04-23 Jia Liu, Kevin W. Aylor, Zhenqi Liu
In the article cited above, Fig. 7G mistakenly featured the same images as Fig. 7E due to an error during manuscript preparation. The corresponding graphs and associated data interpretation were not affected, and the conclusions remain unchanged. The correct image for Fig. 7G appears below. The authors apologize for the error. The online version of the article (https://doi.org/10.2337/db22-0745) has
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Ten Years of Improving Glycemic Control in Pediatric Diabetes Care: Data From the Norwegian Childhood Diabetes Registry Diabetes Care (IF 16.2) Pub Date : 2024-04-22 Heiko Bratke, Eva Biringer, Anastasia Ushakova, Hanna D. Margeirsdottir, Siv Janne Kummernes, Pål R. Njølstad, Torild Skrivarhaug
OBJECTIVE To evaluate, from 2013 to 2022, how HbA1c, the incidence of acute complications, and use of diabetes technology changed at the national level in Norway and how glycemic control was associated with use of diabetes technology, carbohydrate counting, or participation in a quality improvement project. RESEARCH DESIGN AND METHODS This longitudinal observational study was based on 27,214 annual
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Non-adherence to cardiometabolic medication as assessed by LC-MS/MS in urine and its association with kidney and cardiovascular outcomes in type 2 diabetes mellitus Diabetol. (IF 8.2) Pub Date : 2024-04-22 Sara Denicolò, Vera Reinstadler, Felix Keller, Stefanie Thöni, Susanne Eder, Hiddo J. L. Heerspink, László Rosivall, Andrzej Wiecek, Patrick B. Mark, Paul Perco, Johannes Leierer, Andreas Kronbichler, Herbert Oberacher, Gert Mayer
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Earth Day: time for transformational change Lancet Diabetes Endocrinol. (IF 44.5) Pub Date : 2024-04-20 The Lancet Diabetes & Endocrinology
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Trends in Incidence of Hospitalization for Hypoglycemia and Diabetic Ketoacidosis in Individuals With Type 1 or Type 2 Diabetes With and Without Severe Mental Illness in Denmark From 1996 to 2020: A Nationwide Study Diabetes Care (IF 16.2) Pub Date : 2024-04-19 Stine H. Scheuer, Gregers S. Andersen, Bendix Carstensen, Lars Diaz, Vanja Kosjerina, Nanna Lindekilde, Sarah H. Wild, Caroline A. Jackson, Frans Pouwer, Michael E. Benros, Marit E. Jørgensen
OBJECTIVE To examine trends in incidence of acute diabetes complications in individuals with type 1 or type 2 diabetes with and without severe mental illness (SMI) in Denmark by age and calendar year. RESEARCH DESIGN AND METHODS We conducted a cohort study using nationwide registers from 1996 to 2020 to identify individuals with diabetes, ascertain SMI status (namely, schizophrenia, bipolar disorder
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Early-Onset Type 2 Diabetes and Tirzepatide Treatment: A Post Hoc Analysis From the SURPASS Clinical Trial Program Diabetes Care (IF 16.2) Pub Date : 2024-04-19 Philip Zeitler, Rodolfo J. Galindo, Melanie J. Davies, Brandon K. Bergman, Vivian T. Thieu, Claudia Nicolay, Sheryl Allen, Robert J. Heine, Clare J. Lee
OBJECTIVE We evaluated baseline characteristics of participants with early-onset type 2 diabetes (T2D) from the SURPASS program and tirzepatide’s effects on glycemic control, body weight (BW), and cardiometabolic markers. RESEARCH DESIGN AND METHODS This post hoc analysis compared baseline characteristics and changes in mean HbA1c, BW, waist circumference (WC), lipids, and blood pressure (BP) in 3
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Continuous glucose monitoring with structured education in adults with type 2 diabetes managed by multiple daily insulin injections: a multicentre randomised controlled trial Diabetol. (IF 8.2) Pub Date : 2024-04-19 Ji Yoon Kim, Sang-Man Jin, Kang Hee Sim, Bo-Yeon Kim, Jae Hyoung Cho, Jun Sung Moon, Soo Lim, Eun Seok Kang, Cheol-Young Park, Sin Gon Kim, Jae Hyeon Kim
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The Expanding Problem of Regional Adiposity: Revisiting a 1985 Diabetes Classic by Ohlson et al. Diabetes (IF 7.7) Pub Date : 2024-04-19 Olga T. Gupta, Rana K. Gupta
Body fat distribution is a predictor of metabolic health in obesity. In this Classics in Diabetes article, we revisit a 1985 Diabetes article by Swedish investigators Ohlson et al. This work was one of the first prospective population-based studies that established a relationship between abdominal adiposity and the risk for developing diabetes. Here, we discuss evolving concepts regarding the link